Article
Chemistry, Physical
Liang Wang, Ming Li, Yongle Li, Bin Wu, Hailong Chen, Ruining Wang, Tao Xu, Huazhang Guo, Weitao Li, Jarin Joyner, Xingcan Shen, Mengying Le, Robert Vajtai, Pulickel M. Ajayan, Wei Ren, Minghong Wu
Summary: A molecular fusion route was designed to synthesize bright orange fluorescent graphene quantum dots (GQDs), which exhibited excellent optical properties and targeting capability for cell nucleus imaging. Enriched nitrogen doping in GQDs facilitated their penetration through the cell membrane to target the nucleus, providing a basis for designing nucleus-targeting probes in the future.
Article
Chemistry, Multidisciplinary
Yuichi Ueya, Masakazu Umezawa, Eiji Takamoto, Moe Yoshida, Hisanori Kobayashi, Masao Kamimura, Kohei Soga
Summary: The polarity of PSt NPs can be adjusted to obtain highly emissive OTN-PSt-PEG NPs, which exhibit excellent dispersion stability and biocompatibility with the use of PEG. This approach is expected to facilitate the design of high emissivity OTN-NIR fluorescent imaging probes.
Article
Spectroscopy
Zheng Yang, Tiantian Xu, Xu Zhang, Hui Li, Xiaodan Jia, Shunsheng Zhao, Zaiwen Yang, Xiangrong Liu
Summary: In this study, a water-soluble and highly fluorescent nanosensor based on N-doped carbon quantum dots (CDs) was successfully fabricated for selective sensing of hypochlorite. The nanosensor showed high stability under various interferences and exhibited significant selectivity towards ClO-. It could detect ClO- concentration in the range of 0.1-50 μmol.L-1 with a sensitivity of 0.03 μmol.L-1. Additionally, the nanosensor could be applied for determination of ClO- in environmental water and visualizing ClO- in living cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Biochemistry & Molecular Biology
Saman Sargazi, Iqra Fatima, Maria Hassan Kiani, Vahideh Mohammadzadeh, Rabia Arshad, Muhammad Bilal, Abbas Rahdar, Ana M. Diez-Pascual, Razieh Behzadmehr
Summary: Fluorescent-based bioprobes have unique attributes that make them suitable for creating highly sensitive nano-biosensors for detecting various biological and chemical agents. These sensors are superior to other analytical instrumentation techniques in terms of being biodegradable, eco-friendly, and more economical and cost-effective. This paper provides a comprehensive overview of the electrochemical sensors that use nanomaterials to detect biological macromolecules based on fluorescent emission spectra.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Colman Moore, Yong Cheng, Natalia Tjokro, Brendan Zhang, Matthew Kerr, Mohammed Hayati, Kai Chiao Joe Chang, Nisarg Shah, Casey Chen, Jesse Jokerst
Summary: We report a dual-modal fluorescent and photoacoustic imaging probe for the detection of gingipain proteases secreted by P. gingivalis. The probe showed significant photoacoustic enhancement and fluorescence activation, with low detection limits. It demonstrated good diagnostic efficacy in porcine jaws and gingival crevicular fluid samples from periodontal disease subjects. Additionally, photoacoustic imaging of the probe was achieved in murine brains ex vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Subir Paul, Anindita Bhattacharya, Niladri Hazra, Kousik Gayen, Prosenjit Sen, Arindam Banerjee
Summary: This study demonstrates the one-step preparation of lipophilic carbon dots and their usage in selectively imaging lipid droplets. This provides a new approach for studying lipid droplets inside living cells.
Article
Pharmacology & Pharmacy
Govinda Gorle, Ganesh Gollavelli, Gowreeswari Nelli, Yong-Chien Ling
Summary: Graphene oxide quantum dots (GOQDs) were prepared using a straightforward and environmentally friendly method involving black carbon as a feedstock and H2O2 as a green oxidizing agent. The process utilized microwave energy and only required two minutes. The GOQDs exhibited stable blue fluorescence at 440 nm and had a size of 20 nm. Thorough analysis using SEM, TEM, AFM, FT-IR, and XPS confirmed the chemical characteristics and morphology of the QDs. The biocompatibility test showed excellent survival rates and an IC50 of 200 mu g/mL in CT26 cells, while in vivo toxicity assessment in zebrafish embryos found no abnormalities even at a high concentration of 400 mu g/mL after 96 h post fertilization. The GOQDs showed excellent internal distribution in cells and throughout the zebrafish body, making them promising materials for nano-imaging and diagnostic probes in nanomedicine.
Article
Chemistry, Multidisciplinary
Peng Yang, Xin Zhou, Jianhua Zhang, Jian Zhong, Fang Zhu, Xianhu Liu, Zhipeng Gu, Yiwen Li
Summary: Fluorescent polymer dots (PDs) were successfully prepared from natural polyphenols via one-pot co-polymerization under mild conditions without the use of organic solvents or harsh chemicals. The resulting PDs exhibited good photostability and biocompatibility, as well as high selectivity towards copper ions. This green and facile strategy opens up new possibilities for the design and preparation of natural molecule-based PDs for biomedical and environmental applications.
Article
Chemistry, Multidisciplinary
Yujia Zheng, Qianqian Li, Jing Wu, Ziyi Luo, Wenyi Zhou, Anguo Li, Yanling Chen, Tuerxunayi Rouzi, Tian Tian, Hui Zhou, Xiaodong Zeng, Yang Li, Xiaoding Cheng, Yongchang Wei, Zixin Deng, Fuling Zhou, Xuechuan Hong
Summary: Novel NIR-II small-molecule probe H4-PEG-Glu showed effective imaging and treatment targeting mitochondria in acute myeloid leukemia cells, inducing cell apoptosis and exhibiting moderate cytotoxicity without laser irradiation. Enhanced chemo- and photothermal therapy effects were observed with laser irradiation, presenting high synergistic effects in vivo and specific tumor imaging in AML patient-derived PDX mouse models.
Review
Chemistry, Multidisciplinary
Luanjing Li, Jiahe Wang, Shihan Xu, Chunxia Li, Biao Dong
Summary: This paper reviews the recent research progress and applications of metal ion fluorescent probes, and discusses the future development direction.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Analytical
Chang Guo, Qiangqiang Nie, Suying Xu, Leyu Wang
Summary: Dual-modal imaging systems can provide complementary information by developing F-19-grafted fluorescent carbonized polymer dots, which enable fluorescence imaging and F-19 MRI simultaneously, showing great potential for biological imaging and early diagnosis applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Cara E. Bradsher, Cayla D. Ontko, Alexandra C. Koziel, James R. McBride, Sandra J. Rosenthal
Summary: This research has found that ferroelectric behavior can be achieved in nanoparticles through ion exchange, with fluorescence retention achieved through CdS shelling before ion exchange, containing defects in the CdS shell rather than the fluorescent CdSe cores. The ferroelectric response remains constant with an increase in the number of CdS monolayers, while fluorescence retention also increases, reaching 99% at 8 monolayers, allowing for the addition of ferroelectric applications to the growing list of quantum dot applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Analytical
Shaojie Wang, Yongbo Wang, Yuanna Ning, Qiming Liu
Summary: Antibiotic residues pose a serious threat to ecosystems and food safety, driving the need for convenient, visual, and on-site detection methods. This study developed a near-infrared fluorescent probe and analysis platform based on a smartphone for quantification and on-site detection of metronidazole (MNZ). The study demonstrated that NIR fluorescence analysis and the inner filter effect (IFE) between the probe and target improved sensitivity and selectivity for MNZ detection. Reliable and satisfactory results were obtained for quantitative detection of MNZ in real food samples. Furthermore, a portable visual analysis platform in a smartphone showed great potential for commercialization.
Article
Chemistry, Multidisciplinary
Ting Meng, Zifei Wang, Ting Yuan, Xiaohong Li, Yunchao Li, Yang Zhang, Louzhen Fan
Summary: This study presents a gram-scale synthesis of red/green/blue solid-state fluorescent carbon quantum rings with high quantum yields, offering a potential alternative to REE-free phosphor-converted white LEDs. These R/G/B-SBF-CQRs-based LEDs emit warm white light with low CCT, high CRI, and high luminous efficiency, comparable to REE-phosphor-based LEDs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Analytical
Yao Huang, Fengyu Tian, Leilei Sun, Chenhui Ji, Craig A. Grimes, Qingyun Cai
Summary: An activated near-infrared transparency window fluorescent probe was designed for accurate detection and localization of micrometastases. The probe showed stable activation properties and achieved tumor-specific NIR-II fluorescence imaging. In vivo experiments demonstrated precise localization of melanomas with a diameter of < 0.1 mm in lung micrometastases. This work provides a potential strategy for the development of novel tools for localization and visualization of micrometastases.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Biomedical
Doudou Hu, Dongdong Li, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: This paper discusses the potential of vanadium compounds in cancer treatment and the advantages of vanadium-based nanomaterials as a multimodal platform, as well as their synthesis routes and applications as therapeutic and diagnostic agents for tumors.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yanting Yu, Keqi Xiang, Mingzhi Xu, Yuqiang Li, Jiajunzi Cui, Lanqiong Zhang, Xiaohu Tang, Xianqi Zhu, Lili Qian, Meng Zhang, Yan Yang, Qingsong Yu, Youqing Shen, Zhihua Gan
Summary: The intercellular connections in the tumor microenvironment are considered to be the driving force for acquired drug resistance and proliferative burst, presenting a major obstacle in cancer treatment.
Article
Chemistry, Multidisciplinary
Nasha Qiu, Guowei Wang, Jinqiang Wang, Quan Zhou, Mengyu Guo, Yaling Wang, Xuhao Hu, Huige Zhou, Ru Bai, Min You, Zhen Zhang, Chunying Chen, Ying Liu, Youqing Shen
Summary: A novel IL12 gene-delivery vector was designed to efficiently transfect both cancer cells and TAMs, turning them into a factory for IL12 production, which effectively activates anticancer immune responses and remodels the tumor microenvironment. The intravenously administered vector slows tumor growth and doubles survival in three animal models with minimal systemic toxicities.
ADVANCED MATERIALS
(2021)
Review
Engineering, Biomedical
Doudou Hu, Wei Zhang, Jianbin Tang, Zhuxian Zhou, Xiangrui Liu, Youqing Shen
Summary: Breakthroughs in molecular mechanisms underlying immune-suppressive tumor microenvironment and paradigm shifts in cancer-immunity response cycle have changed cancer immunotherapy landscape. Addressing serious side effects from systemic autoimmunity and autoinflammatory responses is a challenge, with bioengineering and delivery technologies providing potential solutions. Developing immunotoxicity-related animal models is also deemed significant.
Review
Engineering, Biomedical
Dongdong Li, Doudou Hu, Hongxia Xu, Hirak K. Patra, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Nigel Slater, Youqing Shen
Summary: Transdermal drug delivery is promising, especially through superficial routes. Microneedles can overcome limitations and deliver drugs into the dermal layer efficiently. They have been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy.
Article
Chemistry, Multidisciplinary
Shengjun Xu, Sunbin Ling, Qiaonan Shan, Qianwei Ye, Qifan Zhan, Guangjiang Jiang, Jianyong Zhuo, Binhua Pan, Xue Wen, Tingting Feng, Haohao Lu, Xuyong Wei, Haiyang Xie, Shusen Zheng, Jiajia Xiang, Youqing Shen, Xiao Xu
Summary: Resistance to sorafenib in hepatocellular carcinoma is closely linked to cancer stemness, with the lack of effective methods to reverse this stemness being a major obstacle in current HCC therapeutics. The development of Gal-SLPs, which target HCC and co-deliver sorafenib and shUSP22, shows promising results in suppressing USP22 expression, inhibiting multidrug resistance, and efficiently inhibiting HCC cell viability and proliferation. In vivo studies using a sorafenib-insensitive patient-derived xenograft model demonstrate potent antitumor effects and biosafety of Gal-SLPs, suggesting their potential in clinical HCC treatment.
Article
Chemistry, Multidisciplinary
Xiaodan Xu, Xiaoxuan Zhou, Bing Xiao, Hongxia Xu, Doudou Hu, Yue Qian, Hongjie Hu, Zhuxian Zhou, Xiangrui Liu, Jianqing Gao, Nigel K. H. Slater, Youqing Shen, Jianbin Tang
Summary: The study prepared glutathione-responsive hyaluronic acid-coated iron oxide nanoparticles for highly sensitive diagnosis of liver metastasis using MRI contrast, which effectively differentiates metastatic tumors from surrounding liver tissues.
Review
Materials Science, Multidisciplinary
He Ma, Song Wang, Bing Yu, Xin Sui, Youqing Shen, Hailin Cong
Summary: Bio-nanochannels in living organisms selectively transport ions through cell membranes and inspire the development of artificial ion nanochannels. Polymer-based biomimetic nanochannels offer good mechanical stability, high-performance ion transport, and designability. This review mainly focuses on the fabrication and application of polymer-based biomimetic nanochannels, especially in environmentally responsive biosensor and energy conversion.
SCIENCE CHINA-MATERIALS
(2021)
Review
Engineering, Biomedical
Yingbin Su, Bing Yu, Song Wang, Hailin Cong, Youqing Shen
Summary: In recent years, there has been an active exploration of new imaging methods with high biological imaging performance, particularly in the NIR-II region. The use of small organic molecule fluorophores has attracted attention due to their good biocompatibility properties, showing promise for future developments in imaging research.
Review
Chemistry, Multidisciplinary
Shuaibing Guo, Bing Yu, Fengyuan Gao, Song Wang, Youqing Shen, Hailin Cong
Summary: Three-dimensional colloidal crystal materials have unique optical properties and spatial structure, with potential for preparing three-dimensionally ordered microporous materials. This review covers various preparation methods, effects of parameters on assembly, and main applications of 3DCCs.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jing Liu, Zhihao Zhao, Nasha Qiu, Quan Zhou, Guowei Wang, Haiping Jiang, Ying Piao, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: In this study, it was found that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces PD-L1 expression in cancer cells and enhances doxorubicin-induced immunogenic cell death, promoting T cell infiltration and reducing tumor growth in preclinical models.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Siqin Chen, Yin Zhong, Wufa Fan, Jiajia Xiang, Guowei Wang, Quan Zhou, Jinqiang Wang, Yu Geng, Rui Sun, Zhen Zhang, Ying Piao, Jianguo Wang, Jianyong Zhuo, Hailin Cong, Haiping Jiang, Jun Ling, Zichen Li, Dingding Yang, Xin Yao, Xiao Xu, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and weak interaction with phospholipids can effectively eradicate large tumours and patient-derived tumour xenografts in mice by facilitating their transcytosis-mediated extravasation and infiltration into tumours, showcasing potential for translational anticancer nanomedicines.
NATURE BIOMEDICAL ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Yaowei Zhu, Lili Li, Bin Sun, Min Zhang, Chunmei Zhang, Chunsheng Xiao, Li Chen
Summary: The use of near-infrared II (NIR-II) fluorescence imaging for in vivo diagnosis is appealing due to its deep tissue penetration and low tissue autofluorescence. However, the aggregation-caused quenching (ACQ) effect hinders NIR-II imaging and its application. This study introduced a V-configuration donor unit, 2,8-dibromo-6H,12H-5,11-methanodibenzo[b,f][1,5]diazocine, to prepare a twisted backbone donor-acceptor (D-A) polymer P-TB, and compared it with the planar D-A polymer P-TP. P-TB exhibited no obvious ACQ effect up to 600 μM and showed the same phenomenon during in vivo NIR-II imaging in mice, indicating the beneficial role of V-configuration donor units in weakening the ACQ effect. This work presents a promising approach for designing conventional NIR-II fluorescent polymers by manipulating the configuration of donor units.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Pharmacology & Pharmacy
Peng Zhang, Yaowei Zhu, Chunsheng Xiao, Xuesi Chen
Summary: Theranostics has attracted great attention for its ability to combine real-time cancer diagnosis with efficient treatment. Activatable dual-functional molecular agents can be synthesized by combining imaging agents, therapeutic agents, stimuli-responsive linkers, and/or targeting molecules. These agents can be activated by overexpressed physiological stimuli or external triggers at tumor sites to release imaging agents and cytotoxic drugs, offering advantages such as a high signal-to-noise ratio, low toxicity, and improved therapeutic effects. This review summarizes recent advances in dual-functional molecular agents for cancer theranostics, including molecular designs, synthetic strategies, activatable mechanisms, and biomedical applications, as well as discussing challenges and opportunities in this field.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Materials Science, Biomaterials
Jingyuan Xiao, Hailin Cong, Song Wang, Bing Yu, Youqing Shen
Summary: Photodynamic therapy is crucial in free radical therapy, but tumor microenvironment hypoxia poses a major obstacle. A new strategy of in situ production of O-2/radicals in solid tumors has been proposed to overcome this challenge and introduce active free radical nano-generators for tumor therapy.
BIOMATERIALS SCIENCE
(2021)
