期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 25, 页码 13923-13928出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202103845
关键词
cancer; enantioselective; hydrogen transfer; iridium; ruthenium
资金
- Welch Foundation [F-0038]
- NIH [RO1-GM093905]
This research synthesized the potent spliceosome modulator pladienolide B with 10 stereogenic centers in 10 steps. Asymmetric alcohol-mediated carbonyl crotylations catalyzed by ruthenium and iridium were used to form the C20-C21 and C10-C11 C-C bonds with syn- and anti-diastereoselectivity, respectively.
The potent spliceosome modulator pladienolide B, which bears 10 stereogenic centers, is prepared in 10 steps (LLS). Asymmetric alcohol-mediated carbonyl crotylations catalyzed by ruthenium and iridium that occur with syn- and anti-diastereoselectivity, respectively, were used to form the C20-C21 and C10-C11 C-C bonds.
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