Article
Immunology
Joseph R. Podojil, Andrew C. Cogswell, Ming-Yi Chiang, Valerie Eaton, Igal Ifergan, Tobias Neef, Dan Xu, Khyati A. Meghani, Yanni Yu, Sophia M. Orbach, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Lonnie D. Shea, Joshua J. Meeks, Stephen D. Miller
Summary: This study found that the use of ONP-302 can control tumors by reprogramming myeloid cells through the activation of the STING/IL-15/NK cell mechanism, and enhance the efficacy of anti-PD-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Margaret Hallisey, Jenna Dennis, Elizabeth P. Gabriel, Alyssa Masciarelli, Jiajia Chen, Charlotte Abrecht, Martha Brainard, William M. Marcotte, Han Dong, Emma Hathaway, Mubin Tarannum, Juliana A. Vergara, Abigail N. Schork, Kevin Tyan, Giuseppe Tarantino, David Liu, Rizwan Romee, Osama E. Rahma, Mariano Severgnini, Stephen Hodi, Joanna Baginska
Summary: We developed a comprehensive method using mass cytometry to assess functional changes in immune populations and killing activity of peripheral blood mononuclear cells after cocultures with cancer cells. A 43-marker mass cytometry panel was applied to cocultures of immune cells from healthy donors with different cancer cell lines. This method enables discrimination of cancer cells from immune populations without specific cancer cell markers and simultaneous evaluation of phenotypical changes in both populations.
LABORATORY INVESTIGATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shiyi Li, Li Su, Qingxian Luan, Guojing Liu, Wenmin Zeng, Xiaoqian Yu
Summary: This study investigated the role of IL-35-induced Bregs in periodontitis. The results showed that IL-35 could expand CD1d(hi)CD5(+) B10 cells and increase the production of IL-10 and IL-35. Administration of IL-35 also reduced alveolar bone loss and inhibited inflammatory responses.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Multidisciplinary Sciences
Shushu Zhao, Shuting Wu, Sheng Jiang, Xiaoyu Zhou, Gan Zhao, Bin Wang
Summary: Most cancer immunotherapy approaches focus on stimulating CD8(+) T cells to reject tumor cells. However, the suppressive micro-environment created by regulatory T cells (Tregs) has limited the success of preclinical approaches in clinical settings. A recent study showed that transient interruption of Tregs induced CD8(+) T cell responses against tumors in an animal model. The study also demonstrated that transient Treg depletion during primary tumor challenge can result in long-lasting protection and activation of skin-resident memory T cells (sT(RM)) for rejecting rechallenged tumors.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Jana-Julia Siegler, Margareta P. Correia, Tomas Hofman, Isabel Prager, Emrullah Birgin, Nuh N. Rahbari, Carsten Watzl, Ana Stojanovic, Adelheid Cerwenka
Summary: ILC3s are cytokine-producing lymphocytes that directly respond to tumor cells, leading to enhanced IFN-gamma release and TRAIL-dependent cytotoxicity against cancer cells. This suggests that ILC3s may play a role in anti-tumor immunity and could be further utilized for cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yulin Wang, Fabian De Labastida Rivera, Chelsea L. Edwards, Teija C. M. Frame, Jessica A. Engel, Luzia Bukali, Jinrui Na, Susanna S. Ng, Dillon Corvino, Marcela Montes de Oca, Patrick T. Bunn, Megan S. F. Soon, Dean Andrew, Jessica R. Loughland, Jia Zhang, Fiona H. Amante, Bridget E. Barber, James S. Mccarthy, J. Alejandro Lopez, Michelle J. Boyle, Christian R. Engwerda
Summary: The development of highly effective malaria vaccines and improvement of drug-treatment protocols are important for malaria elimination. However, the establishment of parasite-specific immune regulatory networks hinder these efforts. This study identified STING as a critical mediator of type I interferon production by CD4+ T cells during malaria infection, leading to the development of specific CD4+ T cells.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Multidisciplinary
Weiwei Wang, Jing Zhao, Changlong Hao, Shudong Hu, Chen Chen, Yi Cao, Zhengyu Xu, Jun Guo, Liguang Xu, Maozhong Sun, Chuanlai Xu, Hua Kuang
Summary: This study discovers the potential of chiral nanomaterials as immunoadjuvants for the prevention and treatment of cancer. Chiral nanoparticles enhance immune response and inhibit tumor growth through the stimulation of specific cell types, showing better therapeutic effects compared to achiral nanoparticles.
ADVANCED MATERIALS
(2022)
Article
Immunology
Maulik Vyas, Marta Requesens, Thao H. Nguyen, Domitille Peigney, Marjan Azin, Shadmehr Demehri
Summary: Despite advances in cancer treatment, metastatic spread of malignant cells remains a major cause of cancer-related deaths. Natural killer (NK) cells and T cells play cooperative roles in the surveillance and control of melanoma metastasis. NK cells limit the seeding of melanoma cells in the lungs, while T cells restrict the growth of metastatic foci. The liver is a prominent site where NK cells clear melanoma cells to regulate their seeding in the lungs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Norberto W. Zwirner, Carolina I. Domaica, Mercedes B. Fuertes
Summary: NK cells can kill target cells through perforin-dependent mechanisms or apoptosis, and secrete cytokines important for immunomodulation. In addition to their role in tumor and virus-infected cell immunity, NK cells have been implicated in regulating T cell responses in autoimmunity, transplantation, and viral infection models.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Yuhan Sun, Alexander James Sedgwick, Md Abdullah-Al-Kamran Khan, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow
Summary: The activation of NK cell function in bladder cancer is regulated by cytokines and secreted factors. IL-2-expanded NK cell phenotype is associated with improved prognosis, while PDGF-DD-activated NK cell phenotype is associated with poor prognosis. High expression of activating NK cell receptors correlates with IL-2-expanded NK cell phenotype and improved prognosis in bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bingqing Zheng, Yating Yu, Zhaoyi Pan, Yujie Feng, Huajun Zhao, Qiuju Han, Jian Zhang
Summary: NK cells play crucial roles in defending against HBV infection. However, dysfunction of NK cells in chronic hepatitis B virus infection is associated with decreased levels of STING adaptor. HBsAg inhibits STING expression in NK cells through the STAT3-STING axis, disrupting NK cell function in HBeAg-negative chronic HBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Motoki Horii, Takashi Matsushita
Summary: B cells play critical roles in autoimmune diseases and tumor immunity by regulating immune responses through mechanisms beyond antibody production. Regulatory B cells negatively regulate immune responses by producing anti-inflammatory cytokines, emphasizing the balance between effector and regulatory B cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Je-Jung Lee, So Young Kim, Songhee H. Kim, Seoyeon Choi, Bin Lee, Jeon-Soo Shin
Summary: In this study, the role of PD-L1 in cancer progression and its regulation of cancer prevention were investigated. It was found that PD-L1 depletion induced senescence in cancer cells by strongly inducing STING expression. Nuclear PD-L1 silencing increased STING promoter activity, indicating a negative regulation of STING expression by PD-L1 through transcriptional modulation. Furthermore, PD-L1 was shown to bind to the STING promoter region, directly controlling STING expression to promote cancer growth. Combining PD-L1 silencing with the senescence-inducing chemotherapeutic agent doxorubicin further enhanced the efficacy of PD-L1 targeting.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Yanyan Da, Yuxia Liu, Yuan Hu, Wenzeng Liu, Junpeng Ma, Nan Lu, Chengsheng Zhang, Cai Zhang
Summary: STING agonist cGAMP can directly activate NK cells and enhance their cytotoxicity against pancreatic cancer cells. Combination with cGAMP also demonstrates stronger antitumor efficacy.
Article
Multidisciplinary Sciences
Minseon Lee, Dongjoo Kim, Soonjo Kwon
Summary: In this study, a hypergravity exposure system was used to enhance breast cancer cell responsiveness to natural killer cells for immunotherapy. The hypergravity treatment led to cytoskeletal changes and increased cytotoxicity of breast cancer cells, potentially improving efficiency of cell-based immunotherapies.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Katherine C. Barnett, Yuying Xie, Takanori Asakura, Dingka Song, Kaixin Liang, Sharon A. Taft-Benz, Haitao Guo, Shuangshuang Yang, Kenichi Okuda, Rodney C. Gilmore, Jennifer F. Loome, Thomas H. Oguin III, Gregory D. Sempowski, Scott H. Randell, Mark T. Heise, Yu Leo Lei, Richard C. Boucher, Jenny P. -Y. Ting
Summary: Elevated levels of cytokines IL-1(3 and IL-6 are associated with severe COVID-19. Investigating the underlying mechanisms, it was found that primary human airway epithelia (HAE) are not the source of IL-1(3 released upon SARS-CoV-2 infection. The SARS-CoV-2 E protein upregulates inflammasome gene transcription via TLR2 in leukocytes, while infected HAE supply a second signal, including genomic and mitochondrial DNA, to stimulate leukocyte IL-1(3 release.
CELL HOST & MICROBE
(2023)
Article
Agriculture, Dairy & Animal Science
Dingka Song, Xuebai He, Yiming Chi, Zhao Zhang, Jing Shuai, Hui Wang, Qiuming Li, Mengze Du
Summary: This study investigated the prevalence and drug resistance of Salmonella in captive reptiles in the Beijing area. The results showed that captive reptiles had a high prevalence of drug-resistant Salmonella strains and exhibited toxicity to human colon cells. These findings highlight the potential threat of zoonotic salmonellosis from pet reptiles in Beijing, China.
Article
Hematology
Kelly S. Olsen, Othmane Jadi, Sarah Dexheimer, Dante S. Bortone, Steven P. Vensko, Sarah Bennett, Hancong Tang, Marisa Diiorio, Tanvi Saran, David Dingfelder, Qianqian Zhu, Yiwen Wang, Christopher A. Haiman, Loreall Pooler, Xin Sheng, Amy Webb, Marcelo C. Pasquini, Philip L. McCarthy, Stephen R. Spellman, Eric Weimer, Theresa Hahn, Lara Sucheston-Campbell, Paul M. Armistead, Benjamin G. Vincent
Summary: T-cell responses to minor histocompatibility antigens (mHAs) play a role in graft-versus-leukemia (GVL) effects and graft-versus-host disease (GVHD) in allogeneic hematopoietic cell transplantation. This study discovered a large set of novel GVL mHAs based on predicted immunogenicity, tissue expression, and sharing among donor-recipient pairs. The identification of shared mHAs shows promise for expanding mHA-targeting immunotherapeutics.
Article
Multidisciplinary Sciences
Maryamsadat Seyedsadr, Yan Wang, Manal Elzoheiry, Sowmya Shree Gopal, Soohwa Jang, Gayel Duran, Inna Chervoneva, Ezgi Kasimoglou, John A. Wrobel, Daniel Hwang, James Garifallou, Xin Zhang, Tabish H. Khan, Ulrike Lorenz, Maureen Su, Jenny P. Ting, Bieke Broux, Abdolmohamad Rostami, Dhanashri Miskin, Silva Markovic-Plese
Summary: The objective of this study is to investigate the mechanisms of inflammatory cell migration to the CNS induced by IL-11. It was found that myeloid cells have the highest frequency of IL-11 production among PBMC subsets. Patients with RRMS have an increased frequency of IL-11+ monocytes, IL-11+ and IL-11R+ CD4+ lymphocytes, and IL-11R+ neutrophils compared to healthy controls. IL-11+ monocytes, CD4+ lymphocytes, and neutrophils accumulate in the CSF. IL-11/IL-11R signaling in monocytes represents a therapeutic target in RRMS.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Nutrition & Dietetics
Dingka Song, Xiuli Wang, Yongjing Ma, Ning-Ning Liu, Hui Wang
Summary: Colorectal cancer (CRC) is a prevalent and life-threatening cancer type with limited therapeutic options. Dysbiosis of gut microbiota contributes to its development, while the beneficial role of microorganism derived substances called postbiotics in CRC has been uncovered. However, the molecular identity, mechanism of action, and routes of administration of postbiotics, particularly their role in CRC, are still lacking. This review outlines the current research on the beneficial effects of gut microbiota derived postbiotics against CRC, which will pave the way for future precision-medicine approaches in developing novel therapeutic strategies.
FRONTIERS IN NUTRITION
(2023)
Review
Oncology
Yibing Wei, Dingka Song, Ran Wang, Tingting Li, Hui Wang, Xiaoguang Li
Summary: Immunotherapies have emerged as a new strategy in treating cancers, but their effectiveness is limited by low efficiency and side effects. Manipulation of gut microbiota through implantation or antibiotics has been evaluated as a way to enhance cancer immunotherapies. The role of dietary fungal supplementation in modulation of gut microbiota and promoting cancer immunotherapies remains unclear.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
An-Jun Wang, Dingka Song, Yue-Mei Hong, Ning-Ning Liu
Summary: Colorectal cancer (CRC) is a complex disease influenced by both genetic and environmental factors, including the gut microbiota. Understanding the molecular mechanisms of the gut microbiota-host interaction can contribute to the understanding and management of CRC. However, deciphering the effects of genetic variants and their interactions with the gut microbiota is challenging. Multi-omics approaches, such as metagenomics combined with metabolomics and genomics, are still in the early stages and can provide valuable insights for the prevention, diagnosis, and treatment of CRC.
Article
Cell Biology
Bhalchandra Mirlekar, Yan Wang, Sirui Li, Mi Zhou, Sarah Entwistle, Tristan De Buysscher, Ashley Morrison, Gabriela Herrera, Cameron Harris, Benjamin G. Vincent, Jenny P. -Y. Ting, Naim Rashid, William Y. Kim, Jen Jen Yeh, Yuliya Pylayeva-Gupta
Summary: The dysregulation of B cells in patients and tumor-bearing mice often leads to the failure of anti-tumor immune responses. By targeting the signaling network in B cells, the differentiation of B cells into anti-tumor plasma cells can be restored, resulting in increased accumulation of effector T cells and plasma cells in tumors and making pancreatic tumors sensitive to immunotherapy.
CELL REPORTS MEDICINE
(2022)
Article
Biochemical Research Methods
Li Wang, John A. Wrobel, Ling Xie, Xian Chen
Summary: The study presents an alternative proteogenomic approach for identifying candidate prognostic markers in cancer cell lines and human breast cancer specimens, which involves the pull-down of protein complexes with intronic splicing enhancer probes followed by tandem mass spectrometry peptide sequencing. This method can help identify new prognostic markers for stratifying patients with poor prognosis.