The Quantity of Autocrine IL-2 Governs the Expansion Potential of CD8+T Cells

Recurrence of Melanoma Following T Cell Treatment: Continued Antigen Expression in a Tumor That Evades T Cell Recruitment

(2015) Trudy Straetemans et al.   MOLECULAR THERAPY

Plasticity in programming of effector and memory CD8+T-cell formation

(2015) Ramon Arens et al.   IMMUNOLOGICAL REVIEWS

Adoptive Immunotherapy for Cancer or Viruses

(2014) Marcela V. Maus et al.   Annual Review of Immunology

Serial Transfer of Single-Cell-Derived Immunocompetence Reveals Stemness of CD8+ Central Memory T Cells

(2014) Patricia Graef et al.   IMMUNITY

T Cell Factor 1 Represses CD8+Effector T Cell Formation and Function

(2014) Machteld M. Tiemessen et al.   JOURNAL OF IMMUNOLOGY

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

(2014) Stefani Spranger et al.   Journal for ImmunoTherapy of Cancer

The Stoichiometric Production of IL-2 and IFN-  mRNA Defines Memory T Cells That Can Self-Renew After Adoptive Transfer in Humans

(2012) A. Wang et al.   Science Translational Medicine

Differential B7–CD28 Costimulatory Requirements for Stable and Inflationary Mouse Cytomegalovirus-Specific Memory CD8 T Cell Populations

(2011) Ramon Arens et al.   JOURNAL OF IMMUNOLOGY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Autocrine IL-2 is required for secondary population expansion of CD8+ memory T cells

(2011) Sonia Feau et al.   NATURE IMMUNOLOGY

CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis

(2011) A. McNally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolonged Interleukin-2Rα Expression on Virus-Specific CD8+ T Cells Favors Terminal-Effector Differentiation In Vivo

(2010) Vandana Kalia et al.   IMMUNITY

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

(2010) Matthew E. Pipkin et al.   IMMUNITY

CD27 sustains survival of CTLs in virus-infected nonlymphoid tissue in mice by inducing autocrine IL-2 production

(2009) Victor Peperzak et al.   JOURNAL OF CLINICAL INVESTIGATION

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

(2008) Carolina Berger et al.   JOURNAL OF CLINICAL INVESTIGATION

CD8+ T cell efficacy in vaccination and disease

(2008) Victor Appay et al.   NATURE MEDICINE