Pulmonary myeloid cell uptake of biodegradable nanoparticles conjugated with an anti-fibrotic agent provides a novel strategy for treating chronic allergic airways disease

A Novel Approach for Non-Invasive Lung Imaging and Targeting Lung Immune Cells

(2020) Amlan Chakraborty et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis

(2020) Anita A. Pinar et al.   PHARMACOLOGY & THERAPEUTICS

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

(2020) Anita A. Pinar et al.   Frontiers in Pharmacology

iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared with a clinically used corticosteroid

(2019) Simon G. Royce et al.   FASEB JOURNAL

Epidemiology of Asthma in Children and Adults

(2019) Shyamali C. Dharmage et al.   Frontiers in Pediatrics

Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery

(2019) Amlan Chakraborty et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

(2019) Felipe Tapia Cáceres et al.   FASEB JOURNAL

Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases

(2018) Maggie Lam et al.   PHARMACOLOGY & THERAPEUTICS

Relaxin reverses inflammatory and immune signals in aged hearts

(2018) Brian Martin et al.   PLoS One

Insights into endotoxin-mediated lung inflammation and future treatment strategies

(2018) Amlan Chakraborty et al.   Expert Review of Respiratory Medicine

MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens

(2017) S Y Thomas et al.   Mucosal Immunology

Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling

(2017) Lei Chen et al.   Oncotarget

Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels

(2016) François Mazuel et al.   ACS Nano

Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma

(2016) Grégory Seumois et al.   JOURNAL OF IMMUNOLOGY

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

(2016) Mohammed Akhter Hossain et al.   Chemical Science

Investigating the cytotoxicity of iron oxide nanoparticles in in vivo and in vitro studies

(2015) Sarieh Ghasempour et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Monoclonal Antibody–Conjugated Superparamagnetic Iron Oxide Nanoparticles for Imaging of Epidermal Growth Factor Receptor–Targeted Cells and Gliomas

(2015) Ketao Mu et al.   Molecular Imaging

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

(2014) M Sarwar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intranasally administered serelaxin abrogates airway remodelling and attenuates airway hyperresponsiveness in allergic airways disease

(2014) S. G. Royce et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Medical nanoparticles for next generation drug delivery to the lungs

(2014) S. H. van Rijt et al.   EUROPEAN RESPIRATORY JOURNAL

Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease

(2014) Chrishan S. Samuel et al.   HYPERTENSION

Identification of Myeloid Cell Subsets in Murine Lungs Using Flow Cytometry

(2013) Rinat Zaynagetdinov et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis

(2013) Simon G. Royce et al.   PHARMACOLOGY & THERAPEUTICS

Relaxin Family Peptides and Their Receptors

(2013) R. A. D. Bathgate et al.   PHYSIOLOGICAL REVIEWS

Airway Hyperresponsiveness in Asthma: Mechanisms, Clinical Significance, and Treatment

(2012) John D. Brannan et al.   Frontiers in Physiology

Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease

(2011) Eliezer Masliah et al.   PLoS One

Collagen remodelling by airway smooth muscle is resistant to steroids and  2-agonists

(2010) J. E. Bourke et al.   EUROPEAN RESPIRATORY JOURNAL

Lipopolysaccharide inhibits macrophage phagocytosis of apoptotic neutrophils by regulating the production of tumour necrosis factor α and growth arrest-specific gene 6

(2010) Xueying Feng et al.   IMMUNOLOGY

Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging

(2009) Omid Veiseh et al.   ADVANCED DRUG DELIVERY REVIEWS

Relaxin Reverses Airway Remodeling and Airway Dysfunction in Allergic Airways Disease

(2009) Simon G. Royce et al.   ENDOCRINOLOGY

Deposition, Retention, and Translocation of Ultrafine Particles from the Central Airways and Lung Periphery

(2008) Winfried Möller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

(2008) Ishanee Mookerjee et al.   FASEB JOURNAL

The Airway Epithelium is Central to the Pathogenesis of Asthma

(2008) Stephen T. Holgate   ALLERGOLOGY INTERNATIONAL