TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway

Ferristatin II, an Iron Uptake Inhibitor, Exerts Neuroprotection against Traumatic Brain Injury via Suppressing Ferroptosis

(2022) Ying Cheng et al.   ACS Chemical Neuroscience

Acute treatment with TrkB agonist LM22A-4 confers neuroprotection and preserves myelin integrity in a mouse model of pediatric traumatic brain injury

(2021) Jessica L. Fletcher et al.   EXPERIMENTAL NEUROLOGY

Protective effects of combined treatment with mild hypothermia and edaravone against cerebral ischemia/reperfusion injury via oxidative stress and Nrf2 pathway regulation

(2020) Hang Yu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

CDDO-Me Distinctly Regulates Regional Specific Astroglial Responses to Status Epilepticus via ERK1/2-Nrf2, PTEN-PI3K-AKT and NFκB Signaling Pathways

(2020) Ji-Eun Kim et al.   Antioxidants

Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer

(2020) Chuntao Quan et al.   CANCER LETTERS

α‐Lipoic acid alleviates ferroptosis in the MPP + ‐induced PC12 cells via activating the PI3K/Akt/Nrf2 pathway

(2020) Lin Liu et al.   CELL BIOLOGY INTERNATIONAL

Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis

(2020) Tongyu Rui et al.   JOURNAL OF PINEAL RESEARCH

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Renal control of disease tolerance to malaria

(2019) Susana Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traumatic brain injury: global collaboration for a global challenge

(2019) Angelos G Kolias et al.   LANCET NEUROLOGY

A Role for Postsynaptic Density 95 and its Binding Partners in Models of Traumatic Brain Injury

(2019) Mihir V. Patel et al.   JOURNAL OF NEUROTRAUMA

N-Acetyl Serotonin Protects Neural Progenitor Cells Against Oxidative Stress-Induced Apoptosis and Improves Neurogenesis in Adult Mouse Hippocampus Following Traumatic Brain Injury

(2019) Qingzhi Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

(2019) Yang Li et al.   CELL DEATH AND DIFFERENTIATION

Attenuation of white matter damage following Deferoxamine treatment in rats after spinal cord injury

(2019) Jiantao Shi et al.   World Neurosurgery

miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2

(2019) Xiao Xiao et al.   Molecular Brain

A TrkB receptor agonist N-acetyl serotonin provides cerebral protection after traumatic brain injury by mitigating apoptotic activation and autophagic dysfunction

(2019) Tongyu Rui et al.   NEUROCHEMISTRY INTERNATIONAL

Intranasally Delivered Wnt3a Improves Functional Recovery after Traumatic Brain Injury by Modulating Autophagic, Apoptotic, and Regenerative Pathways in the Mouse Brain

(2018) James Ya Zhang et al.   JOURNAL OF NEUROTRAUMA

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice

(2018) Bao-Shu Xie et al.   CNS Neuroscience & Therapeutics

Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration

(2018) Shashank Masaldan et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tachykinin NK1 receptor antagonist L-733,060 and substance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice

(2018) Qianqian Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway

(2018) Junmin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease

(2017) Tahir Ali et al.   MOLECULAR NEUROBIOLOGY

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

(2017) Richard Rubenstein et al.   JAMA Neurology

Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells

(2017) Jae-Myung Yoo et al.   Redox Biology

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

TrkB-enhancer facilitates functional recovery after traumatic brain injury

(2017) John Marshall et al.   Scientific Reports

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: autophagy and the PI3K/AKT pathways as a potential mechanism

(2016) Yongyue Gao et al.   JOURNAL OF SURGICAL RESEARCH

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation

(2015) Rahul Agrawal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice

(2015) Xin-Yu Lu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Iron Deposition Is Positively Related to Cognitive Impairment in Patients with Chronic Mild Traumatic Brain Injury: Assessment with Susceptibility Weighted Imaging

(2015) Liyan Lu et al.   Biomed Research International

Neurobehavioral sequelae of traumatic brain injury: evaluation and management

(2015) THOMAS W. MCALLISTER   World Psychiatry

N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury

(2014) H. Zhou et al.   JOURNAL OF NEUROSCIENCE

Reversible Behavioral Phenotypes in a Conditional Mouse Model of TDP-43 Proteinopathies

(2014) J. A. Alfieri et al.   JOURNAL OF NEUROSCIENCE

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats

(2014) Jinbing Zhao et al.   Translational Stroke Research

Small Molecules Activating TrkB Receptor for Treating a Variety of CNS Disorders

(2013) Yan Zeng et al.   CNS & Neurological Disorders-Drug Targets

Correction: Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

(2013) Cong Cao et al.   PLOS BIOLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury

(2012) Lijun Zhang et al.   NEUROLOGICAL SCIENCES

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

(2011) C.-L. Luo et al.   NEUROSCIENCE

Hemoglobin and Iron Handling in Brain after Subarachnoid Hemorrhage and the Effect of Deferoxamine on Early Brain Injury

(2010) Jin-Yul Lee et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

N-acetylserotonin activates TrkB receptor in a circadian rhythm

(2010) Sung-Wuk Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deferoxamine Treatment for Intracerebral Hemorrhage in Aged Rats

(2010) Masanobu Okauchi et al.   STROKE

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY