期刊
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
卷 43, 期 2-3, 页码 371-387出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10295-015-1704-8
关键词
Combinatorial biosynthesis; Synthetic biology; Enzyme engineering; Polyketide synthases; Non-ribosomal peptide synthases
资金
- National Science Foundation [CHE-1151299]
- NIH [1R01GM104258-01]
Many therapeutically relevant natural products are biosynthesized by the action of giant mega -enzyme assembly lines. By leveraging the specificity, promiscuity, and modularity of assembly lines, a variety of strategies has been developed that enables the biosynthesis of modified natural products. This review briefly summarizes recent structural advances related to natural product assembly lines, discusses chemical approaches to probing assembly line structures in the absence of traditional biophysical data, and surveys efforts that harness the inherent or engineered promiscuity of assembly lines for the synthesis of non-natural polyketides and non -ribosomal peptide analogues.
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