Article
Chemistry, Physical
Rafael Hernandez-Tenorio, Aracely Hernandez-Ramirez, Monika Moeder, Jorge Luis Guzman-Mar
Summary: This study investigated the removal of oxcarbazepine from water through photolysis and heterogeneous photocatalysis processes, and monitored the formation of transformation products. The results showed that oxcarbazepine was completely degraded within 30 minutes using both methods.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Environmental Sciences
Soichiro Hirashima, Tomoko Amimoto, Yoko Iwamoto, Kazuhiko Takeda
Summary: Fipronil is a widely used insecticide, and its photodegradation products in aqueous systems can cause long-term contamination and should be taken seriously.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Xiaobin Xu, Qingyan Hu, Dingjiang Liu, Haibo Qiu, Mohammed Shameem, Ning Li
Summary: A LC-MS method was developed to analyze the composition of proteinaceous particles in therapeutic mAb drug products. This workflow provides a useful tool for studying particle formation mechanisms and monitoring the protein composition of particles during therapeutic mAb development.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Biochemical Research Methods
Ibraam E. Mikhail, Masoomeh Tehranirokh, Andrew A. Gooley, Rosanne M. Guijt, Michael C. Breadmore
Summary: This review summarizes various sample clean-up and analyte enrichment strategies that can be directly coupled with ESI-MS and nano-ESI-MS for the analysis of biological fluids, including solid phase extraction, solid phase micro-extraction, slug flow micro-extraction/nano-extraction, and more.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Review
Medical Laboratory Technology
Philippe Massonnet, Elodie Grifnee, Jordi Farre-Segura, Justine Demeuse, Loreen Huyghebaert, Thomas Dubrowski, Patrice Dufour, Matthieu Schoumacher, Stephanie Peeters, Caroline Le Goff, Etienne Cavalier
Summary: Immunocapture is a mature method for sample preparation in quantitation of peptides and proteins. This review provides an overview of clinical applications of immunocapture methods, including protocols with and without enzymatic digestion. The advantages and limitations of these approaches are discussed, along with challenges related to mass spectrometer selection. The potential of these techniques in proteomics-based clinical medicine is demonstrated, paving the way for personalized medicine.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Medical Laboratory Technology
Stephanie Rankin-Turner, Liam M. Heaney
Summary: Mass spectrometry (MS) has become a powerful and versatile tool in clinical laboratory, with advancements in biomarker detection, protein measurement, therapeutic drug monitoring, and automation leading to potential revolution in clinical testing.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Genetics & Heredity
Bhavesh S. Parmar, Marlies K. R. Peeters, Kurt Boonen, Ellie C. Clark, Geert Baggerman, Gerben Menschaert, Liesbet Temmerman
Summary: Transcriptome and ribosome sequencing have identified numerous non-canonical transcripts in C. elegans, leading to the discovery of a large number of non-canonical proteins and splice variants through tandem mass spectrometry. Diverse proteomic and peptidomic strategies have also helped in detecting additional novel non-canonical proteins, providing a valuable resource for further research.
FRONTIERS IN GENETICS
(2021)
Article
Biochemical Research Methods
Runmin Yang, Jingjing Ma, Shu Zhang, Yu Zheng, Lusheng Wang, Daming Zhu
Summary: This study introduces a new storage format called mzMD for MS datasets and presents an algorithm to query this format for summarizing a given data window. Experimental results demonstrate the high speed and stability of mzMD in retrieving high-quality data window summaries.
Article
Chemistry, Multidisciplinary
Hao Gu, Guoxin Dai, Siyu Liu, Yanbing Zhai, Qian Xu, Hongqiang Wu, Wei Xu
Summary: Liquid chromatography tandem mass spectrometry (LC-MS/MS) is an important analytical technique in clinical diagnostics. A compact LC-MS instrument was developed, consisting of an assembled liquid chromatograph and a miniature ion trap mass spectrometer. The use of LC improved the mixture analysis capability and detection sensitivity of the miniature mass spectrometer. This compact LC-MS instrument shows potential for clinical diagnosis.
CHINESE CHEMICAL LETTERS
(2023)
Article
Chemistry, Analytical
Veronica Termopoli, Viviana Consonni, Davide Ballabio, Roberto Todeschini, Marco Orlandi, Fabio Gosetti
Summary: This study investigated the photodegradation of the antidepressant escitalopram in water, considering the presence of nitrate and bicarbonate. Nitrate was found to significantly affect the degradation. Several transformation products were identified, and the degradation pathway and mechanism were proposed. The method was successfully applied to analyze surface water samples, and the toxicological profile and environmental behavior of the transformation products were computationally evaluated.
Article
Chemistry, Medicinal
Yuliia Orlova, Alessa A. Gambardella, Ivan Kryven, Katrien Keune, Piet D. Iedema
Summary: The autoxidation of triglyceride is a complex system involving numerous intermediate species and a complex network of reactions. A graph theory-based algorithm is used to automatically discover the chemical reaction network responsible for the complexity of mass spectra, which is then applied to match experimental mass spectra with computationally predicted molecular graphs. This methodology can be easily applied to study other oils and their mixtures.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2021)
Article
Medical Laboratory Technology
Jordi Farre-Segura, Neus Fabregat-Cabello, Chiara Calaprice, Laurent Nyssen, Stephanie Peeters, Caroline Le Goff, Etienne Cavalier
Summary: A rapid and specific LC-MS/MS method for glucagon quantitation has been developed and validated, showing stability and accuracy in comparison to other immunoassay methods. This method could potentially establish a standardized approach for glucagon analysis in routine care settings.
CLINICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Alireza Sedrpoushan, Hoda Haghi, Mohammad Sohrabi
Summary: This study focused on the chemistry of Diploschistes diacapsis using liquid chromatography electrospray ionization tandem mass spectrometry. Seven compounds from D. diacapsis lichen species were discovered and analyzed. The maceration method proved effective for lichen extraction. The findings can contribute to flora data and improve mass spectrometry library information, providing a foundation for biological and pharmacological studies.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Mi Luo, Liyun Zheng, Suwei Wang, Jianghua Zhu, Zhuohong Tang, Pingming Gao
Summary: A 2D LC-QTOF/MS/MS method was developed to characterize four major degradation products of metformin under different conditions, with two impurities never reported before identified for the first time in this study.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Li Zhang, Liqiong Meng, Hua Wang, Dongliang Lu, Xin Luo
Summary: The present study developed a liquid chromatography-tandem mass spectrometry method for comprehensive determination of organophosphate triesters, diesters, and hydroxylated degradation products in sediment. The method showed good analytical performance and applicability, and it is of great significance for the study of OPEs and their degradation products in marine environment.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Organic
Thibault Tannoux, Nicolas Casaretto, Sophie Bourcier, Vincent Gandon, Audrey Auffrant
Summary: The reaction between a 1-azido-(2-halogenomethyl)benzene and a phosphine gives different products depending on the nature of the halogen, the phosphine itself, and the solvent employed. While PPh3 (2 equiv) reacts with the chloro reagent in toluene to give the expected iminophosphorane- phosphonium adduct, trialkylphosphines (PCy3 and PEt3) surprisingly furnish an aminophosphonium substituted by a zwitterionic indazole. The bicyclic product can also form from PPh3 using the bromo reagent in acetonitrile.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
Mouna Mahjoubi, Simone Cappello, Santina Santisi, Afef Najjari, Yasmine Souissi, Ameur Cherif
Summary: Bioremediation is an effective strategy for eliminating pollutants by transforming toxic petroleum components into less harmful metabolites. Diversity of bacterial communities shift during oil-biodegradation process, with a decrease in diversity and an increase in abundance of hydrocarbonoclastic species, such as Alcanivorax. This shift is associated with a high degradation rate of crude oil, decreased sediment toxicity, and potential for future selection of efficient consortia for hydrocarbon contaminated site cleanup.
SOIL & SEDIMENT CONTAMINATION
(2022)
Article
Multidisciplinary Sciences
Mouna Mahjoubi, Habibu Aliyu, Mohamed Neifar, Simone Cappello, Habib Chouchane, Yasmine Souissi, Ahmed Salaheddine Masmoudi, Don A. Cowan, Ameur Cherif
Summary: The study demonstrates that the Pseudomonas BUN14 strain has a versatile hydrocarbon degradation capacity, making it a promising candidate for bioremediation in polluted saline environments.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Murielle Gaugain, Amandine Raynaud, Sophie Bourcier, Eric Verdon, Dominique Hurtaud-Pessel
Summary: A method was developed to detect antibiotic concentrations in animal feed, which was validated for accuracy and precision. The study also examined drug levels in real samples, with no cross-contamination found.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Humanities, Multidisciplinary
Bin Han, Leon-Bavi Vilmont, Hyoung-Jin Kim, Bertrand Lavedrine, Shouji Sakamoto, Michel Sablier
Summary: Korean hand papermaking is a well-known cultural tradition in the Korean peninsula, but scientific analysis of paper itself is rare. This study chemically investigated over three hundred Korean handmade papers and analyzed their property data, revealing that the paper structure is determined by the material preparing and making craft, which influences the physical properties of the paper. Different sheet formation techniques affect paper density, fiber orientation, and physical properties, impacting paper performance and applications.
Article
Chemistry, Analytical
Baptiste Zuber, Sophie Cersoy, Marc Herbin, Michel Sablier, Veronique Rouchon
Summary: This study aims to facilitate the characterization of beeswax-rosin mixtures used for sealing wet collections. By using DSC and ATR-FTIR methodologies on model mixtures and historical sealants, promising results were obtained. The impact of ageing or possible addition of third-party fatty materials such as animal fat or vegetal oil on the results was also discussed.
VIBRATIONAL SPECTROSCOPY
(2021)
Review
Chemistry, Applied
Manel Ben Ouaghrem, Segolene de Vaugelade, Sophie Bourcier, Christophe Genty, Stephane Pirnay, Stephane Bouchonnet
Summary: Chlorphenesin, used as a preservative in cosmetic products, was found to produce three by-products during photolysis, with the overall ecotoxicity increasing with irradiation time. Among the degradation compounds identified, 4-chlorophenol is likely a contributing factor to the increased toxicity in the photolyzed solution.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Soumaya Kouidhi, Oumaima Zidi, Soukaina Abdelwahed, Yasmine Souissi, Najla Trabelsi, Alaeddine Redissi, Manel Hamdi, Emna Trabelsi, Yosra Amara, Taher Bhiri, Rim Khrouf, Boulbaba Selmi, Sami Achour, Ameur Cherif, Wissem Mnif, Amor Mosbah
Summary: This study investigated the biological properties and chemical composition of different parts of Lobularia maritima, with roots showing the highest antioxidant activity and flower, leaf, and root fractions exhibiting antimicrobial and antifungal activities. Analysis of active fractions identified various compounds, indicating the potential of Lobularia maritima as a promising source of therapeutic compounds.
JOURNAL OF CHEMISTRY
(2021)
Article
Archaeology
Kang Lee, Michel Sablier, Toshiharu Enomae, Masamitsu Inaba
Summary: This study measured the volatile organic compounds (VOCs) generated from naturally aged Japanese hanging scrolls and their model samples using SPME-GC-MS. Different painting papers and raw materials were found to have an effect on the degradation state of hanging scrolls. VOC-based degradation markers were identified and their applicability for evaluating the degradation of actual Japanese hanging scrolls was considered.
STUDIES IN CONSERVATION
(2023)
Article
Biotechnology & Applied Microbiology
Khouloud Hammami, Yasmine Souissi, Amal Souii, Awatef Ouertani, Darine El-Hidri, Marwa Jabberi, Habib Chouchane, Amor Mosbah, Ahmed Slaheddine Masmoudi, Ameur Cherif, Mohamed Neifar
Summary: This study investigated an extremophilic bacterium isolated from saline sediment in the Tunisian desert for its ability to produce microbial polyhydroxyalkanoates (PHA). The bacterium, Halomonas desertis G11, was found to accumulate intracellular PHA granules and was optimized for maximum PHA yield using glycerol as a substrate. Genomic analysis revealed the presence of structural genes involved in PHA metabolism. These findings suggest that this extremophilic bacterium has potential as a cell factory for the conversion of renewable glycerol into high-value PHA products.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Energy & Fuels
Amal Souii, Afwa Gorrab, Rania Ouertani, Awatef Ouertani, Khouloud Hammami, Nesrine Saidi, Yasmine Souissi, Habib Chouchane, Ahmed Slaheddine Masmoudi, Haitham Sghaier, Ameur Cherif, Mohamed Neifar
Summary: The extremophilic bacteria Microbacterium metallidurans TL13, isolated from tannery wastewater, shows potential for degrading plant cell wall and producing biofuel. Through genomic and enzymatic analyses, TL13 reveals genes encoding various enzymes involved in cellulose and hemicellulose degradation. The presence of these genes is well synchronized with the higher enzymatic activities observed in TL13 under saline conditions. TL13 strain also demonstrates efficient hydrolysis of untreated Posidonia oceanica waste into fermentable sugars, making it a promising green tool for seagrass-based biorefinery.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Chemistry, Applied
Shiwei Ren, Amirhossein Habibi, Pingping Ni, Hindia Nahdi, Fatima Zahra Bouanis, Sophie Bourcier, Gilles Clavier, Michel Frigoli, Abderrahim Yassar
Summary: A new variant of the indophenine reaction was used to synthesize a series of quinoidal molecules. The previously reported method had low yield and selectivity, with the formation of by-products. A modified protocol using tertiary alcohol as a starting material was proposed to increase yield and avoid complex purification issues. The influence of the pi-bridge conjugation length on the electronic structure of the quinoidal compounds was investigated.
Article
Chemistry, Physical
Agathe Fayet, Sophie Bourcier, Nicolas Casaretto, Bastien Nay, Gilles Frison
Summary: The Hock rearrangement is an acid catalyzed reaction involving organic hydroperoxides and resulting in an oxidative cleavage of adjacent C-C bonds. Its mechanism has not been studied in detail. In this work, we conducted a theoretical study on the Hock rearrangement using InCl3 as a Lewis acid catalyst. We aimed to understand the mechanism of this reaction and rationalize the influence of substrate electronic properties. Our investigation revealed the co-existence of several energetically close reaction pathways and suggested that In2Cl6 species coordinated to the substrate play a central role in the catalytic cycle.
Article
Environmental Sciences
Mouna Mahjoubi, Simone Cappello, Yasmine Souissi, Sabrina Patania, Ameur Cherif
Summary: This study evaluated the ability of selected bacterial strains to degrade crude oil and its components, and found that bioremediation is an effective strategy to reduce pollution. One bacterial consortium showed high degradation capability and demonstrated significant potential for bioremediation.
TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
(2023)
Article
Archaeology
Bin Han, Jijia Niang, Huiyun Rao, Nanning Lyu, Hirotaka Oda, Shouji Sakamoto, Yimin Yang, Michel Sablier
Summary: Through multidisciplinary scientific investigations, ancient paper fragments from the Samye Monastery in south Tibet dated to the 12th-13th century CE have been analyzed, revealing the unique use of sizing technique employing starch-milk sizing and the combined use of organic and inorganic materials as paper fillers in Tibetan papermaking. This detailed analysis provides insights into the production technology of ancient handmade Tibetan papers.
JOURNAL OF ARCHAEOLOGICAL SCIENCE-REPORTS
(2021)
