Review
Medicine, General & Internal
Barbara Alexandra do Amaral Couto, Juliana Campos Hasse Fernandes, Mariana Saavedra-Silva, Hernan Roca, Rogerio Moraes Castilho, Gustavo Vicentis de Oliveira Fernandes
Summary: Objective: This study reviewed the literature on local or systemic administration of antisclerostin and its effects on osseointegration of dental/orthopedic implants and bone remodeling potential. Materials and Methods: An extensive search was conducted to identify relevant case reports, case series, clinical trials, and animal studies. Results: 19 articles were included, showing that antisclerostin administration positively impacted bone-implant contact, bone mineral density, bone area/volume, and bone thickness in the osseointegration group, and increased bone mineral density, trabecular bone, and bone formation in the bone remodeling group. Conclusion: More studies are needed to better evaluate the effects of antisclerostin on osseointegration of dental implants, but the findings suggest that it can accelerate and stimulate bone remodeling and neoformation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Wenhao Wang, Jie Shen, Yuan Meng, Miaoman Ye, Shaozhang Lin, Qi Zhao, Le Wang, Kenneth M. C. Cheung, Shuilin Wu, Yufeng Zheng, Xuanyong Liu, Paul K. Chu, Kelvin W. K. Yeung, Zhi-Yong Zhang
Summary: Regardless of the advancement of synthetic bone substitutes, allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone diseases. Nevertheless, the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term failure. Hence, improving osseointegration and transplantation efficiency remains important. The alteration of bone tissue microenvironment (TME) to facilitate osseointegration has been generally recognized.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Seong-Su Park, Ume Farwa, Ihho Park, Byoung-Gi Moon, Soo-Bin Im, Byong-Taek Lee
Summary: Magnesium and its alloys are widely used as biodegradable and biocompatible biomaterials. In this study, an Mg alloy bone plate coated with Sr-D-Ca-P and Sr-D-Ca-P/PLLA-HAp was developed and evaluated for its biodegradability and biocompatibility in both in vitro and in vivo experiments. The results showed that both coatings delayed the degradation process and exhibited excellent biocompatibility. The Sr-D-Ca-P/PLLA-HAp coated bone plate had a slower degradation rate and promoted bone remodeling compared to the bare Mg alloy and Sr-D-Ca-P coated bone plate.
MATERIALS TODAY BIO
(2023)
Article
Mathematics, Interdisciplinary Applications
Zhihong Dong, Xu Wu, Xun Xi, Li Jun, Peitao Wang, Li Peng, Jiliang Pan
Summary: The corrosion of rockbolt has a significant impact on the long-term performance of anchoring structures. This study presents a novel numerical method to investigate the pull-out failure of corroded rockbolt. The results show that as the corrosion develops, the bond strength and critical displacement decrease, and the effect of corrosion on strength reduction is more significant under higher confining pressure.
COMPUTATIONAL PARTICLE MECHANICS
(2023)
Article
Chemistry, Physical
Marcin Kozakiewicz
Summary: The study showed that the axial pull-out force of magnesium alloy screws during resorption was significantly higher than that of polymer screws, but decreased rapidly within eight weeks and eventually equalized. Therefore, the reduction in force during the use of magnesium screws needs to be taken into account to provide more stable resorbable metallic osteosynthesis.
Article
Chemistry, Multidisciplinary
Young-Chang Park, Dong-Sik Chae, Kyung-Yil Kang, Yao Ding, Sung-Jun Park, Jonghun Yoon
Summary: This study examined the fixation performances of cephalomedullary nail for intertrochanteric fracture, using biomedical polyurethane foam blocks to simulate human bones. Tensile and compression tests were conducted to analyze the anisotropy of the foam, and pull-out performances of screw and helical blades were evaluated. The results showed that the clamping force of the screw was higher than the helical blade, and stable fixation is suggested when the pull-out force exceeds the projected force.
APPLIED SCIENCES-BASEL
(2021)
Article
Orthopedics
Zakary Wankier, Carolyn Taylor, Alex Drew, Erik Kubiak, Jayant Agarwal, Sarina Sinclair
Summary: This study utilized CT imaging and three-dimensional modeling techniques to analyze bone remodeling around a percutaneous osseointegrated implant in transfemoral amputees. Results showed increases in cortical bone area and thickness around the implant at 52 weeks postoperatively, with minimal changes in medullary canal parameters.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Materials Science, Textiles
Ying Ma, Zhifei He, Xiang Chen, Congying Deng, Yang Zhao, Sheng Lu
Summary: This paper proposes two numerical and one analytical models to investigate the pull-out behavior and energy transfer mechanism of yarn. The results show that the digital element approach model provides a more accurate representation of pull-out force and transferred energy compared to the other two models. Additionally, the study finds that the yarn surface shape and material properties have a significant impact on the pull-out behavior. Furthermore, a parametric study reveals that the transverse force is sensitive to the tensile pre-load and can be used as an indicator for detecting residual stress in fabric.
TEXTILE RESEARCH JOURNAL
(2022)
Article
Chemistry, Applied
Zhe Xiao, Lin-Hao Liu, Teng Liu, Dan Yang, Xiang Jia, Yu-Kun Du, Shuo-Qi Li, Wen-Jiu Yang, Yong-Ming Xi, Rong-Chang Zeng
Summary: Polyelectrolyte-coated magnesium alloy was prepared using layer-by-layer assembly with poly(allylamine hydro-chloride) (PAH) and sodium alginate (ALG). The influence of genipin as a crosslinking agent on the coatings' microscopic features and corrosion resistance was examined. The results showed that the crosslinked coating exhibited improved anticorrosive property and enhanced cytocompatibility, suggesting that crosslinking treatment could improve the performance of LbL assembled multilayer coatings.
PROGRESS IN ORGANIC COATINGS
(2023)
Review
Materials Science, Multidisciplinary
Meifeng He, Lvxin Chen, Meng Yin, Shengxiao Xu, Zhenyu Liang
Summary: Magnesium alloy is a third-generation biomedical material that promotes bone tissue regeneration. It has the advantages of biodegradability, closer Young's modulus to human bone, osteoinductive and antimicrobial properties. However, its rapid corrosion rate and mechanical integrity compromise pose challenges for bone implantation. Various machining, alloying, and optimization techniques are used to improve the properties of magnesium implants. The review also investigates the corrosion and wear behavior of magnesium alloys and the impact of coating on biocompatibility and corrosion properties.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Engineering, Biomedical
Kenda Sabouni, Yetkin Ozturk, Erkan Kacar, Gamze Torun Kose, Fatma Nese Kok, Muhammet Kursat Kazmanli, Mustafa Kamil Urgen, Sakip Onder
Summary: In this study, the effect of (Ti, Mg)N thin film coated Ti6Al4V plates and screws on mineralization/osseointegration was investigated. The results showed that the Mg-containing coatings enhanced mineralization, cell attachment, and hydroxyapatite growth, leading to increased attachment at the implant tissue interface.
BIO-MEDICAL MATERIALS AND ENGINEERING
(2023)
Article
Engineering, Mechanical
Ming Li, Wei Tian, JunShan Hu, ChangRui Wang, ZhangHu Shi, WenHe Liao
Summary: This study systematically investigated the influence of riveting die configuration and squeeze force on the mechanical properties and fatigue behavior of riveted joints. The results showed that the riveting die configuration has significant effects on pull-out strength, and increasing squeeze force can improve the average fatigue life.
ENGINEERING FAILURE ANALYSIS
(2022)
Article
Construction & Building Technology
Francesca Ceroni, Hossein Darban, Nicola Caterino, Raimondo Luciano
Summary: This study proposes design formulations for the maximum pull-out force in injected anchors, based on extensive numerical analyses and comparisons with experimental results, to enhance the lateral resistance of masonry structures. By adjusting various parameters, key factors influencing the maximum pull-out force are identified and integrated into strength models for evaluation and fitting, leading to the establishment of preliminary design provisions and validation methods.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yuyang Chen, Tao Ying, Yao Yang, Jingya Wang, Xiaoqin Zeng
Summary: This study proposes a new method to improve the corrosion resistance of MgNd alloy by micro-alloying Zr, which accelerates the precipitation process and facilitates the formation of a dense and compact corrosion layer. The corrosion rate decreases significantly from 32.69 mL/cm2/day to 0.072 mL/cm2/day. Zr tends to form nano-scale oxide clusters on the Mg surface, serving as pre-precipitation sites.
Article
Metallurgy & Metallurgical Engineering
Jiarun Li, Zhuoyuan Chen, Jiangping Jing, Jian Hou
Summary: Alloying with yttrium can enhance the corrosion resistance of Mg-6%Al-3%Zn alloy, promote the protectiveness of the oxide layer, and provide an effective barrier to prevent corrosive ions from penetrating and reacting with the Mg matrix.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Article
Engineering, Biomedical
Julius Sundermann, Sarah Oehmichen, Steffen Sydow, Laura Burmeister, Bastian Quaas, Robert Haensch, Ursula Rinas, Andrea Hoffmann, Henning Menzel, Heike Bunjes
Summary: Different surface modifications of PCL fiber mats influence the binding and release of BMP-2, with polydopamine coating showing the highest binding capacity. Functionalization with chitosan nanogel considerably increases BMP-2 binding on all hydrophilized surfaces and results in sustained release without loss of bioactivity.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Engineering, Biomedical
Leal-Marin Sara, Kern Thomas, Hofmann Nicola, Pogozhykh Olena, Framme Carsten, Borgel Martin, Figueiredo Constanca, Glasmacher Birgit, Gryshkov Oleksandr
Summary: Human amniotic membrane (hAM) is widely used in tissue engineering, particularly in skin dressing and corneal treatment, due to its extracellular matrix structure and excellent biological properties. Recent research focuses on enhancing hAM performance by creating scaffolds mimicking the native membrane structure. Preservation techniques for maintaining biological functions such as angiogenesis, anti-inflammation, antifibrotic, and antibacterial activity are also essential for native hAM and tissue-engineered products.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2021)
Article
Dentistry, Oral Surgery & Medicine
T. Hildebrand, L. Nogueira, P. T. Sunde, D. Orstavik, B. Glasmacher, H. J. Haugen
Summary: The methodology introduced in this study utilizes phosphotungstic acid (PTA) as a contrast-enhancement agent to visualize dental ultrastructures, including cellular and soft tissue components, by performing high-resolution nano-CT scans. The staining protocol allows for the concomitant visualization of hard tissues along with cellular layers and soft tissues in teeth.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Oleksandr Gryshkov, Vitalii Mutsenko, Dmytro Tarusin, Diaa Khayyat, Ortwin Naujok, Ekaterina Riabchenko, Yuliia Nemirovska, Arseny Danilov, Alexander Y. Petrenko, Birgit Glasmacher
Summary: Alginate, a versatile natural biomaterial, is widely used in the biomedical field for its unique features such as biocompatibility and biodegradability. Core-shell capsules made from low viscosity high-G alginate show superior stability during in vitro culture and promote the formation of viable self-assembled cellular structures and maintenance of MSCs functionality compared to other materials. The proposed workflow of preparation, culture, and cryopreservation of core-shell capsules with self-assembled cellular structures appears to be a promising strategy for their off-the-shelf availability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Julius Sundermann, Steffen Sydow, Laura Burmeister, Andrea Hoffmann, Henning Menzel, Heike Bunjes
Summary: This study investigated the release performance of BMP-2 from PCL fiber mat-based implant prototypes coated with chitosan nanogel, highlighting the significant effects of chitosan and solubilizing additives on the recovery rate of BMP-2 in in vitro release experiments.
Article
Cell Biology
Beatrice Oelze, Kirsten Elger, Patrik Schadzek, Laura Burmeister, Anika Hamm, Sandra Laggies, Virginia Seiffart, Gerhard Gross, Andrea Hoffmann
Summary: The research suggests that the inflammatory mediator TAK1 in LPS-treated murine MSCs may have anti-inflammatory properties through the regulation of IL-6 expression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemical Research Methods
Carla Lizbeth Segovia-Trinidad, Bastian Quaas, Zhaopeng Li, Antonina Lavrentieva, Yvonne Roger, Thomas Scheper, Andrea Hoffmann, Ursula Rinas
Summary: Smad8 is a transcriptional regulator in the TGF-beta signaling pathway, with cSmad8 showing constitutive activity and tendon cell inducing potential. By engineering cSmad8 to include the HIV TAT signal, researchers successfully achieved cellular internalization and demonstrated biological activity in C3H10T1/2 cells.
PROTEIN EXPRESSION AND PURIFICATION
(2021)
Article
Chemistry, Multidisciplinary
Muhammad Imran Rahim, Katharina Doll, Nico S. Stumpp, Michael Eisenburger, Meike Stiesch
Summary: This study presents a novel method of using Streptococcus as a coating to prevent infectious biofilms on implants, effectively inhibiting the biofilm-forming capabilities of various periodontal pathogens. The bacterial adhesion force on the coated implants decreases, indicating the potential of this approach in preventing fatal biofilm infections on biomaterials.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Imran Rahim, Andreas Winkel, Alexandra Ingendoh-Tsakmakidis, Stefan Lienenklaus, Christine S. Falk, Michael Eisenburger, Meike Stiesch
Summary: This study investigates the systemic impact of chronic peri-implant inflammation on the expression of inflammatory cytokines and finds that the type and composition of initial infection play an important role in the systemic induction of cytokines. The findings suggest that multispecies infections can lead to complications associated with biomaterial-related infection in patients.
Article
Biochemistry & Molecular Biology
Marjan Kheirmand Parizi, Katharina Doll, Muhammad Imran Rahim, Carina Mikolai, Andreas Winkel, Meike Stiesch
Summary: This study investigated the antibacterial properties and cytocompatibility of silver nitrate and strontium acetate in dental applications. Combined application enhanced antibacterial effects and improved cell responses, offering a promising strategy for combating peri-implantitis and improving osseointegration in implant therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Sara Knigge, Marc Mueller, Lara Fricke, Tobias Schilling, Birgit Glasmacher
Summary: Magnesium is a promising metal for resorbable cardiovascular implants due to its biocompatibility, corrosion tendency, and mechanical properties. A protective polymeric layer can slow down the corrosion rate, and coatings can improve tissue interaction. This study examines the corrosion mechanism of coated magnesium and finds that spin coatings provide efficient protection with a significantly lower corrosion rate. However, the degradation of the protective layer is accelerated by magnesium corrosion.
Article
Pharmacology & Pharmacy
Leonie Berten-Schunk, Yvonne Roger, Heike Bunjes, Andrea Hoffmann
Summary: The design of implants for tissue transitions is challenging, and the rotator cuff in the shoulder is an example of such a transition. Electrospun fiber mats of PCL loaded with CS/TPP nanoparticles and TGF-beta(3) were used to optimize the implant for enthesis regeneration. Higher loading concentrations of TGF-beta(3) led to increased release, larger cell pellets, and enhanced chondrogenic differentiation of MSCs.
Article
Engineering, Biomedical
Merle Kempfert, Elmar Willbold, Sebastian Loewner, Cornelia Blume, Johannes Pitts, Henning Menzel, Yvonne Roger, Andrea Hoffmann, Nina Angrisani, Janin Reifenrath
Summary: Chronic tendon ruptures are common in orthopedics and the use of traditional surgical methods with implants is necessary. The study demonstrated the potential of 3D-printed PCL scaffolds as suitable candidates for tendon implants, with enhanced cytocompatibility achieved through surface modifications.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Review
Polymer Science
Christina Maria Winkler, Antonia Isabel Kuhn, Gesine Hentschel, Birgit Glasmacher
Summary: This study explores the advantages of using hydrogels as PIV channel materials and their properties in cardiovascular applications. Hydrogels have optical and mechanical properties that can match the refractive index of the fluid. By measuring the optical and mechanical properties, suitable hydrogel materials can be selected.
Article
Thermodynamics
Ali Chitsazan, Georg Klepp, Birgit Glasmacher
Summary: Jet impingements enhance heat and mass transfer rates in industrial drying machines. The study of heat transfer between multiple jets and a moving curved surface is difficult due to changing boundaries and surface curvature effects. The use of the SST k-omega turbulence model has shown reasonable accuracy in simulating real geometries for industrial drying applications.
INTERNATIONAL JOURNAL OF HEAT AND TECHNOLOGY
(2021)
