期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 5, 期 4, 页码 704-754出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200900634
关键词
anti-Alzheimer's drugs; antitumor agents; bryostatin; protein kinase c; total synthesis
资金
- Medical Research Council [G0802079] Funding Source: Medline
- MRC [G0802079] Funding Source: UKRI
In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune. Evans, Nishiyama and Yamamura. Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001-2009 since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.
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