Article
Environmental Sciences
Lixin Yang, Yinping Liu, Ze Cui, Yongmao Zhang, Jianbo Zhang, Kaoqi Lian
Summary: This study used a metabolomics approach to investigate the toxicity of SCCPs in rats, finding that high-dose SCCP exposure resulted in liver and kidney injury, affecting pathways related to energy metabolism, amino acid metabolism, glycerophospholipid metabolism, nucleotide metabolism, and vitamin B metabolism. Fluctuating levels of phospholipids and nucleotides may contribute to the neurotoxicity of SCCPs, while down regulation of folic acid induced by SCCPs may lead to malformations during early development in laboratory animals.
ENVIRONMENTAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Kun Chang, Peng Gao, Ying-Yuan Lu, Peng-Fei Tu, Yong Jiang, Xiao-Yu Guo
Summary: This study comprehensively analyzed the quinoline alkaloids in the root bark of Dictamnus dasycarpus, identifying a total of 73 quinoline alkaloids, including substances newly discovered in the plant. A total of 98 BXP-related constituents were detected in rat plasma, urine and feces, revealing their metabolic pathways. This integrated strategy provides valuable insights for further research on the pharmacological effects and potential toxic substances of BXP.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Mengting Liu, Zhiqin Liu, Zhuang Dong, Xianglin Zou, Jianguo Zeng, Zihui Yang
Summary: This study investigated the metabolites of sanguinarine (SAN) in rats. Using UPLC-Q-TOF-MS/MS technology, 12 metabolites were identified, and their metabolic pathways were inferred. This research is important for further understanding the metabolic mechanism of SAN in vivo and in vitro.
Article
Chemistry, Applied
Xi Juan Zhao, Peng Mei Guo, Wen Hui Pang, Tao Tan, Yao Hai Zhang, Bi Ning Jiao
Summary: This study investigated the secondary metabolites of Jindou kumquat and identified the dominant characteristic metabolites. The findings provide a basis for further evaluation and utilization of Fortunella germplasms.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Agriculture, Multidisciplinary
Huifang Zhao, Yang Liu, Yuqing Huang, Qiyu Liang, Shengguan Cai, Guoping Zhang
Summary: This study used ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry technology to investigate the temporal changes of metabolites during malting in different barley varieties and compare the metabolite profiles in kilned malt. The results showed that specific metabolic events occurred during steeping, with Franklin barley variety showing earlier and greater changes. Additionally, there were differences in metabolite composition between malt barley and non-malt barley in the kilned malt samples.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Integrative & Complementary Medicine
Zhe Li, Lkhaasuren Ryenchindorj, Bonan Liu, Ji Shi, Chao Zhang, Yue Hua, Pengpeng Liu, Guoshun Shan, Tianzhu Jia
Summary: The processing of Chinese materia medica can significantly alter the composition of active compounds, such as phenylethanoid glycosides and iridoids. In vivo studies showed that processing affects the disposition of these compounds in the body, with phase II metabolic processes playing a key role. This research provides valuable insights into the impact of processing on the efficacy of medicinal plants.
Article
Clinical Neurology
Yan Kong, Yu-Qing Feng, Ya-Ting Lu, Shi-Sui Feng, Zheng Huang, Qian-Yi Wang, Hui-Min Huang, Xue Ling, Zhi-Heng Su, Yue Guo
Summary: The study identified potential biomarkers and metabolic pathways of cerebral infarction using a serum metabonomics method, showing high specificity and sensitivity for the diagnosis of cerebral infarction. The findings suggest that metabonomics can be a useful approach for understanding the pathophysiology of stroke and developing clinical biomarkers.
NEUROLOGICAL RESEARCH
(2022)
Article
Chemistry, Applied
E. Sun, Xuan Li, Fengjuan Xu, Mingyu Li, Ke Ding, Ling Wang, Yingjie Wei, Xiaobin Jia
Summary: In this study, an ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS) was used to analyze the metabolites of Sagittatoside B in rats. A total of 17 metabolites were detected or tentatively identified from rat plasma, bile, urine, and feces. The major metabolic pathways of Sagittatoside B in rats involved hydrolysis, hydrogenation, hydroxylation, dehydrogenation, demethylation, decarbonylation, and conjugation with glucuronic acid and different sugars. This research provides valuable insights into the metabolism of Sagittatoside B and serves as a reference for the metabolism of active flavonoid compounds.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agriculture, Multidisciplinary
Mingjin Li, Yunzhi Zhang, Jiawei Yan, Fengjiao Ding, Chunmei Chen, Sitong Zhong, Minxuan Li, Yanyu Zhu, Panpan Yue, Pengchun Li, Shijun You, Shan Jin
Summary: Beauty tea was made from fresh leaves of Camellia sinensis Jinxuan cultivar, which were punctured by tea green leafhoppers to different extents. The study identified differential metabolites related to tea polyphenols, lipids, and saccharides in the fresh leaves and dry beauty tea. The quality of beauty tea was influenced by the levels of leafhopper puncturing through the presence of specific characteristic volatiles.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xiuyun Li, Chenglun Zhang, Enhui Wu, Liang Han, Xiangliang Deng, Zhongfeng Shi
Summary: This study aimed to investigate the effects and mechanisms of action of Osthole (OST) in breast cancer 4T1 cells. The results showed that OST inhibited cell proliferation, blocked cells from remaining in S-phase, and induced apoptosis. OST mainly affected phospholipid biosynthesis, methyl histidine metabolism, pyrimidine metabolism, and beta-oxidation of very long-chain fatty acid pathways in 4T1 cells, possibly via inhibition of mTOR/SREBP1/FASN signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Su Guan, Kun Liu, Zimeng Liu, Liping Zhou, Bingjie Jia, Zichen Wang, Yao Nie, Xuyu Zhang
Summary: This study identified potential metabolic biomarkers to improve the diagnostic accuracy of sepsis, through metabolomic profiling and regression analysis. A model incorporating ten metabolic biomarkers and traditional physiological indicators showed better differentiation for sepsis diagnosis. The study suggests metabolomic profiling could be an effective tool for sepsis diagnosis.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Chemistry, Analytical
Yuefei Wang, Xia Gao, Jiajia Wang, Ming Tang, Boyang Yu, Zhenzhong Wang, Liang Cao, Xialin Chen, Mengyu Qian, Shanli Wang, Wei Xiao
Summary: This study used UPLC-Q-TOF/MS to analyze the main components and their metabolites of Sinomenium acutum stem in rats. The study identified 41 compounds, including 25 prototype components and 107 metabolites. The metabolic pathways involved hydroxylation, demethylation, dehydrogenation, glucuronidation, and acetylation. This study provides important insights into the metabolism of Sinomenium acutum stem and its pharmacological mechanism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Article
Medical Laboratory Technology
Zheng Zhong, Yukai Huang, Qidang Huang, Shaoling Zheng, Zhixiang Huang, Weiming Deng, Tianwang Li
Summary: This study investigated the serum metabolic profiling of gout patients compared to healthy controls using UPLC-Q-TOF/MS, revealing significant differences in metabolites between the two groups. Bilirubin was identified as a potential biomarker for gout, and primary bile acid biosynthesis was suggested as a novel metabolic pathway.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemical Research Methods
Hong Huang, Chuanming Fang, Hongxia Niu, Xiangjun Yin, Jiazhao Ruan, Mengying Wei, Yuan Zhou
Summary: Metabolic profiling was used to investigate changes in plasma and urine metabolites following Aβ injection and donepezil treatment in rats. Donepezil improved cognitive impairment induced by Aβ through restoring metabolic disorders. This study provides basic data for understanding the effects of Aβ and donepezil on plasma and urine metabolites in rat models of AD.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)