Metabolic Dysregulation Induced inPlasmodium falciparumby Dihydroartemisinin and Other Front-Line Antimalarial Drugs

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle

(2015) Hangjun Ke et al.   Cell Reports

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

(2014) A. K. Lukens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical signatures and new drug targets for gametocytocidal drug development

(2014) Wei Sun et al.   Scientific Reports

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin Catabolism

(2014) Ian A. Lewis et al.   PLoS Genetics

Benznidazole Biotransformation and Multiple Targets in Trypanosoma cruzi Revealed by Metabolomics

(2014) Andrea Trochine et al.   PLoS Neglected Tropical Diseases

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

(2013) Thomas Antoine et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Kinetic Flux Profiling Elucidates Two Independent Acetyl-CoA Biosynthetic Pathways inPlasmodium falciparum

(2013) Simon A. Cobbold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Plasmodium PI(4)K to eliminate malaria

(2013) Case W. McNamara et al.   NATURE

The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases

(2013) Thomas Spangenberg et al.   PLoS One

Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins

(2013) K. K. Hanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin

(2013) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

(2012) Jill M. Combrinck et al.   ACS Chemical Biology

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

(2012) G. A. Biagini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Second Target of the Antimalarial and Antibacterial Agent Fosmidomycin Revealed by Cellular Metabolic Profiling

(2011) Baichen Zhang et al.   BIOCHEMISTRY

Isotopomer Profiling ofLeishmania mexicanaPromastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

(2011) Eleanor C. Saunders et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

(2011) S. Meister et al.   SCIENCE

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY

Mitochondrial Electron Transport Inhibition and Viability of Intraerythrocytic Plasmodium falciparum

(2010) H. J. Painter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Thousands of chemical starting points for antimalarial lead identification

(2010) Francisco-Javier Gamo et al.   NATURE

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Host-Parasite Interactions Revealed by Plasmodium falciparum Metabolomics

(2009) Kellen L. Olszewski et al.   Cell Host & Microbe

Co-inhibition ofPlasmodium falciparum S-Adenosylmethionine Decarboxylase/Ornithine Decarboxylase Reveals Perturbation-specific Compensatory Mechanisms by Transcriptome, Proteome, and Metabolome Analyses

(2008) Anna C. van Brummelen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

(2008) A. M. Lehane et al.   JOURNAL OF CELL SCIENCE

A domino effect in antifolate drug action in Escherichia coli

(2008) Yun Kyung Kwon et al.   Nature Chemical Biology

A Genetically Hard-Wired Metabolic Transcriptome in Plasmodium falciparum Fails to Mount Protective Responses to Lethal Antifolates

(2008) Karthikeyan Ganesan et al.   PLoS Pathogens