Article
Materials Science, Biomaterials
Hilaria Mollica, Yi Juan Teo, Alrina Shin Min Tan, Damien Zhi Ming Tan, Paolo Decuzzi, Andrea Pavesi, Giulia Adriani
Summary: The study presents an in vitro 3D PDAC-TME model to observe and quantify T cell infiltration, demonstrating that the presence of EC-lining reduces T cell infiltration significantly, and activated T cells migrate more efficiently towards cancer cells compared to not-activated cells.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rory K. M. Long, Livia Piatti, Francois Korbmacher, Maria Bernabeu
Summary: Three-dimensional engineered blood-brain barrier models offer a better mimicry of the brain microvasculature structure, recapitulate BBB properties, physiology, and function, providing improved control over experimental parameters and compatibility with advanced imaging technologies. These models have the potential to help researchers overcome limitations of traditional research methods and understand parasite interactions with the BBB.
MOLECULAR MICROBIOLOGY
(2022)
Article
Biology
Yiting Zhang, Jianping Hu, Xiaoying Qu, Ke Hu
Summary: The circular RNA circRSU1 is upregulated in diabetic retinopathy patients and its interaction with miR-345-3p leads to increased TAZ levels, which contribute to the development of vascular dysfunction. Diabetic retinopathy is a major cause of visual impairment and blindness in adults with diabetes mellitus. Although circRNAs have been implicated in vascular progression, the exact role of circRNAs in diabetes-induced vascular complications remains largely unknown. The authors found that circRSU1 was significantly upregulated in diabetic retinopathy patients. Further experiments showed that knockdown of circRSU1 alleviated diabetes-induced retinal vascular dysfunction, including decreased levels of vascular endothelial growth factor, reduced inflammatory responses, and diminished oxidative stress. The study also revealed that circRSU1 interacts with miR-345-3p to upregulate TAZ expression, and downregulation of TAZ reversed the vascular dysfunction caused by increased circRSU1 expression under high glucose conditions. In conclusion, the overexpression of circRSU1 promotes vascular dysfunction through its interaction with miR-345-3p to increase TAZ levels in diabetic conditions. The findings suggest that circRSU1 may serve as a potential therapeutic target for treating vascular dysfunction in diabetes mellitus.
COMMUNICATIONS BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Li Sun, Xuefang Li, Hui Luo, Huige Guo, Jie Zhang, Zhigang Chen, Fei Lin, Guoan Zhao
Summary: EZH2 is a catalytic subunit of polycomb repressor complex 2 and plays important roles in endothelial cell homeostasis. It represses gene expression through chromatin compaction by functionally methylating lysine 27 of histone H3. Studies have shown that EZH2 mediates the effects of environmental stimuli on endothelial functions, such as angiogenesis, endothelial barrier integrity, inflammatory signaling, and endothelial mesenchymal transition. This review aims to provide a concise summary of the roles EZH2 plays in endothelial function and explore its therapeutic potential in cardiovascular diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Materials Science, Biomaterials
Zhe Hou, Maolong Xiang, Nuoya Chen, Xiao Cai, Bo Zhang, Rifang Luo, Li Yang, Xiaoyi Ma, Lifeng Zhou, Fugui He, Hongchi Yu, Yunbing Wang
Summary: Magnesium alloy shows promise in cardiovascular stent applications, but it may affect migration and adhesion of endothelial cells, leading to inhibited re-endothelialization within the stent.
REGENERATIVE BIOMATERIALS
(2021)
Article
Medicine, Research & Experimental
Mohammad Shafiq, Zahid Rasool Lone, Pragya Bharati, Himalaya Singh, Kumaravelu Jagavelu, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: This study demonstrates the important role of MK2 in inflammation and endothelial microparticle generation, suggesting that its inhibition may help improve endothelial function in patients with pulmonary hypertension.
Article
Immunology
Emily C. C. Ross, Arne L. ten Hoeve, Jeroen P. J. Saeij, Antonio Barragan
Summary: The study reveals that Toxoplasma gondii infection enhances the trans-endothelial migration of infected dendritic cells (DCs) by upregulating the expression of leukocyte intercellular adhesion molecule-1 (ICAM-1). This enhanced migration is facilitated by the secreted parasite effectors GRA15 and TgWIP, which modulate the interactions between leukocytes and endothelial cells. The findings highlight the importance of leukocyte ICAM-1 in infection-related migration and dissemination of the parasite.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jack Winneberger, Sebastian Schoels, Katrin Lessmann, Javier Randez-Garbayo, Alexander T. Bauer, Ayan Mohamud Yusuf, Dirk M. Hermann, Matthias Gunzer, Stefan W. Schneider, Jens Fiehler, Christian Gerloff, Mathias Gelderblom, Peter Ludewig, Tim Magnus
Summary: The study demonstrated the role of PECAM-1 in regulating trans-endothelial immune cell migration in ischemic brain injury using genetic Pecam-1 depletion and PECAM-1 blockade. The inhibition of PECAM-1 showed reduced infarct volume, edema formation, and brain atrophy in mice. Blocking PECAM-1 could potentially be a target to reduce post-stroke neuroinflammation and enhance post-ischemic brain remodeling.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biology
Zeinab Rekad, Michael Ruff, Agata Radwanska, Dominique Grall, Delphine Ciais, Ellen Van Obberghen-Schilling
Summary: This study identified the role of the RBP SAM68 in endothelial cells, showing its involvement in membrane protrusive activity, conversion of adhesion sites, cell-matrix interactions, and sprouting angiogenesis.
Article
Pharmacology & Pharmacy
Ellen Emi Kato, Luciana Araujo Pimenta, Maira Estanislau Soares de Almeida, Vanessa Olzon Zambelli, Marinilce Fagundes dos Santos, Sandra Coccuzzo Sampaio
Summary: The study demonstrated that CTX inhibits major events involved in angiogenesis, such as tube formation and cell adhesion, proliferation, and migration. These actions were particularly effective against tumor stimuli, highlighting the importance of CTX's anti-angiogenic action in inhibiting tumor progression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ekta Manocha, Alessandra Consonni, Fulvio Baggi, Emilio Ciusani, Valentina Cocce, Francesca Paino, Carlo Tremolada, Arnaldo Caruso, Giulio Alessandri
Summary: Pericytes, as a type of mesenchymal stromal cells, have a crucial role in tissue regeneration and vascular homeostasis. This study found that CD146(+) pericytes from adipose tissue may have a higher efficacy in promoting angiogenesis and vascular stabilization compared to CD146(-) pericytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Carla Roberta Peachazepi Moraes, Ivanio Teixeira Borba-Junior, Franciele De Lima, Jessica Ribeiro Alves Silva, Bruna Bombassaro, Andre C. Palma, Eli Mansour, Licio Augusto Velloso, Fernanda Andrade Orsi, Fabio Trindade Maranhao Costa, Erich Vinicius De Paula
Summary: In this study, the researchers found that the serum from COVID-19 patients can disrupt the endothelial barrier integrity in cell monolayers. They also observed that the levels of soluble Tie2 were increased and soluble VE-cadherin were decreased in these patients compared to healthy individuals. Furthermore, the magnitude of this disruption was proportional to disease severity and levels of VEGF-A and Ang-2. These findings provide important insights into the pathogenesis of acute lung injury in COVID-19 and may contribute to the development of new biomarkers and therapeutic targets.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Developmental Biology
Christina Arapatzi, Georgia Rouni, Vassiliki Kostourou
Summary: Cell-matrix adhesions play a key role in developmental and tumor angiogenesis, with further research needed for better understanding.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Thijs J. Sluiter, Jaap D. van Buul, Stephan Huveneers, Paul H. A. Quax, Margreet R. de Vries
Summary: The vascular endothelium acts as a specialized barrier controlling the passage of fluids and cells, particularly leukocytes. Impaired barrier function in atherosclerosis leads to uncontrolled leukocyte extravasation and vascular leakage, contributing to plaque destabilization and intraplaque hemorrhage.
Article
Biochemistry & Molecular Biology
Ersilia Nigro, Marta Mallardo, Rita Polito, Filippo Scialo, Andrea Bianco, Aurora Daniele
Summary: AdipoRon has significant effects on proliferation, migration, and tube formation of human endothelial cells, while leptin has minimal impact on these factors. Co-treatment with AdipoRon and leptin results in antagonistic effects, reducing tube structures and cell migration. AdipoRon administration leads to increased expression of specific genes associated with angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Shima Ghoroghi, Benjamin Mary, Annabel Larnicol, Nandini Asokan, Annick Klein, Nael Osmani, Ignacio Busnelli, Francois Delalande, Nicodeme Paul, Sebastien Halary, Frederic Gros, Laetitia Fouillen, Anne-Marie Haeberle, Cathy Royer, Coralie Spiegelhalter, Gwennan Andre-Gregoire, Vincent Mittelheisser, Alexandre Detappe, Kendelle Murphy, Paul Timpson, Raphael Carapito, Marcel Blot-Chabaud, Julie Gavard, Christine Carapito, Nicolas Vitale, Olivier Lefebvre, Jacky G. Goetz, Vincent Hyenne
Summary: This study identifies Ral GTPases as central molecules linking the mechanisms of EV secretion and cargo loading to their capacity to disseminate and induce pre-metastatic niches. Depletion of RalA or RalB in cells leads to limited organotropic capacities in vivo and less efficient promotion of metastasis, as well as reduced levels of the adhesion molecule MCAM/CD146 in EVs, which favors EV-mediated metastasis by targeting to the lungs. RalA, RalB, and MCAM/CD146 are factors of poor prognosis in breast cancer patients.
Article
Multidisciplinary Sciences
An Thys, Kilian Trillet, Sara Rosinska, Audrey Gayraud, Tiphaine Douanne, Yannic Danger, Clotilde C. N. Renaud, Luc Antigny, Regis Lavigne, Charles Pineau, Emmanuelle Com, Franck Verite, Julie Gavard, Nicolas Bidere
Summary: The adaptor SHARPIN, together with E3 ligases HOIP and HOIL1, forms the LUBAC complex, which catalyzes the addition of linear ubiquitin chains to substrates. This process is crucial for regulating NF-kappa B signaling downstream of immunoreceptors. Phosphorylation of SHARPIN at serine 165 plays a role in controlling linear ubiquitination of NEMO, affecting NF-kappa B activation in response to TNF alpha. These findings provide insights into the regulation of LUBAC and potential strategies for modulating its activity.
Article
Biochemistry & Molecular Biology
Anda Huna, Beatrice Nawrocki-Raby, Teresita Padilla-Benavides, Julie Gavard, Sylvie Coscoy, David Bernard, Mathieu Boissan
Summary: NME1, not NME2, acts specifically to inhibit EMT and prevent the earliest stages of metastasis. Loss of NME1 leads to a hybrid phenotype associated with higher metastatic potential, while overexpression of NME1 results in a more epithelial phenotype. Additionally, NME1 inhibits key intracellular signaling pathways involved in inducing EMT, such as AKT and MAPK pathways, and affects the distribution and cell-cell adhesion of E-cadherin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Esther Cabanas Morafraile, Javier Perez-Pena, Jesus Fuentes-Antras, Aranzazu Manzano, Pedro Perez-Segura, Atanasio Pandiella, Eva M. Galan-Moya, Alberto Ocana
Summary: Breast cancer is the most common invasive tumor in women and identification of druggable targets to improve current therapies is a major goal. In this study, an in silico analysis of transcriptomic datasets in breast cancer revealed upregulated genes involved in DNA damage response pathways like ATM/ATR, BARD1, and Fanconi Anemia, which correlated with worse prognosis. Understanding these genetic vulnerabilities may help in developing improved therapeutic strategies for breast cancer.
Review
Biochemistry & Molecular Biology
Sara Rosinska, Julie Gavard
Summary: Glioblastoma tumors use various methods to increase blood vessel supply to the tumor mass, but the neo-generated vascular networks are morphologically and functionally abnormal, indicating inefficiency in the vascularization processes. In the perspective of anti-cancer therapies, it is crucial to understand how these neovascularization modalities can be mechanistically hindered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kilian Trillet, Kathryn A. Jacobs, Gwennan Andre-Gregoire, An Thys, Clement Maghe, Jonathan Cruard, Stephane Minvielle, Sara Gonzalez Diest, Guillaume Montagnac, Nicolas Bidere, Julie Gavard
Summary: Research has shown that the glycoprotein GP130 interacts with APLNR in glioblastoma stem-like cells (GSCs), affecting their self-renewal and opening up new possibilities for targeted therapy of cancer stem cells.
JOURNAL OF CELL BIOLOGY
(2021)
Article
Oncology
Juan Luis Santiago, Jose Ramon Munoz-Rodriguez, Miguel Angel de la Cruz-Morcillo, Clara Villar-Rodriguez, Lucia Gonzalez-Lopez, Carolina Aguado, Miriam Nuncia-Cantarero, Francisco Javier Redondo-Calvo, Jose Manuel Perez-Ortiz, Eva Maria Galan-Moya
Summary: In this study, chronic UV-B light exposure led to impairments in transepidermal water loss, stratum corneum hydration, and surface pH in a mouse model with cutaneous field cancerization. The association between permeability barrier impairment and keratinocyte hyperproliferation could be a new target for the management of actinic keratosis and squamous cell carcinomas.
Article
Oncology
Marina Pagnuzzi-Boncompagni, Vincent Picco, Valerie Vial, Victor Planas-Bielsa, Ashaina Vandenberghe, Thomas Daubon, Marie-Alix Derieppe, Christopher Montemagno, Jerome Durivault, Renaud Grepin, Sonia Martial, Jerome Doyen, Julie Gavard, Gilles Pages
Summary: This study suggests that axitinib, an FDA- and EMA-approved antiangiogenic compound, may be an effective and low-toxicity treatment option for pediatric brain cancer, particularly medulloblastoma. The compound shows selective antitumoral effects on tumor cells and can cross the blood-brain barrier. The results support the potential repurposing of axitinib for the treatment of medulloblastoma.
Article
Biochemistry & Molecular Biology
Maria del Mar Noblejas-Lopez, Lucia Gandullo-Sanchez, Eva M. Galan-Moya, Raquel Lopez-Rosa, David Tebar-Garcia, Cristina Nieto-Jimenez, Monica Gomez-Juarez, Miguel Burgos, Atanasio Pandiella, Alberto Ocana
Summary: This article explores the antitumoral activity of a novel compound against CDK9 in breast cancer cells, showing significant inhibitory effects in certain subtypes and particular sensitivity in trastuzumab-resistant cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Alexandre Glemain, Melanie Neel, Antoine Neel, Gwennan Andre-Gregoire, Julie Gavard, Bernard Martinet, Rozenn Le Bloas, Kevin Riquin, Mohamed Hamidou, Fadi Fakhouri, Sarah Bruneau
Summary: Neutrophils play a critical role in autoimmune disorders, and their activation can lead to the release of extracellular vesicles (EVs) that transfer miR-223, miR-142-3p and miR-451 to endothelial cells (ECs), causing endothelial damage and inflammation. Specifically, miR-142-3p and miR-451 expression in ECs results in cell damage, impaired angiogenic repair responses, and the induction of IL-6, IL-8, CXCL10 and CXCL11 expression. The harmful effects of miR-142-3p may be due to its ability to block the activation of ERK1/2 and eNOS-mediated signals in ECs. miR-142-3p also inhibits the expression of RAC1, ROCK2 and CLIC4, three genes critical for EC migration and angiogenic responses. The increased levels of miR-223, miR-142-3p and miR-451 in kidney biopsies from patients with ANCA-associated vasculitis highlight their importance in neutrophil-induced microvascular damage. Inhibiting these miRNAs in ECs may have implications for the treatment of neutrophil-mediated inflammatory diseases.
JOURNAL OF AUTOIMMUNITY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Julie Gavard
Summary: Researchers have discovered that migrasomes, enigmatic organelles with a pomegranate-like shape, release a unique type of lipid-bilayer membrane vesicles called migrasome-derived nanoparticles (MDNP). These MDNPs can be generated through both rupture and budding of migrasomes, unloading their content in the microenvironment. Migrasomes have been linked to various cellular functions, including intercellular communication and disposal of damaged cellular materials.
Article
Medicine, General & Internal
Irene Marcilla-Toribio, Maria Martinez-Andres, Maria Leopolda Moratalla-Cebrian, Ravi Jandhyala, Omolade Femi-Ajao, Eva Maria Galan-Moya
Summary: This study translated and validated a specific Quality of Life instrument for long COVID-19 patients into Spanish, providing a valid tool for objectively measuring the quality of life in this population. The results showed high internal consistency and reliability of the questionnaire, confirming its suitability for assessing the quality of life in long COVID-19 patients.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Review
Pharmacology & Pharmacy
Maria del Mar Noblejas-Lopez, David Tebar-Garcia, Raquel Lopez-Rosa, Ana Alcaraz-Sanabria, Pablo Cristobal-Cueto, Alejandro Pinedo-Serrano, Lorenzo Rivas-Garcia, Eva M. Galan-Moya
Summary: Targeted protein degradation is an alternative therapy for cancer, providing advantages over traditional inhibitors. This review focuses on the current trends in using TAC-based technologies for drug development and clinical applications.
Article
Biology
Clotilde C. N. Renaud, Kilian Trillet, Jane Jardine, Laura Merlet, Ophelie Renoult, Melanie Laurent-Blond, Zoe Catinaud, Claire Pecqueur, Julie Gavard, Nicolas Bidere
Summary: By studying a non-ciliary T-cell line, we found that CEP131 participates in tubulin glycylation and polyglutamylation, as well as microtubule regrowth. It also plays a role in mitochondrial morphology and apoptosis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Oncology
Miguel Burgos, Ivan Cavero-Redondo, Celia Alvarez-Bueno, Eva Maria Galan-Moya, Atanasio Pandiella, Eitan Amir, Alberto Ocana
Summary: High expression of CEACAM6 is correlated with worse overall survival and disease-free survival in cancer patients, with subgroup analysis showing no significant differences between different tumor types.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Cell Biology
Ke Mi, Lizhong Zeng, Yang Chen, Jingya Ning, Siyuan Zhang, Peilin Zhao, Shuanying Yang
Summary: In this study, the researchers explored the role of DHX38 in NSCLC and its underlying molecular mechanism. They found that DHX38 was overexpressed in NSCLC and patients with high DHX38 expression had poor prognosis. DHX38 promoted cell proliferation, migration, and invasion in NSCLC and activated the MAPK pathway. The researchers also identified G3BP1 as a target protein that interacted with DHX38 and showed that DHX38 regulated the expression of G3BP1. Silencing G3BP1 reversed the effects of DHX38 overexpression on tumor cell proliferation, migration, and invasion and inhibited the MAPK pathway activation.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Tiina A. Jokela, Mark A. Dane, Rebecca L. Smith, Kaylyn L. Devlin, Sundus Shalabi, Jennifer C. Lopez, Masaru Miyano, Martha R. Stampfer, James E. Korkola, Joe W. Gray, Laura M. Heiser, Mark A. Labarge
Summary: Microenvironment signals have a significant impact on cell fate and tissue homeostasis. Understanding how different microenvironment factors regulate cellular phenotype has been challenging. In this study, a high-throughput microenvironment microarray was used to identify factors that support the proliferation and maintenance of primary human mammary luminal epithelial cells. Multiple factors that modulate luminal cell number were identified and their effects were confirmed using RNA sequencing and cell-based functional studies. Hepatocyte growth factor (HGF) was found to be robust to individual variation and played a role in expanding luminal cells. Our approach demonstrates the power of high-dimensional cell-based approaches in dissecting microenvironmental signals.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chao He, Yongfeng Ding, Yan Yang, Gang Che, Fei Teng, Haohao Wang, Jing Zhang, Donghui Zhou, Yanyan Chen, Zhan Zhou, Haiyong Wang, Lisong Teng
Summary: This study categorized gastric cancer patients into three stemness subtypes, each demonstrating distinct prognoses, components of tumor microenvironment (TME) infiltration, and varying sensitivity or resistance to treatment. A stemness risk model was constructed to predict treatment response and prognosis.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haile Zhao, Lijuan Feng, Rui Cheng, Man Wu, Xiaozhou Bai, Lifei Fan, Yaping Liu
Summary: miR-29c-3p is overexpressed in benign and malignant ovarian carcinoma and is associated with poor prognosis. Its overexpression modulates tumorigenesis in ovarian cancer cells, including epithelial-mesenchymal transition, proliferation, migration, and invasion, through the regulation of DNMT3A, TET1, and HBP1. miR-29c-3p may serve as a potential biomarker for clinical diagnosis or co-diagnosis of ovarian carcinoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Haiyan Zhao, Fangfang Bi, Mengyuan Li, Yuhan Diao, Chen Zhang
Summary: This study confirmed the tumor suppressor effect of RNF180 on ovarian cancer, elucidated the mechanism of the molecule network related to RNF180 and IPO4 in ovarian cancer, and identified a new therapeutic target for ovarian cancer.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chu Chen, Guanhua Xu, Jiajia Chen, Chunshuai Wu, Jinlong Zhang, Jiawei Jiang, Hongxiang Hong, Zhiming Cui
Summary: This study investigated the role of transcription factor FoxO1 in facet joint osteoarthritis (FJOA) and found that FoxO1 deletion led to severe osteoarthritic changes. Transcriptome sequencing and bioinformatics analysis identified differentially expressed genes (DEGs) and potential key contributors to FJOA. Additionally, over-expression of certain genes and inhibition of others were shown to counteract the impairments caused by FoxO1 deletion in chondrocyte migration and extracellular matrix synthesis. These findings help unravel the molecular mechanisms underlying FJOA and open up promising therapeutic avenues for its treatment.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Wen Deng, Ru Chen, Situ Xiong, Jianqiang Nie, Hailang Yang, Ming Jiang, Bing Hu, Xiaoqiang Liu, Bin Fu
Summary: This study demonstrates that circFSCN1 is upregulated in bladder cancer and associated with cancer-specific survival. CircFSCN1 promotes tumor progression and epithelial-mesenchymal transition in bladder cancer through enhancing MDM2-mediated silencing of p53 by sponging miR-145-5p.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Jun Wu, Weibin Hu, Wenhui Yang, Yihao Long, Kaizhao Chen, Fugui Li, Xiaodong Ma, Xun Li
Summary: Cholesterol biosynthesis and metabolism play critical roles in tumor development and microenvironmental conditions. Squalene Epoxidase (SQLE), the second rate-limiting enzyme in cholesterol synthesis, is found to be uniquely expressed in various cancers, and its expression level is closely associated with tumor mutation burden and microsatellite instability. SQLE expression is negatively correlated with immune cell infiltration. Inhibition of SQLE alters the immune response in the tumor microenvironment. Furthermore, protein metabolism and translation are identified as main binding factors with SQLE.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhihong Zhang, Mingyue Li, Yi Tai, Yue Xing, Hongxiang Zuo, Xuejun Jin, Juan Ma
Summary: ZNF70 plays an important role in colitis-associated colorectal cancer (CAC) by regulating macrophages IL-1 beta secretion to promote HCT116 proliferation. It may serve as a promising target for treating CAC.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zenghong Wu, Gangping Li, Weijun Wang, Kun Zhang, Mengke Fan, Yu Jin, Rong Lin
Summary: This study comprehensively explored the role of immune checkpoints and tumor microenvironment in gastric cancer patients based on genomic data. It constructed an ICIs signature and ICI score to evaluate patient prognosis and heterogeneity.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Yantong Wan, Jieshu Zhou, Panpan Zhang, Xuemei Lin, Hao Li
Summary: This study found that Rac1 plays a role in astrocyte activation and attenuates chronic inflammatory pain by blocking the phosphorylation of NLRP3 inflammasome and NF-kappa B.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Zhen Wang, Diankun She, Lei Liu, Xianming Hua, Hao Zhu, Lingfeng Yu, Han Wang, Yan Zhu, Gentao Fan, Yicun Wang, Meng Xu, Guangxin Zhou
Summary: Circular RNAs (circRNAs) are non-coding RNAs that play a role in the regulation of various cancers, including osteosarcoma (OS). This study identified circSATB2 as a highly expressed circRNA in OS tissues and cell lines, and demonstrated its involvement in promoting OS proliferation and migration. Mechanistically, circSATB2 was found to regulate the progression of OS by sponging miR-661 and FUS to regulate ZNFX1 mRNA. These findings suggest that circSATB2 could serve as a prognostic marker and therapeutic target for osteosarcoma.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Kenichi Ogata, Masafumi Moriyama, Tatsuya Kawado, Hiroki Yoshioka, Aiko Yano, Mayu Matsumura-Kawashima, Seiji Nakamura, Shintaro Kawano
Summary: This study found that extracellular vesicles released by induced pluripotent stem cells can reduce inflammatory cell infiltration, increase saliva volume, and decrease the production of antibodies associated with Sjogren's syndrome in a mouse model. The let-7 family in these vesicles may suppress the expression of TLR4 and NF-kappa B, which leads to the inhibition of pro-inflammatory cytokine production through the MAPK pathway.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Mikayla R. Erdelsky, Sarah A. Groves, Charmi Shah, Samantha B. Delios, M. Bibiana Umana, Donald H. Maurice
Summary: Recent evidence suggests that cAMP signaling within the primary cilium plays a crucial role in promoting adipogenic differentiation of 3T3-L1 preadipocytes. In this study, the researchers identified the specific cAMP phosphodiesterases expressed by these cells and found that inhibition of PDE4 promotes FFAR4-mediated adipogenesis. This work could potentially lead to the discovery of more targeted therapeutic approaches for controlling adipogenesis and differentiation of other stem cells.
CELLULAR SIGNALLING
(2024)
Article
Cell Biology
Chun-Hui Liu, Jun-Jie Zhang, Qian-Jin Zhang, Yang Dong, Zhen-Duo Shi, Si-Hao Hong, Hou-Guang He, Wei Wu, Cong-Hui Han, Lin Hao
Summary: Bladder cancer, the most common malignant tumor in the urinary system, is associated with significantly up-regulated expression of P3H4, which is regulated by METTL3 and plays a crucial role in the proliferation, metastasis, and EMT progression of bladder cancer. Targeting this METTL3-P3H4 pathway may serve as a potential therapeutic strategy for bladder cancer.
CELLULAR SIGNALLING
(2024)
