Replication initiation and genome instability: a crossroads for DNA and RNA synthesis

Nonstochastic Reprogramming from a Privileged Somatic Cell State

(2014) Shangqin Guo et al.   CELL

UvrD facilitates DNA repair by pulling RNA polymerase backwards

(2014) Vitaly Epshtein et al.   NATURE

Mechanisms for Initiating Cellular DNA Replication

(2013) Alessandro Costa et al.   Annual Review of Biochemistry

Bcl2 Induces DNA Replication Stress by Inhibiting Ribonucleotide Reductase

(2013) M. Xie et al.   CANCER RESEARCH

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSα

(2013) Feng Li et al.   CELL

Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

(2013) Frederick W. Alt et al.   CELL

Role of DNA secondary structures in fragile site breakage along human chromosome 10

(2013) Laura W. Dillon et al.   HUMAN MOLECULAR GENETICS

The Replication Domain Model: Regulating Replicon Firing in the Context of Large-Scale Chromosome Architecture

(2013) Benjamin D. Pope et al.   JOURNAL OF MOLECULAR BIOLOGY

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

(2013) J. Ross Chapman et al.   MOLECULAR CELL

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Topoisomerase 1-Mediated Removal of Ribonucleotides from Nascent Leading-Strand DNA

(2013) Jessica S. Williams et al.   MOLECULAR CELL

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

Organization of the Mitotic Chromosome

(2013) N. Naumova et al.   SCIENCE

Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing

(2013) Satoshi Yamazaki et al.   TRENDS IN GENETICS

Mammalian Transcription-Coupled Excision Repair

(2013) W. Vermeulen et al.   Cold Spring Harbor Perspectives in Biology

Regulating DNA Replication in Eukarya

(2013) K. Siddiqui et al.   Cold Spring Harbor Perspectives in Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Senataxin Plays an Essential Role with DNA Damage Response Proteins in Meiotic Recombination and Gene Silencing

(2013) Olivier J. Becherel et al.   PLoS Genetics

Methylation of Histone H3 on Lysine 79 Associates with a Group of Replication Origins and Helps Limit DNA Replication Once per Cell Cycle

(2013) Haiqing Fu et al.   PLoS Genetics

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

(2013) Adam Leman et al.   Genes

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

The Requirement for Cyclin D Function in Tumor Maintenance

(2012) Yoon Jong Choi et al.   CANCER CELL

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

(2012) Amaya Alzu et al.   CELL

Forkhead Transcription Factors Establish Origin Timing and Long-Range Clustering in S. cerevisiae

(2012) Simon R.V. Knott et al.   CELL

Biology of double-hit B-cell lymphomas

(2012) R. Coleman Lindsley et al.   CURRENT OPINION IN HEMATOLOGY

Regulation of DNA replication during development

(2012) J. Nordman et al.   DEVELOPMENT

Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells

(2012) Daniela Cornacchia et al.   EMBO JOURNAL

R-loops cause replication impairment and genome instability during meiosis

(2012) Maikel Castellano-Pozo et al.   EMBO REPORTS

Rif1 is a global regulator of timing of replication origin firing in fission yeast

(2012) M. Hayano et al.   GENES & DEVELOPMENT

Pathogenesis of follicular lymphoma

(2012) Robert Kridel et al.   JOURNAL OF CLINICAL INVESTIGATION

XPG and XPF Endonucleases Trigger Chromatin Looping and DNA Demethylation for Accurate Expression of Activated Genes

(2012) Nicolas Le May et al.   MOLECULAR CELL

R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters

(2012) Paul A. Ginno et al.   MOLECULAR CELL

R Loops: From Transcription Byproducts to Threats to Genome Stability

(2012) Andrés Aguilera et al.   MOLECULAR CELL

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

(2012) Roland Schmitz et al.   NATURE

3D chromatin conformation correlates with replication timing and is conserved in resting cells

(2012) Benoit Moindrot et al.   NUCLEIC ACIDS RESEARCH

Translocation-Capture Sequencing Reveals the Extent and Nature of Chromosomal Rearrangements in B Lymphocytes

(2011) Isaac A. Klein et al.   CELL

Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells

(2011) Roberto Chiarle et al.   CELL

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

“ORCanization” on heterochromatin: Linking DNA replication initiation to chromatin organization

(2011) Arindam Chakraborty et al.   Epigenetics

The effect of the intra-S-phase checkpoint on origins of replication in human cells

(2011) Neerja Karnani et al.   GENES & DEVELOPMENT

R-loop-mediated genomic instability is caused by impairment of replication fork progression

(2011) W. Gan et al.   GENES & DEVELOPMENT

Chromatin Remodeler Sucrose Nonfermenting 2 Homolog (SNF2H) Is Recruited onto DNA Replication Origins through Interaction with Cdc10 Protein-dependent Transcript 1 (Cdt1) and Promotes Pre-replication Complex Formation

(2011) Nozomi Sugimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

(2011) Shichuan Zhang et al.   JOURNAL OF CELL BIOLOGY

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

Hydroxyurea-induced global transcriptional suppression in mouse ES cells

(2010) Peng Cui et al.   CARCINOGENESIS

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks

(2010) Niraj M. Shanbhag et al.   CELL

To promote and protect: Coordinating DNA replication and transcription for genome stability

(2010) Simon R.V. Knott et al.   Epigenetics

Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription

(2010) L. D. Mesner et al.   GENOME RESEARCH

NER Factors Are Recruited to Active Promoters and Facilitate Chromatin Modification for Transcription in the Absence of Exogenous Genotoxic Attack

(2010) Nicolas Le May et al.   MOLECULAR CELL

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

(2010) Han Liu et al.   NATURE

Genome instability due to ribonucleotide incorporation into DNA

(2010) Stephanie A Nick McElhinny et al.   Nature Chemical Biology

Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes

(2010) Arito Yamane et al.   NATURE IMMUNOLOGY

Evaluating genome-scale approaches to eukaryotic DNA replication

(2010) David M. Gilbert   NATURE REVIEWS GENETICS

Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization

(2010) S. G. Prasanth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interface between transcription and mechanisms maintaining genome integrity

(2010) Jesper Q. Svejstrup   TRENDS IN BIOCHEMICAL SCIENCES

DnaA and ORC: more than DNA replication initiators

(2010) Graham Scholefield et al.   TRENDS IN CELL BIOLOGY

Co-Orientation of Replication and Transcription Preserves Genome Integrity

(2010) Anjana Srivatsan et al.   PLoS Genetics

Genome-wide analysis of the replication program in mammals

(2009) Shlomit Farkash-Amar et al.   CHROMOSOME RESEARCH

Domain-wide regulation of DNA replication timing during mammalian development

(2009) Benjamin D. Pope et al.   CHROMOSOME RESEARCH

Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae

(2009) S. R.V. Knott et al.   GENES & DEVELOPMENT

Genome-wide dynamics of replication timing revealed by in vitro models of mouse embryogenesis

(2009) I. Hiratani et al.   GENOME RESEARCH

Decreased replication origin activity in temporal transition regions

(2009) Zeqiang Guan et al.   JOURNAL OF CELL BIOLOGY

Mammalian Rif1 contributes to replication stress survival and homology-directed repair

(2009) Sara B.C. Buonomo et al.   JOURNAL OF CELL BIOLOGY

The S-Phase Checkpoint Is Required To Respond to R-Loops Accumulated in THO Mutants

(2009) B. Gomez-Gonzalez et al.   MOLECULAR AND CELLULAR BIOLOGY

AID Produces DNA Double-Strand Breaks in Non-Ig Genes and Mature B Cell Lymphomas with Reciprocal Chromosome Translocations

(2009) Davide F. Robbiani et al.   MOLECULAR CELL

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

TERRA RNA Binding to TRF2 Facilitates Heterochromatin Formation and ORC Recruitment at Telomeres

(2009) Zhong Deng et al.   MOLECULAR CELL

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

(2009) R. S. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism and Regulation of Class Switch Recombination

(2008) Janet Stavnezer et al.   Annual Review of Immunology

HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1

(2008) B. Miotto et al.   GENES & DEVELOPMENT

DNA replication timing of the human  -globin domain is controlled by histone modification at the origin

(2008) A. Goren et al.   GENES & DEVELOPMENT

Involvement of human ORC and TRF2 in pre-replication complex assembly at telomeres

(2008) Yasutoshi Tatsumi et al.   GENES TO CELLS

Global organization of replication time zones of the mouse genome

(2008) S. Farkash-Amar et al.   GENOME RESEARCH

Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins

(2008) A. W. Thomae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE