Article
Neurosciences
Xueshi Chen, Cheng Gao, Ya'nan Yan, Zhiqi Cheng, Guang Chen, Tongyu Rui, Chengliang Luo, Yuan Gao, Tao Wang, Xiping Chen, Luyang Tao
Summary: Traumatic brain injury (TBI) is a major global cause of death and disability, with various forms of cell death involved including ferroptosis. This study investigated the effect of the FDA approved drug ruxolitinib (Ruxo) on ferroptosis post-TBI, demonstrating its significant inhibitory effect on ferroptosis and neuroprotective effects on TBI-induced neurological deficits.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hejun Zhang, Yalong Gao, Cong Wang, Xingqi Huang, Tuo Li, Kaiji Li, Ruilong Peng, Fanjian Li, Lei Li, Xu Zhang, Lichuan Yin, Shu Zhang, Jianning Zhang
Summary: This study demonstrates the involvement of ferritinophagy and ferroptosis in the intestinal oxidative stress injury following traumatic brain injury (TBI). It provides valuable insights into the mechanisms underlying intestinal damage post-TBI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Mariona Jove, Natalia Mota-Martorell, Elia Obis, Joaquim Sol, Meritxell Martin-Gari, Isidre Ferrer, Manuel Portero-Otin, Reinald Pamplona
Summary: The human brain is highly susceptible to oxidative stress due to its characteristics, but neurons have evolved various adaptive mechanisms to combat oxidative stress and preserve their functionality.
Article
Chemistry, Analytical
Yanyan Chen, Tao Wang, Peisi Xie, Yuanyuan Song, Jianing Wang, Zongwei Cai
Summary: In this study, MALDI-MSI was used to analyze A549 lung cancer multicellular spheroids, revealing that HCQ treatment altered the spatial composition and distribution of lipids in the inner and outer regions of the spheroids.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Chidozie C. Anyaegbu, Harrison Szemray, Sarah C. Hellewell, Nathan G. Lawler, Kerry Leggett, Carole Bartlett, Brittney Lins, Terence McGonigle, Melissa Papini, Ryan S. Anderton, Luke Whiley, Melinda Fitzgerald
Summary: Mild traumatic brain injury (mTBI) can cause structural, cellular, and biochemical changes in the brain that are difficult to detect and may persist chronically. Lipidomic analysis of blood samples, which can easily cross the blood-brain barrier, may provide valuable insights into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to analyze plasma lipid concentrations after 11 days of sham, one (1 x), or two (2 x) mTBI in rats. They identified 18 lipid species that distinguished between different injury conditions and found that the changes in lipid concentrations varied depending on the number of mTBI, suggesting a balance of damage and reparative responses.
Article
Biochemical Research Methods
Saleh M. Khalil, Richard R. Sprenger, Martin Hermansson, Christer S. Ejsing
Summary: Matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) is a useful technique for visualizing the spatial distribution of lipid molecules in tissues. The limitation of confident lipid identification in MSI has been overcome by the development of DDA-imaging technology. This study demonstrates the successful transfer of DDA-imaging technology onto another mass spectrometer and shows its reliability in lipid identification.
JOURNAL OF MASS SPECTROMETRY
(2022)
Article
Neurosciences
Grace Y. Sun, Michael K. Appenteng, Runting Li, Taeseon Woo, Bo Yang, Chao Qin, Meixia Pan, Magdalena Cieslik, Jiankun Cui, Kevin L. Fritsche, Zezong Gu, Matthew Will, David Beversdorf, Agata Adamczyk, Xianlin Han, C. Michael Greenlief
Summary: The study found that a DHA-enriched diet altered phospholipid species and led to a significant increase in the lipid peroxidation product 4-HHE in the brain and other organs of mice. Particularly, the hippocampus showed a notable response to the DHA-enriched diet.
NEUROMOLECULAR MEDICINE
(2021)
Article
Neurosciences
Ping Zheng, Dabin Ren, Cong Yu, Xiaoxue Zhang, Yisong Zhang
Summary: Circular ribonucleic acid (circRNA) plays a critical role in traumatic brain injury. This study identified a DNA methylation-related circRNA, circ_0116449, which may reduce neuronal loss by regulating lipid metabolism.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ying Cheng, Wenhao Qu, Jing Li, Bowen Jia, Yiting Song, Liyu Wang, Tongyu Rui, Qianqian Li, Chengliang Luo
Summary: This study investigated the effects of transferrin receptor 1 (TfR1) on ferroptosis in traumatic brain injury (TBI) by using ferristatin II. The results showed that ferristatin II reduced TfR1 expression after TBI and had inhibitory effects on iron homeostatic imbalance and lipid peroxidation. Additionally, ferristatin II alleviated neuronal injury and neurodegeneration induced by TBI.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ying Cheng, Yuan Gao, Jing Li, Tongyu Rui, Qianqian Li, Huan Chen, Bowen Jia, Yiting Song, Zhiya Gu, Tao Wang, Cheng Gao, Ying Wang, Zufeng Wang, Fudi Wang, Luyang Tao, Chengliang Luo
Summary: Ferroptosis, a form of regulated cell death triggered by iron-dependent lipid peroxidation, is involved in the pathophysiology of traumatic brain injury (TBI). N-acetyl serotonin (NAS), an agonist of TrkB and precursor of melatonin, has beneficial effects on TBI by suppressing ferroptosis through the activation of the TrkB/PI3K/Akt/Nrf2 pathway. NAS shows promise as an anti-ferroptosis agent for TBI treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Aria W. Tarudji, Hunter A. Miller, Evan T. Curtis, Christopher L. Porter, Gary L. Madsen, Forrest M. Kievit
Summary: This study found that using Pro-NPTM nanoparticles with high accumulation and retention capacity can effectively inhibit oxidative stress and reduce brain injury. The treatment effect of Pro-NPTM also differs between male and female mice, suggesting a possible gender-based difference in response to antioxidant nanoparticle delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Kazuaki Yoshinaga, Yuka Usami, Aya Yoshinaga-Kiriake, Hitomi Shikano, Shu Taira, Reiko Nagasaka, Seiya Tanaka, Naohiro Gotoh
Summary: The study on zebrafish models found that dietary DHA is initially structured into PC as a component of intestinal cell membranes, then gradually migrates to peripheral tissues such as muscles. These processes were observed and tracked in zebrafish at different time points.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Cell Biology
Tingting Yu, Shibo Sun
Summary: Ferroptosis, a non-apoptotic cell death, is involved in the development of acute lung injury (ALI). Inhibiting lung cell ferroptosis improves ALI, and several signaling pathways and key factors have been identified to regulate ferroptosis in ALI.
Article
Biochemistry & Molecular Biology
Sin Man Lam, Jie Li, Huan Sun, Weining Mao, Zongmin Lu, Qingshuo Zhao, Chao Han, Xia Gong, Binhua Jiang, Gek Huey Chua, Zhenwen Zhao, Fanwei Meng, Guanghou Shui
Summary: The neural compartmentalization of lipid distribution and metabolism is associated with troglomorphic traits in Sinocyclocheilus cavefish. This includes reductions in DHA-phospholipids and accumulation of arachidonic acid-phospholipids in the brain, demyelination in serotonergic neurons, and systemic reductions in esterified DHAs in the liver. These adaptations serve to reduce energy expenditure and are crucial for the survival of cavefish in cave environments.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Medicine, Research & Experimental
Xiwei Fan, Reuben S. E. Young, Antonia Rujia Sun, Brett R. Hamilton, Udhaya Nedunchezhiyan, Ross Crawford, Stephen J. Blanksby, Indira Prasadam
Summary: This study used mass spectrometry imaging to visualize the distribution of lipase enzymes in bone and cartilage tissue sections and correlated them with immunohistochemistry staining results. The results showed that OA patients exhibited increased expression of PLA(2)G(2)A at the superficial and deep cartilage zones, indicating that tissue-specific inhibition of PLA(2)G(2)A may be a potential therapeutic target for OA.
Review
Cell Biology
Yulia Y. Tyurina, Claudette M. St Croix, Simon C. Watkins, Alan M. Watson, Michael W. Epperly, Tamil S. Anthonymuthu, Elena R. Kisin, Irina I. Vlasova, Olga Krysko, Dmitri V. Krysko, Alexandr A. Kapralov, Haider H. Dar, Vladimir A. Tyurin, Andrew A. Amoscato, Elena N. Popova, Sergey B. Bolevich, Peter S. Timashev, John A. Kellum, Sally E. Wenzel, Rama K. Mallampalli, Joel S. Greenberger, Hulya Bayir, Anna A. Shvedova, Valerian E. Kagan
JOURNAL OF LEUKOCYTE BIOLOGY
(2019)
Article
Critical Care Medicine
Nahmah Kim-Campbell, Catherine Gretchen, Vladimir B. Ritov, Patrick M. Kochanek, Goundappa K. Balasubramani, Elizabeth Kenny, Mahesh Sharma, Melita Viegas, Clifton Callaway, Valerian E. Kagan, Huelya Bayir
PEDIATRIC CRITICAL CARE MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
V. E. Kagan, Y. Y. Tyurina, W. Y. Sun, I. I. Vlasova, H. Dar, V. A. Tyurin, A. A. Amoscato, R. Mallampalli, P. C. A. van der Wel, R. R. He, A. A. Shvedova, D. Gabrilovich, H. Bayir
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Alexandr A. Kapralov, Qin Yang, Haider H. Dar, Yulia Y. Tyurina, Tamil S. Anthonymuthu, Rina Kim, Claudette M. St Croix, Karolina Mikulska-Ruminska, Bing Liu, Indira H. Shrivastava, Vladimir A. Tyurin, Hsiu-Chi Ting, Yijen L. Wu, Yuan Gao, Galina V. Shurin, Margarita A. Artyukhova, Liubov A. Ponomareva, Peter S. Timashev, Rosario M. Domingues, Detcho A. Stoyanovsky, Joel S. Greenberger, Rama K. Mallampalli, Ivet Bahar, Dmitry I. Gabrilovich, Hulya Bayir, Valerian E. Kagan
NATURE CHEMICAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
George S. Hussey, Catalina Pineda Molina, Madeline C. Cramer, Yulia Y. Tyurina, Vladimir A. Tyurin, Yoojin C. Lee, Salma O. El-Mossier, Mark H. Murdock, Peter S. Timashev, Valerian E. Kagan, Stephen F. Badylak
Article
Environmental Sciences
E. R. Kisin, N. Yanamala, D. Rodin, A. Menas, M. Farcas, M. Russo, S. Guppi, T. O. Khaliullin, I. Iavicoli, M. Harper, A. Star, V. E. Kagan, A. A. Shvedova
Review
Neurosciences
Andrew M. Lamade, Tamil S. Anthonymuthu, Zachary E. Hier, Yuan Gao, Valerian E. Kagan, Hulya Bayir
EXPERIMENTAL NEUROLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Thomas Uray, Cameron Dezfulian, Abigail A. Palmer, Kristin M. Miner, Rehana K. Leak, Jason P. Stezoski, Keri Janesko-Feldman, Patrick M. Kochanek, Tomas Drabek
Summary: The study found that there are differences in cytokine responses in serum, heart, and brain between asphyxial cardiac arrest (ACA) and ventricular fibrillation cardiac arrest (VFCA), but the changes in cytokine levels and secondary injuries caused by the two types of cardiac arrest are similar.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Critical Care Medicine
Kate F. Kernan, Rachel P. Berger, Robert S. B. Clark, R. Scott Watson, Derek C. Angus, Ashok Panigrahy, Clifton W. Callaway, Michael J. Bell, Patrick M. Kochanek, Ericka L. Fink, Dennis W. Simon
Summary: This study investigated the association between serum biomarkers of inflammation and neurological outcomes in children following cardiac arrest. Elevated levels of CNTF and IL-17 were found to be independently associated with unfavorable 6-month neurological outcomes, suggesting a potential role in post-cardiac arrest syndrome pathophysiology.
Article
Critical Care Medicine
Jeremy R. Herrmann, Ericka L. Fink, Anthony Fabio, Alicia K. Au, Rachel P. Berger, Keri Janesko-Feldman, Robert S. B. Clark, Patrick M. Kochanek, Travis C. Jackson
Summary: This study investigated the serum levels of FGF21 and GDF-15 in pediatric cardiac arrest patients and found that both levels increased after cardiac arrest. Additionally, therapeutic hypothermia appeared to augment the effects of FGF21.
Article
Biochemistry & Molecular Biology
Travis C. Jackson, Cameron Dezfulian, Vincent A. Vagni, Jason Stezoski, Keri Janesko-Feldman, Patrick M. Kochanek
Summary: This study evaluated the neuroprotective effects of several unexplored PHLPP inhibitors and found that NSC74429 has neuroprotective effects across multiple injury mechanisms. Further research and optimization of drug dosing are necessary.
Editorial Material
Critical Care Medicine
Patrick M. Kochanek, Dennis W. Simon, Amy K. Wagner
Letter
Cardiac & Cardiovascular Systems
Jeremy R. R. Herrmann, Travis C. C. Jackson, Anthony Fabio, Robert S. B. Clark, Rachel P. P. Berger, Keri L. L. Janesko-Feldman, Patrick M. M. Kochanek, Ericka L. L. Fink, POCCA Investigators
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Kara Snyder, Kiersten Gorse, Patrick M. Kochanek, Travis C. Jackson
Summary: The inhibition of the pro-death gene RBM5 does not affect neuronal survival in primary neurons, but it does regulate intracellular responses to injury in a sex-dependent manner.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Hulya Bayir, Tamil S. Anthonymuthu, Yulia Y. Tyurina, Sarju J. Patel, Andrew A. Amoscato, Andrew M. Lamade, Qin Yang, Georgy K. Vladimirov, Caroline C. Philpott, Valerian E. Kagan
CELL CHEMICAL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Raja Narayanasamy, Dandamudi Usharani, Ram Rajasekharan
Summary: This study investigated the role of ABHD16B in lipid metabolism. The overexpression of ABHD16B was found to decrease cellular triacylglycerol levels and increase phospholipid synthesis in yeast cells. Additionally, ABHD16B overexpression led to a reduction in lipid droplets and significant modifications in fatty acid composition. These findings highlight the importance of ABHD16B in lipid homeostasis and provide insights into its regulatory function in cellular lipid metabolism.
CHEMISTRY AND PHYSICS OF LIPIDS
(2024)