The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

An acyltransferase domain of FK506 polyketide synthase recognizing both an acyl carrier protein and coenzyme A as acyl donors to transfer allylmalonyl and ethylmalonyl units

(2015) Hui Jiang et al.   FEBS Journal

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

(2015) Tilmann Weber et al.   TRENDS IN BIOTECHNOLOGY

A non-immunosuppressive FK506 analogue with neuroregenerative activity produced from a genetically engineered Streptomyces strain

(2015) Pramod B. Shinde et al.   RSC Advances

Roles of type II thioesterases and their application for secondary metabolite yield improvement

(2014) Magdalena Kotowska et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Mutational biosynthesis of tacrolimus analogues by fkbO deletion mutant of Streptomyces sp. KCTC 11604BP

(2013) Dong Hwan Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

(2013) Kyu-Sang Hwang et al.   BIOTECHNOLOGY ADVANCES

Enhanced FK506 production inStreptomyces tsukubaensisby rational feeding strategies based on comparative metabolic profiling analysis

(2013) Menglei Xia et al.   BIOTECHNOLOGY AND BIOENGINEERING

Steps towards the synthetic biology of polyketide biosynthesis

(2013) Matthew Cummings et al.   FEMS MICROBIOLOGY LETTERS

FK506 Maturation Involves a Cytochrome P450 Protein-Catalyzed Four-Electron C-9 Oxidation in Parallel with a C-31 O-Methylation

(2013) D. Chen et al.   JOURNAL OF BACTERIOLOGY

Enhancement of FK506 production by engineering secondary pathways of Streptomyces tsukubaensis and exogenous feeding strategies

(2013) Di Huang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Characterization of FK506 Biosynthetic Intermediates Involved in Post-PKS Elaboration

(2013) Yeon Hee Ban et al.   JOURNAL OF NATURAL PRODUCTS

Nerve Repair by Means of Tubulization: Past, Present, Future

(2013) P. Konofaos et al.   JOURNAL OF RECONSTRUCTIVE MICROSURGERY

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

(2013) B. J. Dunn et al.   Journal of the Royal Society Interface

Genome-scale metabolic network guided engineering of Streptomyces tsukubaensis for FK506 production improvement

(2013) Di Huang et al.   Microbial Cell Factories

Roles offkbNin Positive Regulation andtcs7in Negative Regulation of FK506 Biosynthesis in Streptomyces sp. Strain KCTC 11604BP

(2012) SangJoon Mo et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of FK506 Production in Streptomyces tsukubaensis by Genetic Enhancement of the Supply of Unusual Polyketide Extender Units via Utilization of Two Distinct Site-Specific Recombination Systems

(2012) Dandan Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer ‘Streptomyces tsukubaensis’

(2012) Miriam Martínez-Castro et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Application of a combined approach involving classical random mutagenesis and metabolic engineering to enhance FK506 production in Streptomyces sp. RM7011

(2012) SangJoon Mo et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

(2012) Dušan Goranovič et al.   BMC MICROBIOLOGY

Enhancement of tacrolimus productivity in Streptomyces tsukubaensis by the use of novel precursors for biosynthesis

(2012) Jadwiga Turło et al.   ENZYME AND MICROBIAL TECHNOLOGY

Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit

(2012) Yeon Hee Ban et al.   Molecular BioSystems

Novel FK506 and FK520 analogues via mutasynthesis: mutasynthon scope and product characteristics

(2012) Steven J. Moss et al.   MedChemComm

Designed Biosynthesis of 36-Methyl-FK506 by Polyketide Precursor Pathway Engineering

(2012) Anna Lechner et al.   ACS Synthetic Biology

Novel chemobiosynthetic approach for exclusive production of FK506

(2011) Gregor Kosec et al.   METABOLIC ENGINEERING

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces

(2010) Juan-Francisco Martín et al.   CURRENT OPINION IN MICROBIOLOGY

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strain development of Streptomyces sp. for tacrolimus production using sequential adaptation

(2009) Sangwon Jung et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Regulation of tacrolimus production by altering primary source of carbons and amino acids

(2009) B.P. Singh et al.   LETTERS IN APPLIED MICROBIOLOGY

Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants

(2008) Germán Sierra-Paredes et al.   CNS Neuroscience & Therapeutics

Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering

(2008) Carlos Olano et al.   METABOLIC ENGINEERING

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS