Toward Drug Repurposing in Epigenetics: Olsalazine as a Hypomethylating Compound Active in a Cellular Context

Identification of Novel Inhibitors of DNA Methylation by Screening of a Chemical Library

(2013) Alexandre Ceccaldi et al.   ACS Chemical Biology

Virtual Screening Strategies in Drug Discovery: A Critical Review

(2013) A. Lavecchia et al.   CURRENT MEDICINAL CHEMISTRY

Shifting from the single to the multitarget paradigm in drug discovery

(2013) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay

(2013) Jessica A. Kilgore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: insights to unveil inhibitors in chemical databases

(2013) José L. Medina-Franco et al.   MOLECULAR DIVERSITY

Molecular Modeling Studies of the Novel Inhibitors of DNA Methyltransferases SGI-1027 and CBC12: Implications for the Mechanism of Inhibition of DNMTs

(2013) Jakyung Yoo et al.   PLoS One

Drug Repurposing: Far Beyond New Targets for Old Drugs

(2012) T. I. Oprea et al.   AAPS Journal

DNA methylation inhibitors in cancer: Recent and future approaches

(2012) Christina Gros et al.   BIOCHIMIE

Drug Repurposing in Chemical Genomics: Can We Learn from the Past to Improve the Future?

(2012) William H. Bisson   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Recognizing Pitfalls in Virtual Screening: A Critical Review

(2012) Thomas Scior et al.   Journal of Chemical Information and Modeling

Rapid Synthesis of New DNMT Inhibitors Derivatives of Procainamide

(2011) Ludovic Halby et al.   CHEMBIOCHEM

Advances in the computational development of DNA methyltransferase inhibitors

(2011) José L. Medina-Franco et al.   DRUG DISCOVERY TODAY

Synthesis and Biochemical Evaluation of Δ2-Isoxazoline Derivatives as DNA Methyltransferase 1 Inhibitors

(2011) Sabrina Castellano et al.   JOURNAL OF MEDICINAL CHEMISTRY

GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair

(2011) Bongyong Lee et al.   NUCLEIC ACIDS RESEARCH

PubChem's BioAssay Database

(2011) Y. Wang et al.   NUCLEIC ACIDS RESEARCH

Fluorescence-based high-throughput assay for human DNA (cytosine-5)-methyltransferase 1

(2010) Yu Ye et al.   ANALYTICAL BIOCHEMISTRY

DNA Methyltransferase 1-associated Protein (DMAP1) Is a Co-repressor That Stimulates DNA Methylation Globally and Locally at Sites of Double Strand Break Repair

(2010) Gun E. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells

(2010) D. Kuck et al.   MOLECULAR CANCER THERAPEUTICS

Natural products as DNA methyltransferase inhibitors: a computer-aided discovery approach

(2010) Jose L. Medina-Franco et al.   MOLECULAR DIVERSITY

Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation

(2009) Dirk Kuck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation

(2009) J. Datta et al.   CANCER RESEARCH

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Rethinking how DNA methylation patterns are maintained

(2009) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine

(2008) Carlo Stresemann et al.   INTERNATIONAL JOURNAL OF CANCER

The prince and the pauper. A tale of anticancer targeted agents

(2008) Alfonso Dueñas-González et al.   Molecular Cancer