期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 10, 期 4, 页码 976-981出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201403190
关键词
camptothecin; cascade reactions; oxa Diels-Alder reaction; protecting group-free synthesis; synthetic methods; total synthesis
资金
- Ministry of Science and Technology of China [2010CB833202, 2013AA092903]
- National Natural Science Foundation of China [21032002]
- Priority Academic Development Program of Jiangsu Higher Education Institutions
A convergent protecting group-free total synthesis route of camptothecin and 10-hydroxycamptothecin has been developed in this work. Cascade oxidation of 3-(hydroxymethyl)furan-2(5H)-one and in situ intermolecular oxa Diels-Alder reaction with vinyl ether was developed and applied to construct the E-ring, and TMSCl-promoted cascade closure of the D-ring delivered the whole skeleton of the alkaloids in the total synthesis. The new short syntheses were advantageous with regard to step economy, low cost, easily available starting materials and reagents, and convenient operations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据