Article
Chemistry, Organic
Walid Kamal Abdelbasset, Mohammed Q. Sultan, Ayad F. Alkaim, Tulkin Abdullaevich Ashurov, Usama S. Altimari, Baydaa Abed Hussein, Yasser Fakri Mustafa, Ali Thaeer Hammid
Summary: This study presents a simple and efficient method for synthesizing benzothiazoles, which avoids the use of hazardous chemicals and provides an alternative procedure. The use of K2S2O8 as an oxidant allows for the synthesis of benzothiazoles in good to excellent yields.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Bipin Kumar Behera, Archana Kumari Sahu, Ngangbam Renubala Devi, Anil K. Saikia
Summary: An efficient methodology has been developed for the synthesis of tetra- and pentasubstituted pyrroles with two carbonyl groups in the side chain. The protocol can be extended towards the synthesis of pyrrolo-[3,4-d]pyridazine.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yogendra Kumar, Hiriyakkanavar Ila
Summary: A novel synthesis method for 2,3-substituted benzothiophenes has been reported, which involves a tandem base-mediated condensation and intramolecular C-S bond formation, leading to diverse substituted benzothiophenes and heterofused thiophenes with excellent yields.
Article
Chemistry, Organic
Keisuke Minami, Maki Minakawa, Yasuhiro Uozumi
Summary: The reaction of 2,2'-dithiobis(benzenamine)s with various aldehydes in the presence of CuOAc catalyst under air without any additives yielded the corresponding benzothiazoles. When cycloalkylcarbaldehydes were reacted under similar conditions, benzothiazoles and heterocyclic spiro compounds were produced. Gram-scale preparation was successfully carried out under open-flask conditions in the presence of CuOAc catalyst.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Aparna Tyagi, Neha Taneja, Jabir Khan, Chinmoy Kumar Hazra
Summary: In this study, a solvent- and transition-metal-free, iodine-catalyzed C-S bond formation method for the synthesis of beta-keto sulfones using easily accessible methyl ketones and sulfonyl hydrazides is reported. The study also includes the alpha-functionalization of beta-keto sulfones to synthesize beta-keto thiosulfones and alpha-iodo-beta-keto sulfones using iodine-catalyzed carbon-sulfide bond formation under solvent-free conditions and iodine-mediated carbon-iodine bond formation under aqueous conditions, respectively. The analytical studies and control experiments provide insights into a free-radical coupling strategy. Overall, this protocol is simple, scalable, and allows for a broad range of functional group tolerance, providing access to three functionalized organic scaffolds.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Yuanyuan Shi, Zhibo Jiang, Xiaowen Hu, Xiaomin Hu, Renjie Gu, Bingya Jiang, Lijie Zuo, Xingxing Li, Hongmin Sun, Cong Zhang, Lifei Wang, Linzhuan Wu, Bin Hong
Summary: The study elucidated the C-S bond forming activity of cytochrome P450 monooxygenase CxnD in chuangxinmycin biosynthesis, showing that CxnD can generate a unique skeleton structure through in vivo and in vitro analyses. The X-ray crystal structure and structure-based mutagenesis revealed details of substrate binding mode.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Lang Liu, Jun Zhang
Summary: In this study, a simple and practical method was developed for the synthesis of carbonyl-containing thiazoles using commercially available substrates and mild reaction conditions. The obtained products showed promising performance in aggregation-induced emission (AIE) and biological imaging.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mengna Zhao, Qian Miao
Summary: The B3N6-[4]triangulene, a key structural unit of BC4N, was successfully synthesized through nitrogen-directed borylation, showing hydrogen-bonding properties. Its slightly bent triangular polycyclic framework consists of 4 pi-electron N-B-N units and forms hydrogen bonds with other molecules like halide or carboxylate anions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Fusheng Bie, Xuejing Liu, Han Cao, Yijun Shi, Tongliang Zhou, Michal Szostak, Chengwei Liu
Summary: The Pd-catalyzed double-decarbonylative synthesis of aryl thioethers involves an aryl exchange reaction between amides and thioesters, with amides serving as aryl donors and thioesters as sulfide donors. The use of Pd/Xantphos without any additives promotes aryl exchange by C(O)-N/C(O)-S cleavages, allowing for a wide variety of amides and sulfides to be used in the reaction.
Article
Chemistry, Organic
Jinyuan Jiang, Jidan Liu, Zhenke Yang, Jieying Zheng, Xin Tian, Liyao Zheng, Zhao-Qing Liu
Summary: An efficient method has been developed for the direct C-H oxidative annulation of isoquinolones with allyl alcohols, leading to the synthesis of structurally diverse isoindolo[2,1-b]isoquinolin-5(7H)-ones with high atom economy. This protocol is tolerant of a broad spectrum of functionalities and can be conducted in one-pot operation using readily available N-methoxybenzamides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Ashfaq Ahmad, Himangsu Sekhar Dutta, Mohit Kumar, Raziullah, Manoj Kumar Gangwar, Dipankar Koley
Summary: A palladium catalyzed directing group assisted cross-coupling reaction has been developed for the synthesis of β-arylethylamine derivatives. The method is applicable to a wide range of substrates and can tolerate the presence of various external additives.
Article
Chemistry, Multidisciplinary
Huanhuan Li, Yalan Zhang, Yawen Huang, Peigao Duan, Ran Ge, Xiaofeng Han, Wuyuan Zhang
Summary: Performing divergent CH bond functionalization on molecules with multiple reaction sites is a significant challenge in organic chemistry. By using enzymatic catalysis, regio- and chemoselective oxyfunctionalization of sp3 CH bonds that are distant from benzylic sites has been achieved, leading to the synthesis of a variety of gamma-keto arenes with diverse structural and electronic properties.
Article
Chemistry, Multidisciplinary
Laura Koering, Arne Stepen, Bernhard Birenheide, Simon Barth, Maxim Leskov, Roland Schoch, Felix Kraemer, Frank Breher, Jan Paradies
Summary: A series of redox-responsive ferrocenyl-substituted boranes and boronic esters were synthesized, and the oxidation of the ferrocenyl ligand to the ferrocenium increased the Lewis acidity beyond the strength of SbF5. This was investigated experimentally and computationally, and the resulting highly Lewis acidic boron compounds were used for catalytic C-F and S-F bond activation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Organic
U. S. Kanchana, Elizabeth J. Diana, Thomas V. Mathew
Summary: This review summarizes the latest advancements in nickel-catalyzed C-S bond formation reactions, which have attracted attention due to their wide application and the substitution of toxic metals.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Daniel Kim, Guy Pillon, Daniel J. DiPrimio, Patrick L. Holland
Summary: By using a high-spin cobalt(I) complex as the catalyst, efficient conversion of terminal alkenes to Z-2-alkenes with high regioselectivity and stereoselectivity can be achieved. The catalyst operates through a pi-allyl mechanism, which is distinct from the alkyl mechanism used by other Z-selective catalysts. Computational studies suggest that a spin state change enables the catalyst to differentiate stereodefining barriers and produce the Z product.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Xiuyun Sun, Xia Yao, Chao Zhang, Yu Rao
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Multidisciplinary
Jiantao Hu, Tianlong Lan, Yihua Sun, Hui Chen, Jiannian Yao, Yu Rao
CHEMICAL COMMUNICATIONS
(2015)
Article
Chemistry, Multidisciplinary
Yun Lin, Lei Zhu, Yu Lan, Yu Rao
CHEMISTRY-A EUROPEAN JOURNAL
(2015)
Article
Chemistry, Multidisciplinary
Gang Shan, Gui-Yi Huang, Yu Rao, Hui Zhang
CHINESE CHEMICAL LETTERS
(2015)
Article
Chemistry, Organic
Gang Shan, Guiyi Huang, Yu Rao
ORGANIC & BIOMOLECULAR CHEMISTRY
(2015)
Article
Chemistry, Organic
Chao Zhang, Yu Rao
Article
Chemistry, Multidisciplinary
Xinglin Yang, Yonghui Sun, Tian-yu Sun, Yu Rao
CHEMICAL COMMUNICATIONS
(2016)
Article
Chemistry, Multidisciplinary
Xinglin Yang, Tian-Yu Sun, Yu Rao
CHEMISTRY-A EUROPEAN JOURNAL
(2016)
Article
Chemistry, Organic
Yun Lin, Xinglin Yang, Weidong Pan, Yu Rao
Article
Chemistry, Organic
Xinglin Yang, Gang Shan, Liguo Wang, Yu Rao
TETRAHEDRON LETTERS
(2016)
Article
Chemistry, Multidisciplinary
Yong-Hui Sun, Tian-Yu Sun, Yun-Dong Wu, Xinhao Zhang, Yu Rao
Article
Chemistry, Multidisciplinary
Xiuyun Sun, Yonghui Sun, Chao Zhang, Yu Rao
CHEMICAL COMMUNICATIONS
(2014)
Article
Chemistry, Organic
Yu Zong, Yu Rao
Review
Chemistry, Organic
Shi Chen, Gang Shan, Pengju Nie, Yu Rao
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2015)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)