The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans

Folate and Vitamin B12 Metabolism: Overview and Interaction with Riboflavin, Vitamin B6, and Polymorphisms

(2015) Barry Shane   FOOD AND NUTRITION BULLETIN

Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: Cellular models of de novo purine biosynthesis deficiency disorders

(2013) Nathan Duval et al.   MOLECULAR GENETICS AND METABOLISM

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome

(2013) J. B. French et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Mechanistic Studies of HpxO, a Novel Flavin Adenine Dinucleotide-Dependent Urate Oxidase from Klebsiella pneumoniae

(2012) Katherine A. Hicks et al.   BIOCHEMISTRY

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Mapping Protein-Protein Proximity in the Purinosome

(2012) Yijun Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based prediction of protein–protein interactions on a genome-wide scale

(2012) Qiangfeng Cliff Zhang et al.   NATURE

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

(2012) Barbara Chaneton et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

(2012) K. E. Keller et al.   SCIENCE

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Uric acid, hyperuricemia and vascular diseases

(2011) Ming Jin   Frontiers in Bioscience-Landmark

Mutations of ATIC and ADSL affect purinosome assembly in cultured skin fibroblasts from patients with AICA-ribosiduria and ADSL deficiency

(2011) V. Baresova et al.   HUMAN MOLECULAR GENETICS

Purinosomes under GPCR control

(2011) Klaus Mohr et al.   Nature Chemical Biology

GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis

(2011) Florence Verrier et al.   Nature Chemical Biology

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

Mthfs is an Essential Gene in Mice and a Component of the Purinosome

(2011) Martha S. Field et al.   Frontiers in Genetics

Biochemical and Structural Characterization of a Ureidoglycine Aminotransferase in theKlebsiella pneumoniaeUric Acid Catabolic Pathway

(2010) Jarrod B. French et al.   BIOCHEMISTRY

Dynamic Regulation of a Metabolic Multi-enzyme Complex by Protein Kinase CK2

(2010) Songon An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of novel filament-forming proteins inSaccharomyces cerevisiaeandDrosophila melanogaster

(2010) Chalongrat Noree et al.   JOURNAL OF CELL BIOLOGY

The metabolic enzyme CTP synthase forms cytoskeletal filaments

(2010) Michael Ingerson-Mahar et al.   NATURE CELL BIOLOGY

Structural studies of tri-functional human GART

(2010) Martin Welin et al.   NUCLEIC ACIDS RESEARCH

Microtubule-assisted mechanism for functional metabolic macromolecular complex formation

(2010) S. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanisms of a Protein-Based Organelle in Escherichia coli

(2010) S. Tanaka et al.   SCIENCE

Enzymology of Purine and Pyrimidine Antimetabolites Used in the Treatment of Cancer

(2009) William B. Parker   CHEMICAL REVIEWS

Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development

(2009) A. Ng et al.   DEVELOPMENT

Inborn errors of purine and pyrimidine metabolism

(2009) A. Jurecka   JOURNAL OF INHERITED METABOLIC DISEASE

Widespread reorganization of metabolic enzymes into reversible assemblies upon nutrient starvation

(2009) R. Narayanaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural biology of the purine biosynthetic pathway

(2008) Y. Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Reversible Compartmentalization of de Novo Purine Biosynthetic Complexes in Living Cells

(2008) S. An et al.   SCIENCE

Developments in the scientific and clinical understanding of gout

(2008) Alexander So   ARTHRITIS RESEARCH & THERAPY