Article
Chemistry, Multidisciplinary
Suresh Moorthy, Alvaro Castillo Bonillo, Hugues Lambert, Elina Kalenius, Tung-Chun Lee
Summary: A new supramolecular approach has been reported to selectively deactivate the electrophilic alpha-carbon of phenyl diazonium ion through host-guest complexation, thus avoiding undesirable side reactions. This method holds great potential for the reactive chemistry of organic molecules in aqueous media.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Hao Chen, Jin Zhang, Wenting Yu, Yi Cao, Zhaozhen Cao, Yebang Tan
Summary: The study demonstrates the control of viscoelasticity of polymer networks by designing crosslinks with variable molecular dynamics, achieving a quantitative control over mechanical properties and reversible mechanical response. This strategy paves the way for engineering smart responsive materials by tailoring the mechanical properties of polymer networks at the molecular level.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yuan Zhang, Benjamin Ourri, Pierre-Thomas Skowron, Emeric Jeamet, Titouan Chetot, Christian Duchamp, Ana M. Belenguer, Nicolas Vanthuyne, Olivier Cala, Elise Dumont, Pradeep K. Mandal, Ivan Huc, Florent Perret, Laurent Vial, Julien Leclaire
Summary: By incorporating stereo-electronic information on synthetic organic building blocks and templates, and utilizing non-directional interactions, achiral constituents can be selectively assembled into complex covalent architectures with multiple stereogenic elements. This proof of concept has implications beyond supramolecular chemistry and could stimulate the on-demand production of highly structured polyfunctional architectures.
Article
Chemistry, Multidisciplinary
Hang Yin, Roselyne Rosas, Stephane Viel, Michel Giorgi, Valerie Monnier, Laurence Charles, Didier Siri, Didier Gigmes, Youssef Nassar, Floris Chevallier, Christophe Bucher, Ruibing Wang, Anthony Kermagoret, David Bardelang
Summary: This article describes the structural tunability of cucurbit[8]uril (CB[8]) host/guest complexes and their responsiveness to various stimuli in water. A series of versatile 3:2 host/guest complexes were prepared by combining CB[8] with symmetric, linear diviologens, exhibiting remarkable dynamic properties and external ring translocation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Applied
Matheus A. S. Santos, Paula K. Okuro, Larissa R. Fonseca, Rosiane L. Cunha
Summary: The current trend in the food and pharmaceutical industries is the use of colloidal structures to stabilize emulsions, focusing on the potential of protein-polysaccharides, protein-phenolic compounds, and protein-polysaccharides-phenolic compounds complexes. The review addresses the formation of non-covalent or covalent binary and ternary complexes, processes involved in modifying molecules or complex formation, and different strategies of colloidal structures at the water-oil interface, aiming to inspire further research and rational design of novel complexes.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Ye-Jin Kim, Yangjin Lee, WonJae Choi, Myeongjin Jang, Won-Woo Park, Kwanpyo Kim, Q-Han Park, Oh-Hoon Kwon
Summary: The strong interaction between light and matter is utilized to shape two-dimensional materials into nanoscale architectures. By controlling the light fields, ultrafine nanostructures of black phosphorus are achieved. Nanoribbons and nanocubes/cuboids with sizes in the tens of nanometers scale are formed via tailored ablation along tightly confined periodic light fields.
Article
Materials Science, Multidisciplinary
Zheng-Kun Bai, Qing-Mei Ge, Nan Jiang, Hang Cong, Zhu Tao, Mao Liu, Ying Fan
Summary: A novel supramolecular photocatalyst, g-C3N4/ Ag3PO4@Q [7] composite, with the macrocyclic compound of cucurbit [7]uril (Q [7]) block, is successfully prepared by ternary organic-inorganic hybridization. It is applied for the photo-driven degradation of pyroquilon and admire pesticides in the irradiation of visible light. The photocatalyst exhibits high degradation efficiency, stability, and reusability, offering performance advantages of low energy consumption and fast reaction rates compared to reported photocatalysts.
Review
Chemistry, Multidisciplinary
Ziyi Wang, Chen Sun, Kuikun Yang, Xiaoyuan Chen, Ruibing Wang
Summary: Supramolecular polymers, with their unique features and functions, have attracted broad interest in diverse biomedical applications. This Minireview summarizes the recent progress in the design, fabrication, and biomedical applications of CB[n]-based supramolecular polymers (CSPs), categorized as noncovalent and covalent CSPs. The design principles, advantages, and future perspectives of CSPs in the field of biomedicine are also discussed.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Xue Yang, Qian Cheng, Valerie Monnier, Laurence Charles, Hakim Karoui, Olivier Ouari, Didier Gigmes, Ruibing Wang, Anthony Kermagoret, David Bardelang
Summary: Chemists have successfully mimicked the function of natural molecular machines with synthetic systems in organic solvents and exchanged guest molecules in synthetic macrocycles for the production of pH-responsive hydrogels in water. Cucurbiturils may be excellent ring molecules for the construction of advanced molecular machines working in water.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Turkan Kopac
Summary: Proteins are diverse biopolymers that participate in almost all processes in living cells. When nanoparticles interact with proteins, they form a protein corona layer, which influences their interactions. The characteristics of nanoparticles such as size, surface chemistry, and charge play a critical role in determining the behavior of the protein corona.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Xue Yang, Chunyang Li, Michel Giorgi, Didier Siri, Xavier Bugaut, Bastien Chatelet, Didier Gigmes, Mehdi Yemloul, Virginie Hornebecq, Anthony Kermagoret, Sophie Brasselet, Alexandre Martinez, David Bardelang
Summary: Porous organic crystals based on macrocycles have recently shown exceptional sorption and separation properties. In this study, the inclusion of trimethoxybenzyl-azaphosphatrane in the macrocycle cucurbit[8]uril (CB[8]) resulted in the formation of molecular porous host.guest crystals (PHGC-1) with radically new properties. The PHGC-1 crystals demonstrated spontaneous and selective adsorption of iodine at room temperature and atmospheric pressure, offering potential advantages in energy cost reduction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Yawen Li, Qingfang Li, Xiaran Miao, Chunyan Qin, Dake Chu, Liping Cao
Summary: Achiral supramolecular organic framework (SOF-1) can exhibit adaptive chirality induced by specific compounds in water, leading to mirror-image circular dichroism and circularly polarized luminescence. This adaptive chirality can be utilized for determining the enantiopurity of amino acids and distinguishing biological chiral macromolecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Xin-Kun Ma, Xiaolu Zhou, Jing Wu, Fang-Fang Shen, Yu Liu
Summary: This study presents a design strategy for achieving near-infrared excitation and emission of organic phosphorescence materials through two-stage confinement supramolecular assembly. The prepared water-soluble assemblies maintain two-photon absorption and multicolor luminescence in cells or vivo, providing potential applications in bioimaging.
Article
Nanoscience & Nanotechnology
Han Wu, Hua Wang, Feilong Qi, Tian Xia, Yu Xia, Jiang-Fei Xu, Xi Zhang
Summary: A new strategy of activatable host-guest conjugate with self-inclusion property is proposed for supramolecular chemotherapy, which can achieve high-efficiency drug release triggered by intramolecular host-guest self-inclusion. The encapsulation of oxaliplatin in the conjugate leads to the formation of a stable supramolecular drug, and the release of oxaliplatin in the tumor microenvironment shows comparable anti-tumor bioactivity to naked oxaliplatin. This research may open new horizons for programmable and on-demand supramolecular chemotherapy with high anti-tumor efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Chen Sun, Ziyi Wang, Kuikun Yang, Ludan Yue, Qian Cheng, Yan-Long Ma, Siyu Lu, Guosong Chen, Ruibing Wang
Summary: A novel supramolecular-peptide derived nanodrug capable of transforming into microfibers within cancer cells has been developed, leading to enhanced accumulation and retention of the drug in tumor tissue. The polyamine-responsive nanodrug exhibits low toxicity against non-cancerous cells, offering a promising strategy for specific tumor therapy with minimal side effects. This work provides insights into the design of stimuli-responsive nanomaterials for precision medicine.
Article
Chemistry, Analytical
Riccardo Rizzo, Maria Alvaro, Norbert Danz, Lucia Napione, Emiliano Descrovi, Stefan Schmieder, Alberto Sinibaldi, Rona Chandrawati, Subinoy Rana, Peter Munzert, Thomas Schubert, Emmanuel Maillart, Aleksei Anopchenko, Paola Rivolo, Alessandro Mascioletti, Frank Sonntag, Molly M. Stevens, Federico Bussolino, Francesco Michelotti
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Multidisciplinary Sciences
Yang Hsia, Rubul Mout, William Sheffler, Natasha Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Summary: The study introduces a stepwise hierarchical approach using helical repeat and helical bundle proteins as building blocks for building complex, multi-component protein assemblies, and provides a detailed structural characterization of the resulting assemblies.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Moumita Ray, Giorgia Brancolini, David C. Luther, Ziwen Jiang, Roberto Cao-Milan, Alejandro M. Cuadros, Andrew Burden, Vincent Clark, Subinoy Rana, Rubul Mout, Ryan F. Landis, Stefano Corni, Vincent M. Rotello
Summary: Control over supramolecular recognition between proteins and nanoparticles is crucial for therapeutic applications and sensor development. Most current binding approaches use tags, but this study presents a new strategy of co-engineering nanoparticles and proteins for high affinity binding. This strategy maintains high binding affinity even under physiological conditions.
Article
Chemistry, Multidisciplinary
Tanmoy Maity, Siddarth Jain, Manju Solra, Shovan Barman, Subinoy Rana
Summary: This study presents the laccase-like activity of Cu2O nanospheres synthesized using a one-pot polyol-based microwave assisted method. The Cu2O nanospheres exhibit great stability under harsh conditions and demonstrate excellent laccase-like activity. The nanozyme is capable of efficiently oxidizing phenolic pollutants under high-salinity conditions and can be used for colorimetric detection of biomolecules. Notably, the Cu2O nanozyme enables naked-eye detection of the acetylcholinesterase enzyme.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Nanoscience & Nanotechnology
Manju Solra, Sourav Das, Abhay Srivastava, Bhaskar Sen, Subinoy Rana
Summary: The development of superior functional enzyme mimics (nanozymes) is crucial for various practical applications. This study presents a supramolecular coordination bonding-based dynamic vesicle with multienzymatic activity. The nanozyme shows high sensitivity and stability, making it promising for point-of-care diagnostics and environmental remediation. pH variation can control the dynamic laccase-mimetic activity of the active nanozyme, which is a novel finding.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Pradipta Behera, Subbaraj Karunakaran, Jagabandhu Sahoo, Preeti Bhatt, Subinoy Rana, Mrinmoy De
Summary: Two-dimensional MoS2 nanosheets have been widely used in many biological applications. The ligand exchange on 2D-MoS2 can be regulated, which has potential applications in diverse biological processes.
Article
Engineering, Biomedical
Sourav Das, Manju Solra, Subinoy Rana
Summary: This article discusses the potential of using emulsion gels as a drug delivery system for osteoarthritis treatment. Emulsion gels, consisting of hydrogels and oil droplets, can increase biocompatibility and prevent drug degradation. Stimuli-responsive emulsion gels may also have the ability to promote tissue growth and recovery in OA-affected joints.
REGENERATIVE ENGINEERING AND TRANSLATIONAL MEDICINE
(2023)
Article
Chemistry, Analytical
Preeti Bhatt, Manju Solra, Smarak Islam Chaudhury, Subinoy Rana
Summary: We developed a supramolecular self-assembled system (SupraZyme) with multi-enzymatic activity for the sensitive detection of neurotransmitters and organophosphorus pesticides. The system showed oxidase-like activity for NTs detection and peroxidase-like activity for OP pesticides detection.
Article
Multidisciplinary Sciences
Gaurav D. D. Sankhe, Rubesh Raja, Devendra Pratap Singh, Sneha Bheemireddy, Subinoy Rana, P. J. Athira, Narendra M. M. Dixit, Deepak Kumar Saini
Summary: Bacterial two-component systems (TCSs) consist of a sensor histidine kinase (HK) that perceives a specific signal, and a cognate response regulator (RR) that modulates the expression of target genes. In this study, it is found that phosphorylated HKs (HK similar to Ps) can be sequestered by non-cognate RRs, preventing disproportionate responses to weak signals. Mathematical modeling and experiments on Mycobacterium tuberculosis show that non-cognate RRs have higher affinity for HK similar to Ps, leading to their preferential binding and sequestration, which introduces a threshold stimulus strength for eliciting responses to prevent responses to weak signals.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Alisha Kamra, Sourav Das, Preeti Bhatt, Manju Solra, Tanmoy Maity, Subinoy Rana
Summary: Regulation of enzyme activity and biocatalytic cascades on compartmentalized cellular components is essential for cellular adaptation. A transient supramolecular glue with a controllable lifetime based on multivalent supramolecular interactions between surfactants and ATP has been introduced, allowing temporal control of catalytic activities similar to cellular nanoreactors. This system emulates heterogeneous cellular processes and provides opportunities for protocell construction and therapeutic interventions.
Article
Chemistry, Multidisciplinary
Jagabandhu Sahoo, Soumyashree Sahoo, Yogeswari Subramaniam, Preeti Bhatt, Subinoy Rana, Mrinmoy De
Summary: This study presents a reversible biointerface on a 2D-MoS2 platform that can selectively interact with different types of bacteria. The reversible control of strain-selective bactericidal activity is achieved through photoswitching. This method has potential applications in wound healing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Rohit Kapila, Bhaskar Sen, Alisha Kamra, Shana Chandran, Subinoy Rana
Summary: Artificial enzyme equivalents, known as nanozymes, are a practical tool for environmental remediation. This study introduces aggregation-induced emissive Pt(ii) complex that self-assembles in water to provide NanoPtA nanotapes. The NanoPtA structure exhibits specific oxidase-like activity driven by light, leading to efficient degradation of toxic chemicals within minutes.
Article
Pharmacology & Pharmacy
Yi-Wei Lee, Rubul Mout, David C. Luther, Yuanchang Liu, Laura Castellanos-Garcia, Amy S. Burnside, Moumita Ray, Gulen Yesilbag Tonga, Joseph Hardie, Harini Nagaraj, Riddha Das, Erin L. Phillips, Tristan Tay, Richard W. Vachet, Vincent M. Rotello
ADVANCED THERAPEUTICS
(2019)
Meeting Abstract
Chemistry, Multidisciplinary
Yingying Geng, Ngoc Le, Subinoy Rana, Hira Goel, Tatsuyushi Yoshii, Arthur Mercurio, Vincent Rotello
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2018)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
