Review
Chemistry, Inorganic & Nuclear
Sourav De, Sabnaz Kazi, Sabyasachi Banerjee, Subhasis Banerjee, Nandan Sarkar, Suraj Kumar Shah, Yung-Chih Kuo, S. K. Ashok Kumar
Summary: This article reviews the literature on the cytotoxic effects and cellular uptake of metal complexes such as ruthenium, iridium, rhodium, and rhenium, with a particular focus on recently developed metal-based complexes. These complexes primarily target DNA and mitochondria, inducing cancer cell apoptosis to reduce adverse drug reactions.
COORDINATION CHEMISTRY REVIEWS
(2024)
Article
Chemistry, Inorganic & Nuclear
Carley Giffert L. Nongpiur, Danny F. Diengdoh, Nupur Nagar, Krishna Mohan Poluri, Paige M. Gannon, Werner Kaminsky, Mohan Rao Kollipara
Summary: In this study, a series of novel half-sandwich metal complexes were synthesized with different ligands, and the structures were characterized. The antibacterial and antioxidant activities of these compounds were evaluated.
Article
Biochemistry & Molecular Biology
Brondwyn S. McGhie, Janice R. Aldrich-Wright
Summary: Cancer is responsible for over 9 million deaths worldwide each year. Current treatment options have low success rates, especially for late-stage cancers. Researchers globally are continuously searching for alternative treatment options. This study focuses on innovations in inorganic anticancer therapies with photoactive and luminescent properties. Transition metals offer advantages in both chemotherapeutics and luminescence. The study explores the effects of structural changes on the properties and the use of inherent luminescent properties for monitoring cellular localization in photodynamic therapy.
Article
Chemistry, Inorganic & Nuclear
Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Sohnel, Stephen M. F. Jamieson, Christian G. Hartinger
Summary: In this study, organometallic complexes with a piano-stool structure and di- or tridentate ligand systems were reported, showing improved biological activity and impact on cytotoxic activity.
INORGANIC CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Li'an Zhu, Jiangfan Wang, Zhen Wang, Yicong Ye, Shuxin Bai, Shun Li, Yu Tang
Summary: The Ir coated Re (Ir/Re) material shows a lower diffusion activation energy due to the higher defect concentration and thermodynamically unstable grain structure in the ED Re layer, promoting the dominant diffusion of Ir into Re and resulting in a thicker diffusion layer.
INTERNATIONAL JOURNAL OF REFRACTORY METALS & HARD MATERIALS
(2021)
Article
Chemistry, Inorganic & Nuclear
Daniel Obitz, Reece G. Miller, Nils Metzler-Nolte
Summary: The synthesis of bioconjugates of ruthenium(ii) dipyridophenazine complexes with two different cell penetrating peptides (CPPs) was described, with characterization done by various methods. The bioconjugates show similar low vitro cytotoxicity to the parent metal complexes.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Hiwa K. Saeed, Paul J. Jarman, Sreejesh Sreedharan, Rachel Mowll, Alexander J. Auty, Adrien A. P. Chauvet, Carl G. W. Smythe, Jorge Bernardino de la Serna, Jim A. Thomas
Summary: The synthesis of a new heterodinuclear metallointercalator containing Ru-II(dppz) and Re-I(dppn) moieties is reported. Cell-free studies show that the complex has similar photophysical properties and DNA binding affinity as its homoleptic M(dppz) analogue. However, it exhibits different in-cell properties, accumulating preferentially in mitochondria and displaying phototoxicity. These observations demonstrate the impact of small structural changes on the mechanism of action of metal-based therapeutic leads.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Minjin Yoo, Michael J. Krische
Summary: This research synthesized the potent spliceosome modulator pladienolide B with 10 stereogenic centers in 10 steps. Asymmetric alcohol-mediated carbonyl crotylations catalyzed by ruthenium and iridium were used to form the C20-C21 and C10-C11 C-C bonds with syn- and anti-diastereoselectivity, respectively.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Natalia S. Veizaga, Gustavo Mendow, Andres Felipe Quintero-Jaime, Angel Berenguer-Murcia, Sergio de Miguel, Emilia Morallon, Diego Cazorla-Amoros
Summary: The study focuses on the synthesis of mono- and bimetallic Pt-based electrocatalysts for ethanol electrooxidation in acidic media. Incorporation of Re promotes bond breaking of intermediates, while addition of Ir reduces electroactive surface area and decreases electrocatalytic performance.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Review
Chemistry, Inorganic & Nuclear
Thimma Subramanian Prathima, Badruzzaman Choudhury, Md. Gulzar Ahmad, Kaushik Chanda, M. M. Balamurali
Summary: Numerous biologically active metal complexes have been reported for their unique features and enhanced functions in inhibiting cancer progression. However, many of these drugs have failed at various levels of clinical trials despite performing well in the laboratory.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Applied
Nuno M. M. Moura, Kelly A. D. F. Castro, Juliana C. Biazzotto, Juliana A. Prandini, Carlos Lodeiro, Maria A. F. Faustino, Mario M. Q. Simoes, Roberto S. da Silva, Maria G. P. M. S. Neves
Summary: This paper reports the synthesis, characterization, and efficacy of porphyrin derivatives bearing ruthenium or iridium terpyridine units as photosensitizers against resistant melanoma cells. The combination of porphyrin derivatives with ruthenium or iridium ions improves the PDT effect, leading to a decrease in cell viability due to their high singlet oxygen production and cellular uptake. The fluorescent properties of the iridium derivative were observed to be uniformly dispersed in the cells.
Article
Chemistry, Inorganic & Nuclear
Alaka Nanda Pradhan, Shippy Jaiswal, Sundargopal Ghosh
Summary: Based on previous results, this study investigated the reactivity of nido-1 with different group 7 metal carbonyls under photolytic conditions. It was found that the photolysis of nido-1 with [Mn-2(CO)(10)] resulted in the isolation of a rare trimetallic cluster 2 with a triply bridging borylene moiety. Additionally, other trimetallic and heterotrimetallic clusters were synthesized and characterized. DFT calculations were performed to understand the electronic, structural, and bonding features of these metal-rich clusters.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ben Liu, Naoyuki Sekine, Yoshinao Nakagawa, Masazumi Tamura, Mizuho Yabushita, Keiichi Tomishige
Summary: This study investigates the selective synthesis of secondary alcohols from 1,2-alkanediol by C-O hydrogenolysis using Ru-based catalysts and 1,2-propanediol as a model substrate. The modified Ru/SiO2 catalyst with ReOx achieves improved activity. The results show that the Ru-ReOx/SiO2 catalyst preferentially converts 1-propanol to propane, leaving only 2-propanol in the liquid phase. The catalyst is reusable and the characterization of the catalyst reveals the presence of active sites on the ReOx-modified Ru metal surface.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Review
Chemistry, Inorganic & Nuclear
Jinchao Shen, Thomas W. Rees, Liangnian Ji, Hui Chao
Summary: This review explores the fabrication strategies and potential applications of Ru(II) and Ir(III) complex containing nanosystems, highlighting their recent developments in cancer treatment and bioimaging. Challenges and opportunities in this field are also discussed for future research.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Hong Zhang, Li-An Zhu, Shu-Xin Bai, Yi-Cong Ye
Summary: An iridium/rhenium (Ir/Re) double-layer coating was prepared on carbon/carbon (C/C) composites, and its morphologies, bond strengths, and ablation resistance were studied. The results demonstrate that the rhenium interlayer significantly enhances the bond strength between the iridium coating and C/C substrate, and the Ir/Re coating exhibits excellent ablation resistance throughout the high-temperature ablation process.
Article
Chemistry, Multidisciplinary
Matthew D. Newton, Simon D. Fairbanks, Jim A. Thomas, David S. Rueda
Summary: The study demonstrates that the dinuclear ruthenium(II) complex can thread and lock into force-extended DNA in a two-step mechanism, with one stereoisomer showing the highest binding affinity reported. Interestingly, the complex behaves differently on torsionally constrained DNA and negatively supercoiled DNA, making it a potential long-lived luminescent label for biological applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Fabian Droge, Felicity F. Noakes, Stuart A. Archer, Sreejesh Sreedharan, Ahtasham Raza, Craig C. Robertson, Sheila MacNeil, John W. Haycock, Heather Carson, Anthony J. H. M. Meijer, Carl G. W. Smythe, Jorge Bernardino de la Serna, Benjamin Dietzek-Ivansic, Jim A. Thomas
Summary: By combining resonance Raman and time-resolved absorption spectroscopy, as well as computational studies, the excited state dynamics of the new complex were analyzed. It was found that the near-infrared (NIR) emission (λmax = 780 nm) of the complex is attributed to a low-lying Os -> TAP based (MCLT)-M-3 state, despite the existence of several closely lying excited states. The complex, while highly photostable and live-cell permeant, is not cytotoxic or photocytotoxic, making it an ideal probe for optical microscopy.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Martin R. Gill, Paul J. Jarman, Vanessa Hearnden, Simon D. Fairbanks, Marcella Bassetto, John Palmer, Kathryn R. Ayscough, Jim A. Thomas, Carl Smythe
Summary: RuRuPhen blocks the transformation of G-actin monomers to F-actin filaments and disrupts the organization of actin stress fibers in cells. It interferes with actomyosin contractility, cell motility, and late-stage cytokinesis. RuRuPhen also interferes with the recruitment of endosomal sorting complexes required for transport (ESCRT) complex, leading to cytokinetic abscission failure.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Energy & Fuels
Christopher M. Parks, Anthony J. H. M. Meijer, Simon G. Blakey, Ehsan Alborzi, Mohamed Pourkashanian
Summary: Density Functional Theory calculations reveal the mechanism and products of the reactions between various sulfur compounds and hydroperoxides, which is crucial for a better understanding of fuel auto-oxidation.
Article
Chemistry, Organic
Anthony Choi, Anthony J. H. M. Meijer, Ilaria Proietti Silvestri, Iain Coldham
Summary: The kinetic resolution of N-Boc-2-aryl-4-methylenepiperidines using the base n-BuLi with sparteine as a catalyst has been achieved, yielding high enantiomeric ratios of the 2,2-disubstituted products and recovered starting materials. Further investigation revealed the fast rotation rate of the N-Boc group, and lithiation and trapping reactions of the enantioenriched starting materials gave rise to 2,2-disubstituted piperidines with retention of stereochemistry. Functionalization of the 4-methylene group led to a range of 2,4-disubstituted piperidines without loss of enantiopurity, offering potential as valuable building blocks in drug discovery.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Adam N. Hill, Anthony J. H. M. Meijer, J. Grant Hill
Summary: New correlation consistent basis sets have been developed for second-row atoms to be used with neon-core correlation consistent effective core potentials (ccECPs). Sets with additional diffuse functions and adjusted effective core polarization potentials (CPPs) have been analyzed. The accuracy of the basis sets and CPPs is assessed through benchmark calculations, showing improved agreement with all-electron results.
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Editorial Material
Chemistry, Physical
Gabriel G. Balint-Kurti, Ria Broer, Peter H. M. Budzelaar, Hubertus J. J. van Dam, Fokke Dijkstra, Henk Eshuis, Gerrit C. Groenenboom, Martyn F. Guest, Remco W. A. Havenith, Anthony J. H. M. Meijer, Tanja van Mourik, Zahid Rashid
JOURNAL OF PHYSICAL CHEMISTRY A
(2022)
Article
Chemistry, Multidisciplinary
Kirsty Smitten, Hannah M. Southam, Simon Fairbanks, Arthur Graf, Adrien Chauvet, Jim A. Thomas
Summary: The therapeutic action of luminescent dinuclear ruthenium(II) complexes based on the tetrapyridylphenazine, tpphz, bridging ligand on pathogenic strains of Escherichia coli and Enterococcus faecalis has been described previously. In this study, the antimicrobial activity of the complex against pernicious Gram-negative ESKAPE pathogenic strains of Acinetobacter baumannii and Pseudomonas aeruginosa is reported. The compound showed potent activity against A. baumannii and moderately high potency against carbapenem-resistant strains of P. aeruginosa.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Robert E. Ducker, Oscar Siles Bruegge, Anthony J. H. M. Meijer, Graham J. Leggett
Summary: We demonstrate the mechanochemical regulation of a photochemical reaction using an atomic force microscope (AFM) probe to remove photocleavable nitrophenyl protecting groups from alkylsilane films. This process enables nanoscale differentiation of chemical reactivity with high spatial resolution. The study also shows that functionalization of nanolines with nitrilo triacetic acid allows for site-specific immobilization of histidine-tagged green fluorescent protein.
Article
Chemistry, Multidisciplinary
Hiwa K. Saeed, Paul J. Jarman, Sreejesh Sreedharan, Rachel Mowll, Alexander J. Auty, Adrien A. P. Chauvet, Carl G. W. Smythe, Jorge Bernardino de la Serna, Jim A. Thomas
Summary: The synthesis of a new heterodinuclear metallointercalator containing Ru-II(dppz) and Re-I(dppn) moieties is reported. Cell-free studies show that the complex has similar photophysical properties and DNA binding affinity as its homoleptic M(dppz) analogue. However, it exhibits different in-cell properties, accumulating preferentially in mitochondria and displaying phototoxicity. These observations demonstrate the impact of small structural changes on the mechanism of action of metal-based therapeutic leads.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Alexander J. Auty, Paul A. Scattergood, Theo Keane, Tao Cheng, Guanzhi Wu, Heather Carson, James Shipp, Andrew Sadler, Thomas Roseveare, Igor V. Sazanovich, Anthony J. H. M. Meijer, Dimitri Chekulaev, Paul I. P. Elliot, Mike Towrie, Julia A. Weinstein
Summary: Through comparing the effects of different acceptors conjugated into the donor-bridge-acceptor (DBA) systems, the role of driving force and structural changes in directing the photoinduced pathways was revealed. Direct conjugation of a strong acceptor into the bridge can switch the lowest excited state and an increased acceptor strength leads to a decrease in the formation rate and an increase in the lifetime of the charge-separated state.
Article
Chemistry, Multidisciplinary
Alexander J. Auty, Paul A. Scattergood, Theo Keane, Tao Cheng, Guanzhi Wu, Heather Carson, James Shipp, Andrew Sadler, Thomas Roseveare, Igor V. Sazanovich, Anthony J. H. M. Meijer, Dimitri Chekulaev, Paul I. P. Elliot, Mike Towrie, Julia A. Weinstein
Summary: This study investigates the role of driving force and structural changes in directing the photoinduced pathways in donor-bridge-acceptor (DBA) systems. The ultrafast dynamics in different DBA systems with the same donor and bridge, but different acceptors, were compared. It was found that the conjugation of a strong acceptor into the bridge has a significant impact on the lowest excited state and charge-separated state. The stronger acceptor leads to a slower formation rate and longer lifetime of the charge-separated state, as well as an increased rate of intersystem crossing.
Article
Biochemistry & Molecular Biology
Ahtasham Raza, Stuart A. A. Archer, Jim A. A. Thomas, Sheila MacNeil, John W. W. Haycock
Summary: This study reports the anti-metastatic effect of a Ru(ii) complex, which disrupts actin fiber assembly and inhibits the migration and invasiveness of melanoma cells. The complex also inhibits the growth and invasion of melanoma-based tumor models and penetrates the epidermis to inhibit melanoma cell invasion in a skin tissue model.
RSC MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Sumit Kumar Pramanik, Sreejesh Sreedharan, Rajeshwari Tiwari, Sourav Dutta, Noufal Kandoth, Surajit Barman, Stephen O. Aderinto, Samit Chattopadhyay, Amitava Das, Jim A. Thomas
Summary: This review provides an overview of the approaches and techniques used in super-resolution microscopy, and focuses on the advantages of using nanoparticle-based probes in these applications. Different classes of nanoparticles developed for these purposes are critically described, and illustrated with various examples from recent literature.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Noorshida Mohd Ali, Anthony J. H. M. Meijer, Michael D. Ward, Norlinda Daud, Norhayati Hashim, Illyas Md Isa
Summary: Through density functional theory calculations, the research team demonstrated specific solvent-solute interactions of [Ir(ppy)(2)(CN)(2)](-) and its solvent environment in water, revealing the mechanism of water molecules interacting with cyanide ligands through hydrogen bonding.
INDONESIAN JOURNAL OF CHEMISTRY
(2021)