Article
Chemistry, Multidisciplinary
Jenae J. Linville, McKensie L. Mason, Edgar U. Lopez-Torres, Jon R. Parquette
Summary: The ability to integrate multiple components into a nanoscale structure with precision allows for the creation of novel materials with tunable properties. This study successfully demonstrated the integrative co-assembly of two components into a multicomponent nanotube and characterized its structure using various techniques.
Article
Chemistry, Multidisciplinary
Hang Zhao, Emmanuel Ibarboure, Vusala Ibrahimova, Ye Xiao, Elisabeth Garanger, Sebastien Lecommandoux
Summary: This research focuses on the rational design and synthesis of thermoresponsive hybrid polypeptide-polymer conjugates, which are used in combination with an artificial cytoplasm system to study the spatial organization and temperature-responsive dynamic assembly of artificial organelle structures within cell-mimicking entities.
Review
Pharmacology & Pharmacy
Corey. A. Stevens, Kuljeet Kaur, Harm-Anton Klok
Summary: Protein-polymer conjugates combine the stability of polymers with the diversity, specificity, and functionality of biomolecules, resulting in hybrid materials with unique properties for drug delivery applications. Engineering amphiphilicity into these bioconjugate materials can lead to phase separation and assembly of high-order structures, with multiple levels of organization and emergence of new properties at each level influenced by lower levels.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Nanoscience & Nanotechnology
Ankita Kumari, Ipsita Pani, Mohammad Umer Lone, Aditi Aggarwal, Santanu Kumar Pal, Raj Kumar Roy
Summary: Due to simple synthetic strategies, randomly functionalized amphiphilic polymers have become highly researched. Recent studies have shown that these polymers can self-assemble into various nanostructures, similar to amphiphilic block copolymers. The study explored the self-assembly behavior of randomly functionalized hyperbranched polymers and their linear analogues in solution and at the liquid crystal-water interfaces. Regardless of their architecture, the designed amphiphiles formed spherical nanoaggregates in solution and influenced the ordering transitions of liquid crystal molecules at the liquid crystal-water interface. However, the linear analogues required 10 times less amphiphiles compared to the hyperbranched polymers to achieve the same ordering transition of liquid crystal molecules. Additionally, only the linear analogues responded to biorecognition events, which can be attributed to both of the aforementioned differences.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Hsi-Yen Chang, Kuan-Yi Wu, Wei-Chun Chen, Jing-Ting Weng, Chin-Yi Chen, Ankit Raj, Hiro-O Hamaguchi, Wei-Tsung Chuang, Xiaosong Wang, Chien-Lung Wang
Summary: Inspired by nature, WISA utilizes water to regulate the self-assembly of amphiphilic discotic molecules, forming hexagonal columnar structures with adaptive water channels. The dynamic water channels can adjust themselves based on external conditions, controlling the assembly direction.
Review
Engineering, Biomedical
Yu Deng, Wenjun Zhan, Gaolin Liang
Summary: Intracellular self-assembly (ISA) is a powerful strategy for constructing complex nanostructures in cells, and has been widely applied in biomedicine and biomedical engineering. Using peptide conjugates for ISA in tumor imaging and treatment has made significant progress, with potential for other important imaging or therapeutic applications.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Manas Kumar Pradhan, Surya Suresh Puthenpurackal, Aasheesh Srivastava
Summary: A novel enzymatic dimerization-induced self-assembly (e-DISA) procedure using horseradish peroxidase (HRP) and alanine-tyramine conjugates was used to prepare multi-enzyme-loaded uniform hollow organic nanoparticles (NPs). These NPs enabled efficient detection of salivary glucose levels and exhibited good stability and cytocompatibility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Rui Zheng, Jia Yang, Muhetaerjiang Mamuti, Da-Yong Hou, Hong-Wei An, Yuliang Zhao, Hao Wang
Summary: This study designed peptide-cyanine conjugates that self-assemble into structures with controlled cyanine aggregation in cells, demonstrating distinct imaging or photothermal properties. By modifying functional molecules on in vivo self-assembled peptides, the desired biological applications were achieved.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Manuel G. Ricardo, Peter H. Seeberger
Summary: Biomaterials with improved biological features can be obtained by conjugating glycans to nanostructured peptides. Peptide-glycan chimeras were successfully obtained through the merging of peptide and glycan solid-phase syntheses using a bifunctional monosaccharide. Different chimeras containing various sugars and peptides were prepared and exhibited different self-assembling properties.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Manuel G. Ricardo, Peter H. Seeberger
Summary: Biomaterials with improved biological features can be obtained by conjugating glycans to nanostructured peptides. Creating peptide-glycan chimeras requires superb chemoselectivity. We expedite access to such chimeras by merging peptide and glycan solid-phase syntheses employing a bifunctional monosaccharide.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yin-Sheng Xu, Hao Wang, Zeng-Ying Qiao
Summary: This review highlights the application of self-assembled nanomaterials based on peptides in cancer treatment, focusing on the recent advances in in vivo self-assembly strategy. Different responsive assembly strategies have been developed to precisely control the diverse microenvironments of tumor cells, resulting in enhanced drug delivery and improved anticancer efficacy.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Katarina Gvozden, Sanja Novak Ratajczak, Alberto G. Orellana, Emmanuel Kentzinger, Ulrich Rucker, Jan K. G. Dhont, Cristiano De Michele, Emmanuel Stiakakis
Summary: Stiff DNA fragments can self-assemble into various smectic mesophases in concentrated aqueous solutions by selectively screening blunt-end DNA stacking interactions. The strength of attractions can be controlled to stabilize different phases, demonstrating the potential for precise tuning of DNA blunt-ends as monovalent attractive patches in the assembly of nonconventional DNA-based liquid crystal phases.
Article
Optics
Nana Li, Yurun Liang, Xiaotong Liu, Guangming Liang, Qianyao Zhang, Ruilin Zhang, Hongfei Gao, Yulong Xiao
Summary: Two amphiphiles with phenylthiophene and cyanostyrene groups in the rigid core and methyl and oligooxyethylene units at the terminal were synthesized. Their mesomorphic and optical behaviors were investigated using various experimental techniques. The positional isomerism led to distinct transition of self-assembly and optical properties, offering a method for constructing multifunctional molecules with different properties and applications.
JOURNAL OF LUMINESCENCE
(2023)
Article
Chemistry, Organic
Shakti K. Maurya, Sushil Swaroop Pathak, Leela S. Panchakarla, Harkesh B. Singh
Summary: In this study, Fc conjugated selenopeptides were synthesized using a modified SPSS protocol, and their self-assembled nanostructures were investigated. The importance of the Fc unit, aromatic moieties, and weak intermolecular interactions on the self-assembled process was revealed through systematic morphological studies.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shuai Zhang, Jiajun Chen, Jianli Liu, Harley Pyles, David Baker, Chun-Long Chen, James J. De Yoreo
Summary: Biomolecular self-assembly is a fundamental process used by life to create functional materials, but progress in engineering self-assembly at solid-liquid interfaces lags behind that in bulk solutions. Recent research has focused on programming self-assembly of peptides, proteins, and peptoids at solid-liquid interfaces, as well as advancing physical understandings of self-assembly pathways using in situ atomic force microscopy. These developments are leading to novel strategies for designing biomaterials organized at and interfaced with inorganic surfaces.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Valeria Castelletto, Ian W. Hamley
Summary: It has been demonstrated that a conserved coronavirus spike protein peptide can form amyloid structures, which has implications for the stability of the spike protein conformation and potential functional material applications.
Review
Chemistry, Physical
Ian W. Hamley
Summary: Lamellar structures are common in soft materials and exhibit characteristic scattering patterns. Diffuse scattering can provide information about the fluctuations and elastic properties of lamellae, as well as insights into the nature of correlated structures.
Article
Chemistry, Multidisciplinary
Joanna D. Stachowska, Monika B. Gamza, Claire Mellor, Ella N. Gibbons, Marta J. Krysmann, Antonios Kelarakis, Elzbieta Gumieniczek-Chlopek, Tomasz Straczek, Czeslaw Kapusta, Anna Szwajca
Summary: We present a simple strategy to generate a family of carbon dots/iron oxide nanoparticles with tunable composition and excellent properties, including antimicrobial activity and bioimaging capability, showing great potential for the development of advanced diagnostic tools.
Article
Biochemistry & Molecular Biology
Elisabetta Rosa, Lucas de Mello, Valeria Castelletto, Mark L. Dallas, Antonella Accardo, Jani Seitsonen, Ian W. Hamley
Summary: This study investigates the conformation and self-assembly behavior of four lipopeptides, and examines their potential applications in tissue engineering based on cytocompatibility assessments. The results show that all four lipopeptides can self-assemble into nanostructures at specific concentrations. Furthermore, these lipopeptides demonstrate promising prospects in tissue engineering.
Review
Nanoscience & Nanotechnology
Ian W. Hamley
Summary: This review focuses on the self-assembly, structural and functional properties of peptide conjugates containing bulky terminal aromatic substituents, with a particular emphasis on bioactivity. The driving force for self-assembly comes from pi-stacking and hydrophobic interactions, as well as hydrogen bonding, electrostatics, and other forces between short peptides. The balance of these interactions leads to a propensity for self-assembly, even for single amino acid conjugates. The resulting molecules often form hydrogels built from beta-sheet fibrils, with applications in biomaterials, drug delivery, catalysis, and optoelectronics.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Valeria Castelletto, Jani Seitsonen, Ian W. W. Hamley
Summary: This study investigates the self-assembly behavior of two monodisperse lipid A derivatives based on bacterial LPS structures in water and compares them to native Escherichia coli LPS using small-angle X-ray scattering and cryogenic transmission electron microscopy. The critical aggregation concentration and conformation are characterized using fluorescence probe experiments and circular dichroism spectroscopy, respectively. The E. coli LPS forms wormlike micelles, while the synthetic analogues self-assemble into nanosheets or vesicles depending on the number of lipid chains and saccharide head groups. These findings can be rationalized based on the surfactant packing parameter.
Article
Chemistry, Multidisciplinary
Biswanath Hansda, Jhilam Majumder, Biplab Mondal, Akash Chatterjee, Subhadeep Das, Sourav Kumar, Ratan Gachhui, Valeria Castelletto, Ian W. Hamley, Prosenjit Sen, Arindam Banerjee
Summary: A histidine-based amphiphilic peptide (P) was discovered to form an injectable transparent hydrogel with inherent antibacterial property in phosphate buffer solution. The peptide self-assembles into a nanofibrillar network structure and exhibits efficient antibacterial activity against both Gram-positive and Gram-negative bacteria. The hydrogel can also encapsulate and selectively release drugs, making it a potential antibacterial and drug delivering agent.
Article
Biochemistry & Molecular Biology
Valeria Castelletto, Lucas de Mello, Emerson Rodrigo da Silva, Jani Seitsonen, Ian W. Hamley
Summary: Considerable interest has been shown in peptides with the Fmoc protecting group, as it can promote self-assembly and has applications in cell culture biomaterials. New amino acid analogues with the Smoc protecting group have been developed for water-based peptide synthesis. Self-assembly of Smoc-Ala, Smoc-Phe, and Smoc-Arg occurs above the critical aggregation concentration (CAC) and forms nanosheet, nanoribbon, or nanotube structures. Smoc-amino acids show excellent biocompatibility and are taken up by fibroblast cells without cytotoxicity.
Article
Chemistry, Physical
Thiago C. Lourenco, Lucas R. de Mello, Marcelo Y. Icimoto, Renata N. Bicev, Ian W. Hamley, Valeria Castelletto, Clovis R. Nakaie, Emerson R. da Silva
Summary: This study presents a strategy for fabricating highly ordered 1D nanostructures of Bradykinin (BK) using DNA fragments as a template for self-assembly. The nanoscale structure of BK-DNA complexes was revealed, showing the formation of ordered nanofibrils. The complexes retained the native bioactivity of BK and could induce a limited uptake of nucleotides by HEK-293t cells, which has not been previously reported.
Article
Chemistry, Physical
Elisabetta Rosa, Carlo Diaferia, Lucas De Mello, Jani Seitsonen, Ian W. Hamley, Antonella Accardo
Summary: Short and ultra-short peptides are now being used as building blocks for self-assembled materials, with peptide aggregation being influenced by the amino acids in the sequence as well as their ability to interact with each other. By modifying peptides with polymeric moieties, alkyl chains, or other organic molecules, further structural and functional properties can be achieved. In this study, we synthesized and investigated the aggregation behavior of peptide amphiphiles (PAs) containing cationic tetra- or hexa-peptides derivatized with an alkyl chain. These PAs were able to form highly ordered nanostructures and biocompatible hydrogels, showing potential for tissue engineering and diagnostic applications.
Article
Chemistry, Physical
Jinghua Liu, Jingqing Li, Binyuan Liu, Ian W. Hamley, Shichun Jiang
Summary: The Mpemba effect and its inverse can be explained by nonequilibrium thermodynamics. While changes of state in polymers are generally non-equilibrium processes, the Mpemba effect is rarely seen in their crystallization. Polybutene-1 (PB-1) has the lowest critical cooling rate among polyolefins and tends to maintain its original structure and properties in the melt. Experimental observations confirm the presence of the Mpemba effect in both the crystallization of PB-1 in form II and form I obtained at low melting temperatures.
Article
Chemistry, Physical
Biswanath Hansda, Biplab Mondal, Soumyajit Hazra, Krishna Sundar Das, Valeria Castelletto, Ian W. Hamley, Arindam Banerjee
Summary: Peptide-based multicomponent hydrogels offer tunable mechanical properties and physical characteristics, demonstrating good cell compatibility and sustained drug release capabilities, and have the potential to serve as scaffold materials for tissue engineering.
Article
Chemistry, Physical
Biplab Mondal, Vivek Kumar Gupta, Biswanath Hansda, Arpita Bhoumik, Tanushree Mondal, Hemanta K. Majumder, Charlotte J. C. Edwards-Gayle, Ian W. Hamley, Parasuraman Jaisankar, Arindam Banerjee
Summary: Nanoscale self-assembly of peptide constructs is a promising approach for developing functional materials with bioactive properties. This study focuses on peptide amphiphdes that form hydrogels and have shown potential anti-microbial and anti-parasitic activities, particularly against drug-resistant strains of Leishmania. The amphiphdes were synthesized and characterized, and their self-assembly, gelation behavior, and properties were investigated. The results demonstrate that these gelators have both antibacterial and antiparasitic activities, making them promising therapeutic agents against leishmaniasis.
Article
Chemistry, Multidisciplinary
Barbara B. Gerbelli, Pedro L. O. Filho, Bruna Cortez, Pedro T. Sodre, Mauricio D. Coutinho-Neto, Ian W. Hamley, Jani Seitsonen, Wendel A. Alves
Summary: The use of lipopeptide sequences as biomimetic microenvironments of acetylcholinesterase (AChE) has shown higher catalytic activities than natural enzymes in water solution, potentially valuable for pesticide detection.
NANOSCALE ADVANCES
(2022)
Review
Nanoscience & Nanotechnology
Ian W. Hamley
Summary: This review discusses the use of peptide epitopes as antigens in vaccine development, focusing on their potential in clinical trials and as future vaccine candidates. It covers peptides used in immunotherapies for infectious diseases and cancer vaccines, as well as their application in stimulating non-specific immune responses and as self-adjuvanting peptides. The review highlights the specificity of the immune response that can be achieved using peptide epitopes and the potential for future therapies.
ACS APPLIED BIO MATERIALS
(2022)