Review
Biochemistry & Molecular Biology
Krismala Djayanti, Pooja Maharjan, Kwan Hyung Cho, Sehoon Jeong, Man Su Kim, Meong Cheol Shin, Kyoung Ah Min
Summary: With advances in nanotechnology, mesoporous silica nanoparticles (MSNs) have been extensively studied as potential nanocarriers for drug delivery. This review introduces the physicochemical properties and synthesis procedures of MSNs as well as their biomedical applications and clinical trials. MSNs offer advantages such as nanoscale size, high surface area, and porous structures for efficient delivery of high drug-loading content. However, there are still considerations, such as optimizing physicochemical properties and dosage regimens, and addressing biosafety and toxicity issues, for the clinical use of MSNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Tauqir Nasir, Li Shao, Yisong Han, Richard Beanland, Philip N. Bartlett, Andrew L. Hector
Summary: This study successfully prepared Au nanostructures through electrodeposition using mesoporous silica films as hard templates. By optimizing the conditions, pores with sizes below 10 nm were controlled, and the growth of nanostructures was initiated at the electrode surface. The hard templates and Au electrodeposits were characterized using various methods. Finally, the silica templates were removed and stable Au nanoparticles on different electrode surfaces were achieved.
NANOSCALE ADVANCES
(2022)
Review
Multidisciplinary Sciences
Rajkamal Balu, Naba K. Dutta, Ankit K. Dutta, Namita Roy Choudhury
Summary: Intrinsically disordered proteins, such as the native elastic insect protein Resilin, have brought about a significant shift in the structure-function paradigm of proteins. Advances in computational techniques, polypeptide synthesis methods, and modular protein engineering have led to the development of novel resilin-like polypeptides with applications in various fields. The encoding of responsive behavior in amino acid sequence level remains a mystery, but the potential for future research lies in the design and development of new modular RLP-based biomaterials with programmable structure, properties, and functions. Resilin-mimetics have emerged as a biomaterial with versatile potential applications, and further exploration and mimicry of natural materials are ongoing.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Composites
Aanchal Jaisingh, Vishal Goel, Gurpreet Singh Kapur, Leena Nebhani
Summary: Mesoporous silica nanoparticles (MSN) were synthesized through base-catalyzed hydrolysis of tetraethyl orthosilicate in a water-acetone medium. The surface of the MSN was modified using a commercially available silane, 3-(trimethoxysilyl)propyl methacrylate, which was reacted with mono-thioglycerol via a thiol-ene reaction. The modified MSN showed improved properties in terms of anti-blocking, thermal, mechanical, optical, and barrier properties when compared to commercial silica particles. The mechanical properties of the modified MSN-containing films were enhanced, while the films with commercial silica showed decreased mechanical properties. The modified MSN also improved the optical properties of the films, reducing haze and increasing gloss.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Hafiz Ahmed, Shyam Sudhakar Gomte, Eluri Prathyusha, A. Prabakaran, Mukta Agrawal, Amit Alexander
Summary: Mesoporous silica nanoparticles (MSNs) have unique properties that make them attractive to biomedical researchers. Over the past decade, these properties have been extensively explored in various biomedical applications, such as drug delivery, photodynamic therapy, biosensors, and tissue engineering. However, further in vivo studies are needed to analyze the potential adverse reactions and side effects of these nanoparticle-based drug delivery systems for clinical translation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Bahar Aslanbay Guler, Zeliha Demirel, Esra Imamoglu
Summary: From a bioengineering perspective, incorporating microalgae into chemobrionic structures can lead to functional materials with potential in various applications. In this study, the incorporation of Arthrospira platensis microalgae was successfully achieved, resulting in the development of a bioactive and biomimetic material called biochemobrionic. Various characterization analyses confirmed the presence of microalgal biomass and extract, and it was demonstrated that the incorporation of A. platensis extract improved the mechanical strength of the chemobrionics. Cytotoxicity, biodegradability, and antioxidant activity assays further revealed the bioactive potential of the extract-incorporated biochemobrionics.
APPLIED MATERIALS TODAY
(2023)
Review
Chemistry, Analytical
Barbara Sartori, Heinz Amenitsch, Benedetta Marmiroli
Summary: Mesoporous materials show great potential for biotechnological applications due to their high surface area, pore interconnection, and ability for controlled molecule delivery. Functionalized thin films of mesoporous silica and titania offer diverse properties, such as cell growth promotion, biofilm inhibition, and sensor development. Incorporation of these materials into devices with tailored architecture and functionalization can result in advanced micro devices that combine standard micro/nanofluids with functional materials.
Article
Biophysics
Sandra Montalvo-Quiros, Sergio Gomez-Grana, Maria Vallet-Regi, Rafael C. Prados-Rosales, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: Tuberculosis remains a major public health issue with a lack of effective vaccine and the emergence of highly antibiotic-resistant strains of Mycobacterium tuberculosis. Silver nanoparticles show high bactericidal efficacy, but their relatively high toxicity calls for the design of nanocarriers for safe delivery. Mesoporous silica nanoparticles have been used as carriers for silver nanoparticles as antimycobacterial agents, demonstrating good capability against Mtb with different synthetic approaches.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Food Science & Technology
Yaning Shi, Kai Zhou, Dandan Li, Vincent Guyonnet, Maxwell T. Hincke, Yoshinori Mine
Summary: The eggshell membrane (ESM), made mainly of collagen-like proteins, is a novel biomaterial with potential applications in nutraceutical, cosmetic, and pharmaceutical fields. This review discusses the structure, chemical composition, isolation methods of ESM, as well as the role and performance of ESM-derived products in various applications. Safety evaluation of ESM and its potential in different engineering fields are also highlighted for future directions and applications.
Article
Chemistry, Multidisciplinary
Mehraneh Kermanian, Somayeh Sadighian, Ali Ramazani, Mehran Naghibi, Seyed Hojjat Hosseini
Summary: A novel magnetic hybrid silica/hydroxyapatite nanocomposite, MSFeHA, was successfully synthesized and studied as an MRI T2 contrast agent. The biocompatibility and bioaccumulation of the nanocomposite were evaluated through a series of experiments, showing potential clinical application value.
Review
Biotechnology & Applied Microbiology
Ranjith Kumar Kankala, Ya-Hui Han, Hong-Ying Xia, Shi-Bin Wang, Ai-Zheng Chen
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in biomedical applications, but traditional MSNs have limitations such as reduced drug encapsulation efficacy and poor degradability. Hierarchically-engineered MSNs have been developed by tuning the pore sizes, modifying the surfaces, and engineering the siliceous networks. These engineered MSNs have complex structures and can be applied in drug delivery, bioimaging, tissue engineering, and other fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Kai Cheng, Junlei Wang, Xueqin Wang, Zengkai Wang, Liwei Zhang, Ying Li, Lei Liu
Summary: This study successfully prepared novel films of TiO2 nanotubes based on a silk fibroin substrate, which have sufficient mechanical strength and flexibility, with the nanotube structure remaining unchanged and suitable for further applications.
Article
Chemistry, Multidisciplinary
Cheng Xu, Hannah E. Dobson, Mengjie Yu, Wang Gong, Xiaoqi Sun, Kyung Soo Park, Andrew Kennedy, Xingwu Zhou, Jin Xu, Yao Xu, Andrew W. Tai, Yu Leo Lei, James J. Moon
Summary: This study developed a manganese-silica nanoplatform (MnOx@HMSN) that enhances the adjuvant effects of CDNs for vaccination against cancer and SARS-CoV-2. The nanoplatform efficiently co-loaded CDNs and antigens, resulting in robust immune responses and therapeutic efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Toxicology
Priti Singh, Sameer Srivastava, Sunil Kumar Singh
Summary: This study evaluated the interaction between nanosilica and the blood coagulation system, and found that nanosilica has no stimulatory effect on platelets and no effective interaction with coagulation proteins.
TOXICOLOGY IN VITRO
(2022)
Article
Pharmacology & Pharmacy
Daniela Reichinger, Manuel Reithofer, Mariam Hohagen, Mirjana Drinic, Joshua Tobias, Ursula Wiedermann, Freddy Kleitz, Beatrice Jahn-Schmid, Christian F. W. Becker
Summary: Nature provides optimized materials with unique properties and biocompatibility that can be used as biomimetic materials. In this study, biomimetic silica particles were used as a vaccine delivery and adjuvant platform by linking specific peptides to peptide antigens. These antigen-loaded silica particles combine the advantages of biomaterial-based vaccines and the proven intracellular uptake of silica particles, inducing immune responses.
Article
Engineering, Biomedical
Muhammad Imran Rahim, Rainer Eifler, Bushra Rais, Peter P. Mueller
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2015)
Article
Engineering, Biomedical
Andreas Weizbauer, Marc Kieke, Muhammad Imran Rahim, Gian Luigi Angrisani, Elmar Willbold, Julia Diekmann, Thilo Floerkemeier, Henning Windhagen, Peter Paul Mueller, Peter Behrens, Stefan Budde
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2016)
Article
Engineering, Biomedical
Franziska Duda, Marc Kieke, Florian Waltz, Maria E. Schweinefuss, Muhammad Badar, Peter Paul Mueller, Karl-Heinz Esser, Thomas Lenarz, Peter Behrens, Nils Kristian Prenzler
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2015)
Article
Biochemical Research Methods
Hani E. J. Kaba, Natalia Maier, Nicole Schliebe-Ohler, Yvonne Mayer, Peter P. Mueller, Joop van den Heuvel, Johannes Schuchhardt, Katja Hanack, Ursula Bilitewski
JOURNAL OF MICROBIOLOGICAL METHODS
(2015)
Article
Engineering, Biomedical
Bushra Rais, Mario Koester, Muhammad Imran Rahim, Marina Pils, Jan-Marten Seitz, Hansjoerg Hauser, Dagmar Wirth, Peter P. Mueller
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Engineering, Biomedical
Muhammad Imran Rahim, Manfred Rohde, Bushra Rais, Jan-Marten Seitz, Peter P. Mueller
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2016)
Article
Engineering, Biomedical
Muhammad Imran Rahim, Andreas Weizbauer, Florian Evertz, Andrea Hoffmann, Manfred Rohde, Birgit Glasmacher, Henning Windhagen, Gerhard Gross, Jan-Marten Seitz, Peter P. Mueller
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2017)
Article
Engineering, Biomedical
Muhammad Imran Rahim, Ana Tavares, Florian Evertz, Marc Kieke, Jan-Marten Seitz, Rainer Eifler, Andreas Weizbauer, Elmar Willbold, Hans Juergen Maier, Birgit Glasmacher, Peter Behrens, Hansjoerg Hauser, Peter P. Mueller
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2017)
Review
Materials Science, Multidisciplinary
Muhammad Imran Rahim, Sami Ullah, Peter P. Mueller
Article
Engineering, Biomedical
Muhammad Badar, Muhammad Imran Rahim, Marc Kieke, Thomas Ebel, Manfred Rohde, Hansjoerg Hauser, Peter Behrens, Peter P. Mueller
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2015)
Article
Microbiology
Muhammad Imran Rahim, Andreas Winkel, Stefan Lienenklaus, Nico S. Stumpp, Szymon P. Szafranski, Nadine Kommerein, Elmar Willbold, Janin Reifenrath, Peter P. Mueller, Michael Eisenburger, Meike Stiesch
Article
Engineering, Biomedical
N. Wendt, B. Rais, P. P. Mueller, P. Behrens
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2014)
Article
Engineering, Biomedical
A. Tavares, F. Evertz, S. Knigge, M. Rahim, P. P. Mueller, H. J. Maier, B. Glasmacher
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2014)
Article
Engineering, Biomedical
Muhammad Imran Rahim, Florian Evertz, Marc Kieke, Andreas Weizbauer, Henning Windhagen, Elmar Willbold, Birgit Glasmacher, Hansjoerg Hauser, Peter P. Mueller
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2014)
Article
Engineering, Biomedical
B. Rais, C. Tolle, M. Koester, H. Hauser, P. P. Mueller
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2014)
Review
Chemistry, Multidisciplinary
Yikuan Liu, Xiaona Liu, An Su, Chengtao Gong, Shenwei Chen, Liwei Xia, Chengwei Zhang, Xiaohuan Tao, Yue Li, Yonghe Li, Tulai Sun, Mengru Bu, Wei Shao, Jia Zhao, Xiaonian Li, Yongwu Peng, Peng Guo, Yu Han, Yihan Zhu
Summary: Covalent organic frameworks are crystalline porous materials with designable structures and functions, which can acquire multifunctionalities and have versatile applications in gas separation/storage, catalysis, and optoelectronic devices.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Heyang Zhang, Jo Vandesompele, Kevin Braeckmans, Stefaan C. De Smedt, Katrien Remaut
Summary: Gene therapy has the potential to revolutionize the treatment of inherited and acquired diseases, but its success rate is currently limited. This review focuses on the obstacles faced by gene therapies in the human body, such as nucleic acid degradation by abundant nucleases, and discusses strategies to reduce degradation and methods to assess nucleic acid integrity.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Chenxi Duan, Chunming Cui
Summary: Low valent group 14 compounds with diazaborolyl substituents exhibit unique structures and reactivity due to the combination of sigma-electron donation and steric hindrance. The modulation of the HOMO-LUMO gap by the diazaborolyl substituents results in novel reaction patterns in the activation of small molecules and inert chemical bonds.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
David E. Salazar Marcano, Nada D. Savic, Kilian Declerck, Shorok A. M. Abdelhameed, Tatjana N. Parac-Vogt
Summary: Metal-oxo clusters have great potential in various fields and can react with biomolecules, making them promising for applications in disease treatment and energy development. They can also be used in the development of inorganic drugs and bioanalytical tools.
CHEMICAL SOCIETY REVIEWS
(2024)
Review
Chemistry, Multidisciplinary
Lana K. Moree, Logan A. V. Faulkner, James D. Crowley
Summary: In this tutorial review, the general methods for synthesizing heterometallic metallosupramolecular architectures (MSAs), specifically heterometallic cages, are examined. The intrinsic properties and potential applications of these cages as host-guest systems and reaction catalysts are discussed.
CHEMICAL SOCIETY REVIEWS
(2024)