An efficient synthetic route to carbocyclic enaminonitriles via Lewis acid catalysed domino-ring-opening-cyclisation (DROC) of donor–acceptor cyclopropanes with malononitrile

A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors

(2013) Veerappan Jeyachandran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Duality of Donor-Acceptor Cyclopropane Reactivity as a Three-Carbon Component in Five-Membered Ring Construction: [3+2] Annulation Versus [3+2] Cycloaddition

(2013) Yulia A. Volkova et al.   CHEMISTRY-A EUROPEAN JOURNAL

Enantioselective Synthesis of 4,5-Dihydropyrroles via Domino Ring-Opening Cyclization (DROC) of N-Activated Aziridines with Malononitrile

(2013) Manas K. Ghorai et al.   JOURNAL OF ORGANIC CHEMISTRY

Copper-Catalyzed Highly Enantioselective Cyclopentannulation of Indoles with Donor–Acceptor Cyclopropanes

(2013) Hu Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enaminonitriles in Heterocyclic Synthesis: A Route to 1,3-Diaryl-4-aminopyrazole Derivatives

(2013) Hanadi Medrasi et al.   MOLECULES

The Alkynyl Moiety as a Donor for Donor–Acceptor Cyclopropanes

(2013) Stefan Haubenreisser et al.   ORGANIC LETTERS

Tetrahydroquinolines and Benzazepines through Catalytic Diastereoselective Formal [4 + 2]-Cycloaddition Reactions between Donor–Acceptor Cyclopropenes and Imines

(2013) Phong M. Truong et al.   ORGANIC LETTERS

KG-60-Piperazine as a New Heterogeneous Catalyst for Gewald Three-Component Reaction

(2013) Esmail Rezaei-Seresht et al.   SYNTHETIC COMMUNICATIONS

Solventless convenient synthesis of new cyano-2-aminopyridine derivatives from enaminonitriles

(2013) Didier Villemin et al.   TETRAHEDRON LETTERS

Recent Developments in Enantioselective Metal-Catalyzed Domino Reactions

(2012) Hervé Clavier et al.   ADVANCED SYNTHESIS & CATALYSIS

Multicomponent Synthesis of Pyrroles from Cyclopropanes: A One-Pot Palladium(0)-Catalyzed Dehydrocarbonylation/Dehydration

(2012) William J. Humenny et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Donor–acceptor cyclopropanes with Lawesson's and Woollins' reagents: formation of bisthiophenes and unprecedented cage-like molecules

(2012) Johannes Kaschel et al.   CHEMICAL COMMUNICATIONS

Stereocontrolled Domino Reactions

(2012) Hélène Pellissier   CHEMICAL REVIEWS

Highly Diastereoselective Construction of Fused Carbocycles from Cyclopropane-1,1-dicarboxylates and Cyclic Enol Silyl Ethers: Scope, Mechanism, and Origin of Diastereoselectivity

(2012) Jian-Ping Qu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Utility of Enaminonitriles in Heterocyclic Synthesis: Synthesis of Some New Pyrazole, Pyridine, and Pyrimidine Derivatives

(2012) Ahmed A. Fadda et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Stereoselective Double Lewis Acid/Organo-Catalyzed Dimerization of Donor–Acceptor Cyclopropanes into Substituted 2-Oxabicyclo[3.3.0]octanes

(2012) Roman A. Novikov et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Diastereo- and Enantioselective Formal [3 + 2]-Cycloadditions of Substituted Vinylcyclopropanes

(2012) Barry M. Trost et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Enaminonitriles in Heterocyclic Synthesis: Synthesis of New 1,4-Dihydropyridine, Tetrahydropyridine, Nicotinonitrile and Aminopyrazole Derivatives

(2012) Mahmoud M. M. Ramiz et al.   JOURNAL OF THE CHINESE CHEMICAL SOCIETY

Lewis Acid Mediated (3 + 2) Cycloadditions of Donor–Acceptor Cyclopropanes with Heterocumulenes

(2012) Alexander F. G. Goldberg et al.   ORGANIC LETTERS

Polar Intramolecular Cross-Cycloadditions of Cyclopropanes toward Natural Product Synthesis

(2012) Zhongwen Wang   SYNLETT

Polyalkoxy Substituted 4H-Chromenes: Synthesis by Domino Reaction and Anticancer Activity

(2012) Anatoliy M. Shestopalov et al.   ACS Combinatorial Science

Palladium-Catalyzed Diastereo- and Enantioselective Synthesis of Substituted Cyclopentanes through a Dynamic Kinetic Asymmetric Formal [3+2]-Cycloaddition of Vinyl Cyclopropanes and Alkylidene Azlactones

(2011) Barry M. Trost et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An efficient synthesis of hydropyrido[1,2-a]indole-6(7H)-ones via an In(iii)-catalyzed tandem cyclopropane ring-opening/Friedel–Crafts alkylation sequence

(2011) Dadasaheb V. Patil et al.   CHEMICAL COMMUNICATIONS

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

(2011) Oleg Fedorov et al.   CHEMISTRY & BIOLOGY

Design and synthesis of some new thiophene, thienopyrimidine and thienothiadiazine derivatives of antipyrine as potential antimicrobial agents

(2011) Hala M. Aly et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diastereoselective Synthesis of (±)-Deethyleburnamonine Using a Catalytic Cyclopropane Ring-Opening / Friedel-Crafts Alkylation Strategy

(2011) Stefan France et al.   HETEROCYCLES

(3 + 3)-Cyclodimerization of Donor–Acceptor Cyclopropanes. Three Routes to Six-Membered Rings

(2011) Olga A. Ivanova et al.   JOURNAL OF ORGANIC CHEMISTRY

A Short Total Synthesis of (±)-Epimeloscine and (±)-Meloscine Enabled by a Cascade Radical Annulation of a Divinylcyclopropane

(2011) Hanmo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Recent advances in ring-forming reactions of donor–acceptor cyclopropanes

(2011) Mikhail Ya. Mel’nikov et al.   MENDELEEV COMMUNICATIONS

Push−PullAminobithiophenes — Highly Fluorescent Stable Fluorophores

(2011) Yanmei Dong et al.   ORGANIC LETTERS

A Palladium-Catalyzed Vinylcyclopropane (3 + 2) Cycloaddition Approach to the Melodinus Alkaloids

(2011) Alexander F. G. Goldberg et al.   ORGANIC LETTERS

Ring Opening/C–N Cyclization of Activated Aziridines with Carbon Nucleophiles: Highly Diastereo- and Enantioselective Synthesis of Tetrahydroquinolines

(2011) Manas K. Ghorai et al.   ORGANIC LETTERS

Efficient Construction of Oxa- and Aza-[n.2.1] Skeletons: Lewis Acid Catalyzed Intramolecular [3+2] Cycloaddition of Cyclopropane 1,1-Diesters with Carbonyls and Imines

(2010) Siyang Xing et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lewis Acid Catalyzed Highly Stereoselective Domino-Ring-Opening Cyclization of Activated Aziridines with Enolates: Synthesis of Functionalized Chiral γ-Lactams

(2010) Manas K. Ghorai et al.   JOURNAL OF ORGANIC CHEMISTRY

Complexity-Building Annulations of Strained Cycloalkanes and C═O π Bonds

(2010) Matthew J. Campbell et al.   JOURNAL OF ORGANIC CHEMISTRY

Dynamic Kinetic Asymmetric Synthesis of Substituted Pyrrolidines from Racemic Cyclopropanes and Aldimines: Reaction Development and Mechanistic Insights

(2010) Andrew T. Parsons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantiospecific Formal Total Synthesis of (+)-Fawcettimine

(2010) Michael E. Jung et al.   ORGANIC LETTERS

Tandem Cyclopropane Ring-Opening/Conia-ene Reactions of 2-Alkynyl Indoles: A [3 + 3] Annulative Route to Tetrahydrocarbazoles

(2010) Huck K. Grover et al.   ORGANIC LETTERS

Intramolecular annulations of donor–acceptor cyclopropanes

(2010) Terry P. Lebold et al.   PURE AND APPLIED CHEMISTRY

One-step synthesis of thiazolo[3,2-a]pyridines by a multicomponent reaction of β-enaminonitriles, α,β-unsaturated aldehydes, and 2-aminothiol hydrochlorides

(2010) Mónica Pérez Perrino et al.   TETRAHEDRON

Heterocycles from cyclopropanes: applications in natural product synthesis

(2009) Cheryl A. Carson et al.   CHEMICAL SOCIETY REVIEWS

Enaminonitrile in heterocyclic synthesis: Synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety

(2009) Samir Bondock et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Studies with enaminonitriles: Synthesis and chemical reactivity of 2-phenyl-3-piperidin-1-yl acrylonitrile under microwave heating

(2009) Abdellatif M. Salaheldin et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Catalytic Enantioselective Synthesis of Tetrahydrofurans: A Dynamic Kinetic Asymmetric [3 + 2] Cycloaddition of Racemic Cyclopropanes and Aldehydes

(2009) Andrew T. Parsons et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of (+)-Polyanthellin A

(2009) Matthew J. Campbell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Progress Toward the Total Synthesis of (±)-Actinophyllic Acid

(2009) Rishi G. Vaswani et al.   ORGANIC LETTERS

Domino Synthesis of Bridged Bicyclic Tetrahydro-1,2-oxazines: Access to Stereodefined 4-Aminocyclohexanols

(2009) Dwayne A. Dias et al.   ORGANIC LETTERS

Lewis acid-catalyzed reactions of donor–acceptor cyclopropanes with furan derivatives

(2009) Alexey O. Chagarovskiy et al.   TETRAHEDRON

Microwave assisted synthesis of 3-aminoindole-2-carbonitriles from anthranilonitriles via N-unprotected 2-(cyanomethylamino)benzonitriles

(2009) Sophia S. Michaelidou et al.   TETRAHEDRON

Total Synthesis of (−)-Allosecurinine

(2008) Andrew B. Leduc et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cycloadditions of Aromatic Azomethine Imines with 1,1-Cyclopropane Diesters

(2008) Christian Perreault et al.   ORGANIC LETTERS

Improved Protocol for Thorpe Reaction: Synthesis of 4‐Amino‐1‐arylpyrazole using Solid–Liquid Phase‐Transfer Conditions

(2008) Nirmal D. Desai et al.   SYNTHETIC COMMUNICATIONS

An efficient one-pot synthesis of tethered cyclohexadiene enaminonitriles from methyl-ketones: An effective route to quinazolines

(2007) Bennie J. Bench et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Total Synthesis of (±)-Goniomitine via a Formal Nitrile/Donor−Acceptor Cyclopropane [3 + 2] Cyclization

(2007) Christian L. Morales et al.   ORGANIC LETTERS