Article
Biochemistry & Molecular Biology
Elisabetta Rosadoni, Federico Banchini, Sara Bellini, Marco Lessi, Luca Pasquinelli, Fabio Bellina
Summary: This paper reports an unprecedented selective C-5 arylation method using anisole as an environmentally friendly reaction solvent, and highlights the beneficial role of benzoic acid as an additive.
Article
Chemistry, Organic
Chaimae Ouazzani Chahdi, Khalid Boujdi, Nabil El Brahmi, Monique Mathe-Allainmat, Hachim Mouhi Eddine, Mohamed Akssira, Gerald Guillaumet, Jacques Lebreton, Jamal Koubachi, Said El Kazzouli
Summary: An efficient palladium-catalyzed oxidative arylation of substituted 1H-indazole with various arenes and heteroarenes as coupling partners is reported, achieving site selective C7 oxidative arylation through the introduction of an electron-withdrawing group at the C4 position of the 1H-indazole. The desired products are obtained in moderate to good yields using Pd(OAc)(2) as catalyst, phenanthroline as ligand, Ag2CO3 as oxidant, and NaOH as the base. Density functional theory calculations were conducted to gain insight into the reaction mechanism. This method provides a highly effective and atom economical approach for building C7- (het)arylated 1H-indazole compounds.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Benfa Chu, Xuan Wu, Ziwen Fu, Weiping Wu, Bin Wang, Jin Zhu
Summary: The study developed a directed redox-neutral cross-dehydrogenative C-H cross-coupling polymerization method under transition metal catalysis, utilizing the internal oxidant role of the N-amino group to effectively direct one C-H activation event and eliminate defect C-H coupling. The polymerization system features a simple catalytic component, mild reaction conditions, and a broad scope for monomers, polymers, and functionalities.
Article
Chemistry, Organic
Laura Buglioni, Marko Beslac, Timothy Noel
Summary: The electrochemical synthesis of aryl azoles was successfully conducted in a microflow reactor for the first time, avoiding the need for homogeneous transition-metal-based catalysts. By implementing a microflow setup, shorter residence times and good to excellent yields of various azolated compounds were achieved.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Milos Petkovic, Milos Jovanovic, Predrag Jovanovic, Milena Simic, Gordana Tasic, Vladimir Savic
Summary: Pyrrole derivatives with C(2)-aryl substituents are an important and widespread class of heterocyclic compounds. A novel approach combining the dual role of arylating agent as nitrogen protecting group and involved in the arylation step has been developed for the direct arylation synthesis of C(2)-arylpyrroles. The deprotection as a final stage is carried out simultaneously utilizing amines as reacting components, leading to mild conditions and exclusive C(2) selectivity.
SYNTHESIS-STUTTGART
(2022)
Article
Chemistry, Multidisciplinary
Zengzeng Li, Fei Lu, Qingchun Xu, Gang Liu, Ximei Zhao, Guanghui Wang
Summary: A stereoselective copper-catalyzed cascade reaction has been developed for the synthesis of N-vinylsilylindoles with good to excellent yields and perfect stereoselectivity. This ligand-free and cost-effective catalytic system shows potential synthetic applicability as demonstrated by large-scale experiments and downstream synthetic transformations.
Article
Chemistry, Medicinal
Ying Wang, Isabella Haight, Rishi Gupta, Anil Vasudevan
Summary: Building blocks are crucial in drug molecule design, playing a significant role in determining the quality of the final compound. Analysis of the building blocks used in medicinal chemistry can provide insights into synthetic tractability and accessibility, as well as identify opportunities for incorporating underrepresented building blocks to gain intellectual and competitive advantages in drug discovery.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jiawang Liu, Carolin Schneider, Ji Yang, Zhihong Wei, Haijun Jiao, Robert Franke, Ralf Jackstell, Matthias Beller
Summary: This study describes a new method for chemo-, regio-, and stereoselective mono-hydroamidation of (un)symmetrical 1,3-diynes, utilizing an advanced palladium catalyst system with the ligand Neolephos. The success of this novel transformation is demonstrated by the diversification of several structurally complex molecules and marketed drugs, highlighting the synthetic value of the approach for synthesizing useful α-alkynyl-α, β-unsaturated amides. Control experiments and density-functional theory computations indicate the crucial role of the substrate in controlling the regioselectivity of unsymmetrical 1,3-diynes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Yang Liu, Mikael La Roch, Alessia Mori, Alexandre Pradal, Giovanni Poli, Julie Oble
Summary: The article introduces a Pd(II)-catalyzed [3+2] annulation strategy, which replaces α,β-unsaturated-γ-oxy carbonyls with β,γ-unsaturated carbonyl derivatives as bis-electrophiles. The study provides experimental optimization and demonstrates the synthetic versatility in forming diverse heterocyclic structures. This dehydrogenative strategy represents a more economical version than the previous redox-neutral couplings.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Oliver M. Griffiths, Henrique A. Esteves, Yiding Chen, Karin Sowa, Oliver S. May, Peter Morse, David C. Blakemore, Steven Ley
Summary: Executing photoredox reactions in flow can improve reaction concentration, reduce reaction time, achieve better yields, facilitate catalyst preparation, and expand substrate scope, demonstrating broad applicability.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Sarah Nassiri, Mostapha Bousmina, Franck Suzenet, Gerald Guillaumet, Said El Kazzouli
Summary: A new strategy for the C-H/C-H functionalization of 7-azaindazoles at the C6-position through regioselective oxidative arylation using N-oxide activation is reported. This methodology allows selective and original access to C6-arylated 7-azaindazoles with different substituted arenes and heteroarenes.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Hua Yao, Xiaoyang Zhong, Bingqing Wang, Sen Lin, Zhaohua Yan
Summary: A novel and efficient approach for the amine-directed dehydrogenative C(sp(2))-C(sp(3)) coupling of arylamines with acetonitrile was developed using FeCl2 as the catalyst. The method provides a straightforward and green route to arylacetonitriles with good regioselectivity and excellent compatibility of functional groups and aromatic rings.
Article
Chemistry, Multidisciplinary
Barry M. Trost, Zhijun Zuo
Summary: A novel Pd-0-catalyzed highly selective [3+2] spiroannulation reaction has been developed for rapid assembly of a new class of [5,5] spirocyclic carbo- and heterocycles. The regioselectivity of the reaction can be controlled by fine-tuning the Pd-pi-allyl intermediate, with excellent toleration of various coupling partners and enantioselectivities demonstrated through further transformations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Min Zhang, Zhangyi Fu, Anping Luo, Xingwen Pu, Menglei Wang, Ying Huang, Yudong Yang, Jingsong You
Summary: The study presents a concise route for site-selective arylation of polycyclic aromatic hydrocarbons with easily available aryl sources, contributing to the bottom-up preparation of pi-extended PAHs. Additionally, a C8-H annulation protocol has been developed to rapidly assemble benzanthrones by simply switching the solvent to 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP).
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Multidisciplinary
Xin Liu, Yun Zhou, Xiaotian Qi, Renhe Li, Peng Liu, Guangbin Dong
Summary: A site- and regioselective vicinal di-carbo-functionalization of indoles has been realized by the palladium/norbornene (Pd/NBE) cooperative catalysis. The C1-substituted NBE plays a key role in promoting the turnover-limiting oxidative addition step.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biology
Masoomeh Fooladi, Alireza Shirazi, Peyman Sheikhzadeh, Mahsa Amirrashedi, Fatemeh Ghahramani, Mohsen Cheki, Mehdi Khoobi
Summary: This study investigated the efficacy of telmisartan in the recovery process of intestinal tissue after in vivo irradiation using F-18-FDG microPET imaging. The results showed that telmisartan effectively attenuated radiation-induced injury in the intestine, which was consistent with histological analysis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Polymer Science
Farzaneh Sorouri, Pegah Azimzadeh Asiabi, Parastoo Hosseini, Ali Ramazani, Sahar Kiani, Tayebeh Akbari, Mohammad Sharifzadeh, Marzieh Shakoori, Alireza Foroumadi, Loghman Firoozpour, Mohsen Amin, Mehdi Khoobi
Summary: This study introduces a simple strategy for preparing a multifunctional dressing for burn wound treatment using carnosine-enriched bentonite loaded into Carbopol gel. The results suggest that the Carb-CEB gel has improved physicochemical properties and antioxidant activity, leading to accelerated wound healing, tissue repair, and angiogenesis.
Article
Chemistry, Multidisciplinary
Elaheh Babaei, Tuba Tuylu Kucukkilinc, Leili Jalili-Baleh, Hamid Nadri, Esin Oz, Hamid Forootanfar, Elaheh Hosseinzadeh, Tayebeh Akbari, Mehdi Shafiee Ardestani, Loghman Firoozpour, Alireza Foroumadi, Mohammad Sharifzadeh, Bi Bi Fatemeh Mirjalili, Mehdi Khoobi
Summary: In this research, a series of coumarin-based multifunctional anti-AD agents were synthesized and evaluated. Compound 3f showed the best activity, with potent inhibition of AChE and BuChE, as well as significant cell protective effects against H2O2-induced cell death and amyloid toxicity. It also exhibited greater potency in reducing beta-amyloid self and AChE-induced aggregation compared to the standard drug. These findings suggest that compound 3f holds promise as a multi-target-directed ligand against AD.
FRONTIERS IN CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Alireza Najafi, Maryam Keykhaee, Hossein Khorramdelazad, Mohammad Yahya Karimi, Leila Nejatbakhsh Samimi, Nazanin Aghamohamadi, Milad Karimi, Reza Falak, Mehdi Khoobi
Summary: The tumor microenvironment (TME) plays a critical role in tumor progression and resistance to treatment. Tumor-associated macrophages (TAMs) and hypoxia are important factors in the TME. Catalase and catalase-mimicking compounds can reduce hypoxia and promote TAM polarization, showing potential in cancer therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Applied
Morteza Abazari, Tayebeh Akbari, Mahdiye Hasani, Elham Sharifikolouei, Mohammad Raoufi, Alireza Foroumadi, Mohammad Sharifzadeh, Loghman Firoozpour, Mehdi Khoobi
Summary: This study summarizes the preparation, functionalization, and application of polysaccharide-based hydrogels enriched by herbal extracts for various wound healing applications. The structural, biological, and functional impact of polysaccharides and herbal extracts on the characteristics of hydrogels and different phases of the wound healing process are discussed.
CARBOHYDRATE POLYMERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Z. Rasouli, N. Riyahi-Alam, M. Khoobi, S. Haghgoo, E. Gholibegloo, A. Ebrahimpour, H. Ashouri, H. Hashemi
Summary: In this study, the use of gadolinium oxide nanoparticles as contrast agents enabled high-resolution detection of lymph node metastasis in mice and showed potential for breast cancer diagnostic imaging.
CONTRAST MEDIA & MOLECULAR IMAGING
(2022)
Article
Nutrition & Dietetics
Alireza Sadeghi, Ahmad Saedisomeolia, Leili Jalili-Baleh, Mehdi Khoobi, Mohammad Soleimani, Ali Mohammad Fakhr Yasseri, Mir Saeed Yekaninejad, Amirreza Farzin, Erfan Amini, Mohammad Reza Nowroozi
Summary: The intake of FruHis enhances the beneficial effects of lycopene on IGF-1, TPSA, and symptom scores among BPH patients. However, these effects are not statistically significant.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemical Research Methods
Zahra Saffari, Mina Sepahi, Reza Ahangari-Cohan, Mehdi Khoobi, Mojtaba Hamidi-Fard, Amir Ghavidel, Mohammad Reza Aghasadeghi, Dariush Norouzian
Summary: A QCM biosensor was developed for the label-free detection of HBsAg. The biosensor showed excellent detection performance with a wide dynamic range, high sensitivity, and selectivity, comparable with ELISA. It can detect HBsAg in human sera and has the advantages of regeneration ability and low cost.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Chemistry, Physical
Elham Gholibegloo, Anita Ebrahimpour, Tohid Mortezazadeh, Farzaneh Sorouri, Alireza Foroumadi, Loghman Firoozpour, Mehdi Shafiee Ardestani, Mehdi Khoobi
Summary: In this study, gadolinium oxide nanoparticles (Gd2O3 NPs) were loaded with 5-aminolevulinic acid (5-ALA) and assisted by intracellular iron, resulting in their ability to serve as a T1 contrast agent with T2* contrast ability. The NPs exhibited concentration-dependent toxicity against glioblastoma C6 cells and showed higher relaxation rates (R1 and R2*) compared to the controls. These findings suggest that Gd2O3 NPs loaded with 5-ALA and assisted by intracellular iron could be a promising contrast agent for glioblastoma diagnosis in MRI.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Materials Science, Characterization & Testing
Tayebeh Modiri-Delshad, Ali Ramazani, Mehdi Khoobi, Hamid Akbari Javar, Tayebeh Akbari, Mohsen Amin
Summary: Development of novel antimicrobial nanofibrous mats containing phytochemicals is a promising strategy to combat antibiotic resistance in wound healing. This study successfully fabricated electrospun chitosan/polycaprolactone (CS/PCL) nanofiber mats loaded with Morinda communis leaf extract (MCLE) at different concentrations. The physicochemical properties of the nanofiber mats were evaluated using various characterization techniques, and the results showed that the incorporation of MCLE enhanced the antimicrobial activity and hydrophilicity of the mats. The manufactured nanofiber mats demonstrated significant reduction in bacterial count and could be a promising option for wound dressing.
POLYMERS & POLYMER COMPOSITES
(2023)
Article
Oncology
Sogol Saberi, Tayebeh Modiri-Delshad, Shahroo Etemad-Moghadam, Mojgan Alaeddini, Rahele Jamshidloo, Ali Ramazani, Hadiseh Mohammadpour, Reem Hanna, Mehdi Khoobi, Sima Shahabi
Summary: Photodynamic therapy (PDT) is a valuable option for cancer treatment, and natural photosensitizers can enhance its efficacy. In this study, a cubic form of spirulina platensis (SP) was synthesized and compared with naturally-occurring microhelical SP (MSP) and phycocyanin (Pc) in anticancer-PDT. The results showed that both SPs were safe and efficient, while caution should be exercised when using Pc.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Environmental Sciences
Nesa Hamidian, Gholamreza Dehghan, Samaneh Rashtbari, Alireza Khataee, Mehdi Khoobi, Nader Sheibani
Summary: A magnetite/Gd3+/beta-cyclodextrin nanoplatform was prepared and used for the degradation of tetracycline. The nanoplatform showed higher peroxidase-mimic activity than natural enzymes. It was able to degrade tetracycline efficiently and could be reused.
Article
Nanoscience & Nanotechnology
Farzaneh Sorouri, Parastoo Hosseini, Mohammad Sharifzadeh, Sahar Kiani, Mehdi Khoobi
Summary: In this study, a multifunctional injectable hydrogel with antioxidant, neuroprotective, and neuroregenerative effects was designed. The hydrogel showed promising results in inhibiting glial scar progression, reducing inflammation, promoting angiogenesis, and inducing myelinated axon regeneration in a rat spinal cord injury model, leading to a significant improvement in motor performance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Farzaneh Sorouri, Elham Gholibegloo, Tohid Mortezazadeh, Sahar Kiani, Alireza Foroumadi, Loghman Firoozpour, Mehdi Khoobi
Summary: This study introduces a simple method to prepare new MnO2 nanomaterials (MNMs) using tannic acid as a template. The flower-like M1-MnO2 NMs showed biocompatibility and stronger oxidase and peroxidase mimetic activity compared to the near-spherical M2-MnO2. The properties of the synthesized MNMs, such as crystallinity, morphology, pore size, and specific surface area, strongly influenced the signal intensity and r(1) relaxivity in MRI.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
