Article
Allergy
Tomoko Tajiri, Hisako Matsumoto, Makiko Jinnai, Yoshihiro Kanemitsu, Tadao Nagasaki, Toshiyuki Iwata, Hideki Inoue, Hitoshi Nakaji, Tsuyoshi Oguma, Isao Ito, Akio Niimi
Summary: This study investigated the levels of MUC5AC and MUC5B in the sputum of steroid-untreated mild asthmatic patients and healthy controls, and assessed their correlation with clinical indices. The results showed that the levels of MUC5AC and MUC5B were significantly higher in asthma patients and were associated with airway hyperresponsiveness and airway inflammation.
ALLERGOLOGY INTERNATIONAL
(2022)
Article
Respiratory System
F. Schleich, S. Graff, F. Guissard, M. Henket, V. Paulus, R. Louis
Summary: The study found that asthmatics older than 70 years old have more severe bronchial neutrophilic inflammation, poorer lung function, signs of air trapping, and lower airway variability. Older asthmatics have longer disease duration and a lower occurrence of the allergic component.
RESPIRATORY RESEARCH
(2021)
Article
Respiratory System
Simon Couillard, Rahul Shrimanker, Samuel Lemaire-Paquette, Gareth M. Hynes, Catherine Borg, Clare Connolly, Samantha Jane Thulborn, Angela Moran, Sarah Poole, Sophie Morgan, Timothy Powell, Ian Pavord, Timothy Hinks
Summary: By analyzing the changes in inflammatory mediators during a FeNO suppression test, it was found that FeNO non-suppression can be used to identify corticosteroid resistance.
Article
Critical Care Medicine
Ryan C. Murphy, Ying Lai, Matthew Liu, Taha Al-Shaikhly, Matthew C. Altman, William A. Altemeier, Charles W. Frevert, Jason S. Debley, Adrian M. Piliponsky, Steven F. Ziegler, Sina A. Gharib, Teal S. Hallstrand
Summary: This study identified differentially expressed genes associated with exercise-induced bronchoconstriction in individuals with asthma using RNA-sequencing analysis. Experiments suggested that the interactions between airway epithelial cells, mast cells, and eosinophils are closely associated with indirect airway hyperresponsiveness and play a critical role in modulating airway inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Allergy
Hajar Ali, Jeroen Douwes, Jeroen Burmanje, Prachee Gokhale, Julian Crane, Philip Pattemore, Thorsten Stanley, Jacqueline Keenan, Collin Brooks
Summary: This study found that neural and remodeling mechanisms may play a role in asthma, particularly noneosinophilic asthma. Sputum mediators associated with neural, remodeling, and inflammatory mechanisms were found in patients with asthma compared to those without asthma. Eosinophilic asthma had higher levels of inflammatory and remodeling mediators than noneosinophilic asthma.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luigino Calzetta, Marina Aiello, Annalisa Frizzelli, Giuseppina Bertorelli, Beatrice Ludovica Ritondo, Paola Rogliani, Alfredo Chetta
Summary: AHR is a central pathophysiological feature of asthma, involving ASM with pro-inflammatory and immunomodulatory actions. mAbs target various inflammatory mediators to modulate ASM contractility, showing potential in treating severe asthma by preventing AHR.
Review
Pharmacology & Pharmacy
Mojdeh Matloubi, Latifa Koussih, Lianyu Shan, Chelsea Lukawy, Abdelilah S. Gounni
Summary: Asthma is a heterogeneous airway disease characterized by airway inflammation and remodeling, affecting more than 300 million people worldwide and posing a significant burden on society. Semaphorin3E, a critical molecule in lung pathophysiology, plays a role in both lung development and homeostasis. Recent studies have demonstrated that the Semaphorin3E-plexinD1 axis is implicated in asthma, impacting inflammatory and structural cells associated with airway inflammation, tissue remodeling, and airway hyperresponsiveness. This review highlights the potential role of the Semaphorin3E-plexinD1 axis as a therapeutic target in airway allergic diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Luis M. Montano
Summary: Transient receptor potential (TRP) ion channels, particularly TRPV1, TRPV2, and TRPV4, play critical roles in the development of asthma. These channels contribute to environmental sensitization, airway inflammation, airway hyperresponsiveness, and remodeling, and may serve as novel therapeutic targets for asthma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Allergy
Morten Hvidtfeldt, Asger Sverrild, Alexis Pulga, Laurits Frossing, Alexander Silberbrandt, Morten Hostrup, Martin Thomassen, Caroline Sanden, Carl Magnus Clausson, Premkumar Siddhuraj, Daisy Bornesund, Juan Jose Nieto-Fontarigo, Lena Uller, Jonas Erjefalt, Celeste Porsbjerg
Summary: This study investigated the relationship between airway hyperresponsiveness and infiltrating mast cells, as well as the effectiveness of inhaled corticosteroid treatment. The results showed that inhaled corticosteroid treatment significantly improved airway hyperresponsiveness in both patients with high fractional exhaled nitric oxide (FENO) and patients with low FENO. However, there were differences in mast cell phenotypes and distribution between the two groups.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Cancan Zhang, Huisha Xu, Keilah G. Netto, Leon A. Sokulsky, Yiyan Miao, Zhongyuan Mo, Yan Meng, Yingying Du, Chengyong Wu, Liyou Han, Lirong Zhang, Chi Liu, Guojun Zhang, Fuguang Li, Ming Yang
Summary: In this study, the therapeutic potential of GGsTop, a γ-glutamyl transferase inhibitor, on acute asthma exacerbations was investigated using a murine model. The results showed that GGsTop significantly attenuated hallmark features of asthma exacerbation, including airway hyperresponsiveness, mucus hypersecretion, collagen deposition, and expression of inflammatory cytokines. Furthermore, GGsTop restored the level of glutathione and inhibited the activation of the LPS/NFκB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Amlan Chakraborty, Anita A. Pinar, Maggie Lam, Jane E. Bourke, Simon G. Royce, Cordelia Selomulya, Chrishan S. Samuel
Summary: This study conjugated relaxin to nanoparticles and delivered them intranasally to a preclinical rodent model of chronic allergic airways disease and collagen gel contraction from asthma patient-derived myofibroblasts, showing potential anti-remodeling and anti-inflammatory effects, which could be important for treating the central features of asthma.
Article
Physiology
Ryan C. Murphy, Ying Lai, James D. Nolin, Robier A. Aguillon Prada, Arindam Chakrabarti, Michael Novotny, Michael C. Seeds, William A. Altemeier, Michael H. Gelb, Robert Duncan Hite, Teal S. Hallstrand
Summary: Exercise challenge induces alterations in airway phospholipid structure and eicosanoid release in asthma, promoting bronchoconstriction, particularly in individuals with EIB who have higher basal levels of phospholipid turnover.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Respiratory System
Koralia Paschalaki, Christos Rossios, Charis Pericleous, Mairi MacLeod, Stephen Rothery, Gavin C. Donaldson, Jadwiga A. Wedzicha, Vassilis Gorgoulis, Anna M. Randi, Peter J. Barnes
Summary: Cellular senescence is accelerated in smokers and COPD patients. In COPD patients on inhaled corticosteroids, cellular senescence and DNA damage response are reduced. In vitro studies suggest that corticosteroids protect endothelial cells by reducing oxidative stress-induced senescence and apoptosis.
Article
Respiratory System
Thomas Bradbury, Gian Luca Di Tanna, Anish Scaria, Allison Martin, Fu-Qiang Wen, Nan-Shan Zhong, Jin-Ping Zheng, Peter J. Barnes, Bartolome Celli, Norbert Berend, Christine R. Jenkins
Summary: This study explores the effectiveness of low-dose theophylline and prednisone in COPD patients with elevated blood eosinophil counts. The results show that this combination treatment is associated with a significant increase in the annual moderate-severe exacerbation rate in these patients.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Review
Medicine, Research & Experimental
Peter J. Barnes, Jonathan Baker, Louise E. Donnelly
Summary: Autophagy is a cellular process that removes damaged molecules and organelles, and abnormalities in autophagy may contribute to the pathogenesis of chronic diseases like asthma and COPD. Autophagy can be either increased or decreased depending on the cell type and environment, making it challenging to target therapeutically. Some existing drugs can activate or inhibit autophagy, but more selective drugs are being developed.
Letter
Respiratory System
Sophia Havaki, Konstantinos Evangelou, Koralia Paschalaki, Russell Petty, Peter J. Barnes, Vassilis G. Gorgoulis
EUROPEAN RESPIRATORY JOURNAL
(2022)
Editorial Material
Pharmacology & Pharmacy
Peter J. Barnes
Summary: A recent study reveals the role of CCR1 in eosinophilic inflammation and the increased levels of its ligand CCL15 in asthmatic eosinophils. Another study demonstrates that N-truncated forms of CCL15 generated by tissue proteases induce biased CCR1 signaling. These findings may contribute to the development of more effective oral therapy for asthma by producing CCR antagonists.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Review
Allergy
Ian D. Pavord, Peter J. Barnes, Catherine Lemiere, Peter G. Gibson
Summary: Optimizing asthma diagnosis is crucial for reducing the burden of asthma globally. A compound diagnostic approach and label are now required due to the complexity and heterogeneity of different forms of asthma. By recognizing typical symptoms and abnormal physiology, asthma can be identified, and further features such as eosinophilic or type 2 inflammation can be used to give a compound diagnostic label of eosinophilic asthma, which provides important information about future exacerbation risk and treatment responsiveness. Implementing treatable traits and using targeted assessment allows for a specific treatment plan based on a pragmatic and iterative process. (c) 2022 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2023;11:1-8)
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Critical Care Medicine
Mario Cazzola, Paola Rogliani, Peter J. Barnes, Francesco Blasi, Bartolome Celli, Nicola A. Hanania, Fernando J. Martinez, Bruce E. Miller, Marc Miravitlles, Clive P. Page, Ruth Tal-Singer, Maria Gabriella Matera
Summary: This paper reviews the advances in chronic obstructive pulmonary disease research and highlights the need to update the original report. New measurement tools and evaluation methods are proposed to facilitate the development of personalized treatment and precision medicine.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Alvar Agusti, Bartolome R. Celli, Gerard J. Criner, David Halpin, Antonio Anzueto, Peter Barnes, Jean Bourbeau, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mortimer, Alberto Papi, Ian Pavord, Nicolas Roche, Sundeep Salvi, Don D. Sin, Dave Singh, Robert Stockley, Victorina Lopez Varela, Jadwiga A. Wedzicha, Claus F. Vogelmeier
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Article
Respiratory System
Don D. Sin, Dany Doiron, Alvar Agusti, Antonio Anzueto, Peter J. Barnes, Bartolome R. Celli, Gerard J. Criner, David Halpin, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Alberto Papi, Ian Pavord, Nicolas Roche, Dave Singh, Robert Stockley, Victorina Lopez Varlera, Jadwiga Wedzicha, Claus Vogelmeier, Jean Bourbeau, GOLD Sci Comm
Summary: Exposure to air pollution is a major contributor to COPD worldwide. Strong public health policies should be implemented to reduce ambient air pollution, accompanied by public warning systems and advisories to alert patients when air pollution levels exceed acceptable thresholds. Patients should consider using air cleaners and filters when household particulate content exceeds acceptable levels.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Respiratory System
Alvar Agusti, Bartolome R. Celli, Gerard J. Criner, David Halpin, Antonio Anzueto, Peter Barnes, Jean Bourbeau, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mortimer, Alberto Papi, Ian Pavord, Nicolas Roche, Sundeep Salvi, Don D. Sin, Dave Singh, Robert Stockley, M. Victorina Lopez Varela, Jadwiga A. Wedzicha, Claus F. Vogelmeier
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Suhana Ahmad, Norhayati Mohd Noor, E. A. R. Engku Nur Syafirah, Ahmad Adebayo Irekeola, Rafidah Hanim Shueb, Yean Yean Chan, Peter J. Barnes, Rohimah Mohamud
Summary: This study evaluated the efficacy and safety of anti-tumor necrosis factor (TNF) as a supplementary therapy for patients with severe asthma. The results showed that anti-TNF treatment improved asthma control, but there was limited evidence for improvement in lung function and reduction of asthma exacerbation. Therefore, prescribing anti-TNF in adults with severe asthma is unlikely.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2023)
Article
Biology
Vanessa Ho, Jonathan R. Baker, Keith R. Willison, Peter J. Barnes, Louise E. Donnelly, David R. Klug
Summary: An amplification-free sandwich hybridisation assay using a microfluidic platform is developed to detect single miRNA molecules in single cells. The absolute quantification of miRNAs at a single cell level is achieved and validated using real-time qPCR. The sensitivity of the assay is demonstrated by quantifying single miRNA molecules in nasal fluid, showing its potential utility in clinical studies.
COMMUNICATIONS BIOLOGY
(2023)
Review
Primary Health Care
Jennifer K. Quint, Amnon Ariel, Peter J. Barnes
Summary: Inhaled corticosteroids (ICS) are commonly used for asthma treatment, but their role in chronic obstructive pulmonary disease (COPD) is still a topic of debate. Recent trials have shown that ICS combined with dual bronchodilator therapy can significantly reduce exacerbations in COPD patients. However, the suggestion of a mortality benefit associated with ICS in these trials has been rejected. Observational evidence suggests that dual bronchodilation is associated with better outcomes than triple therapy in a broad population of COPD patients. It is recommended that ICS be reserved for patients with frequent or severe exacerbations and high blood eosinophils or those with concomitant asthma.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2023)
Letter
Biochemistry & Molecular Biology
Hugo C. J. Ombredane, Peter S. Fenwick, Peter J. Barnes, Mona Bafadhel, Kazuhiro Ito, Louise E. Donnelly, Jonathan R. Baker
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Meeting Abstract
Respiratory System
J. Devulder, J. R. Baker, L. Odqvist, L. E. Donnelly, P. J. Barnes
EUROPEAN RESPIRATORY JOURNAL
(2022)