Article
Nanoscience & Nanotechnology
Yingbin Su, Lin Yuan, Yu Wang, Chang Wang, Mengyu Cao, Shida Gong, Hailin Cong, Bing Yu, Youqing Shen
Summary: In this study, an S-D-A-D-S type small molecule FEA was designed and synthesized, but a new double receptor (A-A) type small molecule FEAA was accidentally obtained in the synthesis process. Compared with FEA, FEAA exhibits superior fluorescence performance and prevents fluorescence quenching effectively. FEAA nanoparticles show good fluorescence, photoacoustic, and photothermal effects, making it an excellent multifunctional NIR-II organic small molecule fluorophore.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Environmental
Daifeng Li, Chi Zhang, Xiaoyan Tai, Denghui Xu, Jianzhong Xu, Pengfei Sun, Quli Fan, Zhen Cheng, Yi Zhang
Summary: This study developed a novel nanoplatform, P2NPs, with strong photothermal therapy and dual-modal optical tracking capabilities. In vitro and in vivo experiments demonstrated the potential of this platform in the treatment of osteosarcoma.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Materials Science, Multidisciplinary
Danni Hu, Xinlong Du, Fan Qu, Zelan Yang, Pengfei Chen, Qingming Shen, Han Miao, Pengfei Sun, Quli Fan
Summary: In this study, a NIR-II absorption conjugated polymer was designed and synthesized to achieve multifunctionality including NIR-II fluorescence imaging, NIR-II photoacoustic imaging, and NIR-II photothermal therapy. The developed water-soluble nanoparticles showed promising performance in tumor imaging and therapy.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Engineering, Biomedical
Xiaoxiao Fan, Qiming Xia, Shunjie Liu, Zheng Zheng, Yiyin Zhang, Tianxiang Wu, Yixuan Li, Guping Tang, Ben Zhong Tang, Jun Qian, Hui Lin
Summary: Fluorescence imaging-guided surgery is a significant technique for precision surgery. This study proposes a hybrid navigation surgery using NIR-II and visible fluorescence assisted by aggregation-induced emission nanoparticles (AIE NPs). The combination of NIR-II and visible fluorescence allows for deep tissue localization and easy surgical navigation, improving the surgical process.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Physical
Tao Chen, Lichao Su, Lisen Lin, Xiaoguang Ge, Feicheng Bai, Meng Niu, Chenlu Wang, Jibin Song, Shaolei Guo, Huanghao Yang
Summary: This study presents a novel theranostics nanoplatform for cancer therapy and diagnosis, incorporating tungsten trioxide, gold nanoparticles, and up-conversion nanoparticles. The nanoplatform improves photoacoustic imaging performance and acts as an efficient radiosensitizer for radio-chemo anti-cancer therapy. Additionally, it accurately guides cancer radiotherapy and reduces side effects on normal tissues.
Article
Chemistry, Physical
Siyu Lu, Liru Xue, Meng Yang, Jingjing Wang, Yang Li, Yuxin Jiang, Xuechuan Hong, Mingfu Wu, Yuling Xiao
Summary: Ovarian cancer is often diagnosed in the middle or late stages due to the lack of specific initial diagnostic methods. Dual-modal near-infrared II fluorescence/photoacoustic imaging shows great potential in early ovarian cancer diagnosis and image-guided surgery. A novel organic NIR-II dye and water-soluble nanoparticles were developed for targeted imaging and surgery, improving the early detection and prognosis of ovarian cancer.
Article
Chemistry, Multidisciplinary
Hua Gu, Weijian Liu, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
Summary: In this study, a series of single-molecule photosensitizers were synthesized with extended emission wavelength by introducing pi-bridges. The results showed a direct correlation between the pi-bridge and the generation ability of singlet oxygen and photothermal conversion efficiency. When a specific pi-bridge was introduced, the photosensitizer exhibited enhanced singlet oxygen yield and photothermal conversion efficiency.
Article
Polymer Science
Yaojun Li, Jingtao Ye, Yang Li, Minling Jiang, Tingyu Shi, Huayu Qiu, Shouchun Yin
Summary: In this study, a nitrilation strategy is proposed to design photothermal agents with high fluorescence quantum yield and good photothermal conversion ability. Experimental results show that after nitrilation, the photothermal conversion efficiency and fluorescence quantum yield of nanoparticles are significantly enhanced, and both biological safety and cellular internalization ability are improved. These characteristics enable the nanoparticles to support high-resolution near-infrared second window fluorescence imaging/photoacoustic imaging-guided photothermal therapy in vivo.
Article
Chemistry, Multidisciplinary
Yulin Zhu, Hanjian Lai, Heng Guo, Dinglu Peng, Liang Han, Ying Gu, Zixiang Wei, Duokai Zhao, Nan Zheng, Dehua Hu, Lei Xi, Feng He, Leilei Tian
Summary: In this study, BDTR9-OC8 and BDTR9-C8 nanoparticles with different side chain rigidities were investigated for their phototheranostic properties. It was found that BDTR9-C8 nanoparticles exhibited enhanced NIR-II FLI and PAI brightness compared to BDTR9-OC8 nanoparticles. The enhanced signals were attributed to the amorphous condensed state of BDTR9-C8 nanoparticles, which facilitated the transportation of photo-generated excitons and phonons. Additionally, both nanoparticles showed excellent photothermal conversion efficiency and have potential applications in photothermal therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Silue Zeng, Jingqin Chen, Rongkang Gao, Rui Chen, Qiang Xue, Yaguang Ren, Liangjian Liu, Chuanyu Tang, Haoyu Hu, Ning Zeng, Sai Wen, Hai Zhang, Chengbo Liu, Chihua Fang
Summary: This study develops a new theranostic strategy for photoacoustic-guided oxygen delivery, controlled release, and photodynamic therapy. By using near-infrared-II photoacoustic imaging, the strategy achieves precise thermal-triggered oxygen release in situ of the tumor, evaluated by real-time multispectral photoacoustic imaging of blood oxygen levels during photodynamic therapy. This approach provides a novel and effective method for the treatment of hepatocellular carcinoma and therapeutic monitoring.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Yichen He, Yi Pan, Xin Zhao, Weijiao Fan, Yu Cai, Xiaozhou Mou
Summary: In this study, a novel NIR-II optical absorptive conjugated polymer (PDTP-TBZ) was successfully constructed by combining an intense electron donor dithienopyrrole (DTP) with a strong electron acceptor thiadiazolobenzotriazole (TBZ). The c(RGDfK) cyclic peptide was then modified on the surface of PT NPs to obtain multifunctional nanodiagnostic reagents (cRGD@PT NPs) that can effectively target GBM neovascularization and tumor cells. Both in vitro and in vivo experiments demonstrated that cRGD@PT NPs possess high photothermal conversion efficiency and practical photoacoustic imaging capability under 1064 nm laser irradiation. The results of this study suggest that cRGD@PT NPs have great potential in efficient NIR-II PTT guided by accurate PAI, which provide a good perspective for the treatment and diagnosis of GBM.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Ying Zhang, Yan Li, Jinyan Li, Fei Mu, Jing Wang, Chuang Shen, Hao Wang, Feng Huang, Bo Chen, Zhimin Luo, Lianhui Wang
Summary: Novel noble-metal alloy nanozymes DNA-Ag@Pd NCs were synthesized using DNA as templates, exhibiting high photothermal conversion efficiency and peroxidase-mimicking activity. They also showed good stability and biocompatibility in vitro and in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemical Research Methods
Zhifang Li, Cheng Zhang, Xuan Zhang, Jian Sui, Long Jin, Lisheng Lin, Qinrui Fu, Hongxin Lin, Jibin Song
Summary: Photoacoustic imaging (PAI) is a promising technique for the diagnosis and treatment of diseases. In the second near-infrared (NIR-II) window, PAI can effectively overcome the interference of tissue fluorescence and obtain high resolution images. NIR-II PA contrast agents have been developed to improve the performance of PAI in disease diagnosis and treatment. The applications of NIR-II PA contrast agents in medical imaging, such as cancer imaging and inflammation detection, are discussed.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Engineering, Biomedical
Ruitong Xu, Di Jiao, Qin Long, Xiaolin Li, Ke Shan, Xianglong Kong, Hanlin Ou, Dan Ding, Qiyun Tang
Summary: This study applied the dual-modality imaging technique of photoacoustic imaging (PAI)/the second near-infrared window fluorescence imaging (NIR-II FI) to the diagnosis and treatment of neuroendocrine neoplasms (NENs) and their sentinel lymph nodes (SLNs). The developed aggregation-induced emission luminogens (AIEgens) demonstrated good PAI properties and intense NIR-II fluorescence emission. The combination of PAI and NIR-II FI improved the detection of NENs and the accuracy of intraoperative SLNs dissection, providing a new strategy for the precise treatment of NENs.
Article
Chemistry, Multidisciplinary
Baoli Yin, Qiaoqiao Qin, Zhe Li, Youjuan Wang, Xinlin Liu, Yongchao Liu, Shuangyan Huan, Xiaobing Zhang, Guosheng Song
Summary: The study developed a novel NIR-II molecule with improved activation efficiency and targeted therapy for tongue cancer through rational design of the molecular structure.
Article
Engineering, Biomedical
Doudou Hu, Dongdong Li, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: This paper discusses the potential of vanadium compounds in cancer treatment and the advantages of vanadium-based nanomaterials as a multimodal platform, as well as their synthesis routes and applications as therapeutic and diagnostic agents for tumors.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yanting Yu, Keqi Xiang, Mingzhi Xu, Yuqiang Li, Jiajunzi Cui, Lanqiong Zhang, Xiaohu Tang, Xianqi Zhu, Lili Qian, Meng Zhang, Yan Yang, Qingsong Yu, Youqing Shen, Zhihua Gan
Summary: The intercellular connections in the tumor microenvironment are considered to be the driving force for acquired drug resistance and proliferative burst, presenting a major obstacle in cancer treatment.
Article
Chemistry, Multidisciplinary
Nasha Qiu, Guowei Wang, Jinqiang Wang, Quan Zhou, Mengyu Guo, Yaling Wang, Xuhao Hu, Huige Zhou, Ru Bai, Min You, Zhen Zhang, Chunying Chen, Ying Liu, Youqing Shen
Summary: A novel IL12 gene-delivery vector was designed to efficiently transfect both cancer cells and TAMs, turning them into a factory for IL12 production, which effectively activates anticancer immune responses and remodels the tumor microenvironment. The intravenously administered vector slows tumor growth and doubles survival in three animal models with minimal systemic toxicities.
ADVANCED MATERIALS
(2021)
Review
Engineering, Biomedical
Doudou Hu, Wei Zhang, Jianbin Tang, Zhuxian Zhou, Xiangrui Liu, Youqing Shen
Summary: Breakthroughs in molecular mechanisms underlying immune-suppressive tumor microenvironment and paradigm shifts in cancer-immunity response cycle have changed cancer immunotherapy landscape. Addressing serious side effects from systemic autoimmunity and autoinflammatory responses is a challenge, with bioengineering and delivery technologies providing potential solutions. Developing immunotoxicity-related animal models is also deemed significant.
Review
Engineering, Biomedical
Dongdong Li, Doudou Hu, Hongxia Xu, Hirak K. Patra, Xiangrui Liu, Zhuxian Zhou, Jianbin Tang, Nigel Slater, Youqing Shen
Summary: Transdermal drug delivery is promising, especially through superficial routes. Microneedles can overcome limitations and deliver drugs into the dermal layer efficiently. They have been tested for pre-clinical chemotherapy, photothermal therapy, photodynamic therapy, and immunotherapy.
Article
Chemistry, Multidisciplinary
Shengjun Xu, Sunbin Ling, Qiaonan Shan, Qianwei Ye, Qifan Zhan, Guangjiang Jiang, Jianyong Zhuo, Binhua Pan, Xue Wen, Tingting Feng, Haohao Lu, Xuyong Wei, Haiyang Xie, Shusen Zheng, Jiajia Xiang, Youqing Shen, Xiao Xu
Summary: Resistance to sorafenib in hepatocellular carcinoma is closely linked to cancer stemness, with the lack of effective methods to reverse this stemness being a major obstacle in current HCC therapeutics. The development of Gal-SLPs, which target HCC and co-deliver sorafenib and shUSP22, shows promising results in suppressing USP22 expression, inhibiting multidrug resistance, and efficiently inhibiting HCC cell viability and proliferation. In vivo studies using a sorafenib-insensitive patient-derived xenograft model demonstrate potent antitumor effects and biosafety of Gal-SLPs, suggesting their potential in clinical HCC treatment.
Article
Engineering, Biomedical
Nasha Qiu, Yun Liu, Qi Liu, Yanzuo Chen, Limei Shen, Mengying Hu, Xuefei Zhou, Youqing Shen, Jianqing Gao, Leaf Huang
Summary: CEL not only induces strong immunogenic cell death (ICD), but also downregulates the expression of PD-L1 in tumor cells. This allows CEL to activate dendritic cells (DCs) and T-cells simultaneously, while interrupting the PD-1/PD-L1 signaling pathway between T-cells and tumor cells. This approach shows promise as a more cost-effective immunotherapy strategy against melanoma compared to traditional immune checkpoint inhibitors.
Article
Chemistry, Applied
Muhammad Usman, Adeel Ahmed, Bing Yu, Song Wang, Youqing Shen, Hailin Cong
Summary: A new adsorbent NTA-beta-CD-CS was synthesized for the simultaneous removal of dyes and metals, showing high adsorption capacities and excellent regeneration performance, making it potentially promising for treating wastewater from various industries.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Junjun Li, Rong Du, Qiong Bian, Danping Zhang, Siqian Gao, Anran Yuan, Xiaoying Ying, Youqing Shen, Jianqing Gao
Summary: In this study, a novel HA material modified with ATEMPO was synthesized to promote angiogenesis and prevent excessive ROS production, leading to alleviation of oxidative stress response and enhancement of chronic wound healing. Through experiments in rat models, it was found that HA-g-TEMPO significantly improved wound closure efficacy and potentially reduced scar formation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Materials Science, Multidisciplinary
He Ma, Song Wang, Bing Yu, Xin Sui, Youqing Shen, Hailin Cong
Summary: Bio-nanochannels in living organisms selectively transport ions through cell membranes and inspire the development of artificial ion nanochannels. Polymer-based biomimetic nanochannels offer good mechanical stability, high-performance ion transport, and designability. This review mainly focuses on the fabrication and application of polymer-based biomimetic nanochannels, especially in environmentally responsive biosensor and energy conversion.
SCIENCE CHINA-MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Shuaibing Guo, Bing Yu, Fengyuan Gao, Song Wang, Youqing Shen, Hailin Cong
Summary: Three-dimensional colloidal crystal materials have unique optical properties and spatial structure, with potential for preparing three-dimensionally ordered microporous materials. This review covers various preparation methods, effects of parameters on assembly, and main applications of 3DCCs.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jing Liu, Zhihao Zhao, Nasha Qiu, Quan Zhou, Guowei Wang, Haiping Jiang, Ying Piao, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: In this study, it was found that the histone demethylase inhibitor 5-carboxy-8-hydroxyquinoline (IOX1) reduces PD-L1 expression in cancer cells and enhances doxorubicin-induced immunogenic cell death, promoting T cell infiltration and reducing tumor growth in preclinical models.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Siqin Chen, Yin Zhong, Wufa Fan, Jiajia Xiang, Guowei Wang, Quan Zhou, Jinqiang Wang, Yu Geng, Rui Sun, Zhen Zhang, Ying Piao, Jianguo Wang, Jianyong Zhuo, Hailin Cong, Haiping Jiang, Jun Ling, Zichen Li, Dingding Yang, Xin Yao, Xiao Xu, Zhuxian Zhou, Jianbin Tang, Youqing Shen
Summary: Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and weak interaction with phospholipids can effectively eradicate large tumours and patient-derived tumour xenografts in mice by facilitating their transcytosis-mediated extravasation and infiltration into tumours, showcasing potential for translational anticancer nanomedicines.
NATURE BIOMEDICAL ENGINEERING
(2021)
Review
Materials Science, Biomaterials
Jingyuan Xiao, Hailin Cong, Song Wang, Bing Yu, Youqing Shen
Summary: Photodynamic therapy is crucial in free radical therapy, but tumor microenvironment hypoxia poses a major obstacle. A new strategy of in situ production of O-2/radicals in solid tumors has been proposed to overcome this challenge and introduce active free radical nano-generators for tumor therapy.
BIOMATERIALS SCIENCE
(2021)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.