Direct Assembly of Aldehydes, Amino Esters, and Anilines into Chiral Imidazolidines via Bronsted Acid Catalyzed Asymmetric 1,3-Dipolar Cycloadditions

A chiral Bronsted acid catalyzed 1,3-dipolar cycloaddition reaction directly assembles aldehydes, amino esters, and anilines into synthetically useful chiral imidazolidines with high levels of stereoselectivity (up to 91/9 dr and 98% ee).