Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

Discovery of Dual Orexin Receptor Antagonists (DORAs) for the Treatment of Insomnia

(2012) Paul J. Coleman et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Orexin Receptors: Pharmacology and Therapeutic Opportunities

(2011) Thomas E. Scammell et al.   Annual Review of Pharmacology and Toxicology

Discovery process and pharmacological characterization of a novel dual orexin 1 and orexin 2 receptor antagonist useful for treatment of sleep disorders

(2011) Romano Di Fabio et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

(2011) Christopher J. Winrow et al.   JOURNAL OF NEUROGENETICS

Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists

(2010) Paul J. Coleman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat

(2010) Paul J. Coleman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Orexin Receptor Antagonists: A New Concept In CNS Disorders?

(2010) John Gatfield et al.   ChemMedChem

Orexin receptor antagonists: a review of promising compounds patented since 2006

(2010) Paul J Coleman et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Discovery of the Dual Orexin Receptor Antagonist [(7R)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

(2010) Christopher D. Cox et al.   JOURNAL OF MEDICINAL CHEMISTRY

Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding

(2009) Christopher D. Cox et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of a Potent, CNS-Penetrant Orexin Receptor Antagonist Based on anN,N-Disubstituted-1,4-diazepane Scaffold that Promotes Sleep in Rats

(2009) David B. Whitman et al.   ChemMedChem

Comparative Tolerability of Newer Agents for Insomnia

(2009) Gary Zammit   DRUG SAFETY