Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton

Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex

(2011) Daria V. Ilatovskaya et al.   FASEB JOURNAL

Dynamic maintenance of asymmetric meiotic spindle position through Arp2/3-complex-driven cytoplasmic streaming in mouse oocytes

(2011) Kexi Yi et al.   NATURE CELL BIOLOGY

Arp2/3 Complex Regulates Asymmetric Division and Cytokinesis in Mouse Oocytes

(2011) Shao-Chen Sun et al.   PLoS One

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

(2010) Alissa A. Hare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New mechanisms and functions of actin nucleation

(2010) Elif Nur Firat-Karalar et al.   CURRENT OPINION IN CELL BIOLOGY

Synthetic Triterpenoids Target the Arp2/3 Complex and Inhibit Branched Actin Polymerization

(2010) Ciric To et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin-based motility drives baculovirus transit to the nucleus and cell surface

(2010) Taro Ohkawa et al.   JOURNAL OF CELL BIOLOGY

Efficient Drug Lead Discovery and Optimization

(2009) William L. Jorgensen   ACCOUNTS OF CHEMICAL RESEARCH

Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly

(2009) Syed A. Rizvi et al.   CHEMISTRY & BIOLOGY

Halogen–water–hydrogen bridges in biomolecules

(2009) Peng Zhou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Characterization of two classes of small molecule inhibitors of Arp2/3 complex

(2009) B. J. Nolen et al.   NATURE

Actin, a Central Player in Cell Shape and Movement

(2009) T. D. Pollard et al.   SCIENCE

The structural basis of actin filament branching by the Arp2/3 complex

(2008) Isabelle Rouiller et al.   JOURNAL OF CELL BIOLOGY

Perspective on Free-Energy Perturbation Calculations for Chemical Equilibria

(2008) William L. Jorgensen et al.   Journal of Chemical Theory and Computation

Discovery of Human Macrophage Migration Inhibitory Factor (MIF)-CD74 Antagonists via Virtual Screening

(2008) Zoe Cournia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of Azoles as Anti-Human Immunodeficiency Virus Agents Guided by Free-Energy Calculations

(2008) Jacob G. Zeevaart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Benchmarking the Reliability of QikProp. Correlation between Experimental and Predicted Values

(2007) Leukothea Ioakimidis et al.   Quantitative structure-activity relationships & combinatorial science