☆ 4.5 Article

Kupffer cells support extramedullary erythropoiesis induced by nitrogen-containing bisphosphonate in splenectomized mice

CELLULAR IMMUNOLOGY (2011)

期刊

CELLULAR IMMUNOLOGY

卷 271, 期 1, 页码 197-204

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE

DOI: 10.1016/j.cellimm.2011.06.025

关键词

Nitrogen-containing bisphosphonate (NBP); Kupffer cell; Extramedullary erythropoiesis

类别

Cell Biology Immunology

资金

Ministry of Education, Culture, Sports, Science and Technology of Japan [21592342, 20592148]
High-Tech Research Center from Ministry of Education, Culture, Sports, Science and Technology, Japan

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摘要

Our previous study indicated that injecting nitrogen-containing bisphosphonate (NBP) induced the site of erythropoiesis to shift from the bone marrow (BM) to the spleen. This was due to the depletion of BM-resident macrophages, which support erythropoiesis. In this study, we examined NBP treatment-induced extramedullary hematopoiesis in splenectomized mice, focusing on hepatic hematopoiesis. NBP-treated mice did not display anemia or significant change in erythropoietin production, while megakaryopoiesis and erythropoiesis were constantly observed in the liver. Erythroblastic islands were detected in the sinusoidal lumen. Kupffer cells expressed VCAM-1 following NBP treatment, which is an important factor for erythroblast differentiation. Cl2MBP-liposome treatment depleted the erythroblastic islands, and decreased the number of hematopoietic cells in the liver, as determined by colony forming assays. Together, these results indicate that Kupffer cells support erythropoiesis, acting as stromal cells in the liver, and that they might act as a niche for hematopoietic precursor cells in an emergency. (C) 2011 Elsevier Inc. All rights reserved.

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