Nucleophilic Attack of α-Aminoalkyl Radicals on CarbonNitrogen Triple Bonds to Construct α-Amino Nitriles: An Experimental and Computational Study

Mild Metal-Free Intramolecular Oxidative Alkylation of a Csp3H Bond Adjacent to a Nitrogen Atom: A Versatile Approach to Ring-Fused Tetrahydroquinolines

(2013) Gen Zhang et al.   ADVANCED SYNTHESIS & CATALYSIS

Silver-Catalyzed Nitrogenation of Alkynes: A Direct Approach to Nitriles through CC Bond Cleavage

(2013) Tao Shen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β-Unsaturated Ketones

(2013) Jing Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Efficient and Selective Aerobic Cross-Dehydrogenative-Coupling Reaction Photocatalyzed by a Platinum(II) Terpyridyl Complex

(2013) Jian-Ji Zhong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible-light mediated heterogeneous C–H functionalization: oxidative multi-component reactions using a recyclable titanium dioxide (TiO2) catalyst

(2013) Carlos Vila et al.   GREEN CHEMISTRY

Brønsted Acid Cocatalysts in Photocatalytic Radical Addition of α-Amino C–H Bonds across Michael Acceptors

(2013) Laura Ruiz Espelt et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Cyanation of Aryl Halides with CuSCN

(2013) Guo-Ying Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Iodide-Catalyzed Synthesis of N-Nitrosamines via C–N Cleavage of Nitromethane

(2013) Jie Zhang et al.   JOURNAL OF ORGANIC CHEMISTRY

Simple and Sustainable Iron-Catalyzed Aerobic C–H Functionalization of N,N-Dialkylanilines

(2013) Maxim O. Ratnikov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigation of Oxidative Mannich Reaction with tert-Butyl Hydroperoxide. The Role of Transition Metal Salt

(2013) Maxim O. Ratnikov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cross Dehydrogenative Coupling via Base-Promoted Homolytic Aromatic Substitution (BHAS): Synthesis of Fluorenones and Xanthones

(2013) Sebastian Wertz et al.   ORGANIC LETTERS

Unprecedented Construction of C═C Double Bonds via Ir-Catalyzed Dehydrogenative and Dehydrative Cross-Couplings

(2013) Shao-zhen Nie et al.   ORGANIC LETTERS

A Copper-Catalyzed Synthesis of 3-Aroylindoles via a sp3 C–H Bond Activation Followed by C–C and C–O Bond Formation

(2013) Anupal Gogoi et al.   ORGANIC LETTERS

Visible Light Photoredox-Catalyzed Multicomponent Reactions

(2013) Magnus Rueping et al.   ORGANIC LETTERS

Copper-Mediated Transformation of Organosilanes to Nitriles with DMF and Ammonium Iodide

(2013) Zhen Wang et al.   ORGANIC LETTERS

Copper-Mediated Direct Aryl C–H Cyanation with Azobisisobutyronitrile via a Free-Radical Pathway

(2013) Hao Xu et al.   ORGANIC LETTERS

Metal-free oxidative tandem coupling of activated alkenes with carbonyl C(sp2)–H bonds and aryl C(sp2)–H bonds using TBHP

(2013) Ming-Bo Zhou et al.   Chemical Science

Continuous Flow Organocatalytic C–H Functionalization and Cross-Dehydrogenative Coupling Reactions: Visible Light Organophotocatalysis for Multicomponent Reactions and C–C, C–P Bond Formations

(2013) Magnus Rueping et al.   ACS Catalysis

Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions

(2013) Vaibhav P. Mehta et al.   RSC Advances

Direct Functionalization Processes: A Journey from Palladium to Copper to Iron to Nickel to Metal-Free Coupling Reactions

(2012) James J. Mousseau et al.   ACCOUNTS OF CHEMICAL RESEARCH

A Metal-Free Oxidative Esterification of the Benzyl CH Bond

(2012) Jie Feng et al.   ADVANCED SYNTHESIS & CATALYSIS

Synthesis of Aromatic Nitriles Using Nonmetallic Cyano-Group Sources

(2012) Jinho Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Promoted CC Bond Cleavage: Photocatalytic Generation of Iminium Ions and Amino Radicals

(2012) Shunyou Cai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective Iodine-Catalyzed Intermolecular Oxidative Amination of C(sp3)H Bonds with ortho-Carbonyl-Substituted Anilines to Give Quinazolines

(2012) Yizhe Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Amidation and Esterification of Aldehydes with Activating Reagents by a Cross-Coupling Strategy

(2012) Bin Tan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cross Coupling of Acyl and Aminyl Radicals: Direct Synthesis of Amides Catalyzed by Bu4NI with TBHP as an Oxidant

(2012) Zhaojun Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mild Metal-Free Tandem α-Alkylation/Cyclization ofN-Benzyl Carbamates with Simple Olefins

(2012) Heinrich Richter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxidative Cyanation of Tertiary Amines with Ethyl Cyanoformate over a Niobia-Supported Iron-Exchanged Molybdophosphoric Acid Catalyst

(2012) Kasanneni Tirumala Venkateswara Rao et al.   ChemCatChem

Tetrabutylammonium iodide catalyzed allylic sulfonylation of α-methyl styrene derivatives with sulfonylhydrazides

(2012) Xiaoqing Li et al.   CHEMICAL COMMUNICATIONS

I2 promoted domino oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles via metal-free sp3 C–H functionalization

(2012) Yan-Ping Zhu et al.   CHEMICAL COMMUNICATIONS

Visible-light-mediated addition of α-aminoalkyl radicals generated from α-silylamines to α,β-unsaturated carbonyl compounds

(2012) Yoshihiro Miyake et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed cyanation of arenes using benzyl nitrile as a cyanide anion surrogate

(2012) Jisong Jin et al.   CHEMICAL COMMUNICATIONS

Copper-catalyzed C–N bond formation through C–H/N–H activation: a novel approach to the synthesis of multisubstituted ureas

(2012) Honglai Jiang et al.   CHEMICAL COMMUNICATIONS

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

(2012) Anup Bhunia et al.   CHEMICAL SOCIETY REVIEWS

Iron-Catalyzed Oxidative Amidation of Tertiary Amines with Aldehydes

(2012) Yuanming Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Light-Mediated Heterogeneous Cross Dehydrogenative Coupling Reactions: Metal Oxides as Efficient, Recyclable, Photoredox Catalysts in CC Bond-Forming Reactions

(2012) Magnus Rueping et al.   CHEMISTRY-A EUROPEAN JOURNAL

Direct sp3CH Amination of Nitrogen-Containing Benzoheterocycles Mediated by Visible-Light-Photoredox Catalysts

(2012) Yoshihiro Miyake et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible-Light-Mediated Utilization of α-Aminoalkyl Radicals: Addition to Electron-Deficient Alkenes Using Photoredox Catalysts

(2012) Yoshihiro Miyake et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper-Mediated Sequential Cyanation of Aryl C–B and Arene C–H Bonds Using Ammonium Iodide and DMF

(2012) Jinho Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Comparative Mechanistic Study of Cu-Catalyzed Oxidative Coupling Reactions with N-Phenyltetrahydroisoquinoline

(2012) Esther Boess et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potassium iodide catalyzed simultaneous C3-formylation and N-aminomethylation of indoles with 4-substituted-N,N-dimethylanilines

(2012) Lan-Tao Li et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tetrabutylammonium Iodide Catalyzed Synthesis of Allylic Ester with tert-Butyl Hydroperoxide as an Oxidant

(2012) Erbo Shi et al.   ORGANIC LETTERS

Tandem Cyclization of α-Cyano α-Alkynyl Aryl Ketones Induced by tert-Butyl Hydroperoxide and Tetrabutylammonium Iodide

(2012) Ying-Chieh Wong et al.   ORGANIC LETTERS

Copper-Mediated Selective Cyanation of Indoles and 2-Phenylpyridines with Ammonium Iodide and DMF

(2012) Jinho Kim et al.   ORGANIC LETTERS

Visible Light Photoredox Catalysis: Generation and Addition of N-Aryltetrahydroisoquinoline-Derived α-Amino Radicals to Michael Acceptors

(2012) Paul Kohls et al.   ORGANIC LETTERS

Azobisisobutyronitrile Initiated Aerobic Oxidative Transformation of Amines: Coupling of Primary Amines and Cyanation of Tertiary Amines

(2012) Lianghui Liu et al.   ORGANIC LETTERS

Ethyl Cyanoacetate: A New Cyanating Agent for the Palladium-Catalyzed Cyanation of Aryl Halides

(2012) Shuyan Zheng et al.   ORGANIC LETTERS

Palladium-Assisted Regioselective C–H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source

(2012) Shuguang Xu et al.   ORGANIC LETTERS

Metal-free oxidative amide formation with N-hydroxysuccinimide and hypervalent iodine reagents

(2012) Haoyi Yao et al.   TETRAHEDRON LETTERS

Room temperature synthesis of isoquino[2,1-a][3,1]oxazine and isoquino[2,1-a]pyrimidine derivatives via visible light photoredox catalysis

(2012) Jun Xuan et al.   RSC Advances

Double Duty for Cyanogen Bromide in a Cascade Synthesis of Cyanoepoxides

(2011) Zhou Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In Situ Generated (Hypo)Iodite Catalysts for the Direct α-Oxyacylation of Carbonyl Compounds with Carboxylic Acids

(2011) Muhammet Uyanik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-Light-Induced Oxidation/[3+2] Cycloaddition/Oxidative Aromatization Sequence: A Photocatalytic Strategy To Construct Pyrrolo[2,1-a]isoquinolines

(2011) You-Quan Zou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light photoredox catalyzed oxidative Strecker reaction

(2011) Magnus Rueping et al.   CHEMICAL COMMUNICATIONS

Direct amidation of azoles with formamides via metal-free C–H activation in the presence of tert-butyl perbenzoate

(2011) Tao He et al.   CHEMICAL COMMUNICATIONS

Synthesis of tert-butyl peresters from aldehydes by Bu4NI-catalyzed metal-free oxidation and its combination with the Kharasch–Sosnovsky reaction

(2011) Wei Wei et al.   CHEMICAL COMMUNICATIONS

Visible light-induced intramolecular cyclization reactions of diamines: a new strategy to construct tetrahydroimidazoles

(2011) Jun Xuan et al.   CHEMICAL COMMUNICATIONS

The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

(2011) Xinyi Ren et al.   CHEMICAL COMMUNICATIONS

Catalytic Dehydrogenative Cross-Coupling: Forming Carbon−Carbon Bonds by Oxidizing Two Carbon−Hydrogen Bonds

(2011) Charles S. Yeung et al.   CHEMICAL REVIEWS

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Bu4NI-Catalyzed CO Bond Formation by Using a Cross-Dehydrogenative Coupling (CDC) Reaction

(2011) Long Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Graphene oxide and Rose Bengal: oxidative C–H functionalisation of tertiary amines using visible light

(2011) Yuanhang Pan et al.   GREEN CHEMISTRY

Tropylium Ion Mediated α-Cyanation of Amines

(2011) Julia M. Allen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Cyanomethylation of Aryl Halides through Domino Suzuki Coupling–Isoxazole Fragmentation

(2011) Juraj Velcicky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Transformation ofN,N-Dimethylformamide to −CN: Pd-Catalyzed Cyanation of Heteroarenes via C–H Functionalization

(2011) Shengtao Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Collective synthesis of natural products by means of organocascade catalysis

(2011) Spencer B. Jones et al.   NATURE

Functionally Diverse Nucleophilic Trapping of Iminium Intermediates Generated Utilizing Visible Light

(2011) David B. Freeman et al.   ORGANIC LETTERS

Direct Condensation of Sulfonamide and Formamide: NaI-Catalyzed Synthesis ofN-Sulfonyl Formamidine Using TBHP as Oxidant

(2011) Shulin Chen et al.   ORGANIC LETTERS

Lewis Acid Catalyzed Direct Cyanation of Indoles and Pyrroles withN-Cyano-N-phenyl-p-toluenesulfonamide (NCTS)

(2011) Yang Yang et al.   ORGANIC LETTERS

Eosin Y Catalyzed Visible Light Oxidative C–C and C–P bond Formation

(2011) Durga Prasad Hari et al.   ORGANIC LETTERS

A Metal-Free Amination of Benzoxazoles – The First Example of an Iodide-Catalyzed Oxidative Amination of Heteroarenes

(2011) Tanja Froehr et al.   ORGANIC LETTERS

Photochemically Induced Radical Transformation of C(sp3)–H Bonds to C(sp3)–CN Bonds

(2011) Shin Kamijo et al.   ORGANIC LETTERS

Copper-Mediated Cyanation of Aryl Halide with the Combined Cyanide Source

(2011) Guoying Zhang et al.   ORGANIC LETTERS

A Mild and Efficient Palladium-Catalyzed Cyanation of Aryl Chlorides with K4[Fe(CN)6]

(2011) Pui Yee Yeung et al.   ORGANIC LETTERS

Discovery of an  -Amino C-H Arylation Reaction Using the Strategy of Accelerated Serendipity

(2011) A. McNally et al.   SCIENCE

Iron oligopyridine complexes as efficient catalysts for practical oxidation of arenes, alkanes, tertiary amines and N-acyl cyclic amines with Oxone

(2011) Peng Liu et al.   Chemical Science

Autoxidative Carbon-Carbon Bond Formation from Carbon-Hydrogen Bonds

(2010) Áron Pintér et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Gold-complexes catalyzed oxidative α-cyanation of tertiary amines

(2010) Yan Zhang et al.   CHEMICAL COMMUNICATIONS

Direct C−H Transformation via Iron Catalysis

(2010) Chang-Liang Sun et al.   CHEMICAL REVIEWS

Beyond Traditional Cross Couplings: The Scope of the Cross Dehydrogenative Coupling Reaction

(2010) Caroline J. Scheuermann   Chemistry-An Asian Journal

Mild oxidation of hydrocarbons by tert-butyl hydroperoxide catalyzed by electron deficient manganese(III) corroles

(2010) Suranjana Bose et al.   JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL

tert-Butoxide-Mediated Arylation of Benzene with Aryl Halides in the Presence of a Catalytic 1,10-Phenanthroline Derivative

(2010) Eiji Shirakawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organocatalysis in Cross-Coupling: DMEDA-Catalyzed Direct C−H Arylation of Unactivated Benzene

(2010) Wei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles

(2010) Chong Qin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A New Combined Source of “CN” fromN,N-Dimethylformamide and Ammonia in the Palladium-Catalyzed Cyanation of Aryl C−H Bonds

(2010) Jinho Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An efficient organocatalytic method for constructing biaryls through aromatic C–H activation

(2010) Chang-Liang Sun et al.   Nature Chemistry

Hydroacylation of α,β-unsaturated esters via aerobic C–H activation

(2010) Vijay Chudasama et al.   Nature Chemistry

Iron-CatalyzedN-Alkylation of Azoles via Oxidation of C−H Bond Adjacent to an Oxygen Atom

(2010) Shiguang Pan et al.   ORGANIC LETTERS

TBHP/I2-Mediated Domino Oxidative Cyclization for One-Pot Synthesis of Polysubstituted Oxazoles

(2010) Huanfeng Jiang et al.   ORGANIC LETTERS

An Efficient Transformation from Benzyl or Allyl Halides to Aryl and Alkenyl Nitriles

(2010) Wang Zhou et al.   ORGANIC LETTERS

A Simple and Efficient Approach to the Synthesis of 2-Phenylquinazolines via sp3C−H Functionalization

(2010) Jintang Zhang et al.   ORGANIC LETTERS

Quaternary Ammonium (Hypo)iodite Catalysis for Enantioselective Oxidative Cycloetherification

(2010) M. Uyanik et al.   SCIENCE

Catalytic Oxidative Coupling Reactions for the Formation of Carbon-Carbon Bonds without Carbon-Metal Intermediates

(2010) Martin Klussmann et al.   SYNTHESIS-STUTTGART

Catalytic Oxidative Synthesis of Nitriles Directly from Primary Alcohols and Ammonia

(2009) Takamichi Oishi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Room-Temperature CH Bond Activation of Methane by Bare [P4O10].+

(2009) Nicolas Dietl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Transformation of Methyl Arenes to Aryl Nitriles at Room Temperature

(2009) Wang Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Catalyzed CH Activation/CC Cross-Coupling Reactions: Versatility and Practicality

(2009) Xiao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iron catalyzed oxidative cyanation of tertiary amines

(2009) Wei Han et al.   CHEMICAL COMMUNICATIONS

Oxidative coupling of amines and ketones by combined vanadium- and organocatalysis

(2009) Abhishek Sud et al.   CHEMICAL COMMUNICATIONS

An efficient copper-catalyzed oxidative Mannich reaction between tertiary amines and methyl ketones

(2009) Youming Shen et al.   CHEMICAL COMMUNICATIONS

Methane Activation by Metal-Free Radical Cations: Experimental Insight into the Reaction Intermediate

(2009) Giulia de Petris et al.   CHEMISTRY-A EUROPEAN JOURNAL

Selective Functionalization of sp3C−H Bonds Adjacent to Nitrogen Using (Diacetoxyiodo)benzene (DIB)

(2009) Xing-Zhong Shu et al.   JOURNAL OF ORGANIC CHEMISTRY

Chemoselective C−H Bond Activation: Ligand and Solvent Free Iron-Catalyzed Oxidative C−C Cross-Coupling of Tertiary Amines with Terminal Alkynes. Reaction Scope and Mechanism

(2009) Chandra M. Rao Volla et al.   ORGANIC LETTERS

Free-Radical-Initiated Coupling Reaction of Alcohols and Alkynes: Not C−O but C−C Bond Formation

(2009) Zhong-Quan Liu et al.   ORGANIC LETTERS

CuBr-Mediated Oxyalkylation of Vinylarenes under Aerobic Conditions via Cleavage of sp3C−H Bonds α to Oxygen

(2009) Kai Cheng et al.   ORGANIC LETTERS

CuBr-Catalyzed Oxidative Difluoromethylation of Tertiary Amines with Difluoroenol Silyl Ethers

(2009) Lingling Chu et al.   ORGANIC LETTERS

Copper/Diethyl Azodicarboxylate Mediated Regioselective Alkynylation of Unactivated Aliphatic Tertiary Methylamine with Terminal Alkyne

(2009) Xiaoliang Xu et al.   ORGANIC LETTERS

Cross-Dehydrogenative Coupling (CDC): Exploring C−C Bond Formations beyond Functional Group Transformations

(2008) Chao-Jun Li   ACCOUNTS OF CHEMICAL RESEARCH

Ruthenium catalyzed biomimetic oxidation in organic synthesis inspired by cytochrome P-450

(2008) Shun-Ichi Murahashi et al.   CHEMICAL SOCIETY REVIEWS

Ruthenium-Catalyzed Oxidative Cyanation of Tertiary Amines with Molecular Oxygen or Hydrogen Peroxide and Sodium Cyanide: sp3C−H Bond Activation and Carbon−Carbon Bond Formation

(2008) Shun-Ichi Murahashi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY