Review
Biochemistry & Molecular Biology
Miao Miao, Xue Wang, Tian Liu, Yan-Jie Li, Wen-Qian Yu, Tong-Mei Yang, Shou-Dong Guo
Summary: Atherosclerosis, a major factor of cardiovascular disease, is influenced by inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, have tissue- and cell-specific expression and regulate genes involved in lipid metabolism, inflammation, and redox homeostasis. Despite controversies, accumulating evidence supports the role of PPAR activation in attenuating atherosclerosis. Recent advances provide valuable insights into the mechanisms of PPAR activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Chun Li, Jiyu Li, Ethyn G. Loreno, Sumitra Miriyala, Manikandan Panchatcharam, Xiaohong Lu, Hong Sun
Summary: The study demonstrates that light alcohol consumption can alleviate post-ischemic inflammation and protect against cerebral ischemia/reperfusion injury through the activation of PPAR gamma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Lei Xu, Yifei Chen, Shoujie Feng, Zeyan Liu, Ying Ye, Ranran Zhou, Lijun Liu
Summary: This study found that PEDF can inhibit LPS-induced ALI in rats and reduce the expression of inflammatory factors and lung cell apoptosis. PEDF inhibits lung epithelial cell injury by upregulating the expression of PPAR-gamma.
BMC PULMONARY MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Zecai Zhang, Yueqi Cui, Siyu Liu, Jiang Huang, Yu Liu, Yulong Zhou, Zhanbo Zhu
Summary: This study investigated the protective effects and potential mechanisms of zingerone (ZO) extracted from ginger on dextran sulfate sodium (DSS)-induced mouse ulcerative colitis (UC). The results showed that ZO alleviated weight loss, reduced disease activity index scores, and improved pathological changes in colon tissue. Mechanism analysis revealed that ZO inhibited the activation of the nuclear factor-kappa B pathway and regulated peroxisome proliferator-activated receptor gamma (PPAR gamma) expression. The findings suggest that ZO supplementation may be a new dietary strategy for UC treatment.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Manale El Kharbili, Katja Aviszus, Sarah K. Sasse, Xiaoyun Zhao, Karina A. Serban, Susan M. Majka, Anthony N. Gerber, Fabienne Gally
Summary: The resolution of inflammation is an actively regulated process. This study shows that FABP5 and PPARγ reciprocally regulate each other, forming a positive feedback loop that mediates macrophage pro-resolving programming.
Article
Gastroenterology & Hepatology
Maria Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodriguez, Luis Leiva-Vega, Aranzazu Pintor-Chocano, Daniel Horrillo, Lourdes Hernandez-Cosido, Jorge L. Torres, Eva Novoa, Ruben Nogueiras, Gema Medina-Gomez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio
Summary: Obesity leads to chronic low-grade inflammation, causing diabetes, steatosis, and insulin resistance. Activation of the p38 pathway in macrophages plays a crucial role in this inflammation, suggesting p38 inhibition as a potential treatment for obesity comorbidities. However, lack of p38 activation in myeloid cells worsens high-fat diet-induced obesity, diabetes, and steatosis. Deficient p38 activation increases macrophage IL-12 production, leading to inhibition of hepatic FGF21 and reduction of thermogenesis in the brown fat.
Article
Pharmacology & Pharmacy
Jialing Ma, Peng Zeng, Lipei Liu, Mengmeng Zhu, Juan Zheng, Chengyi Wang, Xiaokang Zhao, Wenquan Hu, Xiaoxiao Yang, Yajun Duan, Jihong Han, Qing R. Miao, Yuanli Chen
Summary: This study found that PPAR gamma ligands can enhance the expression of NGBR in the liver and reduce ER stress and inflammation by selectively activating PPAR gamma. These findings reveal the potential mechanism of NGBR in regulating insulin sensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jorge Antonio Silva-Gomez, Marina Galicia-Moreno, Ana Sandoval-Rodriguez, Hipolito Otoniel Miranda-Roblero, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: The study evaluated the effects of PFD on early stages of liver cancer development, showing that PFD can prevent tissue damage, reduce fibrosis and inflammation, and promote apoptosis in the experimental model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
David Ogburn, Sophia Bhalla, Nan Leffler, Arjun Mohan, Anagha Malur, Achut G. Malur, Matthew McPeek, Barbara P. Barna, Mary Jane Thomassen
Summary: The study identified an M2 macrophage phenotype in Mmp12KO mice and found that granuloma resolution in Mmp12KO mice at 60 days post-instillation requires an M2a macrophage phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mauricio T. Nascimento, Ravena S. O. Cordeiro, Cayo Abreu, Camila P. Santos, Fabio Peixoto, Gabriela A. Duarte, Thiago Cardoso, Camila I. de Oliveira, Edgar M. Carvalho, Lucas P. Carvalho
Summary: Patients with cutaneous leishmaniasis caused by Leishmania braziliensis infection suffer from an exaggerated inflammatory response. Pioglitazone, a drug used to treat diabetes, can help reduce inflammation without affecting the clearance of L. braziliensis by monocytes. Pioglitazone may serve as an adjunctive treatment for CL caused by L. braziliensis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Oncology
Tiange Chi, Mina Wang, Xu Wang, Ke Yang, Feiyu Xie, Zehuan Liao, Peng Wei
Summary: PPARs are lipid sensors and metabolic regulators, with PPAR-γ showing potential in inhibiting cell proliferation, inducing apoptosis, and disrupting inflammation. However, safety concerns including drug interactions need to be addressed for clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yong Hao, Shuwei Bai, Jing Peng, Ronghua Hong, Jie Ding, Zezhi Li, Yangtai Guan
Summary: The study suggests that TRIM27 mediates ubiquitination of PPAR gamma, leading to increased expression of cleaved Caspase-3 and IL-1 beta, promoting Glu-induced apoptosis and IL-1 beta release in HT22 cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Immunology
Mengjiao Wu, Qingfei Li, Kangsen Mai, Qinghui Ai
Summary: FFAR4 exhibits anti-inflammatory effects in large yellow croaker by reducing the expression of pro-inflammatory genes and increasing PPAR gamma expression, showing potential as a target for inflammatory regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manoj K. Singh, Rohit Yadav, Akash Kumar Bhaskar, Shantanu Sengupta, Chetana Sachidanandan
Summary: Non-alcoholic Fatty Liver Disease (NAFLD) is not only prevalent in obese individuals, but also in lean individuals, especially in South Asian population. In this study, researchers developed a diet-independent model of NAFLD in zebrafish and found that IL6 overexpression in the zebrafish could lead to hepatic fat accumulation, similar to NAFLD patients. They also discovered that treating the IL6-overexpressing zebrafish with the PPAR-gamma agonist Rosiglitazone could ameliorate the fatty liver phenotype. This research highlights the potential of the IL6-OE zebrafish model for small molecule screening to identify compounds that can reverse hepatic lipid accumulation in lean NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biology
Audrey Antoine, Coraline De Sousa Do Outeiro, Coline Charnay, Corinne Belville, Fanny Henrioux, Denis Gallot, Loic Blanchon, Regine Minet-Quinard, Vincent Sapin
Summary: Phthalates, as reprotoxic pollutants, are found everywhere in the environment. They may disrupt the PPAR gamma pathway and lead to premature rupture of fetal membranes.
Article
Peripheral Vascular Disease
Huan Hu, Masafumi Eguchi, Takako Miki, Takeshi Kochi, Isamu Kabe, Akiko Nanri, Graham A. Macgregor, Tetsuya Mizoue, Feng J. He
Summary: The cross-sectional analysis did not show a significant association between serum sodium and blood pressure at baseline. However, the prospective analysis revealed that an elevated serum sodium level was associated with an increased risk of developing hypertension.
HYPERTENSION RESEARCH
(2022)
Article
Engineering, Electrical & Electronic
Lei Yu, Feng He, Yi Su, Zhen Dong
Summary: The study proposes a high degrees of freedom transmitting strategy for coherent FDA radar, which effectively combines spatial transmit array weighting and temporal piecewise waveform design to achieve flexible beam scanning characteristics. The method fully utilizes the transmitting DOFs of radar, enabling beam pattern shaping and spatial waveform diversity with transmitting energy allocation.
IET RADAR SONAR AND NAVIGATION
(2022)
Article
Materials Science, Ceramics
Bing Zhang, Feng He, Xiuhua Cao, Mingjie Wei, Congcong Zheng, Junlin Xie
Summary: Alteration of TiO2 and B2O3 contents can affect the sintering behavior and crystallization of glass-ceramics, leading to increased crystallinity and homogenization of grain size, as well as promoting the precipitation of the SrTiO3 phase.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Mingjuan Shi, Feng He, Zhiqiang Zhou, Xiaorong Yang, Junlin Xie
Summary: Influence of the crystallisation temperature on the structure and properties of Li2O-Al2O3-SiO2 (LAS) glass-ceramics with high aluminium content was investigated. Glass-ceramics with ultra-low CTE and high transmittance were successfully prepared by the melt-quenching method and a two-step heat treatment. The crystallisation behaviour of the glass was studied via DSC and XRD. Besides, FTIR, Raman and FE-SEM were used to explore the structure of the samples under different crystallisation temperatures. A beta-quartz solid solution with nano-size precipitated from the glass after the heat treatment and when the crystallisation temperature was 820 degrees C, the bending strength and microhardness reached 156 MPa and 1082.09 HV, respectively.
Review
Pharmacology & Pharmacy
Juntao Zhang, Fangyang Fan, Aifeng Liu, Chao Zhang, Qi Li, Chenglong Zhang, Feng He, Man Shang
Summary: In this study, the molecular mechanism of ICA for the treatment of KOA was investigated using network pharmacology, molecular docking, and literature research. Core targets for KOA treatment include TNF, IGF1, MMP9, PTGS2, ESR1, MMP2, among others, with main biological processes involving regulation of inflammatory response and collagen catabolic process. The most likely pathways involved were the IL-17 signaling pathway, TNF signaling pathway, and Estrogen signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yuewen Sun, Yuan Li, Feng J. He, Hueiming Liu, Jingwen Sun, Rong Luo, Chunlei Guo, Puhong Zhang
Summary: This study evaluated the implementation of the AppSalt program in schools in China, showing a high overall retention rate of 97%. About 80% of participants completed all app-based salt reduction courses. The smartphone app was perceived as a feasible and engaging health education tool. Barriers to implementation at primary schools were identified through interviews with participants and stakeholders.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Physics, Fluids & Plasmas
Ruilin Cui, Tianliang Zhang, Qian Yuan, Feng He, Ruoyu Han, Jiting Ouyang
Summary: In this study, the discharge characteristics and heating mechanisms of argon helicon plasma in different wave coupled modes with and without blue core were investigated. The results showed the existence of at least two distinct wave coupled modes, with one having a significant blue core and the other without. The emission intensity and electron density were measured, and it was found that the ion line intensity was dependent on both electron density and temperature, while the atom line intensity tended to be saturated in wave coupled modes due to neutral depletion. Theoretical analysis revealed that helicon waves were the dominant mechanism of power deposition or central heating of electrons in both modes.
PLASMA SCIENCE & TECHNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yunhua Xiao, Jing Yuan, Chongshuang Yang, Junru Xiong, Liangyu Deng, Qinghua Liang, Chuang He, Liangshan Li, Fengtian He, Xuequan Huang
Summary: The study demonstrates that I-125 radioactive particles induce cell apoptosis and protective autophagy of HCC. Inhibition of autophagy by silencing ATG9B enhances the radiosensitivity of HCC to I-125 radioactive particles.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Chemistry, Physical
De Fang, Sensheng Hou, Yanli Ye, Qiqi Jin, Feng He, Junlin Xie
Summary: Fe3O4, alpha-Fe2O3 and gamma-Fe2O3 catalysts show excellent activities for the selective catalytic reduction of NOx by NH3. The properties of the iron oxides have significant effects on the SCR activities, including oxidation-reduction ability, surface acidity distribution, BET surface area, and surface adsorbed oxygen. The DFT calculations and experimental results confirm the superior performance of Fe3O4 catalyst.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Physical
Qiqi Jin, De Fang, Yanli Ye, Sensheng Hou, Feng He, Junlin Xie
Summary: The role of Cu, Co, or Ni species in exchanged zeolite catalysts for NH3-SCR has been studied using different preparation methods. Ammonia wet ion exchange method (AWIE) was found to be effective in increasing ionic species and improving ion polymerization degree in NaY zeolites. Cu, Co, and Ni substituted Y zeolite prepared by AWIE method showed better SCR performance than conventional wet ion exchange method (CWIE). The coordination states and chemical environments of Cu, Co, and Ni exchanged species affected the redox and adsorption properties of catalysts. Cu-NH3-IE catalyst exhibited a wider SCR temperature window compared to Co-NH3-IE and Ni-NH3-IE catalysts due to its more stable NH3 adsorption, lower temperature, and smaller reduction peak area. The balance of NH3 adsorption and oxidation was proposed as the key factor for achieving high N2 selectivity. This work provides a new approach for improving the activity and N2 selectivity of zeolite catalysts over a broad temperature range.
APPLIED SURFACE SCIENCE
(2022)
Editorial Material
Cell Biology
Haojun Xiong, Liangbo Sun, Jiqin Lian, Fengtian He
Summary: In this study, the researchers revealed for the first time that the acetylation level of ATG4B at lysine residue 39 (K39) plays a crucial role in regulating its activity and autophagy. The deacetylation of ATG4B K39 by SIRT2 enhances ATG4B activity and autophagic flux, which can be countered by EP300/p300. Starvation treatment promotes the deacetylation of ATG4B K39 by suppressing EP300 and activating SIRT2, leading to the initiation of autophagy. The findings suggest that acetylation-mediated regulation of ATG4B activity is involved in the response to nutritional deficiency.
Article
Nutrition & Dietetics
Fang Fan, Yinghua Li, Li Li, Xueqiong Nie, Puhong Zhang, Yuan Li, Rong Luo, Gang Zhang, Lanlan Wang, Feng J. He
Summary: Salt intake in China is high and increases the risk of hypertension and cardiovascular disease. A study found that salt-related knowledge, attitudes, and behaviors are inversely associated with 24-hour urinary sodium excretion. The results suggest the need for large-scale health education, particularly targeting rural areas, individuals with low education levels, and older people, to reduce salt intake.
Article
Environmental Sciences
Jinge Ma, Feng He, Tianci Qi, Zhe Sun, Ming Shen, Zhigang Cao, Di Meng, Hongtao Duan, Juhua Luo
Summary: Lake Dianchi is one of the most eutrophic lakes in China, and the occurrence of algal blooms poses a significant threat to the water ecosystem. This study reconstructed a unified time series of bloom areas in Lake Dianchi using Landsat and MODIS images combined with the Floating Algae Index (FAI), and analyzed the dynamics, seasonal characteristics, and spatial distribution of algal blooms. The study also analyzed the relationship between environmental factors and algal blooms, highlighting the importance of rainy season images in reconstructing time series based on different sensors.
Article
Materials Science, Multidisciplinary
Yan Li, Hui Chen, Hanjian Lai, Xue Lai, Tahir Rehman, Yulin Zhu, Yunpeng Wang, Qinghe Wu, Feng He
Summary: This study investigates the impact of hydrogen bonding on the performance of Q-PHJ solar cells by designing two polymers with different organic functional groups. Results indicate that the acetoxy-substituted polymer has higher photovoltaic performance and better crystallinity.
ACS MATERIALS LETTERS
(2022)
Article
Engineering, Environmental
Pijun Gong, Feng He, De Fang, Junlin Xie
Summary: The hydrothermally synthesized lamellar framework Sm-CeZrTiAl amorphous mixed oxides exhibit enhanced NH3-SCR performance and improved resistance to K poisoning. The good nano-Al2O3 flake skeleton structure, high specific surface area, and rich pore channels contribute to the excellent K poisoning-resistance of the catalyst. Sm doping increases the number of surface acid sites, especially strong acid sites, promoting the conversion of NO to N2. The synergy between Sm/La and Ce facilitates catalytic reduction and prevents Ce species from being poisoned.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
