Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

The role of TLR2, TLR4 and CD36 in macrophage activation and foam cell formation in response to oxLDL in humans

(2014) Luis Chávez-Sánchez et al.   HUMAN IMMUNOLOGY

Selective Antibody Intervention of Toll-like Receptor 4 Activation through Fc γ Receptor Tethering

(2014) Limin Shang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hsp70 Translocates into the Plasma Membrane after Stress and Is Released into the Extracellular Environment in a Membrane-Associated Form that Activates Macrophages

(2014) V. L. Vega et al.   JOURNAL OF IMMUNOLOGY

CD44 Suppresses TLR-Mediated Inflammation

(2014) H. Kawana et al.   JOURNAL OF IMMUNOLOGY

Role of Human CD36 in Bacterial Recognition, Phagocytosis, and Pathogen-Induced JNK-Mediated Signaling

(2014) I. N. Baranova et al.   JOURNAL OF IMMUNOLOGY

Biological role of Toll-like receptor-4 in the brain

(2014) Teresa Trotta et al.   JOURNAL OF NEUROIMMUNOLOGY

Membrane raft association is a determinant of plasma membrane localization

(2014) B. B. Diaz-Rohrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages

(2013) Junfei Jin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Multimolecular Signaling Complexes Enable Syk-Mediated Signaling of CD36 Internalization

(2013) Bryan Heit et al.   DEVELOPMENTAL CELL

An interplay between scavenger receptor A and CD14 during activation of J774 cells by high concentrations of LPS

(2013) Maciej Czerkies et al.   IMMUNOBIOLOGY

CD14 Mediates Binding of High Doses of LPS but Is Dispensable for TNF-αProduction

(2013) Kinga Borzęcka et al.   MEDIATORS OF INFLAMMATION

Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14

(2013) Sachiko Watanabe et al.   PLoS One

Hyaluronic Acid Oligosaccharides Suppress TLR3-Dependent Cytokine Expression in a TLR4-Dependent Manner

(2013) Margaret Y. Kim et al.   PLoS One

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Effects of Membrane Trafficking on Signaling by Receptor Tyrosine Kinases

(2013) M. Miaczynska   Cold Spring Harbor Perspectives in Biology

Role of CD14 in host protection against infections and in metabolism regulation

(2013) Ivan Zanoni et al.   Frontiers in Cellular and Infection Microbiology

Alarmins, inflammasomes and immunity

(2013) DavidM Ojcius et al.   Biomedical Journal

Bruton’s Tyrosine Kinase Mediates FcγRIIa/Toll-Like Receptor–4 Receptor Crosstalk in Human Neutrophils

(2012) Agnieszka Krupa et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Scavenger receptor A (SR-A) is required for LPS-induced TLR4 mediated NF-κB activation in macrophages

(2012) Honghui Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Functions of the Lyn tyrosine kinase in health and disease

(2012) Evan Ingley   Cell Communication and Signaling

Polarized sorting and trafficking in epithelial cells

(2012) Xinwang Cao et al.   CELL RESEARCH

Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM–TRIF-dependent signaling pathway

(2012) Yanyan Wang et al.   CELLULAR IMMUNOLOGY

Intact rough- and smooth-form lipopolysaccharides fromEscherichia coliseparated by preparative gel electrophoresis exhibit differential biologic activity in human macrophages

(2012) Elder Pupo et al.   FEBS Journal

Oxidized LDLs Inhibit TLR-induced IL-10 Production by Monocytes: A New Aspect of Pathogen-Accelerated Atherosclerosis

(2012) Małgorzata Bzowska et al.   INFLAMMATION

Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells

(2012) Martin Avila et al.   Innate Immunity

TRAF6 Protein Couples Toll-like Receptor 4 Signaling to Src Family Kinase Activation and Opening of Paracellular Pathway in Human Lung Microvascular Endothelia

(2012) Anguo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitoylation of MPP1 (Membrane-palmitoylated Protein 1)/p55 Is Crucial for Lateral Membrane Organization in Erythroid Cells

(2012) Agnieszka Łach et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-like Receptor Agonists and Febrile Range Hyperthermia Synergize to Induce Heat Shock Protein 70 Expression and Extracellular Release

(2012) Aditi Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate and Lipopolysaccharide Trigger Synergistic Ceramide Production in Primary Macrophages

(2012) Joel D. Schilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice

(2012) Ivan Zanoni et al.   JOURNAL OF CLINICAL INVESTIGATION

The Crystal Structure of Human Soluble CD14 Reveals a Bent Solenoid with a Hydrophobic Amino-Terminal Pocket

(2012) S. L. Kelley et al.   JOURNAL OF IMMUNOLOGY

Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways

(2012) Shurong Huang et al.   JOURNAL OF LIPID RESEARCH

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

(2012) Erdinc Sezgin et al.   Nature Protocols

Receptor-Independent Interaction of Bacterial Lipopolysaccharide with Lipid and Lymphocyte Membranes; the Role of Cholesterol

(2012) Filip Ciesielski et al.   PLoS One

Lipid Lateral Organization on Giant Unilamellar Vesicles Containing Lipopolysaccharides

(2011) Jakubs Kubiak et al.   BIOPHYSICAL JOURNAL

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

LPS-Induced Formation of Immunoproteasomes: TNF-α and Nitric Oxide Production are Regulated by Altered Composition of Proteasome-Active Sites

(2011) Julia Reis et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Cell surface ceramide controls translocation of transferrin receptor to clathrin-coated pits

(2011) Abo Bakr Abdel Shakor et al.   CELLULAR SIGNALLING

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Similarities and differences of innate immune responses elicited by smooth and rough LPS

(2011) Ivan Zanoni et al.   IMMUNOLOGY LETTERS

Endotoxin·albumin complexes transfer endotoxin monomers to MD-2 resulting in activation of TLR4

(2011) Gregory A Esparza et al.   Innate Immunity

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase Cγ-2 and Intracellular Calcium Are Required for Lipopolysaccharide-induced Toll-like Receptor 4 (TLR4) Endocytosis and Interferon Regulatory Factor 3 (IRF3) Activation

(2011) Chih-Yuan Chiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPS induces phosphorylation of actin-regulatory proteins leading to actin reassembly and macrophage motility

(2011) Galyna Kleveta et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Class B Scavenger Receptor Types I and II and CD36 Mediate Bacterial Recognition and Proinflammatory Signaling Induced by Escherichia coli, Lipopolysaccharide, and Cytosolic Chaperonin 60

(2011) I. N. Baranova et al.   JOURNAL OF IMMUNOLOGY

Hck Tyrosine Kinase Regulates TLR4-Induced TNF and IL-6 Production via AP-1

(2011) M. J. Smolinska et al.   JOURNAL OF IMMUNOLOGY

Myeloid Differentiation Factor-2 Interacts with Lyn Kinase and Is Tyrosine Phosphorylated Following Lipopolysaccharide-Induced Activation of the TLR4 Signaling Pathway

(2011) Pearl Gray et al.   JOURNAL OF IMMUNOLOGY

Raft domains of variable properties and compositions in plasma membrane vesicles

(2011) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury

(2010) Satish Gowda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Spontaneous insertion of lipopolysaccharide into lipid membranes from aqueous solution

(2010) Jahangir Md. Alam et al.   CHEMISTRY AND PHYSICS OF LIPIDS

The Rab11a GTPase Controls Toll-like Receptor 4-Induced Activation of Interferon Regulatory Factor-3 on Phagosomes

(2010) Harald Husebye et al.   IMMUNITY

Lipopolysaccharide induces raft domain expansion in membrane composed of a phospholipid-cholesterol-sphingomyelin ternary system

(2010) Kaoru Nomura et al.   Innate Immunity

Studies on the Role of Acid Sphingomyelinase and Ceramide in the Regulation of Tumor Necrosis Factor α (TNFα)-converting Enzyme Activity and TNFα Secretion in Macrophages

(2010) Krasimira A. Rozenova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling

(2010) P. Otahal et al.   JOURNAL OF IMMUNOLOGY

Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF-  Production Induced by Lipopolysaccharide

(2010) S. Jozefowski et al.   JOURNAL OF IMMUNOLOGY

Activation of Murine Macrophages via TLR2 and TLR4 Is Negatively Regulated by a Lyn/PI3K Module and Promoted by SHIP1

(2010) S. Keck et al.   JOURNAL OF IMMUNOLOGY

New Insights into the Regulation of Signalling by Toll-Like Receptors and Nod-Like Receptors

(2010) Rebecca C. Coll et al.   Journal of Innate Immunity

Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol

(2010) Xuewei Zhu et al.   JOURNAL OF LIPID RESEARCH

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Themis2/ICB1 Is a Signaling Scaffold That Selectively Regulates Macrophage Toll-Like Receptor Signaling and Cytokine Production

(2010) Matthew J. Peirce et al.   PLoS One

Palmitoylation regulates raft affinity for the majority of integral raft proteins

(2010) I. Levental et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Impaired Cd14 and Cd36 Expression, Bacterial Clearance, and Toll-Like Receptor 4-Myd88 Signaling in Caveolin-1-Deleted Macrophages and Mice

(2010) Tsung-Huang Tsai et al.   SHOCK

Toll like receptor 4 in atherosclerosis and plaque destabilization

(2009) Wijnand K. den Dekker et al.   ATHEROSCLEROSIS

Src-mediated regulation of inflammatory responses by actin polymerization

(2009) Joo Young Kim et al.   BIOCHEMICAL PHARMACOLOGY

Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice

(2009) Jing Liu et al.   CIRCULATION RESEARCH

Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids

(2009) Delphine Milhas et al.   FEBS LETTERS

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

(2009) Jin Young Kang et al.   IMMUNITY

Multiple roles of Lyn kinase in myeloid cell signaling and function

(2009) Patrizia Scapini et al.   IMMUNOLOGICAL REVIEWS

Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner

(2009) Scott W. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Roles of Hydrophobic Residues in Both MD-2 and Toll-like Receptor 4 in Activation by Endotoxin

(2009) Nuša Resman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Inhibitory Fc IIb Receptor Dampens TLR4-Mediated Immune Responses and Is Selectively Up-regulated on Dendritic Cells from Rheumatoid Arthritis Patients with Quiescent Disease

(2009) M. H. Wenink et al.   JOURNAL OF IMMUNOLOGY

Tetraspanin CD9 Negatively Regulates Lipopolysaccharide-Induced Macrophage Activation and Lung Inflammation

(2009) Mayumi Suzuki et al.   JOURNAL OF IMMUNOLOGY

Heat shock proteins and immune system

(2009) Min-Fu Tsan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Engagement of CD44 by hyaluronan suppresses TLR4 signaling and the septic response to LPS

(2009) Jun Muto et al.   MOLECULAR IMMUNOLOGY

CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation

(2009) Ivan Zanoni et al.   NATURE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer

(2009) L. A. J. O'Neill et al.   PHARMACOLOGICAL REVIEWS

Order of lipid phases in model and plasma membranes

(2009) H.-J. Kaiser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Talk between TLR4 and FcγReceptorIII (CD16) Pathways

(2009) Daniel Rittirsch et al.   PLoS Pathogens

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

(2008) Tiruneh K. Hailemariam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

(2008) Natsuko Tanimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

TLR4 Signaling Is Coupled to SRC Family Kinase Activation, Tyrosine Phosphorylation of Zonula Adherens Proteins, and Opening of the Paracellular Pathway in Human Lung Microvascular Endothelia

(2008) Ping Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Cellular Free Cholesterol in Macrophage-specificAbca1Knock-out Mice Enhances Pro-inflammatory Response of Macrophages

(2008) Xuewei Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of corneal inflammation by liposomal delivery of short-chain, C-6 ceramide

(2008) Y. Sun et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Quantitative Proteomics Analysis of Macrophage Rafts Reveals Compartmentalized Activation of the Proteasome and of Proteasome-mediated ERK Activation in Response to Lipopolysaccharide

(2008) Suraj Dhungana et al.   MOLECULAR & CELLULAR PROTEOMICS

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Plasma membranes are poised for activation of raft phase coalescence at physiological temperature

(2008) D. Lingwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemokine receptor 4 (CXCR4) is part of the lipopolysaccharide “sensing apparatus”

(2007) Martha Triantafilou et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Chemical inhibition of Src family kinases affects major LPS-activated pathways in primary human macrophages

(2007) Maria J. Smolinska et al.   MOLECULAR IMMUNOLOGY