Article
Cell Biology
Daofeng You, Qiuge Qiao, Katsushige Ono, Mei Wei, Wenyun Tan, Cuihua Wang, Yangong Liu, Gang Liu, Mingqi Zheng
Summary: This study reveals that miR-223-3p plays a negative regulatory role in inflammatory responses in atherosclerosis, possibly through the MEK1/ERK1/2 signaling pathway. MiR-223-3p can alleviate the formation of atherosclerotic plaques and reduce the number of inflammatory cells, providing new therapeutic prospects for the treatment of atherosclerosis.
Article
Chemistry, Medicinal
Ramulu Poddutoori, Kimberly Aardalen, Kiran Aithal, Sanjeev Surendranath Barahagar, Charamanna Belliappa, Mark Bock, Shekar Chelur, Andrea Gerken, Sreevalsam Gopinath, Bjoern Gruenenfelder, Michael Kiffe, Maithreyi Krishnaswami, John Langowski, Sudharshan Madapa, Kishore Narayanan, Chetan Pandit, Sunil Kumar Panigrahi, Mark Perrone, Ravi Kumar Potakamuri, Murali Ramachandra, Anuradha Ramanathan, Rita Ramos, Emine Sager, Susanta Samajdar, Hosahalli S. Subramanya, Devaraja Seethappa Thimmasandra, Eleni Venetsanakos, Henrik Mobitz
Summary: This study reports the discovery of a novel MEK1/2 inhibitor that shows efficacy in both wildtype and mutant MEK1/2 models. The compound was optimized to address its liabilities and showed comparable efficacy to clinical MEK1/2 inhibitors in BRAF-mutant models.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Faiz Bilal, Enrique J. Arenas, Kim Pedersen, Alex Martinez-Sabadell, Behnam Nabet, Elizabeth Guruceaga, Silvestre Vicent, Josep Tabernero, Teresa Macarulla, Joaquin Arribas
Summary: This study demonstrates that SLUG confers resistance to MEK1/2 inhibitors in pancreatic cancer by uncoupling tumor progression from KRAS-RAF-MEK1/2-ERK1/2 signaling, providing new therapeutic opportunities.
Review
Biochemistry & Molecular Biology
Richard M. Lucas, Lin Luo, Jennifer L. Stow
Summary: This article summarizes the important role of ERK1/2 in cell signaling, particularly in immune responses in immune cells. Additionally, it discusses the dysfunctional signaling of ERK1/2 in inflammatory diseases and explores the potential therapeutic benefits of targeting this pathway in inflammation.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Oncology
Laurence Booth, Cameron West, Daniel Von Hoff, John M. Kirkwood, Paul Dent
Summary: The study revealed a lethal interaction between GZ17-6.02 and the MEK1/2 inhibitor trametinib and the B-RAF inhibitor dabrafenib, showing potential in killing melanoma cells and impacting multiple signaling pathways differently.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jian Zhang, Jiaojiao Zhang, Wenli Liu, Rui Ge, Tianyuan Gao, Qiong Tian, Xin Mu, Lingyu Zhao, Xu Li
Summary: UBTF is a DNA binding protein involved in basal transcription and has been found to play a role in carcinogenesis in some cancers. In melanoma, UBTF was found to promote cell proliferation and cell cycle progression by upregulating GIT1 expression, thereby activating the MEK1/2-ERK1/2 signaling pathways. This study suggests that UBTF may be a potential therapeutic target for melanoma treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Teng Xue, Xiaoqiu Liu, Mei Zhang, Qiukai E, Shuting Liu, Maosheng Zou, Ying Li, Zhinan Ma, Yun Han, Paul Thompson, Xuesen Zhang
Summary: The study found that PADI2 plays a role in promoting the progression of endometrial cancer (EC) by facilitating the expression of IGF2BP1 and preventing SOX2 mRNA degradation. Inhibiting PADI2/MEK1 signaling could be a potential therapeutic approach for EC.
Article
Biochemistry & Molecular Biology
Andre Schreiber, Dorothee Viemann, Jennifer Schoening, Sebastian Schloer, Angeles Mecate Zambrano, Linda Brunotte, Aileen Faist, Michael Schoefbaenker, Eike Hrincius, Helen Hoffmann, Markus Hoffmann, Stefan Poehlmann, Ursula Rescher, Oliver Planz, Stephan Ludwig
Summary: The Raf/MEK/ERK signaling pathway may represent a target for therapeutic intervention against SARS-CoV-2 infections, and ATR-002 shows promising potential as a candidate drug with strong antiviral activity and the ability to prevent COVID-19-associated inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Penglei Wang, Xuechao Jia, Bingbing Lu, Han Huang, Jialin Liu, Xuejiao Liu, Qiong Wu, Yamei Hu, Pan Li, Huifang Wei, Tingting Liu, Dengyun Zhao, Lingwei Zhang, Xueli Tian, Yanan Jiang, Yan Qiao, Wenna Nie, Xinli Ma, Ruihua Bai, Cong Peng, Zigang Dong, Kangdong Liu
Summary: In this study, Erianin was found to suppress the activation of the MAPK signaling pathway induced by BRAF V600E or RAS mutations in melanoma and colorectal cancer cells. It inhibited the activities of MEK1/2 and CRAF kinases, leading to the suppression of tumor growth. This discovery provides a promising candidate compound for the treatment of BRAF V600E or RAS mutant melanoma and colorectal cancer.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Cheng Wei, Xiaoyang Zhang, Dazhao Peng, Xu Zhang, Haizhen Guo, Yalin Lu, Lin Luo, Bo Wang, Zesheng Li, Yingjie He, Xuezhi Du, Shu Zhang, Hao Liang, Shenghui Li, Sheng Wang, Lei Han, Jianning Zhang
Summary: This study revealed that upregulation of HOXA11-AS in glioma is associated with poor prognosis. Its ectopic expression promotes proliferation, migration, and invasion of glioma cells, acting as a molecular sponge for let-7b-5p to regulate CTHRC1 expression and activate the beta-catenin/c-Myc pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Shuang-Shuang Dong, Dan-Dan Dong, Zhang-Fu Yang, Gui-Qi Zhu, Dong-Mei Gao, Jie Chen, Yan Zhao, Bin-Bin Liu
Summary: The study demonstrated that exosomal miR-3682-3p derived from HCC cells attenuates angiogenesis by targeting ANGPT1 through RAS-MEK1/2-ERK1/2 signaling, providing novel potential targets for liver cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Geriatrics & Gerontology
Khushboo Srivastava, Rajnikant Mishra
Summary: This study aims to evaluate the expression patterns of Pax6 and its interaction with Ras, Raf, and ERK1/2 in different brain regions of mice. The results indicate age-dependent changes of Pax6, Ras, Raf, and ERK1/2 in different regions of the brain. ERK1/2 shows synergistic activities with Pax6.
Review
Cell Biology
Alessandro Tubita, Ignazia Tusa, Elisabetta Rovida
Summary: Molecularly tailored therapies have revolutionized cancer treatment, yet resistance mechanisms remain a major obstacle. The activation of the MEK5-ERK5 pathway as a resistance mechanism to RAF-MEK1/2-ERK1/2 inhibitors is discussed, emphasizing the need for the development of additional MEK5-ERK5 inhibitors to prevent resistance to cancer therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kathryn Balmanno, Andrew M. Kidger, Dominic P. Byrne, Matthew J. Sale, Nejma Nassman, Patrick A. Eyers, Simon J. Cook
Summary: Innate or acquired resistance to BRAF or MEK1/2 inhibitors often results in sustained or reinstated activation of ERK1/2. To overcome this, ERK1/2 inhibitors have been developed that can inhibit catalytic activity or prevent activation of ERK1/2. In this study, it was found that multiple ERK inhibitors can drive turnover of ERK2, the most abundant isoform, without affecting ERK1. This turnover is caused by ERKi binding to ERK2 and can be prevented by MEKi pre-treatment. ERKi treatment leads to ubiquitination and proteasome-dependent degradation of ERK2. These findings suggest that ERKi act as "kinase degraders" and may have implications for the therapeutic use of ERKi.
BIOCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ying Liu, Wen-da Shi, Qian-Qian Xie, Ji-Gui Wang, Chen-Chen Gu, Zhi-Hui Ji, Jun Xiao, Wei-Quan Liu
Summary: In this study, it is shown that feline calicivirus (FCV) induces the production of cyclooxygenase-2 (COX 2) through the MEK1-ERK1/2 signaling pathway. Screening of FCV proteins revealed that FCV nonstructural protein VPg enhanced COX-2 expression, and in vivo experiments demonstrated that inhibition of MEK1 significantly suppressed COX-2 and IL-6 production caused by FCV infection, resulting in reduced lung inflammation and injury.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)