Recent advances in the catalytic asymmetric 1,3-dipolar cycloaddition of azomethine ylides

Catalytic Enantioselective 1,3-Dipolar Cycloadditions of Azomethine Ylides for Biology-Oriented Synthesis

(2014) Rishikesh Narayan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Silver-catalyzed dynamic systemic resolution of α-iminonitriles in a 1,3-dipolar cycloaddition process

(2014) Lei Hu et al.   CHEMICAL COMMUNICATIONS

An efficient strategy for the synthesis of polysubstituted chromeno[4,3-b]pyrrolidine derivatives

(2014) Li Tian et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Formal [3+3] Cycloaddition of an Azomethine Ylide with 3-Indolylmethanol: Enantioselective Construction of a Six-Membered Piperidine Framework

(2014) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cu(I)-Catalyzed Regio- and Stereoselective [6 + 3] Cycloaddition of Azomethine Ylides with Tropone: An Efficient Asymmetric Access to Bridged Azabicyclo[4.3.1]decadienes

(2014) Huai-Long Teng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metal-Catalyzed [6 + 3] Cycloaddition of Tropone with Azomethine Ylides: A Practical Access to Piperidine-Fused Bicyclic Heterocycles

(2014) Honglei Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Cycloaddition of Münchnones onto [60]Fullerene: Organocatalysis versus Metal Catalysis

(2014) Juan Marco-Martínez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective Synthesis of α-Heteroarylpyrrolidines by Copper-Catalyzed 1,3-Dipolar Cycloaddition of α-Silylimines

(2014) Ana Pascual-Escudero et al.   ORGANIC LETTERS

Catalytic Asymmetric Exo-Selective [C+NC+CC] Reaction

(2014) Ryan Joseph et al.   ORGANIC LETTERS

Bifunctional AgOAc/ThioClickFerrophos complex-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with aryl- and alkylidene malonates

(2014) Sayo Watanabe et al.   TETRAHEDRON LETTERS

Cu(i)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides with dimethyl itaconate and 2-methyleneglutarate

(2014) Hai-Yan Tao et al.   RSC Advances

Synthesis of Glutamic Acid and Highly Functionalized Pyrrolidine Derivatives by Utilizing Tunable Calcium Catalysts for Chemoselective Asymmetric 1,4-Addition and [3+2] Cycloaddition Reactions

(2013) Martin Hut'ka et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric 1,3-Dipolar Cycloadditions of Alkynes with Isatin-Derived Azomethine Ylides: Enantioselective Synthesis of Spiro[indoline-3,2′-pyrrole] Derivatives

(2013) Feng Shi et al.   ADVANCED SYNTHESIS & CATALYSIS

Enantioselective Copper-Catalyzed [3+3] Cycloaddition of Azomethine Ylides with Azomethine Imines

(2013) Hongchao Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fulvenes as Effective Dipolarophiles in Copper(I)-Catalyzed [6+3] Cycloaddition of Azomethine Ylides: Asymmetric Construction of Piperidine Derivatives

(2013) Zhao-Lin He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Discovery of Inhibitors of the Wnt and Hedgehog Signaling Pathways through the Catalytic Enantioselective Synthesis of an Iridoid-Inspired Compound Collection

(2013) Hiroshi Takayama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Synthesis of Functionalized Tropanes Reveals Novel Inhibitors of Hedgehog Signaling

(2013) Rishikesh Narayan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Two Different Ylides: Facile Access to Chiral 1,2,4-Triazinane Frameworks

(2013) Min-Chao Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthetic scope and DFT analysis of the chiral binap–gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes

(2013) María Martín-Rodríguez et al.   Beilstein Journal of Organic Chemistry

An efficient route for the synthesis of phosphorus–selenium macro-heterocycles

(2013) Guoxiong Hua et al.   CHEMICAL COMMUNICATIONS

Catalytic asymmetric exo-selective [6+3] cycloaddition of iminoesters with fulvenes

(2013) Marco Potowski et al.   CHEMICAL COMMUNICATIONS

Efficient construction of highly functionalized spiro[γ-butyrolactone-pyrrolidin-3,3′-oxindole] tricyclic skeletons via an organocatalytic 1,3-dipolar cycloaddition

(2013) Long Wang et al.   CHEMICAL COMMUNICATIONS

Enantioselective synthesis of 4-aminopyrrolidine-2,4-dicarboxylate derivatives via Ag-catalyzed cycloaddition of azomethine ylides with alkylidene azlactones

(2013) María González-Esguevillas et al.   CHEMICAL COMMUNICATIONS

exo-Selective construction of spiro-[butyrolactone-pyrrolidine] via 1,3-dipolar cycloaddition of azomethine ylides with α-methylene-γ-butyrolactone catalyzed by Cu(i)/DTBM-BIPHEP

(2013) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Catalytic stereodivergent functionalization of H2@C60

(2013) Enrique E. Maroto et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric Construction of Quaternary α-Amino Acid Containing Pyrrolidines through 1,3-Dipolar Cycloaddition of Azomethine Ylides to α-Aminoacrylates

(2013) Zheng Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Biomimetic Asymmetric 1,3-Dioplar Cycloaddition: Amino Acid Precursors in Biosynthesis Serve as Latent Azomethine Ylides

(2013) Chang Guo et al.   ORGANIC LETTERS

Phosphoramidite–Cu(OTf)2 Complexes as Chiral Catalysts for 1,3-Dipolar Cycloaddition of Iminoesters and Nitroalkenes

(2013) Luis M. Castelló et al.   ORGANIC LETTERS

Low dimensional nanocarbons – chemistry and energy/electron transfer reactions

(2013) Konstantin Dirian et al.   Chemical Science

Phosphine-Catalyzed [3+2] and [4+3] Annulation Reactions of C,N-Cyclic Azomethine Imines with Allenoates

(2012) Chengfeng Jing et al.   ADVANCED SYNTHESIS & CATALYSIS

Catalytic Asymmetric Synthesis of α-Quaternary Proline Derivatives by 1,3-Dipolar Cycloaddition of α-Silylimines

(2012) Jorge Hernández-Toribio et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Enantioselective Catalytic [6+3] Cycloadditions of Azomethine Ylides

(2012) Marco Potowski et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Cu-catalyzed asymmetric [3+2] cycloaddition of α-iminoamides with activated olefins

(2012) María González-Esguevillas et al.   CHEMICAL COMMUNICATIONS

[5 + 2] Cycloaddition Reactions in Organic and Natural Product Synthesis

(2012) Kai E. O. Ylijoki et al.   CHEMICAL REVIEWS

Emerging chirality in nanoscience

(2012) Yong Wang et al.   CHEMICAL SOCIETY REVIEWS

Stereoselective Construction of Spiro(butyrolactonepyrrolidines) by Highly Efficient Copper(I)/TF-BiphamPhos-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition

(2012) Tang-Lin Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Catalytic Asymmetric exo′-Selective [3+2] Cycloaddition for Constructing Stereochemically Diversified Spiro[pyrrolidin-3,3′-oxindole]s

(2012) Atsuko Awata et al.   CHEMISTRY-A EUROPEAN JOURNAL

An Amine-Catalyzed Enantioselective [3+2] Cycloaddition of Azomethine Ylides and α,β-Unsaturated Aldehydes: Applications and Mechanistic Implications

(2012) Silvia Reboredo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Scaffold-Inspired Enantioselective Synthesis of Biologically Important Spiro[pyrrolidin-3,2′-oxindoles] with Structural Diversity through Catalytic Isatin-Derived 1,3-Dipolar Cycloadditions

(2012) Feng Shi et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Synthesis of Hexahydropyrrolo-isoquinolines by an Organocatalytic Three-Component Reaction

(2012) Alberto Fraile et al.   CHEMISTRY-A EUROPEAN JOURNAL

Switching the Stereoselectivity: (Fullero)Pyrrolidines “a la Carte”

(2012) Enrique E. Maroto et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Programmable enantioselective one-pot synthesis of molecules with eight stereocenters

(2012) Marco Potowski et al.   Nature Chemical Biology

[C+NC+CC] Coupling-Enabled Synthesis of Influenza Neuramidase Inhibitor A-315675

(2012) Philip Garner et al.   ORGANIC LETTERS

A Facile Access to Enantioenriched Isoindolines via One-Pot Sequential Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition/Aromatization

(2012) Zhaolin He et al.   ORGANIC LETTERS

Cu(I)/DTBM-BIPHEP-catalyzed exo-selective 1,3-dipolar cycloaddition of azomethine ylides with cis-trifluorocrotonate for asymmetric construction of trifluoromethylated pyrrolidines

(2012) Qing-Hua Li et al.   TETRAHEDRON LETTERS

Catalytic asymmetric synthesis of highly substituted pyrrolizidines

(2012) Andrew D. Lim et al.   Chemical Science

Brønsted-Acid-Catalyzed Asymmetric Multicomponent Reactions for the Facile Synthesis of Highly Enantioenriched Structurally Diverse Nitrogenous Heterocycles

(2011) Jie Yu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Catalytic Asymmetric Construction of Spirocycles Containing Pyrrolidine Motifs and Spiro Quaternary Stereogenic Centers via 1,3-Dipolar Cycloaddition of Azomethine Ylides with 2-Alkylidene-Cycloketones

(2011) Tang-Lin Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Complete 2,5-Diastereocontrol in the Organocatalytic Enantioselective [3+2] Cycloaddition of Enals with Azomethine Ylides Derived from α-Iminocyanoacetates: Asymmetric Synthesis of Pyrrolidines with Four Stereocentres

(2011) Silvia Reboredo et al.   ADVANCED SYNTHESIS & CATALYSIS

Chiral Silver Amide Catalyst for the [3+2] Cycloaddition of α-Amino Esters to Olefins

(2011) Yasuhiro Yamashita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hierarchical Selectivity in Fullerenes: Site-, Regio-, Diastereo-, and Enantiocontrol of the 1,3-Dipolar Cycloaddition to C70

(2011) Enrique E. Maroto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dynamic One-Pot Three-Component Catalytic Asymmetric Transformation by Combination of Hydrogen-Bond-Donating and Amine Catalysts

(2011) Shuangzheng Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric construction of trifluoromethylated pyrrolidines via Cu(i)-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with 4,4,4-trifluorocrotonates

(2011) Qing-Hua Li et al.   CHEMICAL COMMUNICATIONS

Highly efficient construction of spirocyclic chromanone–pyrrolidines via Cu(i)/TF–BiphamPhos-catalyzed asymmetric 1,3-dipolar cycloaddition

(2011) Tang-Lin Liu et al.   CHEMICAL COMMUNICATIONS

Organocatalytic enantioselective (3+2) cycloaddition using stable azomethine ylides

(2011) Naiara Fernández et al.   CHEMICAL COMMUNICATIONS

Novel dipolarophiles and dipoles in the metal-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine ylides

(2011) Javier Adrio et al.   CHEMICAL COMMUNICATIONS

Morita–Baylis–Hillman adducts as effective dipolarophiles in Copper(i)-catalyzed 1,3-dipolar cycloaddition with azomethine ylides: asymmetric construction of pyrrolidine derivatives containing quaternary stereogenic center

(2011) Huai-Long Teng et al.   CHEMICAL COMMUNICATIONS

Update 1 of: α,β-Diamino Acids: Biological Significance and Synthetic Approaches

(2011) Alma Viso et al.   CHEMICAL REVIEWS

1,2-Benzoquinones in Diels–Alder reactions, dipolar cycloadditions, nucleophilic additions, multicomponent reactions and more

(2011) Vijay Nair et al.   CHEMICAL SOCIETY REVIEWS

Metal-Free Asymmetric 1,3-Dipolar Cycloaddition of N-Arylmaleimides to Azomethine Ylides Catalyzed by Chiral Tertiary Amine Thiourea

(2011) Jian-Fei Bai et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of Endohedral Metallofullerenes

(2011) Koji Sawai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Phosphine-Catalyzed Annulations of Azomethine Imines: Allene-Dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] Pathways

(2011) Risong Na et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric construction of 3-vinylidene-pyrrolidine derivatives containing allene moiety via Ag(i)/TF-BiphamPhos-catalyzed 1,3-dipolar cycloaddition of azomethine ylides with diethyl 2-(3,3-diphenylpropa-1,2-dienylidene) malonate

(2011) Zhi-Yong Xue et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Ynones with Azomethine Ylides

(2011) Feng Shi et al.   ORGANIC LETTERS

Catalytic Asymmetric exo′-Selective [3+2] Cycloaddition of Iminoesters with Nitroalkenes

(2010) Takayoshi Arai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

exo-Selective asymmetric 1,3-dipolar cycloaddition of azomethine ylides with alkylidene malonates catalyzed by AgOAc/TF-BiphamPhos

(2010) Zhi-Yong Xue et al.   CHEMICAL COMMUNICATIONS

Asymmetric organocatalytic formal double-arylation of azomethines for the synthesis of highly enantiomerically enriched isoindolines

(2010) Chao Wang et al.   CHEMICAL COMMUNICATIONS

Catalytic Asymmetric 1,3-Dipolar Cycloaddition of α-Iminonitriles

(2010) Rocío Robles-Machín et al.   CHEMISTRY-A EUROPEAN JOURNAL

Diastereoselective Silver-Catalyzed 1,3-Dipolar Cycloaddition of Azomethine Ylides with Fluorinated Imine

(2010) Haibo Xie et al.   JOURNAL OF ORGANIC CHEMISTRY

Chiral Silver Amide-Catalyzed Enantioselective [3 + 2] Cycloaddition of α-Aminophosphonates with Olefins

(2010) Yasuhiro Yamashita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products

(2010) Andrey P. Antonchick et al.   Nature Chemistry

Catalytic asymmetric 1,3-dipolar cycloaddition of N-unprotected 2-oxoindolin-3-ylidene derivatives and azomethine ylides for the construction of spirooxindole-pyrrolidines

(2010) Tang-Lin Liu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

N-(2-Pyridylmethyl)imines as Azomethine Precursors in Catalytic Asymmetric [3 + 2] Cycloadditions

(2010) Silvia Padilla et al.   ORGANIC LETTERS

Kinetic Resolution of Racemic 2,3-Allenoates by Organocatalytic Asymmetric 1,3-Dipolar Cycloaddition

(2010) Jie Yu et al.   ORGANIC LETTERS

Ag/ThioClickFerrophos catalyzed highly enantioselective 1,3-dipolar cycloaddition of azomethine ylides with alkenes

(2010) Kenta Shimizu et al.   TETRAHEDRON LETTERS

Reversal of Enantioselectivity between the Copper(I)- and Silver(I)-Catalyzed 1,3-Dipolar Cycloaddition Reactions Using a Brucine-Derived Amino Alcohol Ligand

(2009) Hun Young Kim et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

(2009) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An efficient approach to chiral fullerene derivatives by catalytic enantioselective 1,3-dipolar cycloadditions

(2009) Salvatore Filippone et al.   Nature Chemistry

Highly Enantioselective Catalytic 1,3-Dipolar Cycloaddition Involving 2,3-Allenoate Dipolarophiles

(2009) Jie Yu et al.   ORGANIC LETTERS

Enantioselective Copper-Catalyzed 1,3-Dipolar Cycloadditions

(2008) Levi M. Stanley et al.   CHEMICAL REVIEWS

Reaction Control in the Organocatalytic Asymmetric One-Pot, Three-Component Reaction of Aldehydes, Diethyl α-Aminomalonate and Nitroalkenes: Toward Diversity-Oriented Synthesis

(2008) Yan-Kai Liu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric Organocatalytic Three-Component 1,3-Dipolar Cycloaddition: Control of Stereochemistry via a Chiral Brønsted Acid Activated Dipole

(2008) Xiao-Hua Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Assembly of Aldehydes, Amino Esters, and Anilines into Chiral Imidazolidines via Brønsted Acid Catalyzed Asymmetric 1,3-Dipolar Cycloadditions

(2008) Wei-Jun Liu et al.   ORGANIC LETTERS

X=Y–ZH compounds as potential 1,3-dipoles. Part 64: Synthesis of highly substituted conformationally restricted and spiro nitropyrrolidines via Ag(I) catalysed azomethine ylide cycloadditions

(2008) Ronald Grigg et al.   TETRAHEDRON