Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Qi-Yuan Yang, Rui Ma, Yun-Qiong Gu, Xiao-Fang Xu, Zhen-Feng Chen, Hong Liang
Summary: Targeting metabolic reprogramming to treat cancer, by using arene-ruthenium(II)/osmium(II) complexes to potentiate the anticancer effect of metformin (Met.) via glucose metabolism reprogramming, could increase overall survival and reduce side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Inorganic & Nuclear
Sonia Infante-Tadeo, Vanessa Rodriguez-Fanjul, Cintia C. Vequi-Suplicy, Ana M. Pizarro
Summary: The passage describes the rapid hydrolysis and high basicity of complexes [Os(eta 6-arene)(C,N-phenylpyridine)Z] with chlorido or tethered oxygen as the ligand. It also reveals the structure-activity relationship between Os-CN and Os-NN complexes.
INORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Christoph A. Riedl, Alexander Rosner, Sophia Harringer, Philipp Salomon, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller, Bernhard K. Keppler
Summary: The use of bisphosphonate-functionalized ligands in the synthesis of trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes improved aqueous solubility but decreased antiproliferative activity in vitro.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Srividya Swaminathan, Jebiti Haribabu, Naveen Kumar Kalagatur, Maroli Nikhil, Nithya Balakrishnan, Nattamai S. P. Bhuvanesh, Krishna Kadirvelu, Ponmalai Kolandaivel, Ramasamy Karvembu
Summary: The synthesis of fourteen new Ru-II-arene complexes were characterized and found to exhibit high toxicity towards IMR-32 cancer cells, with two complexes showing the highest activity and the ability to induce apoptosis and cell cycle arrest. These complexes also demonstrated good binding affinity with receptors commonly overexpressed in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Jebiti Haribabu, Nithya Balakrishnan, Punitharaj Vasanthakumar, Ramasamy Karvembu
Summary: This article mainly discusses the structural and molecular alterations in the design and development of Ru(II)-arene complexes with monodentate ligands for anticancer applications, and their behavior in vitro or in vivo.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Tomiris Nabiyeva, Basile Roufosse, Matylda Odachowski, Judith Baumgartner, Christoph Marschner, Akalesh Kumar Verma, Burgert Blom
Summary: A series of osmium arene complexes involving sigma-germyl, germanate, sigma-stannyl, and stannate ligands were synthesized, characterized, and tested for potential anticancer activities. Comprehensive analyses using various techniques were conducted, along with cytotoxicity and apoptosis assays against malignant cancer cell lines. The study revealed that some of the complexes exhibited anti-cancer effects on malignant cancer cells.
Article
Chemistry, Multidisciplinary
Sankar Monika, Rengan Ramesh
Summary: This study reports the synthesis of a new series of organometallic dinuclear ruthenium(ii) arene complexes and investigates their in vitro antiproliferative activity and cancer cell death mechanism. The formation of complexes was confirmed by various spectroscopic techniques. The synthesized complexes showed higher inhibition of cancer cells compared to the standard cisplatin drug, and apoptosis was confirmed through morphological changes and phosphatidylserine externalization.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Stefan Latis, Christoph Marschner, Judith Baumgartner, Sharon Prince, Supratim Biswas, Suparna Chakraborty, Kimberly G. Garcia, Ron M. A. Heeren, Sebastiaan Van Nuffel, Burgert Blom
Summary: This study reports the synthesis and characterisation of piano-stool triphenylstibine and triphenylarsine arene complexes, and their in vitro cytotoxic evaluation on breast cancer cell lines. The tin containing complexes demonstrate remarkable activity and selectivity.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Jakob Kljun, Mihaela Rebernik, Lucia M. Balsa, Jerneja Kladnik, Uros Rapus, Tomaz Trobec, Kristina Sepcic, Robert Frangez, Ignacio E. Leon, Iztok Turel
Summary: Organoruthenium pyrithione complexes, such as [(eta(6)-p-cymene)Ru(pyrithionato)(pta)]PF6, show promise as a new class of anticancer drugs. Our study focuses on finding alternatives to the pta ligand and discovering new structural elements to improve the biological properties of ruthenium anticancer drugs. By replacing the pta ligand with different phosphine, phosphite, and arsine ligands, we identified improved inhibitory potency against the enzyme glutathione S-transferase, as well as investigated cytotoxicity in breast, bone, and colon cancers.
Article
Chemistry, Physical
Viet-Hung Do, P. Prabhu, Yinghao Li, Wenjie Xie, Pinit Kidkhunthod, Guangzhao Wang, Xin Wang, Jong-Min Lee
Summary: Transition metal nitrides with atomically thin Os nanoclusters confined on 2D 6-MoN exhibit enhanced catalytic performance, particularly in hydrogen evolution, due to optimized surface electron configurations and abundant active sites.
Review
Chemistry, Inorganic & Nuclear
Srividya Swaminathan, Rajasekharan Jayakumari Deepak, Ramasamy Karvembu
Summary: The field of bioorganometallic chemistry has seen significant expansion in recent years, particularly in the development of efficient catalysts and anticancer drugs using organometallic complexes. The properties and processes of these complexes, particularly those of ruthenium(II) and osmium(II), rely on electronic and steric factors. These complexes have been widely used as versatile precursors in biological and catalytic applications. By indirectly affecting cellular redox homeostasis through catalytic transfer hydrogenation, they have shown promise in anticancer therapy.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Inorganic & Nuclear
Luis Felipe Hernandez-Ayala, Cynthia Sinai Novoa-Ramirez, Miguel Reina, Lena Ruiz-Azuara
Summary: This study presents the synthesis, characterization, electrochemical studies, DFT calculations, and in vitro evaluation of four novel direct bonded ruthenium-selenium compounds, revealing the impact of intermediate properties and compound structure on cytotoxic activity, with 2c demonstrating the best inhibitory effect on cell proliferation.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Dawid Zych
Summary: This study focuses on the theoretical investigations of mono- and dinuclear complexes, utilizing density functional theory calculations to understand their optical properties and physical parameters. The results have significant implications for the field of chemistry and materials science.
Article
Chemistry, Inorganic & Nuclear
Paul Teare, Caitlin F. Smith, Samuel J. Adams, Sellamuthu Anbu, Barbara Ciani, Lars J. C. Jeuken, Anna F. A. Peacock
DALTON TRANSACTIONS
(2018)
Article
Chemistry, Multidisciplinary
Ignacio Insua, Marion Petit, Lewis D. Blackman, Robert Keogh, Anais Pitto-Barry, Rachel K. O'Reilly, Anna F. A. Peacock, Anne Marie Krachler, Francisco Fernandez-Trillo
Article
Materials Science, Biomaterials
Lily Riordan, Emily F. Smith, Stuart Mills, James Hudson, Sarah Stapley, Naa-dei Nikoi, Stefan Edmondson, Jessica Blair, Anna F. A. Peacock, David Scurr, Graeme Forster, Felicity de Cogan
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Editorial Material
Multidisciplinary Sciences
Anna Peacock
Article
Ophthalmology
Naa-Dei Nikoi, Matthew Berwick, Jack A. Bryant, Lily Riordan, Louise Slope, Anna F. A. Peacock, Felicity de Cogan
Summary: Research suggests that the structural stability of bevacizumab with CPP is not affected by temperature, but physical instability and aggregation occur after five weeks. The addition of the polypeptide leads to increased aggregation, but the complexing of bevacizumab with CPP has no effect on its biological stability or degradation.
CURRENT EYE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Louise N. Slope, Oliver J. Daubney, Hannah Campbell, Scott A. White, Anna F. A. Peacock
Summary: This report highlights the unprecedented phenomenon of location-dependent and size-selective binding to lanthanide sites within miniature protein coiled coil scaffolds. The engineered binding sites show unusual selectivity for moderately large Ln(3+) ions, and it is demonstrated that this selectivity can be programmed into the sequence and manipulated by shifting the binding site. Experimental data, including X-ray crystal structures and CD studies, provide insights into the optimal radius of binding sites within the coiled coil scaffold, contributing to a better understanding of location-dependent metal selectivity in protein structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Editorial Material
Biochemistry & Molecular Biology
Anna F. A. Peacock, Olga Iranzo
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Microbiology
Lamin Saidykhan, Joao Correia, Andrey Romanyuk, Anna F. A. Peacock, Guillaume E. Desanti, Leanne Taylor-Smith, Maria Makarova, Elizabeth R. Ballou, Robin C. May
Summary: This study discovered a simple and effective method to induce titan cells in C. gattii under in vitro conditions, explored the titanisation ability in immunocompetent individuals, and characterized the differences among strains. The study also found that genes associated with cell cycle progression played a crucial role in titanisation, and identified exogenous p-Aminobenzoic acid as a key inducer of titanisation.
Correction
Microbiology
Lamin Saidykhan, Joao Correia, Andrey Romanyuk, Anna F. A. Peacock, Guillaume E. Desanti, Leanne Taylor-Smith, Maria Makarova, Elizabeth R. Ballou, Robin C. May
Article
Chemistry, Inorganic & Nuclear
S. L. Newton, A. Franke, A. Zahl, G. Molinaro, A. Kenwright, D. J. Smith, I. Ivanovic-Burmazovic, M. M. Britton, A. F. A. Peacock
Summary: A class of Gd(III) coiled coils achieve high MRI relaxivity due to their slow rotational correlation time and rapid exchange of three inner sphere waters.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Alexandra M. Webster, Anna F. A. Peacock
Summary: In the past, lanthanides were considered biologically inert, but in recent years the field of native lanthanide biochemistry has emerged, offering opportunities for useful applications due to their interesting photophysical properties. By designing α-helical coiled coil peptides as scaffolds, control over the coordination environment of lanthanide complexes can be achieved, contributing to the expansion of native lanthanide biochemistry.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Louise N. Slope, Michael G. Hill, Catherine F. Smith, Paul Teare, Felicity J. de Cogan, Melanie M. Britton, Anna F. A. Peacock
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Aysha Ali, Gemma A. Bullen, Benjamin Cross, Timothy R. Dafforn, Haydn A. Little, Jack Manchester, Anna F. A. Peacock, James H. R. Tucker
CHEMICAL COMMUNICATIONS
(2019)
Meeting Abstract
Biophysics
A. Shah, L. N. Slope, A. S. Kooduthurai, J. E. Lovett, A. F. A. Peacock
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
Meeting Abstract
Biophysics
A. F. Peacock, L. N. Slope, M. R. Berwick, S. L. Newton, A. Sellamuthu, O. J. Daubney, M. M. Britton
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS
(2017)
