Article
Cell Biology
Junchao Qin, Tao Huang, Jing Wang, Limei Xu, Qianli Dang, Xiuhua Xu, Hongbin Liu, Zhaojian Liu, Changshun Shao, Xiyu Zhang
Summary: This study reveals an essential role of Rad51 in the maintenance of spermatogonia and meiotic progression in mice.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Constanze Depp, Andrew O. Sasmita, Martina H. Vasileva, Patricia Scholz, Yu Zhao, Dilja Krueger-Burg, Sven Wichert, Euan R. Brown, Kyriakos Michail, Klaus-Armin Nave, Stefan Bonn, Francesca Odoardi, Moritz Rossner, Till Ischebeck, Julia M. Edgar, Gesine Saher
Summary: Research has shown that in chronic demyelinating diseases, increased neuronal cholesterol synthesis plays a critical role in remyelination, especially when lipid recycling is defective in the affected area. This finding contributes to understanding disease progression and has implications for therapeutic strategies in patients with multiple sclerosis (MS).
Article
Biology
Pauline Labbe, Victoria Munoz Goyette, Nathalie Thorin-Trescases, Louis Villeneuve, Ines Desanlis, Constance Delwarde, Yan-Fen Shi, Cecile Martel, Carol Yu, Azadeh Alikashani, Maya Mamarbachi, Frederic Lesage, Samuel Mathieu, Jean-Claude Tardif, Patrick Mathieu, Marie Kmita, Eric Thorin
Summary: A study has found that Angiopoietin-like 2 (ANGPTL2) plays a crucial role in valve development during embryogenesis. Knockout mice for the Angptl2 gene exhibit abnormal thickening of the valve leaflets and dysregulation in the balance between cell apoptosis, senescence, and proliferation, as well as a decrease in Notch signaling. These abnormalities lead to spontaneous aortic valve stenosis in adult mice.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikola Sekulovski, Allison E. Whorton, Mingxin Shi, Kanako Hayashi, James A. MacLean
Summary: Insulin signaling is crucial for the development of preovulatory follicles and progression through the antral stage in mice. Knockout of both INSR and IGF1R results in infertility, defects in ovulation, luteinization, steroidogenesis, and early embryo development due to compromised uterine cell proliferation and decidualization. Additionally, insulin signaling acts downstream of ESR1 and PGR in regulating uterine proliferation and implantation.
Article
Fisheries
Xiaoting Zheng, Daisy Vanrompay, Gilbert Van Stappen, Adam F. Feyaerts, Patrick Van Dijck, Peter Bossier
Summary: In this study, three in vivo screening methods were proposed to identify the best candidates from 12 different EOCs. The results showed that some EOCs significantly increased the survival rate of brine shrimp and reduced the in vivo bioluminescence of V. campbellii. The immune gene expression assay was not able to accurately predict the survival rate of brine shrimp and was time-consuming and costly.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yujie Zhou, Lei Cheng, Binyou Liao, Yangyang Shi, Yulong Niu, Chengguang Zhu, Xingchen Ye, Xuedong Zhou, Biao Ren
Summary: The CHK1 gene in Candida albicans plays a key role in oral mucosal infection by damaging epithelial cells and inducing the production of ROS and IL-1 alpha to increase pathogenicity. However, it is not directly related to the adhesion and invasion of epithelial cells.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biology
Ken-ichi Hirano, Hiroyuki Hosokawa, Maria Koizumi, Yusuke Endo, Takashi Yahata, Kiyoshi Ando, Katsuto Hozumi
Summary: The study identified LMO2 as a key player in the survival and maintenance of T-lineage potential in T-cell progenitors by regulating the expression of Bcl11a and Tcf7. Pro-B cells without T-lineage potential failed to activate Tcf7, and deletion of LMO2 resulted in the loss of T-lineage potential.
Article
Immunology
Jiangong Ren, Congxin Dai, Xin Zhou, Joseph A. Barnes, Xi Chen, Yunfei Wang, Liang Yuan, Takashi Shingu, Amy B. Heimberger, Yiwen Chen, Jian Hu
Summary: This study demonstrates that Qki is an essential regulator of microglial phagocytic activity under demyelinating conditions. Depletion of Qki impairs myelin debris clearance, leading to compromised axon integrity and remyelination.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Genetics & Heredity
Natoya J. Peart, Taylor A. Johnson, Sungkyoung Lee, Matthew J. Sears, Fang Yang, Mathieu Quesnel-Vallieres, Huijuan Feng, Yocelyn Recinos, Yoseph Barash, Chaolin Zhang, Brian P. Hermann, P. Jeremy Wang, Christopher B. Geyer, Russ P. Carstens
Summary: Male fertility relies on the continuous production of sperm. Gene expression regulation plays a crucial role in controlling the balance between stem cell self-renewal and gamete production. In this study, an RNA binding protein-RBM46 was identified, which is essential for gamete production and fertility. It binds to specific mRNAs encoding proteins required for differentiation and meiosis during spermatogenesis.
Article
Multidisciplinary Sciences
Zhifan Xie, Xian-Hu Ma, Qiu-Fang Bai, Jie Tang, Jian-He Sun, Fei Jiang, Wei Guo, Chen-Ma Wang, Rui Yang, Yin-Chuan Wen, Fang-Yuan Wang, Yu-Xia Chen, Hai Zhang, David Z. He, Matthew W. Kelley, Shiming Yang, Weiping J. Zhang
Summary: Very little is known about the transcriptional network governing cochlear late-stage maturation and particularly the differentiation of its lateral nonsensory region. ZBTB20 is abundantly expressed in the developing and mature cochlear nonsensory epithelial cells and is essential for cochlear terminal differentiation and maturation and hearing. The absence of ZBTB20 causes profound deafness and various structural defects in the cochlear epithelium.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Endocrinology & Metabolism
Kiran Deep Kaur, Chi Kin Wong, Laurie L. Baggio, Jacqueline L. Beaudry, Shai Fuchs, Brandon L. Panaro, Dianne Matthews, Xiemin Cao, Daniel J. Drucker
Summary: The study revealed that Tcf7 expression is not a critical determinant of glucose homeostasis in mice, and its detection in islet mRNA is mainly due to its expression in islet-associated murine immune cells rather than beta cells. Furthermore, the expression of Tcf7 is localized to islet progenitors during development and immune cells within mature islets.
MOLECULAR METABOLISM
(2021)
Article
Biology
Tomohiro Numata, Kaori Sato-Numata, Meredith C. Hermosura, Yasuo Mori, Yasunobu Okada
Summary: Animal cells can regulate their volume after swelling through the regulatory volume decrease (RVD) mechanism, in which TRPM7 plays a crucial role in enhancing VSOR activity and LRRC8A expression. TRPM7 facilitates VSOR activity by increasing the expression of LRRC8A mRNA and stabilizing the plasmalemmal expression of LRRC8A protein.
COMMUNICATIONS BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fuhai Li, Adrianus C. M. Boon, Andrew P. Michelson, Randi E. Foraker, Ming Zhan, Philip R. O. Payne
Summary: Sex is an important factor associated with COVID-19 mortality. Estrogen, interacting with ESR1/2 receptors, protects COVID-19 patients from death by inhibiting inflammation and immune response caused by SARS-CoV-2 infection. A high level of estradiol in young female COVID-19 patients contributes to their protection, while a decrease in estrogens after about 55 years of age leads to an increased fatality rate in women.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Weirong Xing, Sheila Pourteymoor, Gustavo A. Gomez, Yian Chen, Subburaman Mohan
Summary: The study found that the expression of Phd2 in chondrocytes, rather than Phd3, regulates endochondral bone formation. The compensatory increase in Phd3 expression in chondrocytes of Phd2 cKO mice is not the cause for the increased trabecular bone mass in Phd2 cKO mice.
Article
Endocrinology & Metabolism
Miriayi Alimujiang, Jingjing Sun, Shuqing Chen, Ningning Bai, Shuqin Chen, Fan Hu, Jingyuan Ma, Yuejie Xu, Jun Xu, Xiaojing Ma, Ying Yang
Summary: This study investigates the regulation of survivin expression in mature adipocytes under various nutritional stimuli and the role of survivin in adipocyte function. The findings reveal that survivin expression is regulated by nutritional stress and plays a crucial role in maintaining normal brown adipose tissue mass, thermogenic program, and mitochondrial oxidative phosphorylation.
MOLECULAR METABOLISM
(2022)