Article
Chemistry, Applied
Anastasia Kurbanova, Martin Nigrini, Kinga Golabek, Ondrej Vesely, Jan Vesely
Summary: Synthetic organic chemistry often requires multiple steps and expensive catalysts for the synthesis of functionalised tetrahydropyrans. In this study, we tested zeolites as eco-friendly and industrially relevant catalysts for the synthesis of 2-phenyltetrahydropyran. The results showed that zeolites favor the formation of the desired product, and the reaction kinetics depend on the number of acid sites, rather than the textural properties.
MICROPOROUS AND MESOPOROUS MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xin Nie, Clayton W. Ritter, Marcel Hemming, Sergei I. Ivlev, Xiulan Xie, Shuming Chen, Eric Meggers
Summary: Attaching a nitrene precursor to an intramolecular nucleophile enables a catalytic asymmetric intramolecular oxyamination of alkenes, producing chiral compounds with high yields and excellent enantioselectivities. This method provides access to versatile chiral building blocks and introduces a new strategy for nitrene-mediated asymmetric intramolecular olefin difunctionalization.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Sa-Na Yang, Chang-Hui Liu, Li-Bowen He, Hao Zheng, Chang-Sheng Kuai, Boshun Wan, Ding-Wei Ji, Qing-An Chen
Summary: In this article, a method for selectively and stereoselectively hydrosilylating isoprene using an abundant cobalt catalyst with varying ligands is disclosed. With a less hindered bidentate ligand, the reactions proceed through 4,1-hydrosilylation to produce allylsilanes with excellent regio- and stereoselectivities. Switching to a bulkier ligand efficiently diverts the reactions to 2,1-addition products for the first time. This regiodivergent protocol enables the modular construction of structurally diverse organosilanes with high atom economy and without the formation of stoichiometric byproducts.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Vaishnavi N. Nair, Volga Kojasoy, Croix J. Laconsay, Wang Yeuk Kong, Dean J. Tantillo, Uttam K. Tambar
Summary: The study developed catalyst-controlled regiodivergent rearrangements of onium-ylides derived from indole substrates, with experimental and computational studies revealing different mechanistic pathways. The methodology was successfully applied in the total synthesis of the natural product and further functional group transformations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Luomo Li, Sascha Kail, Sebastian M. Weber, Gerhard Hilt
Summary: Indium tribromide catalyzed the transfer hydrogenation from dihydroaromatic compounds to enones, resulting in the cyclisation to trisubstituted furan derivatives. Protonation from the Wheland complex led to the formation of the product, replacing the indium tribromide substituent. Site-specific deuterium labelling of the dihydroaromatic HD surrogates provided insights into the reaction mechanism by H-D scrambling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Xu Wang, Jin-Ping Fu, Jia-Hui Mo, Yu-Hong Tian, Chun-You Liu, Hai-Tao Tang, Zi-Jun Sun, Ying-Ming Pan
Summary: The palladium-catalysed tandem cyclisation reaction successfully synthesizes a variety of 5-aminoimidazoles under mild conditions with high yields. This elegant domino process involves the effective cleavage of the N-O bond and the formation of new C-C and C-N bonds.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Physical
Pavol Lopatka, Michal Gavenda, Martin Markovic, Peter Koos, Tibor Gracza
Summary: This work describes the total synthesis of jaspine B using highly diastereoselective Pd(II)-catalysed carbonylative cyclisation for the preparation of crucial intermediates. New conditions involving the use of pBQ/LiCl and Fe(CO)(5) were developed, and the application of a flow reactor in large-scale preparation of key lactones was demonstrated.
Review
Chemistry, Organic
Rasmi P. Bhaskaran, Kalinga H. Nayak, Mariswamy K. Sreelekha, Beneesh P. Babu
Summary: Transition metal-catalysed C-H functionalization reactions using copper catalysts have become an efficient and green method for constructing carbon-carbon and carbon-heteroatom bonds. Intramolecular dehydrogenative coupling reactions offer a direct route to complex polycyclic scaffolds. This review focuses on the development and applications of copper-based intramolecular dehydrogenative coupling reactions.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Raphael Saget, Piotr Jaunky, Elisabet Dunach
Summary: A series of highly functionalized carbocycles were efficiently prepared via the selective cyclisation of unsaturated acetals and ketals in the presence of only 1 mol% of Bi(iii) or Fe(iii) triflates as catalysts at room temperature. Different types of products with varying yields were obtained using Bi(OTf)3 and Fe(OTf)3 catalysis.
Article
Chemistry, Multidisciplinary
Yuxuan Zhou, Siyuan Guo, Qiyuan Huang, Qiwei Lang, Gen-Qiang Chen, Xumu Zhang
Summary: A highly efficient Rh/ZhaoPhos-catalysed asymmetric hydrogenation has been developed for the synthesis of various chiral ?-butyrolactones. The reaction demonstrates excellent results with high conversion and enantioselectivity, making it a valuable method for the synthesis of diverse natural products and therapeutic substances. Further transformations using this catalytic methodology have shown promise for the efficient synthesis of enantiomerically enriched drugs.
Article
Chemistry, Multidisciplinary
Mohanan Biji, Bernard Prabha, Ravi S. Lankalapalli, Kokkuvayil Vasu Radhakrishnan
Summary: This review highlights the achievements in utilizing zerumbone and its derivatives for developing pharmacologically relevant molecular scaffolds, focusing on transition-metal catalyzed 1,4-conjugate addition reactions, palladium-catalyzed cross-couplings, transition metal-based Lewis acid promoted interrupted Nazarov cyclisation reactions, and photo-induced transformations.
Article
Chemistry, Organic
Sean R. Barlow, Lily J. Callaghan, Vilius Franckevicius
Summary: The palladium-catalysed cyclisation of propargylic electrophiles with nucleophiles is a useful synthetic approach for the rapid construction of heterocyclic building blocks, but it poses challenges in controlling the chemo-, regio- and stereoselectivity simultaneously. The discovery of alpha-amido malonates as novel bis-nucleophiles in this reaction has shown high chemo- and regioselectivity, as well as moderate enantioselectivity in the formation of functionalised dihydrooxazine heterocycles, expanding the range of available heterocycles for medicinal chemists.
Article
Chemistry, Organic
F. Medici, F. Montinari, E. Donato, L. Raimondi, M. Benaglia
Summary: A convenient catalytic protocol for the synthesis of electron-poor indoles was developed using Zn(II) salts as catalysts for the cyclisation reaction of electron-deficient 2-(alkynyl)-anilines. This protocol was successfully applied to the synthesis of an API precursor. The use of a readily available, non-noble metal enhanced the value of the protocol.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Katarina Stefkova, Matthew J. Heard, Ayan Dasgupta, Rebecca L. Melen
Summary: Triarylboranes have garnered significant attention as catalysts for C-C bond forming reactions due to their remarkable catalytic activities. In this study, the B(C6F5)(3) catalyzed cyclopropenation of arylacetylenes using donor-acceptor diazoesters has been successfully developed, resulting in the synthesis of a wide variety of functionalized cyclopropenes in good to excellent yields.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Chao Du, Xiaoyu Zhou, Weikang Li, Xiuling Wen, Zhuofeng Ke, Cunyuan Zhao
Summary: The study describes a novel octahedral Ni-II catalyst with a paramagnetic nature catalyzing the alpha-alkylation of amides. Results indicate that the catalyst favors the bifunctional pathway and tends to maintain a high-spin state throughout the reaction. This computational study suggests that the spin state has the potential to influence the catalyst structure and reaction mechanism, providing novel insights for the design of Ni-II catalysts with high-spin states.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
D. Christopher Braddock, Areeb Mahtey, Henry S. Rzepa, Andrew J. P. White
CHEMICAL COMMUNICATIONS
(2016)
Article
Chemistry, Organic
Hossay Abas, Sean M. Linsdall, Mathias Mamboury, Henry S. Rzepa, Alan C. Spivey
Article
Chemistry, Multidisciplinary
Matthew J. Harvey, Andrew McLean, Henry S. Rzepa
JOURNAL OF CHEMINFORMATICS
(2017)
Article
Chemistry, Multidisciplinary
Debdeep Mandal, Debabrata Dhara, Avijit Maiti, Lukas Klemmer, Volker Huch, Michael Zimmer, Henry S. Rzepa, David Scheschkewitz, Anukul Jana
CHEMISTRY-A EUROPEAN JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Andrey E. Sheshenev, Ekaterina V. Boltukhina, Andrew J. P. White, King Kuok (Mimi) Hii
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Chemistry, Applied
John B. Brazier, Bao N. Nguyen, Luis A. Adrio, Elena M. Barreiro, Wai Peng Leong, Mark A. Newton, Santiago J. A. Figueroa, Klaus Hellgardt, King Kuok Mimi Hii
Article
Chemistry, Multidisciplinary
Andrey E. Sheshenev, Ekaterina V. Boltukhina, King Kuok (Mimi) Hii
CHEMICAL COMMUNICATIONS
(2013)
Article
Chemistry, Multidisciplinary
Valerie H. L. Wong, T. S. Andy Hor, King Kuok (Mimi) Hii
CHEMICAL COMMUNICATIONS
(2013)
Article
Chemistry, Multidisciplinary
Andrey E. Sheshenev, Ekaterina V. Boltukhina, Anastasiya A. Grishina, Ivana Cisarova, Ilya M. Lyapkalo, King Kuok (Mimi) Hii
CHEMISTRY-A EUROPEAN JOURNAL
(2013)
Article
Chemistry, Multidisciplinary
Almira Kurbangalieva, Duncan Carmichael, K. K. (Mimi) Hii, Anny Jutand, John M. Brown
CHEMISTRY-A EUROPEAN JOURNAL
(2014)
Review
Chemistry, Organic
Elena M. Barreiro, Luis A. Adrio, King Kuok (Mimi) Hii, John B. Brazier
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2013)
Article
Chemistry, Inorganic & Nuclear
Bao N. Nguyen, Luis A. Adrio, Elena M. Barreiro, John B. Brazier, Peter Haycock, King Kuok (Mimi) Hii, Maarten Nachtegaal, Mark A. Newton, Jakub Szlachetko
Article
Chemistry, Inorganic & Nuclear
Elena M. Barreiro, Diego F. D. Broggini, Luis A. Adrio, Andrew J. P. White, Rino Schwenk, Antonio Togni, King Kuok (Mimi) Hii
Article
Chemistry, Multidisciplinary
Henry S. Rzepa
JOURNAL OF CHEMINFORMATICS
(2013)
Article
Chemistry, Multidisciplinary
James I. Murray, Nils J. Floden, Adriano Bauer, Nico D. Fessner, Daniel L. Dunklemann, Opetoritse Bob-Egbe, Henry S. Rzepa, Thomas Burgi, Jeffery Richardson, Alan C. Spivey
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2017)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
