Cell death controlling complexes and their potential therapeutic role

Role of Apoptosis in disease

(2016) B. Favaloro et al.   Aging-US

RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1α-mediated mitochondrial oxidative phosphorylation and glycolysis

(2014) W Chen et al.   CELL DEATH AND DIFFERENTIATION

Delay in Apoptosome Formation Attenuates Apoptosis in Mouse Embryonic Stem Cell Differentiation

(2014) Shiva Akbari-Birgani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

(2014) Huayi Wang et al.   MOLECULAR CELL

Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis

(2014) S. M. Kallenberger et al.   Science Signaling

Molecular mechanisms of regulated necrosis

(2014) Lorenzo Galluzzi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis

(2014) Q Remijsen et al.   Cell Death & Disease

Systems biology of death receptor networks: live and let die

(2014) I N Lavrik   Cell Death & Disease

MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

(2014) Yves Dondelinger et al.   Cell Reports

Control of Life-or-Death Decisions by RIP1 Kinase

(2013) Dana E Christofferson et al.   Annual Review of Physiology

Changes in Apaf-1 Conformation That Drive Apoptosome Assembly

(2013) Shujun Yuan et al.   BIOCHEMISTRY

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

The role of necroptosis, an alternative form of cell death, in cancer therapy

(2013) Xinfang Yu et al.   Expert Review of Anticancer Therapy

Tango7 directs cellular remodeling by the Drosophila apoptosome

(2013) A. D'Brot et al.   GENES & DEVELOPMENT

RIP3: a molecular switch for necrosis and inflammation

(2013) K. Moriwaki et al.   GENES & DEVELOPMENT

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Proteolytic Processing of the Caspase-9 Zymogen Is Required for Apoptosome-mediated Activation of Caspase-9

(2013) Qi Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fas/CD95-Induced Chemokines Can Serve as “Find-Me” Signals for Apoptotic Cells

(2013) Sean P. Cullen et al.   MOLECULAR CELL

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling

(2013) Tamas Sessler et al.   PHARMACOLOGY & THERAPEUTICS

A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53

(2013) M. Kurokawa et al.   Science Signaling

Apoptosome Structure, Assembly, and Procaspase Activation

(2013) Shujun Yuan et al.   STRUCTURE

TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

(2013) D M Moujalled et al.   Cell Death & Disease

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability

(2012) Sungwoon Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apoptosome-dependent caspase activation proteins as prognostic markers in Stage II and III colorectal cancer

(2012) S Hector et al.   BRITISH JOURNAL OF CANCER

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Pick your poison: The Ripoptosome, a cell death platform regulating apoptosis and necroptosis

(2012) Maria Feoktistova et al.   CELL CYCLE

A molecular view on signal transduction by the apoptosome

(2012) Thomas F. Reubold et al.   CELLULAR SIGNALLING

Caspase-2 is an initiator caspase responsible for pore-forming toxin-mediated apoptosis

(2012) Gergely Imre et al.   EMBO JOURNAL

The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome

(2012) Maximilian L. Würstle et al.   EXPERIMENTAL CELL RESEARCH

The ‘complexities’ of life and death: Death receptor signalling platforms

(2012) Laura S. Dickens et al.   EXPERIMENTAL CELL RESEARCH

Cellular FLICE-like inhibitory proteins (c-FLIPs): Fine-tuners of life and death decisions

(2012) Selcen Öztürk et al.   EXPERIMENTAL CELL RESEARCH

Beyond apoptosis: caspase regulatory mechanisms and functions in vivo

(2012) Erina Kuranaga   GENES TO CELLS

Control of innate and adaptive immunity by the inflammasome

(2012) Ceren Ciraci et al.   MICROBES AND INFECTION

PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

(2012) Kiyohiro Ando et al.   MOLECULAR CELL

A Death Effector Domain Chain DISC Model Reveals a Crucial Role for Caspase-8 Chain Assembly in Mediating Apoptotic Cell Death

(2012) Laura S. Dickens et al.   MOLECULAR CELL

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

(2012) Kolja Schleich et al.   MOLECULAR CELL

Rapid engraftment of human ALL in NOD/SCID mice involves deficient apoptosis signaling

(2012) M Queudeville et al.   Cell Death & Disease

FLIPLinduces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity

(2011) Cristina Pop et al.   BIOCHEMICAL JOURNAL

Regulation of CD95/Fas signaling at the DISC

(2011) I N Lavrik et al.   CELL DEATH AND DIFFERENTIATION

The PIDDosome, DNA-damage-induced apoptosis and beyond

(2011) S Janssens et al.   CELL DEATH AND DIFFERENTIATION

Cytochrome c: the Achilles’ heel in apoptosis

(2011) A. V. Kulikov et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs

(2011) Tencho Tenev et al.   MOLECULAR CELL

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

(2011) Shujun Yuan et al.   STRUCTURE

TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members

(2011) N Vanlangenakker et al.   Cell Death & Disease

In vitro reconstitution of the interactions in the PIDDosome

(2010) Tae-ho Jang et al.   APOPTOSIS

Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL

(2010) Nicolai Fricker et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure of an Apoptosome-Procaspase-9 CARD Complex

(2010) Shujun Yuan et al.   STRUCTURE

DNA damage- and stress-induced apoptosis occurs independently of PIDD

(2009) Ira R. Kim et al.   APOPTOSIS

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

TRAIL receptor targeting therapies for non-small cell lung cancer: Current status and perspectives

(2009) J.H. Stegehuis et al.   DRUG RESISTANCE UPDATES

The Apaf-1•procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer

(2009) Srinivas Malladi et al.   EMBO JOURNAL

Caspase-2 activation in the absence of PIDDosome formation

(2009) Claudia Manzl et al.   JOURNAL OF CELL BIOLOGY

Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment

(2009) Peter Geserick et al.   JOURNAL OF CELL BIOLOGY

The mitochondrial death pathway: a promising therapeutic target in diseases

(2009) Sanjeev Gupta et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A New C-Terminal Cleavage Product of Procaspase-8, p30, Defines an Alternative Pathway of Procaspase-8 Activation

(2009) J. C. Hoffmann et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of Cytoplasmic Caspase-2 Activation by Induced Proximity

(2009) Lisa Bouchier-Hayes et al.   MOLECULAR CELL

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

(2009) Lorraine A. O’ Reilly et al.   NATURE

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

CD95 Stimulation Results in the Formation of a Novel Death Effector Domain Protein-containing Complex

(2008) Inna N. Lavrik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology