High-throughput screening for modulators of protein–protein interactions: use of photonic crystal biosensors and complementary technologies

A Cy5-Labeled S100A10 Tracer Used to Identify Inhibitors of the Protein Interaction With Annexin A2

(2010) Chan Li et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Discovery and Development of Natural Product-Derived Chemotherapeutic Agents Based on a Medicinal Chemistry Approach⊥†

(2010) Kuo-Hsiung Lee   JOURNAL OF NATURAL PRODUCTS

Development of high-throughput assays based on fluorescence polarization for inhibitors of the polo-box domains of polo-like kinases 2 and 3

(2009) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

A Time-Resolved Fluorescence–Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization

(2009) Smitha Kota et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Identification of small-molecule inhibitors of the JIP–JNK interaction

(2009) Tracy Chen et al.   BIOCHEMICAL JOURNAL

Tris-Nitrilotriacetic Acids of Subnanomolar Affinity Toward Hexahistidine Tagged Molecules

(2009) Zhaohua Huang et al.   BIOCONJUGATE CHEMISTRY

New small molecule inhibitors of hepatitis C virus

(2009) Wanguo Wei et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy

(2009) M. H. Kang et al.   CLINICAL CANCER RESEARCH

The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions

(2009) Michelle R Arkin et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome

(2009) Edenir I Palmero et al.   CURRENT OPINION IN ONCOLOGY

Structure-Based Drug Design Strategies in Medicinal Chemistry

(2009) Adriano Andricopulo et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Structure-based drug design: From nucleic acid to membrane protein targets

(2009) Magdalena M. Dailey et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Mutational spectra of human cancer

(2009) Gerd P. Pfeifer et al.   HUMAN GENETICS

Surface plasmon resonance imaging for biosensing

(2009) S. Paul et al.   IET Nanobiotechnology

Novel Adenosine-Derived Inhibitors of 70 kDa Heat Shock Protein, Discovered Through Structure-Based Design†

(2009) Douglas S. Williamson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identifying Modulators of Protein−Protein Interactions Using Photonic Crystal Biosensors

(2009) James T. Heeres et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cellular assays as portals to seven-transmembrane receptor-based drug discovery

(2009) Terry P. Kenakin   NATURE REVIEWS DRUG DISCOVERY

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity

(2009) Shuowei Cai et al.   TOXICON

Design of Small-Molecule Peptidic and Nonpeptidic Smac Mimetics

(2008) Haiying Sun et al.   ACCOUNTS OF CHEMICAL RESEARCH

A General Method for Discovering Inhibitors of Protein−DNA Interactions Using Photonic Crystal Biosensors

(2008) Leo L. Chan et al.   ACS Chemical Biology

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One

(2008) Timothy W. Corson et al.   ACS Chemical Biology

Evaluation of Dynamic Mass Redistribution Technology for Pharmacological Studies of Recombinant and Endogenously Expressed G Protein-Coupled Receptors

(2008) Paul H. Lee et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Designing Smac-mimetics as antagonists of XIAP, cIAP1, and cIAP2

(2008) Federica Cossu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure-Based Design and Synthesis of Fluorescent PPARα/δ Co-agonist and Its Application as a Probe for Fluorescent Polarization Assay of PPARδ Ligands

(2008) Yoko Araya et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Label-Free Cell-Based Assays for GPCR Screening

(2008) Ye Fang et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

Drug-Like Inhibitors of Protein-Protein Interactions: A Structural Examination of Effective Protein Mimicry

(2008) D. Fry   CURRENT PROTEIN & PEPTIDE SCIENCE

Predicting druggable binding sites at the protein–protein interface

(2008) Jonathan C. Fuller et al.   DRUG DISCOVERY TODAY

The yeast two-hybrid system and its role in drug discovery

(2008) Nicolas Lentze et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Protein–protein interactions as targets for small-molecule therapeutics in cancer

(2008) Alex W. White et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Label-free optical biosensor for ligand-directed functional selectivity acting on β2adrenoceptor in living cells

(2008) Ye Fang et al.   FEBS LETTERS

The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαiand Downstream Signaling Cascade Activation

(2008) Ralf Schröder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

(2008) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor†

(2008) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles

(2008) Levi L Blazer et al.   NEUROPSYCHOPHARMACOLOGY

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

(2008) J. L. Stebbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA