Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini

The Molecular Mechanism by which PIP2 Opens the Intracellular G-Loop Gate of a Kir3.1 Channel

(2012) Xuan-Yu Meng et al.   BIOPHYSICAL JOURNAL

Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Inwardly Rectifying Potassium (Kir) Channels by Cholesterol and Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)

(2012) Avia Rosenhouse-Dantsker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytosolic GH Loop Regulates the Phosphatidylinositol 4,5-Bisphosphate-induced Gating Kinetics of Kir2 Channels

(2012) Hai-Long An et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

(2011) Avia Rosenhouse-Dantsker et al.   BIOPHYSICAL JOURNAL

Hypercholesterolemia Induces Up-regulation of KAChCardiac Currents via a Mechanism Independent of Phosphatidylinositol 4,5-Bisphosphate and Gβγ

(2011) Wu Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain Reorientation and Rotation of an Intracellular Assembly Regulate Conduction in Kir Potassium Channels

(2010) Oliver B. Clarke et al.   CELL

Comparative analysis of cholesterol sensitivity of Kir channels: Role of the CD loop

(2010) Avia Rosenhouse-Dantsker et al.   Channels

Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles

(2010) Hiroshi Hibino et al.   PHYSIOLOGICAL REVIEWS

Ion-Blocking Sites of the Kir2.1 Channel Revealed by Multiscale Modeling

(2009) Kaihsu Tai et al.   BIOCHEMISTRY

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Cholesterol and Kir channels

(2009) Irena Levitan   IUBMB LIFE

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

(2009) Y. Epshtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P2

(2008) Avia Rosenhouse-Dantsker et al.   Nature Chemical Biology