Distant Cytosolic Residues Mediate a Two-way Molecular Switch That Controls the Modulation of Inwardly Rectifying Potassium (Kir) Channels by Cholesterol and Phosphatidylinositol 4,5-Bisphosphate (PI(4,5)P2)

Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein

(2011) Dev K. Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol Sensitivity of KIR2.1 Is Controlled by a Belt of Residues around the Cytosolic Pore

(2011) Avia Rosenhouse-Dantsker et al.   BIOPHYSICAL JOURNAL

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2

(2011) Scott B. Hansen et al.   NATURE

Enantioselective Protein-Sterol Interactions Mediate Regulation of Both Prokaryotic and Eukaryotic Inward Rectifier K+ Channels by Cholesterol

(2011) Nazzareno D'Avanzo et al.   PLoS One

Comparative analysis of cholesterol sensitivity of Kir channels: Role of the CD loop

(2010) Avia Rosenhouse-Dantsker et al.   Channels

NMR Analyses of the Gβγ Binding and Conformational Rearrangements of the Cytoplasmic Pore of G Protein-activated Inwardly Rectifying Potassium Channel 1 (GIRK1)

(2010) Mariko Yokogawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion-Blocking Sites of the Kir2.1 Channel Revealed by Multiscale Modeling

(2009) Kaihsu Tai et al.   BIOCHEMISTRY

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Cholesterol and Kir channels

(2009) Irena Levitan   IUBMB LIFE

Direct Regulation of Prokaryotic Kir Channel by Cholesterol

(2009) Dev K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Identification of a C-terminus domain critical for the sensitivity of Kir2.1 to cholesterol

(2009) Y. Epshtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

(2009) X. Tao et al.   SCIENCE

A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P2

(2008) Avia Rosenhouse-Dantsker et al.   Nature Chemical Biology