Review
Immunology
Ziqiang Shuai, Shuang Zheng, Kang Wang, Jian Wang, Patrick S. C. Leung, Bin Xu
Summary: Researchers are actively exploring new approaches to treat rheumatoid arthritis through methods such as stem cell transplantation, tolerogenic dendritic cells, and antigen-based tolerogenic vaccines. Current clinical trials show promising results in terms of safety and effectiveness in restoring immune balance and improving symptoms through stem cell transplantation and tolerogenic dendritic cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Han Qiao, Jingtian Mei, Kai Yuan, Kai Zhang, Feng Zhou, Tingting Tang, Jie Zhao
Summary: This study reveals the crucial roles of zinc and oxygen homeostasis in dendritic cells (DCs) during the immune progression of rheumatoid arthritis (RA). It proposes a DC-targeting immune-regulating strategy using ZnO2/Catalase@liposome-Mannose nanoparticles (ZnCM NPs) to induce the transformation of immunogenic DCs (igDCs) into tolerogenic DCs (tDCs) and inhibit T-cell activation. The study demonstrates the promising potential of DC-targeting nanoplatforms in RA treatment and provides insights into ion homeostasis regulation for immune diseases.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Xiufang Wan, Lunmin Bao, Guilan Ma, Tiaoyu Long, Honghong Li, Yundong Zhang, Hongmei Jiang
Summary: Tolerogenic dendritic cells (tolDCs) have the potential to treat rheumatoid arthritis (RA) by inducing immune tolerance. This study found that tolDCs formed microchimerism in rats with collagen-induced arthritis (CIA) and had an effect on the expression of immune checkpoint molecules.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Yu-Meng Zhang, Jian Shen, Jun-Ming Zhao, Jian Guan, Xin-Rui Wei, Dong-Yu Miao, Wei Li, Yi-Cheng Xie, Yu-Qing Zhao
Summary: Cedrol (CE) derived from ginger demonstrates efficacy in ameliorating rheumatoid arthritis through anti-inflammatory and immunological enhancement effects. The mechanism of CE involves inhibition of JAK3 protein phosphorylation, leading to reduced secretion of pro-inflammatory cytokines and inflammation mediators. Pharmacokinetic results show varying absolute bioavailability of CE at different dosages, indicating its potential for further application.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Rheumatology
Achilleas Floudas, Conor M. Smith, Orla Tynan, Nuno Neto, Vinod Krishna, Sarah M. Wade, Megan Hanlon, Clare Cunningham, Viviana Marzaioli, Mary Canavan, Jean M. Fletcher, Ronan H. Mullan, Suzanne Cole, Ling-Yang Hao, Michael G. Monaghan, Sunil Nagpal, Douglas J. Veale, Ursula Fearon
Summary: This study provides a global transcriptomic analysis of the synovial joints in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), revealing the immune-stromal cell interactions in synovial inflammation. The findings highlight the differential transcription profiles and interactions between cell subsets in RA and PsA, suggesting potential targets for targeted therapeutic intervention in these diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Katarina Barbaric Starcevic, Nina Lukac, Mislav Jelic, Alan Sucur, Danka Grcevic, Natasa Kovacic
Summary: This study analyzed the cellular composition of synovial tissue from RA and control patients and found higher proportions of lymphocytes and myeloid cells in RA synovial tissue compared to controls. Additionally, there was a decrease in the proportion of CD200(+)CD105(-) cells and an increase in CD200(-)CD105(+) cells in RA synovial tissue. These cell populations were associated with inflammatory activity and could differentiate between RA and control patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Pei He, Fei-Yan Deng, Bing-Hua Wang, Long-Fei Wu, Xu Zhou, Shu-Feng Lei
Summary: The study identified the role of RPN2 gene in T lymphocyte growth and activation, and its involvement in the pathogenesis of rheumatoid arthritis. RPN2 expression was significantly up-regulated in RA patients and may serve as a diagnostic biomarker.
Article
Multidisciplinary Sciences
Qian-Yue Zhang, Xiao-Ping Ye, Zheng Zhou, Chen-Fang Zhu, Rui Li, Ya Fang, Rui-Jia Zhang, Lu Li, Wei Liu, Zheng Wang, Shi-Yang Song, Sang-Yu Lu, Shuang-Xia Zhao, Jian-Nan Lin, Huai-Dong Song
Summary: By using single-cell RNA sequencing, this study reveals the presence of three stromal cell subtypes in the thyroidal microenvironment of Hashimoto's Thyroiditis, which may contribute to the recruitment of inflammatory immune cells. The study provides a deeper insight into the cellular interactions that might prompt the pathogenesis of Hashimoto's Thyroiditis.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Tuo Liang, Jiarui Chen, Guoyong Xu, Zide Zhang, Jiang Xue, Haopeng Zeng, Jie Jiang, Tianyou Chen, Zhaojie Qin, Hao Li, Zhen Ye, Yunfeng Nie, Chong Liu, Xinli Zhan
Summary: The study revealed a relationship among immune-related genes, tumor-infiltrating immune cells, and immune checkpoints in osteosarcoma patients. By establishing a risk scoring system, the prognosis of patients could be predicted, with low-risk patients showing better outcomes with immune checkpoint inhibitor therapy.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Yi-Jin Wu, Sa-Sa Zhang, Qin Yin, Ming Lei, Qi-Hai Wang, Wen -Gang Chen, Ting -Ting Luo, Peng Zhou, Cong-Lan Ji
Summary: This study found that alpha-Mangostin (MG) can alleviate experimental arthritis, inhibit inflammatory polarization of macrophages/monocytes, and regulate PPAR-gamma and SIRT1 signals. The results showed that MG activates SIRT1 expression by binding PPAR-gamma, thereby suppressing inflammatory responses.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Immunology
Yaling Tian, Ping Shi, Yan Zhou, Rui Yuan, Zhicheng Hu, Yan Tan, Guilan Ma, Lei Yang, Hongmei Jiang
Summary: The study successfully constructed tolDCs, and found that they had long-term tolerogenic potential in vivo, which could improve arthritis in CIA rats with different severity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Nutrition & Dietetics
Vugar Azizov, Mario M. Zaiss
Summary: Alcohol consumption can increase the risk of various diseases, but may also reduce the risk of autoimmune diseases. Alcohol affects intestinal barrier integrity and the microbiome, potentially contributing to the development of rheumatoid arthritis.
Article
Immunology
Mohd Shariq, Neha Quadir, Neha Sharma, Jasdeep Singh, Javaid A. Sheikh, Mohd Khubaib, Seyed E. Hasnain, Nasreen Z. Ehtesham
Summary: RipA activates NF kappa B signaling pathway to induce pro-inflammatory cytokine production, inhibits autophagy and apoptosis, promoting intracellular survival and replication of Mycobacterium tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Fang Zhao, Yini He, Zhihao Zhao, Jiarong He, Hong Huang, Kelong Ai, Liang Liu, Xiong Cai
Summary: This review discusses the role of Notch signaling in rheumatoid arthritis (RA) and its relationship with angiogenesis. It also explores potential strategies targeting the Notch signaling to improve the treatment outcomes of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Rheumatology
Leonie Schittenhelm, Jamie Robertson, Arthur G. Pratt, Catharien M. Hilkens, Vicky L. Morrison
Summary: The study found opposing expression patterns of CD11a and CD11b in dendritic cells (DCs) of rheumatoid arthritis (RA) patients, with CD11a reduced and CD11b increased in inflammatory environments. The research demonstrated that CD11b blockade impaired T cell activation in DC-T cell co-cultures, highlighting the potential of DC integrins as novel intervention targets in RA.
Review
Immunology
Ruben L. Smeets, Brigit E. Kersten, Irma Joosten, Charlotte Kaffa, Wynand Alkema, Hans J. P. M. Koenen, Madelon C. Vonk
AUTOIMMUNITY REVIEWS
(2020)
Article
Immunology
S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I Joosten, H. J. P. M. Koenen
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Article
Immunology
Martin Jaeger, Yvette J. E. Sloot, Rob Ter Horst, Xiaojing Chu, Hans J. P. M. Koenen, Valerie A. C. M. Koeken, Simone J. C. F. M. Moorlag, Charlotte J. de Bree, Vera P. Mourits, Heidi Lemmers, Helga Dijkstra, Marco Medici, Antonius E. van Herwaarden, Irma Joosten, Leo A. B. Joosten, Yang Li, Johannes W. A. Smit, Mihai G. Netea, Romana T. Netea-Maier
Summary: The study demonstrates the crucial role of thyroid hormones, specifically T4 and TSH, in regulating the homeostasis of lymphocyte populations, particularly in affecting T cell and B cell populations significantly. Mendelian randomization and genomic analysis further support the link between thyroid hormones and immune responses, highlighting the importance of fT4 in lymphocyte homeostasis.
Article
Endocrinology & Metabolism
Emma J. Kooistra, Aline H. de Nooijer, Wout J. Claassen, Inge Grondman, Nico A. F. Janssen, Mihai G. Netea, Frank L. van de Veerdonk, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers
Summary: In COVID-19 patients requiring mechanical ventilation in the ICU, a higher BMI is not related to a different immunological response, unfavorable respiratory mechanics, or impaired outcome.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Review
Medicine, Research & Experimental
Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries, Hans J. P. M. Koenen
Summary: Aza and DAC show promising potential in alleviating inflammatory disorders and preventing solid organ rejection and GvHD in pre-clinical animal models. Increasing Treg appears to be a common mechanism for preventing inflammatory disorders through Aza/DAC. However, the lack of essential methodological details in reported studies may lead to an overestimation of the true effects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Pieter Langerhorst, Arie B. Brinkman, Martijn M. VanDuijn, Hans J. C. T. Wessels, Patricia J. T. A. Groenen, Irma Joosten, Alain J. van Gool, Jolein Gloerich, Blanca Scheijen, Joannes F. M. Jacobs
Summary: The research demonstrates the use of clonal immunoglobulin gene fingerprints as a suitable MRD target for MS-MRD analyses in patients with MM, offering promising clinical applications.
CLINICAL CHEMISTRY
(2021)
Article
Immunology
Nico A. F. Janssen, Inge Grondman, Aline H. de Nooijer, Collins K. Boahen, Valerie A. C. M. Koeken, Vasiliki Matzaraki, Vinod Kumar, Xuehui He, Matthijs Kox, Hans J. P. M. Koenen, Ruben L. Smeets, Irma Joosten, Roger J. M. Brueggemann, Ilse J. E. Kouijzer, Hans G. van der Hoeven, Jeroen A. Schouten, Tim Frenzel, Monique H. E. Reijers, Wouter Hoefsloot, Anton S. M. Dofferhoff, Marjan J. van Apeldoorn, Marc J. T. Blaauw, Karin Veerman, Coen Maas, Arjan H. Schoneveld, Imo E. Hoefer, Lennie P. G. Derde, Marcel van Deuren, Jos W. M. van der Meer, Reinout van Crevel, Evangelos J. Giamarellos-Bourboulis, Leo A. B. Joosten, Michel M. van den Heuvel, Jacobien Hoogerwerf, Quirijn de Mast, Peter Pickkers, Mihai G. Netea, Frank L. van de Veerdonk
Summary: The study conducted plasma cytokine measurements and proteomics analysis on 147 COVID-19 patients, uncovering a hyperinflammatory innate immune state and potential biomarkers. It revealed T-cell exhaustion in critically ill patients, with intact or hyperresponsive innate immune responses.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Patrick P. G. Mulder, Marcel Vlig, Bouke K. H. L. Boekema, Matthea M. Stoop, Anouk Pijpe, Paul P. M. van Zuijlen, Evelien de Jong, Bram van Cranenbroek, Irma Joosten, Hans J. P. M. Koenen, Magda M. W. Ulrich
Summary: Severe burn injury induces persistent systemic inflammation marked by continuous release of immature neutrophils and shifts in T cell composition toward a more pro-inflammatory phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Wouter A. van der Heijden, Lisa Van de Wijer, Farid Keramati, Wim Trypsteen, Sofie Rutsaert, Rob ter Horst, Martin Jaeger, Hans J. P. M. Koenen, Hendrik G. Stunnenberg, Irma Joosten, Paul E. Verweij, Jan van Lunzen, Charles A. Dinarello, Leo A. B. Joosten, Linos Vandekerckhove, Mihai G. Netea, Andre J. A. M. van der Ven, Quirijn de Mast
Summary: Chronic inflammation and immune dysfunction are important factors in the development of non-AIDS-related comorbidities. The study found that monocytes in PLHIV exhibit an exacerbated proinflammatory profile, potentially leading to long-term HIV complications.
Article
Immunology
Wynand Alkema, Hans Koenen, Brigit E. Kersten, Charlotte Kaffa, Jacqueline W. B. Dinnissen, Jan G. M. C. Damoiseaux, Irma Joosten, Sophie Driessen-Diks, Renate G. van der Molen, Madelon C. Vonk, Ruben L. Smeets
Summary: The study found that 79% of systemic sclerosis (SSc) patients tested positive for one or more SSc-associated autoantibodies. There was high agreement between different diagnostic methods for detecting SSc-specific autoantibodies, but lower agreement for SSc-associated autoantibodies and less prevalent SSc-specific autoantibodies. Further standardization is needed for low prevalent SSc-specific and SSc-associated autoantibodies.
Article
Immunology
Annelieke E. C. A. B. Willemsen, Xuehui He, Bram van Cranenbroek, Paul C. de Jong, Maaike de Boer, Irma Joosten, Hans J. P. M. Koenen, Carla M. L. van Herpen, Winald R. Gerritsen
Summary: This study found that baseline CD4+ effector cells and NKT cells were associated with antitumor response and pulmonary toxicity in breast cancer patients treated with everolimus. The percentage of CD4+ effector cells may predict antitumor responses, while the baseline percentage of NKT cells may predict pulmonary toxicity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Allergy
Yessica A. Rodriguez-Rosales, Jeroen D. Langereis, Mark A. J. Gorris, Juul M. P. A. van den Reek, Esther Fasse, Mihai G. Netea, I. Jolanda M. de Vries, Laia Gomez-Munoz, Bram van Cranenbroek, Andreas Korber, Wiebke Sondermann, Irma Joosten, Elke M. G. J. de Jong, Hans J. P. M. Koenen
Summary: Patients with psoriasis exhibit a distinct neutrophil profile in circulation, with two different subsets present in psoriatic skin, including a subset resembling aged neutrophils. These aged neutrophils display suboptimal functions and induce inflammatory cytokine production by T cells through neutrophil extracellular trap formation. Targeted biological treatment may help to control sustained neutrophil-mediated inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Tuomo Mantere, Kornelia Neveling, Celine Pebrel-Richard, Marion Benoist, Guillaume van der Zande, Ellen Kater-Baats, Imane Baatout, Ronald van Beek, Tony Yammine, Michiel Oorsprong, Faten Hsoumi, Daniel Olde-Weghuis, Wed Majdali, Susan Vermeulen, Marc Pauper, Aziza Lebbar, Marian Stevens-Kroef, Damien Sanlaville, Jean Michel Dupont, Dominique Smeets, Alexander Hoischen, Caroline Schluth-Bolard, Laila El Khattabi
Summary: The study investigated the use of optical genome mapping (OGM) to detect known chromosomal aberrations, with results showing OGM's ability to accurately detect various types of chromosomal abnormalities, including complex rearrangements. High-resolution OGM achieved 100% concordance compared to standard assays for aberrations without centromeric breakpoints.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Genetics & Heredity
Kornelia Neveling, Tuomo Mantere, Susan Vermeulen, Michiel Oorsprong, Ronald van Beek, Ellen Kater-Baats, Marc Pauper, Guillaume van der Zande, Dominique Smeets, Daniel Olde Weghuis, Marian J. P. L. Stevens-Kroef, Alexander Hoischen
Summary: Optical genome mapping (OGM) has shown excellent concordance with diagnostic standard assays in hematological malignancies, demonstrating its potential to replace classical cytogenetic tests and rapidly map novel leukemia drivers for both simple and complex cases.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Cenna Doornbos, Ronald van Beek, Ernie M. H. F. Bongers, Dorien Lugtenberg, Peter. H. M. Klaren, Lisenka E. L. M. Vissers, Ronald Roepman, Machteld M. Oud
Summary: This study developed a robust, standardized approach to accurately diagnose a subset of skeletal ciliopathies. By comparing healthy individuals and patients from three different ciliopathy subgroups, the study illustrated the potential for standardized analysis of cilium phenotypes to discriminate between ciliopathy subgroups.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2021)