期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 19, 期 1, 页码 82-86出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201203824
关键词
aldehydes; amidation; amines; iron; oxidation
资金
- National Science Foundation of China [20832002, 21072223, 21272267]
- State Key Laboratory of Heavy Oil Processing [2012-1-06]
- Fundamental Research Funds for the Central Universities
- Research Funds of Renmin University of China [10XNL017]
Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.
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