Expanding the roles of chromatin insulators in nuclear architecture, chromatin organization and genome function

Characterization of constitutive CTCF/cohesin loci: a possible role in establishing topological domains in mammalian genomes

(2013) Yuanyuan Li et al.   BMC GENOMICS

Poly(ADP-ribosyl)ation Regulates Insulator Function and Intrachromosomal Interactions in Drosophila

(2013) Chin-Tong Ong et al.   CELL

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment

(2013) Jennifer E. Phillips-Cremins et al.   CELL

The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary

(2013) A. A. Soshnev et al.   DEVELOPMENT

Messenger RNA is a functional component of a chromatin insulator complex

(2013) Leah H Matzat et al.   EMBO REPORTS

CTCF mediates theTERTenhancer-promoter interactions in lung cancer cells: Identification of a novel enhancer region involved in the regulation ofTERTgene

(2013) Vegard Eldholm et al.   INTERNATIONAL JOURNAL OF CANCER

Chromatin insulator bodies are nuclear structures that form in response to osmotic stress and cell death

(2013) Todd Schoborg et al.   JOURNAL OF CELL BIOLOGY

Genomic and Proteomic Analyses of Prdm5 Reveal Interactions with Insulator Binding Proteins in Embryonic Stem Cells

(2013) Giorgio Giacomo Galli et al.   MOLECULAR AND CELLULAR BIOLOGY

A Network Model of the Molecular Organization of Chromatin in Drosophila

(2013) Joke G. van Bemmel et al.   MOLECULAR CELL

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

(2013) Scott R. Floyd et al.   NATURE

Functional implications of genome topology

(2013) Giacomo Cavalli et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila

(2013) Su Jun Lim et al.   NUCLEIC ACIDS RESEARCH

Insulator protein Su(Hw) recruits SAGA and Brahma complexes and constitutes part of Origin Recognition Complex-binding sites in the Drosophila genome

(2013) Nadezhda E. Vorobyeva et al.   NUCLEIC ACIDS RESEARCH

Polycomb Domain Formation Depends on Short and Long Distance Regulatory Cues

(2013) Bernd Schuettengruber et al.   PLoS One

High-Resolution Mapping of the Spatial Organization of a Bacterial Chromosome

(2013) T. B. K. Le et al.   SCIENCE

Chromatin and DNA Replication

(2013) D. M. MacAlpine et al.   Cold Spring Harbor Perspectives in Biology

Vertebrate GAGA factor associated insulator elements demarcate homeotic genes in the HOX clusters

(2013) Surabhi Srivastava et al.   Epigenetics & Chromatin

The Compass-like Locus, Exclusive to the Ambulacrarians, Encodes a Chromatin Insulator Binding Protein in the Sea Urchin Embryo

(2013) Vincenzo Cavalieri et al.   PLoS Genetics

Binding of TFIIIC to SINE Elements Controls the Relocation of Activity-Dependent Neuronal Genes to Transcription Factories

(2013) Luca Crepaldi et al.   PLoS Genetics

The Majority of Primate-Specific Regulatory Sequences Are Derived from Transposable Elements

(2013) Pierre-Étienne Jacques et al.   PLoS Genetics

The Drosophila eve Insulator Homie Promotes eve Expression and Protects the Adjacent Gene from Repression by Polycomb Spreading

(2013) Miki Fujioka et al.   PLoS Genetics

Long distance relationships: Enhancer–promoter communication and dynamic gene transcription

(2012) Judith Marsman et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

(2012) Tom Sexton et al.   CELL

Waves of Retrotransposon Expansion Remodel Genome Organization and CTCF Binding in Multiple Mammalian Lineages

(2012) Dominic Schmidt et al.   CELL

ISWI contributes to ArsI insulator function in development of the sea urchin

(2012) M. Yajima et al.   DEVELOPMENT

Mitotic chromosome condensation in vertebrates

(2012) Paola Vagnarelli   EXPERIMENTAL CELL RESEARCH

Nature and function of insulator protein binding sites in the Drosophila genome

(2012) Y. B. Schwartz et al.   GENOME RESEARCH

The BEAF-32 insulator coordinates genome organization and function during the evolution of Drosophila species

(2012) J. Yang et al.   GENOME RESEARCH

Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains

(2012) K. Van Bortle et al.   GENOME RESEARCH

Widespread plasticity in CTCF occupancy linked to DNA methylation

(2012) H. Wang et al.   GENOME RESEARCH

Genome-wide Studies of CCCTC-binding Factor (CTCF) and Cohesin Provide Insight into Chromatin Structure and Regulation: FIGURE 1.

(2012) Bum-Kyu Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUMO conjugation is required for the assembly of Drosophila Su(Hw) and Mod(mdg4) into insulator bodies that facilitate insulator complex formation

(2012) A. Golovnin et al.   JOURNAL OF CELL SCIENCE

CTCF Occupation of the Herpes Simplex Virus 1 Genome Is Disrupted at Early Times Postreactivation in a Transcription-Dependent Manner

(2012) M. K. Ertel et al.   JOURNAL OF VIROLOGY

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains

(2012) Chunhui Hou et al.   MOLECULAR CELL

The long-range interaction landscape of gene promoters

(2012) Amartya Sanyal et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

Architecture of the human regulatory network derived from ENCODE data

(2012) Mark B. Gerstein et al.   NATURE

Genome-wide studies of the multi-zinc finger Drosophila Suppressor of Hairy-wing protein in the ovary

(2012) Alexey A. Soshnev et al.   NUCLEIC ACIDS RESEARCH

The chromatin insulator CTCF and the emergence of metazoan diversity

(2012) P. Heger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FACS Purification and Transcriptome Analysis of Drosophila Neural Stem Cells Reveals a Role for Klumpfuss in Self-Renewal

(2012) Christian Berger et al.   Cell Reports

Systematic Dissection of Roles for Chromatin Regulators in a Yeast Stress Response

(2012) Assaf Weiner et al.   PLOS BIOLOGY

Tissue-Specific Regulation of Chromatin Insulator Function

(2012) Leah H. Matzat et al.   PLoS Genetics

Chromatin is an ancient innovation conserved between Archaea and Eukarya

(2012) Ron Ammar et al.   eLife

Elba, a novel developmentally regulated chromatin boundary factor is a hetero-tripartite DNA binding complex

(2012) Tsutomu Aoki et al.   eLife

Functional analysis of transcription factor binding sites in human promoters

(2012) Troy W Whitfield et al.   GENOME BIOLOGY

Genome-wide identification and characterization of replication origins by deep sequencing

(2012) Jia Xu et al.   GENOME BIOLOGY

Analysis of variation at transcription factor binding sites in Drosophila and humans

(2012) Mikhail Spivakov et al.   GENOME BIOLOGY

Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change

(2011) Ki-Hyeon Seong et al.   CELL

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Insulators form gene loops by interacting with promoters in Drosophila

(2011) M. Erokhin et al.   DEVELOPMENT

The role of the Suppressor of Hairy-wing insulator protein in Drosophila oogenesis

(2011) Ryan M. Baxley et al.   DEVELOPMENTAL BIOLOGY

Human tRNA genes function as chromatin insulators

(2011) Jesse R Raab et al.   EMBO JOURNAL

RNAi-independent role for Argonaute2 in CTCF/CP190 chromatin insulator function

(2011) N. Moshkovich et al.   GENES & DEVELOPMENT

Dioxin receptor and SLUG transcription factors regulate the insulator activity of B1 SINE retrotransposons via an RNA polymerase switch

(2011) A. C. Roman et al.   GENOME RESEARCH

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

(2011) Maria Sideridou et al.   JOURNAL OF CELL BIOLOGY

Specific Sites in the C Terminus of CTCF Interact with the SA2 Subunit of the Cohesin Complex and Are Required for Cohesin-Dependent Insulation Activity

(2011) T. Xiao et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Chromatin Organization and Inducible Gene Expression by a Drosophila Insulator

(2011) Ashley M. Wood et al.   MOLECULAR CELL

Nucleation of nuclear bodies by RNA

(2011) Sergey P. Shevtsov et al.   NATURE CELL BIOLOGY

The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements

(2011) Constance Richter et al.   NATURE CELL BIOLOGY

Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription

(2011) Zhixiong Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Topoisomerase II Modulates Insulator Function in Drosophila

(2011) Edward Ramos et al.   PLoS One

The CCCTC-Binding Factor (CTCF) of Drosophila Contributes to the Regulation of the Ribosomal DNA and Nucleolar Stability

(2011) Paola A. Guerrero et al.   PLoS One

A chromatin insulator driving three-dimensional Polycomb response element (PRE) contacts and Polycomb association with the chromatin fiber

(2011) I. Comet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome Organization by a Nucleoid-Associated Protein in Live Bacteria

(2011) W. Wang et al.   SCIENCE

Coordination of KSHV Latent and Lytic Gene Control by CTCF-Cohesin Mediated Chromosome Conformation

(2011) Hyojeung Kang et al.   PLoS Pathogens

Where splicing joins chromatin

(2011) Jarmila Hnilicová et al.   Nucleus

Cohesin organizes chromatin loops at DNA replication factories

(2010) E. Guillou et al.   GENES & DEVELOPMENT

Conserved nucleosome positioning defines replication origins

(2010) M. L. Eaton et al.   GENES & DEVELOPMENT

The gypsy Insulator of Drosophila melanogaster, Together With Its Binding Protein Suppressor of Hairy-Wing, Facilitate High and Precise Expression of Transgenes in Arabidopsis thaliana

(2010) W. She et al.   GENETICS

A global analysis of C. elegans trans-splicing

(2010) M. A. Allen et al.   GENOME RESEARCH

Vertebrate Homologue of Drosophila GAGA Factor

(2010) Navneet Kaur Matharu et al.   JOURNAL OF MOLECULAR BIOLOGY

Insulators, Not Polycomb Response Elements, Are Required for Long-Range Interactions between Polycomb Targets in Drosophila melanogaster

(2010) H.-B. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

A three-dimensional model of the yeast genome

(2010) Zhijun Duan et al.   NATURE

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

Insulators and promoters: closer than we think

(2010) Jesse R. Raab et al.   NATURE REVIEWS GENETICS

Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus

(2010) John D Cleary et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mapping of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation

(2010) Hideki Tanizawa et al.   NUCLEIC ACIDS RESEARCH

Evaluation and comparison of the insulation efficiency of three enhancer-blocking insulators in plants

(2010) Yazhou Yang et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Cell type specificity of chromatin organization mediated by CTCF and cohesin

(2010) Chunhui Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orphan Nuclear Bodies

(2010) M. Carmo-Fonseca et al.   Cold Spring Harbor Perspectives in Biology

A Comprehensive Map of Insulator Elements for the Drosophila Genome

(2010) Nicolas Nègre et al.   PLoS Genetics

CTCF Prevents the Epigenetic Drift of EBV Latency Promoter Qp

(2010) Italo Tempera et al.   PLoS Pathogens

Loss of the insulator protein CTCF during nematode evolution

(2009) Peter Heger et al.   BMC MOLECULAR BIOLOGY

Chromatin insulators specifically associate with different levels of higher-order chromatin organization in Drosophila

(2009) Heather A. Wallace et al.   CHROMOSOMA

A chromatin insulator mediates transgene homing and very long-range enhancer-promoter communication

(2009) M. Fujioka et al.   DEVELOPMENT

Active promoters and insulators are marked by the centrosomal protein 190

(2009) Marek Bartkuhn et al.   EMBO JOURNAL

Three subclasses of a Drosophila insulator show distinct and cell type-specific genomic distributions

(2009) A. M. Bushey et al.   GENES & DEVELOPMENT

Transcription Independent Insulation at TFIIIC-Dependent Insulators

(2009) L. Valenzuela et al.   GENETICS

Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading

(2009) H. K. MacAlpine et al.   GENOME RESEARCH

The Phylogenetic Distribution of Non-CTCF Insulator Proteins Is Limited to Insects and Reveals that BEAF-32 Is Drosophila Lineage Specific

(2009) Todd A. Schoborg et al.   JOURNAL OF MOLECULAR EVOLUTION

Modulation of Chromatin Boundary Activities by Nucleosome-Remodeling Activities in Drosophila melanogaster

(2009) M. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

A transformation booster sequence (TBS) from Petunia hybrida functions as an enhancer-blocking insulator in Arabidopsis thaliana

(2009) Jean-Michel Hily et al.   PLANT CELL REPORTS

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Cohesin Is Required for Higher-Order Chromatin Conformation at the Imprinted IGF2-H19 Locus

(2009) Raffaella Nativio et al.   PLoS Genetics

Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

(2008) Vania Parelho et al.   CELL

Boundary swapping in the Drosophila Bithorax complex

(2008) C. Iampietro et al.   DEVELOPMENT

Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators

(2008) William Stedman et al.   EMBO JOURNAL

‘Insulator bodies’ are aggregates of proteins but not of insulators

(2008) Anton Golovnin et al.   EMBO REPORTS

Evolution of the mammalian transcription factor binding repertoire via transposable elements

(2008) G. Bourque et al.   GENOME RESEARCH

Global analysis of the insulator binding protein CTCF in chromatin barrier regions reveals demarcation of active and repressive domains

(2008) S. Cuddapah et al.   GENOME RESEARCH

The CTCF Insulator Protein Is Posttranslationally Modified by SUMO

(2008) M. J. MacPherson et al.   MOLECULAR AND CELLULAR BIOLOGY

Cohesin mediates transcriptional insulation by CCCTC-binding factor

(2008) Kerstin S. Wendt et al.   NATURE

DNA methylation landscapes: provocative insights from epigenomics

(2008) Miho M. Suzuki et al.   NATURE REVIEWS GENETICS

Direct Repression of KNOX Loci by the ASYMMETRIC LEAVES1 Complex of Arabidopsis

(2008) M. Guo et al.   PLANT CELL

CTCF-dependent enhancer-blocking by alternative chromatin loop formation

(2008) C. Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CTCF physically links cohesin to chromatin

(2008) E. D. Rubio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BEAF Regulates Cell-Cycle Genes through the Controlled Deposition of H3K9 Methylation Marks into Its Conserved Dual-Core Binding Sites

(2008) Eldon Emberly et al.   PLOS BIOLOGY

The Insulator Binding Protein CTCF Positions 20 Nucleosomes around Its Binding Sites across the Human Genome

(2008) Yutao Fu et al.   PLoS Genetics