Neurovascular development and links to disease

Glioblastoma angiogenesis: VEGF resistance solutions and new strategies based on molecular mechanisms of tumor vessel formation

(2012) Shingo Takano   Brain Tumor Pathology

Semaphorin3A, Neuropilin-1, and PlexinA1 Are Required for Lymphatic Valve Formation

(2012) Karine Bouvrée et al.   CIRCULATION RESEARCH

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

Context-Dependent Proangiogenic Function of Bone Morphogenetic Protein Signaling Is Mediated by Disabled Homolog 2

(2012) Jun-Dae Kim et al.   DEVELOPMENTAL CELL

Death Receptors DR6 and TROY Regulate Brain Vascular Development

(2012) Stephen J. Tam et al.   DEVELOPMENTAL CELL

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Retinal Vascular Endothelial Cell Development As a Consequence of Impaired Integrin  V 8-Mediated Activation of Transforming Growth Factor- 

(2012) T. D. Arnold et al.   JOURNAL OF NEUROSCIENCE

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

Endothelial Expression of TGFβ Type II Receptor Is Required to Maintain Vascular Integrity during Postnatal Development of the Central Nervous System

(2012) Kathleen R. Allinson et al.   PLoS One

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

The astrocyte-expressed integrin  v 8 governs blood vessel sprouting in the developing retina

(2011) S. Hirota et al.   DEVELOPMENT

Arterial-venous network formation during brain vascularization involves hemodynamic regulation of chemokine signaling

(2011) J. Bussmann et al.   DEVELOPMENT

Coordinating cell behaviour during blood vessel formation

(2011) I. Geudens et al.   DEVELOPMENT

Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis

(2011) D. Stenzel et al.   DEVELOPMENT

Neurovascular development in the embryonic zebrafish hindbrain

(2011) Florian Ulrich et al.   DEVELOPMENTAL BIOLOGY

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch

(2011) Fangfei Li et al.   DEVELOPMENTAL CELL

Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism

(2011) J. Kim et al.   GENES & DEVELOPMENT

Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice

(2011) Yoko Fukushima et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development

(2011) Ha-Long Nguyen et al.   LABORATORY INVESTIGATION

Distinct signalling pathways regulate sprouting angiogenesis from the dorsal aorta and the axial vein

(2011) David M. Wiley et al.   NATURE CELL BIOLOGY

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures

(2011) Simin F. Rymo et al.   PLoS One

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

(2011) K. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier

(2011) M. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microarray analysis of retinal endothelial tip cells identifies CXCR4 as a mediator of tip cell morphology and branching

(2010) G. A. Strasser et al.   BLOOD

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry

(2010) S. El Hallani et al.   BRAIN

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease

(2010) D. A. McDonald et al.   HUMAN MOLECULAR GENETICS

Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity

(2010) Rebecca A. Stockton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Pericytes are required for blood–brain barrier integrity during embryogenesis

(2010) Richard Daneman et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature

(2010) Andrew Scott et al.   PLoS One

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Neuropilin, you gotta let me know

(2010) Quenten Schwarz et al.   Cell Adhesion & Migration

Cell adhesion and signaling networks in brain neurovascular units

(2009) Joseph H McCarty   CURRENT OPINION IN HEMATOLOGY

Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube

(2009) J. M. James et al.   DEVELOPMENT

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neurovascular link in health and disease: an update

(2009) Inmaculada Segura et al.   TRENDS IN MOLECULAR MEDICINE

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor

(2008) L. M. Acevedo et al.   BLOOD

Compartment-specific transcription factors orchestrate angiogenesis gradients in the embryonic brain

(2008) Anju Vasudevan et al.   NATURE NEUROSCIENCE

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE