Article
Oncology
Yi Fang, Min Chen, Guangfei Li, Yue Yang, Peijie He, Jian Chen, Lei Cheng, Haitao Wu
Summary: The characteristics of fibroblast cells in head and neck precancerous lesion and their ability to secrete inflammatory cytokines and affect CD8(+)T cell functions were investigated. Fibroblasts in vocal fold leukoplakia and cancer-associated fibroblasts in head and neck squamous cell carcinoma displayed similar cellular functions and robust inflammatory cytokine secretions. Fibroblasts from vocal fold leukoplakia induced apoptosis, depletion of CD8(+) T cells, and recruitment of regulatory T cells. An autocrine loop involving IL-6, TGF-beta, and the IL-6/JAK2/STAT3 pathway was observed in vocal fold leukoplakia fibroblasts. Inhibition of this pathway with a monoclonal antibody targeting IL-6R showed promising results in suppressing the progression of oral leukoplakia in vitro and in vivo.
Article
Microbiology
Arne L. Ten Hoeve, Laurence Braun, Matias E. Rodriguez, Gabriela C. Olivera, Alexandre Bougdour, Lucid Belmudes, Yohann Coute, Jeroen P. J. Saeij, Mohamed-Ali Hakimi, Antonio Barragan
Summary: This study reveals how the intracellular parasite Toxoplasma gondii exploits the chemotactic migration ability of macrophages, highlighting the migratory plasticity of differentiated cells in the mononuclear phagocyte system. The parasite effector GRA28 cooperates with host chromatin remodelers to drive the migration of parasitized macrophages. These findings provide insights into the mechanisms underlying the dissemination of T. gondii and the interaction between the parasite and host cells.
CELL HOST & MICROBE
(2022)
Article
Immunology
Joseph E. Rupert, Ashok Narasimhan, Daenique H. A. Jengelley, Yanlin Jiang, Jianguo Liu, Ernie Au, Libbie M. Silverman, George Sandusky, Andrea Bonetto, Sha Cao, Xiaoyu Lu, Thomas M. O'Connell, Yunlong Liu, Leonidas G. Koniaris, Teresa A. Zimmers
Summary: The study revealed that most patients with pancreatic adenocarcinoma suffer from cachexia, which is mainly due to tissue crosstalk mediated via IL-6 signaling affecting muscle and adipocytes, providing targetable mechanisms for cachexia treatment.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Parasitology
Leyllane Rafael Moreira, Ana Carla Silva, Cintia Nascimento da costa Olivera, Claudeir Dias da Silva, Amanda Vasconcelos Nascimento, Kamila Kassia dos Santos Oliveira, Ana Karine de Araujo Soares, Karina Lidianne Alcantara Saraiva, Milena de Paiva Cavalcanati, Virginia Maria Barros Delorena
Summary: This study evaluated the parasite load and immunomodulation caused by Benznidazole (BZ) treatment in adipocytes infected with T. cruzi.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)
Article
Immunology
Sara Dahou, Mohammed Chems-Eddine Smahi, Wafa Nouari, Zoheir Dahmani, Souheila Benmansour, Lamia Ysmail-Dahlouk, Maroua Miliani, Fadela Yebdri, Nassima Fakir, Mohammed Yassine Laoufi, Mouad Chaib-Draa, Amina Tourabi, Mourad Aribi
Summary: Vitamin C has immunomodulatory effects on human endothelial cells during S. aureus infection, promoting cell survival and function, preventing exacerbation of inflammatory response, and inducing bactericidal activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Juan Ji, Zhaoyu Bi, Ling Tian, Shufeng Hou, Qian Zhang, Song Li
Summary: The study aimed to investigate the effect and mechanism of Szechwan Lovage Rhizome extract on renal function and inflammatory responses in acute pyelonephritis rats infected with Escherichia coli. The results showed that the extract improved renal function and inhibited inflammatory responses by inhibiting the IL-6/STAT3 axis, suggesting it as a potential treatment option for acute pyelonephritis in the future.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Hematology
Yanling Xiao, Astrid G. S. van Halteren, Xin Lei, Jelske Borst, Eline Steenwijk, Tom de Wit, Joanna Grabowska, Rhianne Voogd, Paul Kemps, Jennifer Picarsic, Cor van den Bos, Jannie Borst
Article
Multidisciplinary Sciences
Eliza Mari Kwesi-Maliepaard, Muhammad Assad Aslam, Mir Farshid Alemdehy, Teun van den Brand, Chelsea McLean, Hanneke Vlaming, Tibor van Welsem, Tessy Korthout, Cesare Lancini, Sjoerd Hendriks, Tomasz Ahrends, Dieke van Dinther, Joke M. M. den Haan, Jannie Borst, Elzo de Wit, Fred van Leeuwen, Heinz Jacobs
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Oncology
Jesper van Eck van der Sluijs, Diede van Ens, Soley Thordardottir, Denise Vodegel, Inge Hermens, Anniek B. van der Waart, J. H. Frederik Falkenburg, Michel G. D. Kester, Iris de Rink, Mirjam H. M. Heemskerk, Jannie Borst, Nicolaas P. M. Schaap, Joop H. Jansen, Yanling Xiao, Harry Dolstra, Willemijn Hobo
Summary: Allogeneic stem cell transplantation followed by DC vaccination shows potential for hemato-oncology patients, but obtaining sufficient numbers of natural DCs, particularly cDC1s, remains a challenge. A culture protocol using donor-derived HPCs has been developed to address this issue.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Immunology
Xin Lei, Jara Palomero, Iris de Rink, Tom de Wit, Martijn van Baalen, Yanling Xiao, Jannie Borst
Summary: This study reveals that Flagellin can recruit circulating M phi/OC progenitors into infected tissues through the TLR5 axis, which then stimulates these progenitors to differentiate locally into M phi s. This novel finding suggests that this pathway may enhance host protection against bacterial infection at mucosal sites, in addition to monocyte recruitment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jannie Borst, Julia Busselaar, Douwe M. T. Bosma, Ferry Ossendorp
Summary: The article explains the importance of the PD-1 checkpoint in cancer treatment by outlining how it regulates the CD8(+) T cell response. It also discusses the role of PD-1 during T cell priming and emphasizes the importance of CD4(+) T cell help in optimizing CTL efficacy.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Cell Biology
Elisa Matas-Rico, Elselien Frijlink, Irene van der Haar Avila, Apostolos Menegakis, Maaike van Zon, Andrew J. Morris, Jan Koster, Fernando Salgado-Polo, Sander de Kivit, Telma Lanc, Antonio Mazzocca, Zoe Johnson, John Haanen, Ton N. Schumacher, Anastassis Perrakis, Inge Verbrugge, Joost H. van den Berg, Jannie Borst, Wouter H. Moolenaar
Summary: The study reveals that ATX secreted by melanoma cells repels tumor-infiltrating lymphocytes and circulating CD8(+) T cells, acting as a chaperone for LPA. Mechanistically, T cell repulsion is mainly involved G alpha(12/13)-coupled LPAR6, suppressing CD8(+) T cell infiltration and affecting tumor regression.
Article
Immunology
Mark Mensink, Thi Ngoc Minh Tran, Esther A. Zaal, Ellen Schrama, Celia R. Berkers, Jannie Borst, Sander de Kivit
Summary: CD4(+) T cells play a role in immune responses depending on the environment and stage, with nutrient availability also impacting their functionality. TNFR2 has been identified as key in regulating T cells, particularly Tregs. This study provides new evidence for the role of TNFR2 in metabolic regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Raquel S. Laureano, Jenny Sprooten, Isaure Vanmeerbeerk, Daniel M. Borras, Jannes Govaerts, Stefan Naulaerts, Zwi N. Berneman, Benoit Beuselinck, Kalijn F. Bol, Jannie Borst, An Coosemans, Angeliki Datsi, Jitka Faucikova, Lisa Kinget, Bart Neyns, Gerty Schreibelt, Evelien Smits, Rudiger Sorg, Radek Spisek, Kris Thielemans, Sandra Tuyaerts, Steven De Vleeschouwer, I. Jolanda M. de Vries, Yanling Xiao, Abhishek D. Garg
Summary: DC-based vaccination for cancer treatment has advanced significantly over recent decades, but still shows suboptimal anti-tumor efficacy in the clinic. Current efforts are focused on improving the immunogenicity and efficacy of DC vaccines in oncology.
Article
Oncology
Lars Guelen, Thierry O. Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Nikolina Babala, Jozef Wagenaars, Veronica Juan, David Rosen, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Judith Stammen-Vogelzangs, Ying Yu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Yiwei Zhang, Richard Wnek, Sean Troth, Elliot Chartash, Konstantin Dobrenkov, Svetlana Sadekova, Andrea van Elsas, Jason K. Cheung, Laurence Fayadat-Dilman, Jannie Borst, Amy M. Beebe, Hans Van Eenennaam
Summary: MK-5890, a novel CD27 agonistic antibody, has the potential to complement PD-1 checkpoint inhibition in cancer immunotherapy and is currently undergoing clinical evaluation.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Xin Lei, Indu Khatri, Tom de Wit, Iris de Rink, Marja Nieuwland, Ron Kerkhoven, Hans van Eenennaam, Chong Sun, Abhishek D. Garg, Jannie Borst, Yanling Xiao
Summary: Despite their low abundance, cDC1s play a crucial role in anti-cancer immunity and are positively associated with patient survival. This study demonstrates that contact with activated CD4(+) T-cells enables cDC1s to induce a CTL response. The transcriptomic signature of helped cDC1s correlates with tumor infiltration by CTLs, Thelper(h)-1 cells, and overall survival.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Mark Mensink, Ellen Schrama, Eloy Cuadrado, Derk Amsen, Sander de Kivit, Jannie Borst
Summary: This study finds that induced Treg cells in humans have distinct protein expression patterns compared to blood-derived inherent Treg and conventional T cells. While induced Treg cells share some signaling and metabolic proteins with inherent Treg cells, they are more similar to conventional T cells.
SCIENTIFIC REPORTS
(2022)