Article
Engineering, Biomedical
Enya Li, Caroline K. Brennan, Aaron Ramirez, Jo A. Tucker, Nina Butkovich, Vijaykumar S. Meli, Anastasia A. Ionkina, Edward L. Nelson, Jennifer A. Prescher, Szu-Wen Wang
Summary: By assembling luciferases onto nanoparticles, advantageous properties for applications ranging from single-cell imaging to in vivo biodistribution can be achieved.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Analytical
Daohong Wu, Hanwen Lu, Jingrui Wang, Ling Wu, Lin Liu, Xinyao Yi, Jianxiu Wang, Hailin Tang
Summary: Circular RNAs have a closed loop structure and are extensively present in mammalian cells. Evidence suggests their potential association with triple-negative breast cancer. A sandwich structure with ferrocene-capped gold nanoparticle probes was used for sensitive detection of circRNA in clinical samples, demonstrating high potential for clinical applications.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Mengying Deng, Jing Yuan, Haibin Yang, Xuli Wu, Xiaoyuan Wei, Yang Du, Garry Wong, Yuyong Tao, Gang Liu, Zongwen Jin, Jun Chu
Summary: This study introduced a bright green fluorescent protein, Clover4, obtained through structure-guided mutagenesis, which showed improved performance in LUMABS sensors for antibody detection in serum. The Clover4-LUMABS sensors exhibited a larger dynamic range and lower limit of detection compared to previous sensors, offering a promising approach for fast and highly sensitive antibody detection.
Article
Crystallography
Abdul Ghaffar Memon, Iftikhar Ahmed Channa, Asif Ahmed Shaikh, Jabran Ahmad, Abdul Fatah Soomro, Abdulmoseen Segun Giwa, Zenab Tariq Baig, Wael A. A. Mahdi, Sultan Alshehri
Summary: This study successfully synthesized gold nanoparticles using citrate reduction method and characterized their properties and morphology through various techniques. The gold nanoparticles exhibited superior UV-absorbance and crystalline structure, indicating potential applications in various fields.
Article
Biochemistry & Molecular Biology
Robin Roychaudhuri, Moataz M. Gadalla, Timothy West, Solomon H. Snyder
Summary: The study reveals the presence of endogenous D-cysteine in mammals and introduces a novel bioluminescent assay for its quantitative estimation in tissues. The findings highlight the enrichment of D-cysteine in embryonic brains and its higher levels in human brain white matter compared to gray matter.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Keith B. Boyle, Cara J. Ellison, Paul R. Elliott, Martina Schuschnig, Krista Grimes, Marc S. Dionne, Chihiro Sasakawa, Sean Munro, Sascha Martens, Felix Randow
Summary: Invasive bacteria can enter host cells and expose danger signals such as glycans and sphingomyelin to the cytosol through the rupture of bacteria-containing vacuoles. The receptor TECPR1 is identified as responsible for sensing and responding to cytosolically exposed sphingomyelin by recruiting ATG5 to mediate lipid conjugation of LC3. The specificity of the ATG5/ATG12-E3 ligase is conferred by interchangeable receptor subunits, ATG16L1 and TECPR1, resembling certain multi-subunit ubiquitin E3 ligases.
Article
Biophysics
Lanlan Zhou, Linling Zhang, Liu Yang, Wei Ni, Yong Li, Yunhua Wu
Summary: A DNA-guided bioluminescence strategy was developed for the detection of dysregulated circulating miRNAs with high sensitivity and reliability. This method allows smartphone-based miRNA assays, making it suitable for resource-limited regions, and accurately identifies abnormal miRNAs in clinical samples from lung cancer patients.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biotechnology & Applied Microbiology
Xiongtao Yu, Silan Bai, Lishi Wang
Summary: In this work, gold nanoparticles@Ti3C2 MXenes nanocomposites were used to construct an electrochemical circulating tumor DNA biosensor via toehold-mediated DNA strand displacement reaction. The biosensor has a linear detection range of 10 fM-10 nM and a detection limit of 0.38 fM, and can efficiently distinguish single base mismatched DNA sequences. The biosensor has been successfully applied for the sensitive detection of KRAS gene G12D, showing great potential for clinical analysis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Zahra Jafar-Nezhad Ivrigh, Arafeh Bigdeli, Somayeh Jafarinejad, Mohammad Reza Hormozi-Nezhad
Summary: In this study, a condition-based single component sensor array was proposed for the quantification and classification of antidepressants. By tuning the pH and ionic strength, the array achieved excellent sensitivity and selectivity in detecting the target analytes. The results of multivariate calibration and classification in human urine demonstrated the practicality of the array in complex biological fluids.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Jing Yang, Wei Zhong, Qi Yu, Jin Zou, Yansha Gao, Shuwu Liu, Songbai Zhang, Xiaoqiang Wang, Limin Lu
Summary: A simple and label-free electrochemical aptasensor based on gold nanoparticle-loaded 2D transition metal carbides (MXene) has been developed for ultra-sensitive determination of chloramphenicol. The aptasensor exhibits a good linear relationship and low detection limit, making it suitable for accurate determination of chloramphenicol concentration in honey samples.
Article
Nanoscience & Nanotechnology
Zhenrui Xue, Minli You, Ping Peng, Haoyang Tong, Wanghong He, Ang Li, Ping Mao, Ting Xu, Feng Xu, Chunyan Yao
Summary: The study aimed to develop a simple and highly specific qPCR-based single-base mutation detection method, which successfully established the Taqman-MGB nanoPCR system by adding different concentrations of gold nanoparticles, improving the specificity of mutation detection with a performance of detecting mutations as low as 0.95%.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Vadim R. Viviani, Jaqueline Rodrigues Silva, Paulo Lee Ho
Summary: A novel bioluminescent fusion protein was developed in this study, showing higher bioluminescence activity and sustained emission in immunoassays. It successfully detected various antigens and antibodies, with potential application in Western Blotting.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Fan He, Jinyi Yang, Tingting Zou, Zhenlin Xu, Yuanxin Tian, Wenjia Sun, Hong Wang, Yuanming Sun, Hongtao Lei, Zijian Chen, Juewen Liu, Xuecai Tan, Yudong Shen
Summary: A gold nanoparticle-based immunochromatographic assay was developed for simultaneous detection of sildenafil and its analogues, with qualitative and quantitative analysis capabilities in a rapid manner.
ANALYTICA CHIMICA ACTA
(2021)
Review
Food Science & Technology
Silu Hou, Jingjiao Ma, Yuqiang Cheng, Zhaofei Wang, Yaxian Yan
Summary: This article systematically summarizes the emerging strategies for enhancing the detection sensitivity of traditional gold nanoparticles-based nanosensors in food-borne mycotoxins. By modifying and developing antigens and antibodies, as well as improving signal amplification materials such as gold nanoparticles, the sensitivity of the sensors can be improved. Representative examples are provided to illustrate the potential mechanisms of each strategy in enhancing signal intensity and their potential applications in biosensing.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Analytical
Xianli Chen, Yong Liang
Summary: A differential colorimetric sensor array was developed for the simultaneous and accurate identification of nine proteins, showing promising potential for early disease diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Zachary J. Urbach, Sarah S. Park, Steven L. Weigand, James E. Rix, Byeongdu Lee, Chad A. Mirkin
Summary: The study demonstrates that in a magnetic field, cubic Fe3O4 nanoparticles functionalized with DNA can exhibit unexpected crystallographic alignment of the entire superlattice, expanding the potential of crystal engineering with DNA through physical and chemical control.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Ho Fung Cheng, Shunzhi Wang, Chad A. Mirkin
Summary: Recent studies have shown that PAEs can behave as electron equivalents at small size and low DNA grafting density, however, the polydispersity in the number of DNA strands on the surfaces of these NPs limits the structural uniformity and tailorability of NP-based EEs. By assembling molecularly precise EEs with complementary NP-based PAEs, three distinct metallic phases can be formed, demonstrating that molecular-based EEs can influence specific phase formation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Chemistry, Analytical
Eun-Song Lee, Jeong Min Lee, Hea-Jin Kim, Young-Pil Kim
Summary: This review discusses recent advances in fluorogenic aptasensors and their applications in in vitro diagnosis and cellular imaging. These sensors, modulated by small molecules, show rapid fluorescence turn-on signals with high target specificity and low background noise, making them valuable tools in biosensing and bioimaging.
Review
Biochemistry & Molecular Biology
Duc Loc Sai, Jieun Lee, Duc Long Nguyen, Young-Pil Kim
Summary: Photodynamic therapy (PDT) utilizes photosensitive drugs that generate reactive oxygen species when exposed to light, killing cancer cells. Recent advancements in protein-based photosensitive drugs, nanomaterials, and luminescence are improving the effectiveness of PDT. Researchers are focusing on developing strategies to enhance tumor treatment outcomes and address challenges such as drug side effects and light delivery.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Chemistry, Analytical
Jin Oh Lee, Nakchul Choi, Jin-Won Lee, Simon Song, Young-Pil Kim
Summary: The study presented a rapid electrokinetic detection method for LMW thiols based on the interaction between OhrRBS and DNA elements, achieving rapid determination of LMW thiols in microfluidic channels coupled with ion concentration polarization. This method allowed for quick separation of fluorescence zones of dsDNA-protein complex in response to LMW thiols in microfluidic channels.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biophysics
Eun-Song Lee, Eun-Ji Kim, Tae-Ki Park, Da-Woon Bae, Sun-Shin Cha, Tae-Wuk Kim, Young-Pil Kim
Summary: GNP-SELEX is a visual, proofreading, and self-monitoring platform that enables rapid determination of target-specific aptamer library enrichment through colorimetric changes, without the need for target modification or extra monitoring processes. The rational design and identification of high selectivity and binding affinity ssDNA aptamers for small molecules allows for their detection in real samples, making it a useful tool for developing aptasensors for diverse targets.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Medicinal
Zhengwei Zhang, Jingjie Ge, Kai Jing, Yefeng Chen, Yihui Guan, Hexin Xie, Jianhua Zhu
Summary: This study reports an optimized synthesis method for the radiotracer 6-[F-18]fluoro-L-DOPA, which is reliable and compatible with different types of automated radiosynthesizers. PET/CT imaging of 23 patients using this radiotracer demonstrated its clinical value in non-invasive diagnosis of congenital hyperinsulinism and localization of pancreatic lesions.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Yefeng Chen, Chenghong Xue, Jie Wang, Minqiu Xu, Yuyao Li, Yiru Ding, Heng Song, Weipan Xu, Hexin Xie
Summary: This study presents the unprecedented applications of malachite green as a switchable fluorophore for real-time imaging of membrane enzymes and noncatalytic proteins in live cells. The fluorescence intensity of malachite green can be significantly enhanced by covalent binding with endogenous proteins, enabling the monitoring of enzyme activities and protein visualization. The findings highlight the potential of malachite green as a versatile tool for studying membrane protein dynamics.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Medicinal
Liqiang Hu, Huixin Yang, Tao Yu, Fangfang Chen, Runqiu Liu, Shuyuan Xue, Shuangzhan Zhang, Wuyu Mao, Changge Ji, Hao Wang, Hexin Xie
Summary: This study demonstrates the effectiveness of stereochemically altered cephalosporins as potent inhibitors against NDM-1, a major cause of antibiotic resistance. The findings provide a new approach to combat antibiotic resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Fadilatul Jannah, Jieun Lee, Hyun-Jung Seong, Jong-Man Kim, Young-Pil Kim
Summary: A photodynamic color sensor for visualizing photoinduced singlet oxygen (1O2) was reported using 10,12-pentacosadiynoic acid (PCDA) vesicles and a mini singlet oxygen generator (miniSOG). The miniSOG produced 1O2 through photoactivation, which reacted with the PCDA vesicles, resulting in a rapid color change from colorless PCDA to blue-colored polydiacetylene (PDA) vesicles. This color change allowed for the rapid and simple detection of photoinduced 1O2 and its scavengers.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Multidisciplinary Sciences
Dongkyu Kang, Hyung Shik Kim, Soohyun Han, Yeonju Lee, Young-Pil Kim, Dong Yun Lee, Joonseok Lee
Summary: The authors designed a Nd-Yb co-doped nanomaterial as a near-infrared long-lifetime imaging-guided water-heating probe, demonstrating photothermal ablation in a glioblastoma pre-clinical model.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Sung Hyun Park, Soohyun Han, Sangwoo Park, Hyung Shik Kim, Kyung-Min Kim, Suyeon Kim, Dong Yun Lee, Joonseok Lee, Young-Pil Kim
Summary: To address the issues of target specificity and light transmission in photodynamic therapy (PDT), a cancer cell-targeted photosensitizer using photoprotein-conjugated upconversion nanoparticles (UCNPs) was developed. The UCNP-KR-LP showed high target specificity and efficient light transmission to deep tissues, generating reactive oxygen species via NIR-to-green light conversion. This nanocomposite demonstrated significant PDT efficacy in deep-seated tumors located beneath porcine skin tissues and in tumor xenograft mouse models.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Andrology
Seung Hyun Park, Young -Pil Kim, Jeong Min Lee, Dong-Wook Park, Ju Tae Seo, Myung Chan Gye
Summary: The purpose of this study was to investigate the mechanism regulating the phosphorylation of glycogen synthase kinase 3 (GSK3) and its correlation with sperm motility in humans. The researchers found that the inhibitory phosphorylation of GSK3α (Ser21) was negatively correlated with its kinase activity in high-motility spermatozoa, and this correlation was regulated by Ca2+, PKA, Akt, and PP1. These findings may provide new drug targets for enhancing human sperm motility.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Yeonju Lee, Kyung-Min Kim, Duc Long Nguyen, Fadilatul Jannah, Hyun-Jung Seong, Jong-Man Kim, Young-Pil Kim
Summary: This study demonstrates the importance of cyclized recombinant proteins in terms of cell permeability and stability. Cyclized proteins show higher permeability and resistance to enzymatic degradation compared to linear proteins. This strategy can improve photodynamic therapy outcomes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Gae-Baik Kim, Jeong Min Lee, Duc Long Nguyen, Joonseok Lee, Young-Pil Kim
Summary: In this study, a cell-based fluorescent peptide method was demonstrated for monitoring protease activity. By utilizing MMP2 secreted by living cancer cells, the activatable peptide is able to be delivered intracellularly and exhibit fluorescence response. This approach is expected to enable rapid visualization of protease activity in living cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
